research topics in clinical biochemistry

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research topics in clinical biochemistry

Articles making an impact in Biochemistry and Molecular & Cell Biology

Browse specially curated selections of high-impact research from the biochemistry and molecular & cell biology journals published by Oxford University Press. The collections feature a mixture of:

The most read articles published in the first half of 2022.

Untapped research sections containing articles selected by Editors-in-Chief as worthy of more attention from the research community.

And most read, most cited and most discussed articles published in 2020 and 2021.

All articles are freely available for you to read, download, and enjoy.

Analytical Chemistry

High-impact research from chemical senses.

Chemical Senses publishes on all aspects of chemoreception in both humans and animals, including techniques and the development and application of new methods for investigating chemoreception and chemosensory structures.

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The Journal of AOAC INTERNATIONAL publishes original research and studies covering the latest in basic and applied research in analytical sciences related to foods, drugs, agriculture, the environment, and more.

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Journal of Chromatographic Science presents the latest practice and theory of chromatography, focusing on papers describing practical and preparative applications and analytical methods for a broad range of laboratory work.

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Bioscience, Biotechnology, and Biochemistry publishes research providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters.

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Function publishes research that contributes to defining the mechanistic basis of living systems in health and disease and extending the physiological understanding of biological function across basic, translational, and clinical sciences.

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Glycobiology provides a unique forum dedicated to research into the biological functions of glycans, including glycoproteins, glycolipids, proteoglycans and free oligosaccharides, and on proteins that specifically interact with glycans.

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Integrative Biology publishes innovative interdisciplinary research in molecular and cellular life sciences, at the interface of bioscience, bioengineering, and biotechnology.

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The Journal of Biochemistry publishes the results of original research in the fields of biochemistry, molecular biology, cell, and biotechnology.

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Metallomics publishes cutting-edge investigation that elucidate the identification, distribution, dynamics, role and impact of metals and metalloids in biological systems.

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Antibody Therapeutics provides a forum for the publication of the latest advances and challenges in the discovery, research, development, manufacturing, and methodology of therapeutic antibodies for the global scientific community.

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Biology of Reproduction publishes original research on a broad range of topics as well as reviews on topics of current importance or controversy field of reproductive biology.

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Briefings in Functional Genomics is an international forum reviewing the use, development and exploitation of functional genomic approaches in all areas of biological research.

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DNA Research covers sequencing and characterization of genomes, analysis of gene function and useful techniques, equipment, and computer algorithms and their applications tostructural and functional analysis of genes and genomes.

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NAR Cancer is a fully open access journal publishing original research and Survey and Summary articles at the intersection of the nucleic acids research and cancer fields.

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Biochemistry articles within Nature

Article | 13 May 2024

Plasmid targeting and destruction by the DdmDE bacterial defence system

Jack P. K. Bravo
, Delisa A. Ramos
& David W. Taylor

Article | 08 May 2024

Structural mechanism of angiogenin activation by the ribosome

Anna B. Loveland
, Cha San Koh
& Andrei A. Korostelev

Nature Podcast | 08 May 2024

Alphafold 3.0: the AI protein predictor gets an upgrade

Deepmind’s protein-structure predictor adds other molecules to the mix, and a big step towards a ‘nuclear clock’.

Benjamin Thompson
& Nick Petrić Howe

Technology Feature | 08 May 2024

Powerful ‘nanopore’ DNA sequencing method tackles proteins too

Latest methods bring the speed, portability, and long read lengths of nanopore sequencing to proteomics.

Caroline Seydel

News & Views | 08 May 2024

Vaccine-enhancing plant extract could be mass produced in yeast

The Chilean soapbark tree is the source of QS-21 — a valuable but hard-to-obtain vaccine additive. Yeast strains engineered to express all components of the QS-21 biosynthetic pathway provide an alternative route to this therapeutic.

Article 08 May 2024 | Open Access

The intrinsic substrate specificity of the human tyrosine kinome

An atlas of the substrate specificities for the human tyrosine kinome reveals diversity of motif specificities and enables identification of kinase–substrate relationships and kinase regulation in phosphoproteomics experiments.

Tomer M. Yaron-Barir
, Brian A. Joughin
& Jared L. Johnson

Boron catalysis in a designer enzyme

A completely genetically encoded boronic-acid-containing designer enzyme was created and characterized using X-ray crystallography, high-resolution mass spectrometry and 11 B NMR spectroscopy, allowing chemistry that is unknown in nature and currently not possible with small-molecule catalysts.

Lars Longwitz
, Reuben B. Leveson-Gower
& Gerard Roelfes

Ligand cross-feeding resolves bacterial vitamin B 12 auxotrophies

Two species of auxotrophic marine bacteria are shown to share precursors to synthesize the essential cofactor vitamin B 12 , and such ligand cross-feeding may be a common phenomenon in the ocean and other ecosystems.

Gerrit Wienhausen
, Cristina Moraru
& Meinhard Simon

Article | 01 May 2024

Structural and molecular basis of choline uptake into the brain by FLVCR2

FLVCR2 is expressed in the blood–brain barrier of mouse and human, and is the major mediator of choline uptake into the brain.

Rosemary J. Cater
, Dibyanti Mukherjee
& Filippo Mancia

Stereoselective amino acid synthesis by photobiocatalytic oxidative coupling

We report on the oxidative cross-coupling of organoboron reagents and amino acids via pyridoxal biocatalysis to produce non-canonical amino acids, uncovering stereoselective, intermolecular free-radical transformations.

Tian-Ci Wang
, Binh Khanh Mai
& Yang Yang

News | 24 April 2024

First glowing animals lit up the oceans half a billion years ago

Family tree of ‘octocorals’ pushes origin of bioluminescence back to 540 million years ago, when the first animal species developed eyes.

Freda Kreier

Research Briefing | 24 April 2024

A chemical method for selective labelling of the key amino acid tryptophan

A broadly applicable method allows selective, rapid and efficient chemical modification of the side chain of tryptophan amino acids in proteins. This platform enables systematic, proteome-wide identification of tryptophan residues, which can form a bond (called cation–π interaction) with positively charged molecules. Such interactions are key in many biochemical processes, including protein-mediated phase separation.

Article 24 April 2024 | Open Access

Mechanism of single-stranded DNA annealing by RAD52–RPA complex

Single-stranded DNA annealing is driven by RAD52 open rings in association with RPA.

Chih-Chao Liang
, Luke A. Greenhough
& Stephen C. West

Article | 17 April 2024

Stepwise activation of a metabotropic glutamate receptor

We propose a model for a sequential, multistep activation mechanism of metabotropic glutamate receptor subtype 5, including a series of structures in lipid nanodiscs, from inactive to fully active, with agonist-bound intermediate states.

Kaavya Krishna Kumar
, Haoqing Wang
& Brian K. Kobilka

Article 17 April 2024 | Open Access

Streptomyces umbrella toxin particles block hyphal growth of competing species

Streptomyces are discovered to produce antibacterial protein complexes that selectively inhibit the hyphal growth of related species, a function distinct from that of the small-molecule antibiotics they are known for.

Qinqin Zhao
, Savannah Bertolli
& Joseph D. Mougous

Promiscuous G-protein activation by the calcium-sensing receptor

Structures of the human calcium-sensing receptor can be bound into complex with G proteins from three different Gα subtypes while maintaining G-protein-binding specificity.

, Jinseo Park
& Qing R. Fan

Article 10 April 2024 | Open Access

Emergence of fractal geometries in the evolution of a metabolic enzyme

Citrate synthase from the cyanobacterium Synechococcus elongatus is shown to self-assemble into Sierpiński triangles, a finding that opens up the possibility that other naturally occurring molecular-scale fractals exist.

Franziska L. Sendker
, Yat Kei Lo
& Georg K. A. Hochberg

Article | 10 April 2024

Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids

Glucocorticoids reprogram the mitochondrial metabolism of macrophages, resulting in increased and sustained production of the anti-inflammatory metabolite itaconate and, as a consequence, inhibition of the inflammatory response.

Jean-Philippe Auger
, Max Zimmermann
& Gerhard Krönke

Article 03 April 2024 | Open Access

Structural basis of Integrator-dependent RNA polymerase II termination

Cryo-electron microscopy structures of the human Integrator complex in three different functional states shed light on how Integrator terminates RNA polymerase II (Pol II) transcription by disengaging Pol II from the DNA template.

Isaac Fianu
, Moritz Ochmann
& Patrick Cramer

Molecular insights into capsular polysaccharide secretion

An ensemble of cryo-electron microscopy structures of the KpsMT ABC transporter in complex with the KpsE co-polymerase and a glycolipid substrate reveal how capsular polysaccharides are recognized and translocated across bacterial cell membranes.

Jeremi Kuklewicz
& Jochen Zimmer

Article 20 March 2024 | Open Access

Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site

Cryo-electron microscopy structures of human RAD51 in complex with the nucleosome show that RAD51 can adopt two conformations—rings and filaments—and reveal how RAD51 binds to the nucleosome through its N-terminal lobe domain.

Takuro Shioi
, Suguru Hatazawa
& Hitoshi Kurumizaka

Where I Work | 18 March 2024

I study small organisms to tackle big climate problems

Marine biologist Gabriel Renato Castro cultivates compounds from cyanobacteria to support agriculture and the environment.

Nikki Forrester

Article | 18 March 2024

Structural insights into vesicular monoamine storage and drug interactions

Monoamines and neurotoxicants share a binding pocket in VMAT1 featuring polar sites for specificity and a wrist-and-fist shape for versatility, and monoamine enrichment in storage vesicles arises from dominant import via favoured lumenal-open transition of VMAT1 and protonation-precluded binding during its cytoplasmic-open transition.

, Huaping Chen
& Weikai Li

Article | 13 March 2024

Time-resolved cryo-EM of G-protein activation by a GPCR

Time-resolved cryo-EM is used to capture structural transitions during G-protein activation stimulated by a G-protein-coupled receptor.

Makaía M. Papasergi-Scott
, Guillermo Pérez-Hernández
& Georgios Skiniotis

Article 13 March 2024 | Open Access

Substrate-induced condensation activates plant TIR domain proteins

Binding of the substrates NAD + and ATP to the plant Toll/interleukin-1 receptor (TIR) domain proteins induces phase separation and, thereby, activation of TIR enzymatic and immune signalling activity.

& Jijie Chai

Research Briefing | 11 March 2024

Dysregulated cellular stress management becomes a source of stress

Stress responses protect cells from harmful conditions, but once the stress has resolved, these responses must be actively turned off to avoid cell damage that might lead to the development of neurodegenerative disease.

Matters Arising | 06 March 2024

Model uncertainty obscures major driver of soil carbon

, Rose Z. Abramoff
& Daniel S. Goll

Review Article | 28 February 2024

Ion and lipid orchestration of secondary active transport

This Review describes the various mechanisms of ion-coupled transport across membranes and how the activities of transporter proteins are modulated by the composition of the lipid bilayer.

& Olga Boudker

Article 28 February 2024 | Open Access

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

The ubiquitin proteasomal system degrades nuclear cGAS in cycling cells.

Pengbiao Xu
& Andrea Ablasser

Article | 28 February 2024

CST–polymerase α-primase solves a second telomere end-replication problem

Incomplete duplication of the C-rich telomeric repeat strand by lagging-strand DNA synthesis is counteracted by DNA synthesis mediated by CST–polymerase α-primase.

Hiroyuki Takai
, Valentina Aria
& Titia de Lange

Technology Feature | 27 February 2024

How phase separation is revolutionizing biology

Imaging and molecular manipulation reveal how biomolecular condensates form and offer clues to the role of phase separation in health and disease.

Elie Dolgin

Article 21 February 2024 | Open Access

The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons

Attachment of the ubiquitin-like modifier UFM1 to 60S ribosomes has a critical function in the release and recycling of stalled or terminated ribosomes from the endoplasmic reticulum membrane.

Linda Makhlouf
, Joshua J. Peter
& Yogesh Kulathu

IL-10 constrains sphingolipid metabolism to limit inflammation

IL-10 exerts its anti-inflammatory activity in macrophages by increasing the expression of enzymes that promote fatty acid desaturation and downstream regulation of the transcription factor REL.

Autumn G. York
, Mathias H. Skadow
& Richard A. Flavell

Article | 21 February 2024

Activation of Thoeris antiviral system via SIR2 effector filament assembly

A study reports that the Theoris anti-phage defence system is activated through helical filament assembly of the ThsA effector and details the activation mechanism.

Giedre Tamulaitiene
, Dziugas Sabonis
& Virginijus Siksnys

Article | 07 February 2024

Allosteric modulation and G-protein selectivity of the Ca 2+ -sensing receptor

Cryo-electron microscopy structures of the human calcium-sensing receptor in complex with G i and G q proteins reveal how this receptor activates distinct G protein subtypes and how its function is modulated by a variety of ligands.

, Cheng-Guo Wu

Article 07 February 2024 | Open Access

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

We find that bile salt hydrolase N -acyltransferase activity can form bacterial bile acid amidates that are positively correlated with the colonization of gut bacteria that assist in the regulation of the bile acid metabolic network.

Bipin Rimal
, Stephanie L. Collins
& Andrew D. Patterson

Bile salt hydrolase acyltransferase activity expands bile acid diversity

Acyltransferase activity of the enzyme bile salt hydrolase is identified and shown to mediate microbial bile acid conjugation, diversifying the bile acid pool and expanding their role in gut physiology.

Douglas V. Guzior
, Maxwell Okros
& Robert A. Quinn

Structural basis of ribosomal 30S subunit degradation by RNase R

Cryo-electron microscopy structures of intermediates formed during the degradation of the 30S ribosomal unit shed light on how the 3′ to 5′ exonuclease ribonuclease R controls the ribosomal degradation process.

Lyudmila Dimitrova-Paternoga
, Sergo Kasvandik
& Helge Paternoga

Article | 31 January 2024

Conformational ensembles of the human intrinsically disordered proteome

A computational model generates conformational ensembles of 28,058 intrinsically disordered proteins and regions (IDRs) in the human proteome and sheds light on the relationship between sequence, conformational properties and functions of IDRs.

Giulio Tesei
, Anna Ida Trolle
& Kresten Lindorff-Larsen

Article 31 January 2024 | Open Access

Stress response silencing by an E3 ligase mutated in neurodegeneration

The E3 ligase SIFI is identified as a dedicated silencing factor of the integrated stress response, a finding that has implications for the development of therapeutics for neurodegenerative diseases caused by mitochondrial protein import stress.

Diane L. Haakonsen
, Michael Heider
& Michael Rapé

Article | 24 January 2024

Coordination of cohesin and DNA replication observed with purified proteins

We study the interplay between cohesin and replication by reconstituting a functional replisome using purified proteins, showing how cohesin initially responds to replication and providing a molecular model for the establishment of sister chromatid cohesion.

Yasuto Murayama
, Shizuko Endo
& Hiroyuki Araki

Article 24 January 2024 | Open Access

The HIV capsid mimics karyopherin engagement of FG-nucleoporins

Dissection of the nuclear pore complex provides a model in which the HIV capsid enters the nucleus through karyopherin mimicry, a mechanism likely to be conserved across other viruses.

C. F. Dickson
, S. Hertel
& D. A. Jacques

Article 17 January 2024 | Open Access

Alternative splicing of latrophilin-3 controls synapse formation

Latrophilin-3 organizes synapses through a convergent dual-pathway mechanism in which Gα s signalling is activated and phase-separated postsynaptic protein scaffolds are recruited.

, Chelsea DeLeon
& Thomas C. Südhof

News & Views | 15 January 2024

Snapshots of genetic copy-and-paste machinery in action

LINE-1 DNA elements self-duplicate, inserting the copy into new regions of the genome — a key process in chromosome evolution. Structures of the machinery that performs this process in humans are now reported.

Gael Cristofari

Article 10 January 2024 | Open Access

MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis

The double-strand break sensor MRE11 is identified as a pivotal mediator of cGAS activation in response to multiple types of DNA damage.

Min-Guk Cho
, Rashmi J. Kumar
& Gaorav P. Gupta

Article 20 December 2023 | Open Access

Cryo-EM structures of PP2A:B55–FAM122A and PP2A:B55–ARPP19

Cryo-electron microscopy structures of the PP2A:B55 holoenzyme bound to its inhibitors ARPP19 and FAM122A show distinct binding modes of the two inhibitors.

Sathish K. R. Padi
, Margaret R. Vos
& Wolfgang Peti

Research Briefing | 18 December 2023

Oceans can capture more carbon dioxide than previously thought

The strength of the biological carbon pump was estimated using direct measurements of nutrients collected over decades. The findings indicate that ocean waters can capture and store larger amounts of carbon dioxide than previously estimated. This might have implications for climate-change models.

Article | 18 December 2023

A light-driven enzymatic enantioselective radical acylation

Enzyme-bound ketyl radicals derived from thiamine diphosphate are selectively generated through single-electron oxidation by a photoexcited organic dye and shown to lead to enantioselective radical acylation reactions.

Yuanyuan Xu
, Hongwei Chen
& Xiaoqiang Huang

Article 18 December 2023 | Open Access

De novo design of high-affinity binders of bioactive helical peptides

A study describes a direct computational approach without experimental optimization to design high-affinity proteins that bind small helical peptides.

Susana Vázquez Torres
, Philip J. Y. Leung
& David Baker

Article 14 December 2023 | Open Access

Template and target-site recognition by human LINE-1 in retrotransposition

Human LINE-1 ORF2p relies on upstream single-stranded target DNA to position the adjacent duplex in the endonuclease active site for nicking of the longer DNA strand, with a single nick generating a staggered DNA break.

Akanksha Thawani
, Alfredo Jose Florez Ariza
& Kathleen Collins

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Biochemistry Research for Students (Preparation and Ideas)

In most universities, a senior biochemistry research project is a must before you complete your biochemistry coursework. But that’s not all. At various points of your study, whether studying pure biochemistry or related courses like molecular biology, examiners will require you to write a biochemistry research essay, term paper, or thesis.

To show you are focused on your studies and understand biochemistry better, come up with interesting biochemistry topics, and structure your work perfectly. A biochemistry research paper should capture the examiner’s interest and allow you to prove the content extensively. Ensure the topic is also manageable and compliant with your research environment.

With that, you will get things done in the nick of time without compromising on the quality of your work. No examiner will have a problem with a research essay, assignment, or dissertation that has sense and follows the academic rules. In fact, well-proposed biochemistry research ideas attract lots of funding, and you might be lucky to have a breakthrough in your early career.

Most of the biochemistry topics for research ideas revolve around:

Structure and functioning of various body cells.
Biochemical reactions in humans and plants.
Heredity in living organisms.
Pharmacology and pharmacognosy.
DNA, RNA, and proteins in plants and animals.
Molecular nature of all the bio-molecules.
Micro-organisms.
Enzymes, bioenergetics and thermodynamics.

Interesting Topics in Biochemistry

Many students struggle to think of interesting topics for their courses, and that’s not exceptional in biochemistry. You’ll notice that most of the topics’ interests depend on what a student is passionate about. Here are some interesting biochemistry topics to check out:

Understanding the role of microbial itaconic acid production during fungi synthesis.
Membrane biology and ion transport process in the innate immune response.
Inhibition of sprouty2 in periodontal ligament cells and their extensive biological effects.
Peptide and protein structure in membranes: what role do they play in cell membrane formation?
Understanding the evolution of microbial infections and related effects in the existing surroundings.
The role of B cell receptors in infections and vaccine production.
Human health and bacteriophages of different kinds: How the two correlate.
AN analysis of biofilm formation: From therapeutics to molecular mechanisms, and everything in between.
Close comparison and analysis of nucleic acids (DNA and RNA) in mice and humans.
Understanding the relationship between NDR1/2 and mob-based proteins in cell cycle damage signaling.

Biochemistry Topics for Presentation

If you have an incoming presentation, you must pick your topics carefully. Presentations can be a challenge at times. While some individuals in the audience might not have extensive knowledge of the subject, you must have a detailed understanding of your topic to score better. Here are some of the best biochemistry presentation topics:

A stepwise understanding of the human immune system and the role played in cell regeneration during an infection.
A deep analysis of different plant pathologies with a focus on phytochemicals present and their roles.
A look at the biochemical process that leads to apoptosis in patients with stage IV breast cancer.
Understanding the close relationship in terms of practice in biochemistry and pathological psychiatry.
Understanding different types of polymorphism and how they affect the DNA of human beings.
How hormone formation in children is dependent on the environment and child’s health condition.
The role of human cloning in the production and consumption of various types of vaccines.
The relationship between human molecular adaptation and diet: Does diet play a role?
Understanding how biological processes are dependent on the functioning of the human central nervous system.
Comparison of mice and human circulatory system: Functioning, susceptibility, capacity, and features.

Hot Topics in Biochemistry

Biochemistry has a vast range of hot topics to explore. Since you might not have the chance to write about everything concerning the course, our suggestions narrow your search efforts. Take a look at some of the hot topics in biochemistry below:

How professional breast cancer detection and screening is changing the lives of university students.
The revolution of tissue clearing techniques for optical microscopy as witnessed for the past five years.
Clinical features of acute copper sulfate poisoning and role of biochemistry in management interventions.
The role of malt in various beer quality and effects on beer stability: Industrial biochemistry of beer making.
Solid and liquid-state fermentation in the production of biochemical supplements for human and animal consumption.
Controlled mixed fermentation as witnessed in pharmaceutical product making over the years and the new normal.
The roles of polyphosphate on the virulence of Erwina caratovora bacteria in a range of plants.
An extensive comparison of the significant aspects of biochemical studies at the college and university level in the last half-century.
Analysis of molecular genetics and its close relationship with muscular dystrophy in men and women.
Supporting evidence on children’s growth and development in countries using genetically modified organisms feeding products.

Project Topics for Biochemistry

Would you like to write a project topic on biochemistry that might change the world? Then you need to work on something that excites and allows you to develop a deep interest in your course. Project topics in biochemistry are not complicated, provided you are willing to challenge yourself and learn. Here are some of them for inspiration.

Breast cancer and obesity in women of younger age; the clinical analysis from a biochemistry perspective.
Understanding biochemistry of biomolecules and amino acids and their clinical application in drugs and supplement making.
The future of artificial intelligence and its relevance to biochemistry: The gradual changes witnessed over the last four years.
Understanding stability of 81 analytes in human blood, serum, and plasma during diagnosis in clinical biochemistry set up.
History of clinical biochemistry and why it matters to modern human medicine.
Transforming the liver function tests with new biochemistry diagnostic simple tools; how to make things result-oriented
The role of clinical biochemistry in helping us understand the human immune system.
Understanding and redefining the role of the human bones: How biochemistry transforms the narrative on human bones predisposition.
A detailed clinical biochemistry analysis during pregnancy: tests associated with pregnancies and early child development.
The rise of clinical biochemistry in the present times, from introductory chemistry of life to foundation on infections and disease interventions.

Biochemistry Research Topics for Undergraduates

Choosing an ideal biochemistry research topic as an undergraduate student taking biochemistry at the college or university level can be a complex process for you. We have ten topics that you can choose to base your research on. Let’s take a look at the best biochemistry research topics for undergraduates’ topics:

Microbial food spoilage, resulting disorders, and the best biochemistry control approach to leverage.
Comparative examination of serum calcium level among males using biochemistry testing techniques.
Phytochemical analysis of specific tomato products available in the market for public health safety.
The oxidative stress status of mice fed on oil bean seed meal and show the same applies to biochemical processes in humans.
How biochemical production of top-quality bar soaps compares with most detergents you see in the market today.
What are the health dangers associated with lead in water consumed in most universities?
Critical analysis of Pterocarpus mildbreadii (oha) seed: A detailed phytochemical review.
How to use biochemistry synthesis pathways to create a compound that prevents reactions from taking place.
Evaluation of bacteria components produced using pure starter culture in a biochemistry culture laboratory setup.
What’s the bacteriological quality of meat products in most butcheries in town?

MCAT Biochemistry Topics

You must always take your Medical College Admission Test seriously if you want to get a chance to join your favorite medical school. The test gives you a chance to show that you’re ready to handle the program and maintain an excellent performance throughout. Since you’re looking to get admission, here are the best MCAT biochemistry topics you might want to consider:

Application of mathematical concepts and techniques in biochemistry and their role in general medicine.
How catabolic and anabolic enzyme reactions contribute to cell functionality: Data-based enzymatic reasoning and graphical representations.
Chemical and physical foundations of biological systems that help us appreciate human anatomy.
How critical analysis and reasoning skills acquired in biochemistry play a significant role in medical schools.
How multiple biosynthetic pathways like the citric acid cycle and glycolysis influence human health and functionality?
A look at the psychological, social, and biological foundations of behaviors in relation to human biomolecules.
Understanding the biochemical basis of human psychology.
Critical analysis of biochemistry study areas and how they transform medicine.
Understanding the relationship between Omega-3 fatty acids and blood glucose levels in adults.
How fruits and vegetables regulate blood sugar in patients with diabetes: Biochemical pathways and mechanisms.

Current Biochemistry Topics

There’s no better way to show that you’re a sharp and informed student than knowing what’s happening in the biochemistry academic and practical world. Knowing current biochemistry topics is one way to showcase your awareness. We have compiled this list to help you create a top-quality research paper. Here we go!

How do hydrocarbons in amino acids impact biochemical reactions when the human body gets subjected to medication?
Why biochemistry research is promising when it comes to developing the best methods of initiating new medications to patients.
Understanding the covid-19 vaccines chemical properties and reactions in adult men and women.
Explaining various reactions to vaccines in the trial stage and how biochemistry has helped achieve the desired vaccines effectiveness.
What are the roles of biochemically developed rotavirus vaccines in acute gastroenteritis among infants?
How to best preserve plant extracts meant for experiments in biochemistry? Plant biochemistry and biotechnology research.
The relationship between different types of brain cancer with radiation exposure and genetics.
Understanding measles among infants and the most effective biochemistry based vaccine remedy
The role of biochemistry in governing cell motility during various stages of development.
The role of microscopy, scanning, and serum medical examinations in biochemistry.

Get Biochemistry Writing Help

Are you confused about the best biochemistry project topics to work on? The above topics are an ideal starting point. But completing your assignment with the huge workload that comes with biochemistry is a significant problem. Worry not because you can now get biochemistry writing help from us.

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171 Original Biochemistry Research Topics

Are you a student searching for original and captivating biochemistry research topics? Look no further! In this article, we present you with a comprehensive list of 171 free, unique, and thought-provoking biochemistry research topics. Whether you’re working on a thesis, dissertation, or class assignment, this list offers a wide range of interesting ideas to explore.

Additionally, we provide a short guide on how to do research for a biochemistry paper quickly, equipping you with valuable tips and strategies to streamline your writing process. This guide will help you navigate the complexities of biochemistry writing, allowing you to produce a high-quality paper in no time. Get ready to embark on an exciting journey of scientific exploration and academic success!

What Is Biochemistry?

Biochemistry is the scientific discipline that explores the chemical processes and molecules that occur within living organisms. It focuses on the study of biological macromolecules, such as proteins, nucleic acids, carbohydrates, and lipids, and their roles in cellular functions, metabolism and the overall functioning of living systems.

How To Write An Excellent Biochemistry Paper

Before we get to the biochemistry research topics, we want to make sure you know how to conduct effective research for your paper. Make sure you follow these tips and tricks:

Define your research question: Clearly state the main objective or question you want to address in your biochemistry paper.
Conduct a literature review: Review relevant scientific literature to understand existing knowledge and identify research gaps.
Utilize reputable sources: Gather information from trustworthy academic databases, peer-reviewed journals and reliable scientific websites.
Take organized notes: Record important findings, references and evidence while reading, organizing them by subtopics or themes.
Develop a research plan: Create a timeline and outline tasks, such as experiments or data collection, to stay organized.
Analyze and interpret data: Carefully examine collected data and draw meaningful conclusions that support your research question.

The Latest Biochemistry Research Topics

Stay up-to-date with cutting-edge advancements in biochemistry research with these engaging and thought-provoking topics. Check out our latest biochemistry research topics:

CRISPR-Cas9 for precise genome editing in biochemistry
Epigenetics in cancer development and progression
Protein misfolding and neurodegenerative diseases
Nanotechnology in targeted drug delivery systems
Gut Microbiome and human health
Biochemical pathways in ageing and longevity
Environmental pollutants and human metabolism
Non-coding RNAs in gene regulation and disease
Stem cells in regenerative medicine
Metabolic pathways and personalized medicine
Plant responses to environmental stress and climate change
Mitochondrial bioenergetics and metabolic diseases
CRISPR-based gene therapies for inherited disorders

Amazing Biochemistry Thesis Topic Ideas

Dive into the fascinating world of biochemistry with these captivating thesis topics that will captivate readers and showcase your knowledge. Here are our amazing biochemistry thesis topic ideas:

The role of biochemistry in personalized nutrition
Exploring the biochemical basis of addiction: Neurotransmitters and reward pathways
Biochemical mechanisms underlying the benefits of exercise on mental health
The impact of gut microbiota on brain function
Biochemical processes in the treatment of autoimmune diseases
Investigating the biochemical basis of food allergies
The biochemistry of taste: Understanding the molecular basis of flavors
Unraveling the biochemical mechanisms of memory formation
Biochemical approaches to combating antibiotic resistance in bacteria
Understanding the effects of environmental toxins on humans
Investigating the biochemistry of sleep
Biochemical processes underlying the aging of the skin
The role of biochemistry in developing sustainable solutions for food production

Easy Biochemistry Topics

Simplify complex biochemistry concepts with these accessible topics that make learning and presenting information a breeze. Choose one of our easy biochemistry topics:

Enzyme kinetics: Understanding the rate of biochemical reactions
Protein structure and function: Exploring the building blocks of life
Metabolism: Unraveling the chemical processes that sustain living organisms
DNA replication: Investigating the mechanisms of genetic information duplication
Cellular respiration: Examining how cells produce energy from nutrients
Lipid metabolism: Understanding the breakdown and synthesis of fats
Carbohydrate metabolism: Exploring the processing of sugars in living organisms
Enzyme regulation: Studying how enzymes are controlled and regulated in cells
Hormones and signaling: Investigating chemical messengers in biological communication
Biochemical basis of diseases: Exploring the molecular mechanisms of illnesses
Vitamins and minerals: Understanding the roles of essential nutrients in the body
Biochemical analysis techniques: Examining methods used to study biological molecules
Drug metabolism: Investigating how the body processes and eliminates medications
Molecular genetics: Exploring the relationship between genes and biochemical processes
Biochemical pathways: Mapping out the interconnected reactions that occur in cells

Awesome Topics In Biochemistry

Explore the wonders of biochemistry through these awesome topics in biochemistry that showcase the remarkable discoveries and breakthroughs in the field:

Unraveling protein folding: Understanding three-dimensional structure formation
Personalized medicine: Tailoring treatments based on individual profiles
Decoding neurodegenerative diseases: Molecular mechanisms in Alzheimer’s
CRISPR-Cas9 revolution: Gene editing’s impact on biochemistry
Exploring plant defense biochemistry: Strategies against pathogens
Combating antibiotic resistance: Innovative biochemistry approaches
Gut-brain axis: Linking microbiota and brain function
Synthetic biology’s potential: Novel biochemical design
Cellular signaling: Decoding intracellular communication pathways
Metabolic disorders: Unraveling molecular causes of diabetes
Nanotechnology in biochemistry: Advancements in biomedical applications
Photosynthesis biochemistry: Sunlight to plant energy conversion
Protein-protein interactions: Analyzing dynamic protein connections

Advanced Biochemistry Topics

Challenge yourself with these sophisticated topics that delve into complex biochemistry theories and advancements. Check out our unique advanced biochemistry topics:

Exploring the biochemical intricacies of gene regulation and epigenetics
Biochemical mechanisms of cellular signal transduction
Uncovering the role of biochemistry in stem cell biology
Investigating the biochemical basis of neurodegenerative disorders like Parkinson’s
Biochemical processes underlying the progression of cancer
The role of biochemistry in understanding metabolic disorders
Probing the biochemical basis of pharmacokinetics
Investigating the molecular mechanisms of protein folding diseases
Understanding the biochemistry of lipid metabolism
Exploring the biochemical basis of plant-microbe symbiosis
Investigating the role of biochemistry in DNA repair mechanisms
Unraveling the biochemistry of environmental pollutants
Exploring the biochemical processes involved in cellular senescence

Biochemistry Science Topics

Stand out at your science fair with these innovative biochemistry science fair project ideas that combine biochemistry principles with hands-on experimentation:

pH’s effect on enzyme activity
Temperature’s impact on protein denaturation
Sugar concentration and yeast fermentation
Antioxidant properties of natural compounds
Nutrient effects on plant growth
Preservatives preventing food spoilage
Light wavelengths and photosynthesis
Vitamin C content in fruits and vegetables
Antibiotics’ impact on bacterial growth
Enzymatic browning in fruits and vegetables
Soil types and nutrient availability for plants
Pollutant effects on aquatic biomarkers
Properties of natural and synthetic sweeteners
Detergents breaking down grease and oil

Cool Topics In Biochemistry

Discover the coolest and most intriguing aspects of biochemistry with these topics that will impress and engage your audience. Pick one of our cool topics in biochemistry:

CRISPR-Cas9: Targeted gene editing in biochemistry
Biochemistry of Psychedelics and brain effects
Biochemistry in extreme environments and life potential
Extracellular vesicles: Intercellular communication mechanisms
Venomous animals’ biochemistry and therapeutic potential
Taste perception biochemistry and food preferences
Biochemical basis of circadian rhythms and regulation
Biochemistry’s role in understanding life origins
Plant defense biochemistry against pathogens and pests
Natural products’ biochemistry for drug development
Human microbiome biochemistry and health influence
Drug metabolism: Biochemical mechanisms and interactions
Neurotransmitters’ biochemistry and brain function

Good Biochemistry Topics For Research

Embark on a research journey with these high-quality topics that offer ample opportunities for exploration and discovery in the field of biochemistry. These good biochemistry topics for research are original or you can delegate your work and use medical thesis writing services :

Investigating the role of oxidative stress in age-related diseases
Exploring the biochemistry of cancer metabolism
Analyzing the biochemistry of drug delivery systems for improved efficacy
Studying the role of epigenetics in gene expression and disease development
Investigating the biochemical mechanisms of protein misfolding
Understanding the biochemistry of cellular signaling pathways
Exploring the biochemistry of lipid metabolism in metabolic disorders
Investigating the biochemistry of DNA repair mechanisms and genome stability
Analyzing the role of biochemistry in understanding the gut microbiome
Studying the biochemical basis of neurotransmitter imbalances in psychiatric disorders
Investigating the biochemistry of viral-host interactions
Exploring the biochemical mechanisms underlying antibiotic resistance
Analyzing the biochemistry of plant secondary metabolites

Interesting Biochemistry Topics

Capture attention and spark curiosity with these thought-provoking topics that explore fascinating aspects of biochemistry. All our interesting biochemistry topics are free to use:

DNA nanotechnology: Building structures on a molecular scale
Enzyme engineering: Designing catalysts for specific applications
Metabolic profiling: Analyzing biochemical fingerprints for disease diagnosis
Nanozymes: Harnessing nanomaterials with enzyme-like properties
Biomolecular simulations: Modeling dynamic molecular behaviors using a computer
Bioinformatics: Using computational tools to analyze biological data
Synthetic biology: Designing and creating novel biological systems
Lipidomics: Investigating the diverse roles of lipids in cellular processes
RNA interference: Silencing gene expression for targeted therapies
Glycobiology: Studying the function of carbohydrates in biological systems
Chemical biology: Bridging Chemistry and biology for innovative research
Metabolomics: Profiling small molecules to understand cellular metabolism

Biochemistry Research Topics For Undergraduates

Delve into research as an undergraduate student with these accessible and meaningful biochemistry research topics for undergraduates that align with your academic level:

Analyzing the effects of antioxidants on oxidative stress in cellular models.
Investigating the role of specific enzymes in metabolic pathways.
Studying the biochemical basis of drug interactions and their impact on therapeutic outcomes.
Examining the effects of environmental pollutants on cellular health and function.
Investigating the biochemistry of plant compounds with potential antimicrobial properties.
Exploring the biochemical mechanisms underlying the development of antibiotic resistance.
Analyzing the effects of pH and temperature on enzyme activity.
Investigating the biochemistry of DNA damage and repair mechanisms.
Studying the role of specific proteins in cellular signaling pathways.
Analyzing the biochemical properties of lipids and their role in cellular processes.
Investigating the biochemistry of protein synthesis and post-translational modifications.
Studying the effects of nutritional factors on gene expression and metabolism.
Analyzing the biochemistry of neurotransmitters and their role in neuronal communication.

Hot Biochemistry Topics

Explore the trending and emerging topics in biochemistry that are shaping the future of the field. Select one of our hot biochemistry topics and start writing your paper in minutes:

Precision medicine: Personalized treatments based on biochemical profiles
Immunotherapy: Harnessing the immune system to combat diseases
Epigenetics: Exploring the impact of gene expression regulation on health
Metabolomics: Uncovering the metabolic signatures associated with various conditions
Single-cell analysis: Examining the biochemistry of individual cells
Proteomics: Studying the complete set of proteins in a cell or organism
Bioinformatics: Integrating computational methods to analyze complex biological data
Synthetic biology: Designing novel biological systems with engineered functions
Drug discovery and development: Exploring innovative approaches
Structural biology: Investigating the three-dimensional structures of biomolecules
Cancer metabolism: Understanding the metabolic alterations in cancer cells
Bioengineered organs: Advancements in creating functional and transplantable organs
Metagenomics: Exploring the genetic potential and functional diversity of microbial communities

Popular Ideas For A Biochemistry Paper

Stand out among your peers with these popular and widely-discussed popular ideas for a biochemistry paper that offer ample research material for a compelling essay:

Antioxidants and oxidative stress-related diseases
Drug resistance in cancer cells: Biochemical mechanisms
Nutrition, gene expression, and metabolic health
Biochemistry of neurodegenerative disorders and therapies
Protein structure’s role in drug design and development
Biochemistry of aging and anti-aging strategies
Biochemical pathways and cellular apoptosis in diseases
The link between biochemistry and mental health
DNA repair mechanisms and genomic stability
Biochemistry of microbial biodegradation for environmental cleanup
Plant defense mechanisms against pathogens: Biochemical insights
Environmental toxins and human health: Biochemical perspectives
Biochemical approaches to combat antibiotic resistance

Current Biochemistry Research Topics

Stay current and informed with our current biochemistry research topics. They reflect the latest breakthroughs and ongoing research in the dynamic field of biochemistry:

Single-cell omics: Unraveling cellular heterogeneity at the molecular level.
RNA modifications: Investigating their role in gene expression regulation.
Metabolic reprogramming in cancer: Understanding the therapeutic implications.
Protein engineering and design: Creating novel biomolecules with enhanced functions.
Artificial intelligence in biochemistry: Utilizing machine learning for prediction.
Structural biology: Unveiling the 3D structures of complex biomolecules for drug discovery.
Biochemical profiling of the human microbiome and its impact on health and disease.
Nanomedicine: Designing and optimizing nanoscale drug delivery systems for targeted therapies.
Immunometabolism: Studying the intricate relationship between metabolism and immune response.
Epitranscriptomics: Investigating the role of RNA modifications in cellular processes.
Metabolomics-driven precision medicine: Applying metabolic profiling for personalized treatments.
Biochemical mechanisms of aging: Exploring molecular pathways and interventions for healthy aging.
Exploring the biochemistry of plant-based biofuels for sustainable energy production.

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How do I choose a topic for my biochemistry paper?

Start by exploring current research trends, identifying areas of interest, and brainstorming potential topics. Consult with your instructor or supervisor to ensure your chosen topic aligns with the scope of your assignment.

How can I ensure the accuracy and reliability of my research in a biochemistry paper?

To maintain high-quality standards, conduct thorough literature reviews, use reputable sources, perform rigorous experiments or analyses, and ensure proper controls are in place. Consult with experts or your supervisor for guidance if needed.

How do I balance technical details and clarity in my biochemistry paper?

Aim to present technical information in a concise and understandable manner. Define any specialized terms, provide necessary background information, and use illustrative examples to make complex concepts more accessible to your readers.

How can I make my biochemistry paper more engaging and readable?

Use clear and concise language, provide relevant examples or case studies, incorporate visuals like figures or tables to illustrate data, and consider using subheadings to enhance the organization and flow of your paper.

Make PhD experience your own

Essentials of medical biochemistry: With clinical cases

Jyotsna kailashiya.

Department of Biochemistry Institute of Medical Sciences Banaras Hindu University Varanasi 221 005, Uttar Pradesh, India

Avijit Mukherjee

Debabrata dash.

N.V Bhagavan, Ha Chung-Eun, editors. 2015. 2nd edition. Academic Press, Elsevier Inc: USA. 752. Not mentioned. ISBN 978-0-12-416687-5.

This book has been authored by five eminent academicians and covers basics and fundamentals of biochemistry related to medical science. Also, as the title suggests, it includes clinical cases with important and relevant teaching points in most of the chapters.

The book consists of 37 chapters, each chapter starting with key points, outlining the main concept of the chapter which gives concise summary and upturns interest in the topic. Language is easy to follow. Topics are mentioned as subheadings and are explained in lucid fashion. Although topics are explained in detail, yet beginner level students may experience some difficulty in finding definitions of technical terms.

The first chapter starts with explaining science at a basic level, describing cell, organelles, prokaryotes, eukaryotes, organ systems, evolution, etc ., helpful for beginners to get a vision and an initial understanding of the relevance of basic science in biochemistry. A few topics appear to be put randomly in sequence, for example, the chapter on lipid digestion and absorption is placed before explaining lipids. Chapters also include relevant physiological explanations, eg ., digestion and absorption, and contractile system, which enhance the overall understanding of the topic.

Metabolism has been discussed well. Each and every chapter has been written with utmost delicacy. The inclusion of chapters on topics like cancer, metabolism of xenobiotics, etc . would have made this edition more suitable for MBBS students and students of medical biochemistry. The book includes detailed chapters on immunology and haematology, enough to build basic concepts. Haematological tests important for diagnostics are also mentioned. Endocrinology is allotted five chapters and is explained extensively, describing all systems involved, including the reproductive system. Additional topics and chapters of applied importance such as autophagy, obesity, diabetes mellitus, etc , are also described, which provide a good clinical correlation and understanding of pathophysiology.

Text in the book is supported by well depicted, coloured, clear figures and illustrations. Compact summarizing tables are also given that are useful for quick sight and revision. At the end of each chapter, authors have provided a list of supplemental references and required readings, to encourage further learning. Readers who wish to explore the beyond chapter material will be benefited from it.

Close of each chapter also provides relevant clinical cases/problems, abstracted from previously published articles to illuminate interconnections between biochemistry, molecular biology and medicine. Readers will need to refer to reference values of the tests mentioned in the cases to conclude diagnosis. Clinicians and postgraduate students will easily grasp these clinical cases and explanations, but the undergraduate students may need reading of additional chapters to understand the overall picture plotted in the problem. This additional part of the book is targeted at promoting problem-solving skills, diagnostic acuity and evidence-based medicine in students. These cases are followed by explanations and important facts about the topic as the ‘teaching points’, useful for teachers to focus on important facts of the topic. Clinical conditions relevant to the topics are also mentioned in-between text.

Companion website : http://booksite.elsevier.com/9780124166875 is given on the starting page of the book which links to the webpage of the book providing resources to: multiple choice questions and answers, and all figures and tables from the book available as power point slides. The book is targeted for medical students but may also be useful for researchers in this field as it also mentions the latest areas of research and references to publications.

This book can be recommended as a reference book to the undergraduate and postgraduate students of biochemistry.

Indian Journal of Clinical Biochemistry

The primary mission of the Indian Journal of Clinical Biochemistry is to serve the public interest in health care by providing leadership in clinical laboratory science to national professional societies, the diagnostics industry, government and non-government organizations. The journal also acts as an interdisciplinary bridge between various areas of medicine. It covers laboratory accreditation programmes pertaining to health and disease.

This is the official journal of the Association of Clinical Biochemists of India.

Peer Review

The editor-in-chief assigns manuscripts to managing editors for initial evaluation to check suitability as per journal guidelines. Following this preliminary check, Editor in Chief may either reject manuscripts or send them for review. Those warranting review are then assigned to associate and assistant editors, to oversee the review process before submitting their recommendation to the Editor in Chief for final approval. Single-blind peer review process is followed to evaluate the suitability of an article submitted for publication. Two to three reviewers are selected from the pool of reviewers maintained in journal database, PubMed database and online resources. Post review, corresponding author is provided with the decision which may include acceptance, rejection and major or minor revisions. If revisions are needed, corresponding author is given appropriate time to revise and resubmit the manuscript, which is again subject to review to ensure that manuscript meets the requisite standards of the journal before being accepted for publication.

Praveen Sharma

Latest issue

Volume 39, Issue 2

Latest articles

Linoleic acid supplementation attenuates inflammation and redox imbalance during aging in wistar rats.

Parisha Srivastava
Avnish Kumar Verma
Syed Ibrahim Rizvi

Low Vitamin A Status: A Potential Limiting Factor for Hemoglobin Improvement to Iron–Folic Acid Supplementation in Adolescent Girls with Iron Deficiency Anemia

Subrahamanyam Dantham
Indraja Gaddam
Raghavendra Rao Chowdavarapu

Are Adiponectin and Insulin Resistance Related to Stress Hyperglycaemia in Critically Ill Patients?

Perihan Ülger
Ebru Yildiz
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Diagnostic Significance of Elabela, FABP1, and FABP2 as Biomarkers of Diabetic Nephropathy in Type 2 Diabetic Patients

Samah M. Mohamed
Kholoud S. Ramadan
Ehab A. Ibrahim

The Paradigms and Paradoxes of Sigma Metrics in the Analytical Phase of the Medical Diagnostic Laboratory

Seema Bhargava

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Clinical trials: A significant part of cancer care

Janice ‘Wes’ Brown, infectious disease researcher and physician, dies at 63

Brown developed stem-cell therapies for patients who suffered infections after receiving blood or bone marrow transplants.

May 9, 2024 - By Mark Conley

Janice “Wes” Brown, MD, a professor of blood and marrow transplantation who innovated stem-cell therapies for immunocompromised patients and helped put them into clinical use, died of endometrial cancer April 14. She was 63.

Brown’s research focused on patients who were at risk of life-threatening infections after a bone marrow transplant, solid organ transplant or other forms of cancer treatments leading to immunodeficiency. Her commitment, as both a scientist and clinician, to ease suffering and extend the lives of at-risk patients stood out to colleagues.

“Wes Brown epitomized the relentless initiative that makes Stanford Medicine a pillar of hope for so many,” said Lloyd Minor , MD, dean of the Stanford School of Medicine and vice president for medical affairs at Stanford University. “In the lab, she was instrumental in developing vital therapies for some of our most vulnerable patients, and in the clinic, she showed her compassionate approach to administering these therapies.”

“Wes was a remarkable person,” said Irving Weissman , the Virginia and D.K. Ludwig Professor in Clinical Investigation in Cancer Research. Brown had so impressed him as an inquisitive rookie researcher in his lab in the early 2000s that he came to her for assistance when his mother was recovering from uterine cancer surgery.

“She wasn’t doing well after surgery, so I called Wes,” Weissman said. “She caught on to what was happening immediately and set her on a new regimen.” Weissman’s mom returned to her home in Montana — and to good health — and lived another 20 years. “I owe my mom’s life to Wes,” he added. “She was just that brilliant of a puzzle solver.”

A nose for discovery

In her freshman dormitory as a Stanford University undergrad, someone told Brown that she looked like a Wes, and rather than arguing or taking offense, she ran with it. “Janice never really fit her anyway,” said her good friend Helen Benedetti.

Brown was born in Worcester, Massachusetts, and grew up in suburban Washington, D.C. Her parents were both physicians who immigrated from China for their post-doctoral training. Her husband, Andrew Hoffman , MD, professor of endocrinology, said that watching her parents live out lives in medicine likely provided the early inspiration that pulled her curious mind in a similar direction.

Wes Brown and Andrew Hoffman at the 2023 Big Game. Courtesy of Andrew Hoffman

Brown received her undergraduate degree at Stanford in 1981, then attended medical school at the University of Virginia. She returned to Stanford for her residency in internal medicine. After a stint as an infectious disease clinical fellow and a fellowship in virology in the lab of Ed Mocarski, then professor and chair of microbiology and immunology, she took notice of the work being done with blood-forming stem cells at Weissman’s lab. Soon she was part of it, and that fellowship forged an important path.

She focused on creating stem-cell therapies for three specific types of life-threatening infections faced by immunocompromised patients coming out of blood or bone marrow transplantation. She studied what Weissman’s lab had already established in mouse models and disentangled the mechanisms for skirting the three most lethal pathogens — one bacterial, one fungal, one viral — that faced immunocompromised human patients.

“She did it for three major kinds of infections — with definitive results,” Weissman said. “That hardly ever happens, especially with someone coming in from the world of infectious disease with no experience in blood-forming stem cells.”

Brown had immersed herself in the scientific literature on the three conditions, formed hypotheses on how to attack each, then published papers that turned out to be prescient. “How she predicted it would go is exactly how it went,” Weissman said.

She later joined Weissman at a commercial startup for attacking the dangerous infection cytomegalovirus with research on hematopoietic stem cells. She even continued her lab research after joining the faculty in the blood and marrow transplantation and cellular therapy division, pursuing clinical research dissecting the immune cells that control cytomegalovirus and other viral pathogens.

Hoffman recalled how Brown was able to patent a stem cell therapy and get the therapy through a phase 2 clinical trial. But part of her research passion stemmed from the practical applications she could take into action herself — and that’s where she turned next.

The puzzle solver

Brown volunteered to do clinical rounds with the blood and marrow transplantation program of the late Karl Blume , MD, and started to learn more about how infectious disease attacked the most critically ill patients. She continued that frontline work with immune deficient patients by joining the Bone Marrow Transplant and Cellular Therapy Program faculty, and later helped co-found Stanford Medicine’s Immunocompromised Host Infectious Diseases Clinic .

But, ever the problem solver, Brown wanted to keep one eye on the bigger research needs, Hoffman said. While still making daily rounds with patients, she conducted clinical trials for antiviral drugs and antibiotics and set up protocols for treating immunocompromised patients.

“She had the perfect background of virology and cell biology to do this work,” Hoffman said. “And it was her passion. She looked at a patient’s illness as a puzzle that she had to solve. And she would do anything she could to make sure that she had the right diagnosis. She was tenacious.”

Weissman marveled at the complete career puzzle Brown pieced together. “How often does someone get to make a discovery and then go put it to use?” he said. “To help people live who would’ve died? That’s what she did.”

The Hoffman-Brown family, at Sierra Family Camp (left to right): Andy, Jacob, Samantha, Wes and Zach. Courtesy of Andrew Hoffman

Hoffman recalls his wife frequently making house calls for severely ill patients, knowing she could help extend their lives, or at least bring them comfort. “She was an iconoclast — she wasn’t afraid to make a bold diagnosis that others might not,” he said.

When her good friend and colleague Judith Shizuru , MD, professor of blood and marrow transplantation and cellular therapy, was struggling with a difficult case, Brown was always her first call.

“She would really dig into the details, think outside the box, and she could reach into her own understanding,” Shizuru said. “She could guide you as if she was a third eye. I’ve never encountered another clinician like her. It takes insights, smarts and a real sense of boldness.”

It also helped that she was fully grounded in life — whether inside the lab or clinic, or at home. Weissman remembers what she did for his mother during her recovery from cancer, and how she approached the life-threatening riddles facing so many others.

“She was the kind of doctor who considered the lives of others just as important as her own family,” he said. “And if they’re like your family, you’re not going to stop until you figure it out.”

The mom in the stands

Shizuru still doesn’t understand how Brown and Hoffman did what they did as full-time researchers and clinicians and as parents. “Two working physicians who somehow made it to every one of their kids’ events,” she said. “She was the mom always in the stands, the one who brought the Gatorade.”

Hoffman said his wife had a unique ability to apply multiple passions simultaneously. “From virology to immune cells to the clinical care and research — she loved them all,” Hoffman said. “But most of all she loved being a mother.”

At home on bed rest during her first pregnancy, Brown managed to work on her stem cell research papers. Then she homeschooled the twins until fourth grade while continuing her research.

“While she was bringing this incredibly important science to bear in my lab, she was also homeschooling her twins,” Weissman said. “I have no idea how she did all that — and did it so well. But that was Wes.”

She was in the stands even as the kids got older — at her son Jacob’s Stanford baseball games, at the lacrosse matches of her daughter Samantha and her son Zach, at every Stanford sporting event she could get to.

“She was a very enthusiastic and very loud Stanford fan,” Hoffman said. Jacob was able to get the whole family field passes for last November’s Big Game against Cal — exactly the type of gathering “that made her really happy,” Hoffman said.

Brown was treating patients during the early months of the COVID-19 pandemic when a routine exam uncovered the cancer. She underwent surgery and numerous rounds of radiation and chemotherapy. She and Hoffman spent January through March in Boston at Brigham and Women’s Hospital, hunkered down and enduring a phase 1 clinical trial.

“We researched everything we could — she wasn’t going to give up,” Hoffman said. “Till the end, when she would be hospitalized, and she’d learn the life story of every nurse who took care of her.”

She was a unique person, and her loss is so tough to grieve. It leaves a big hole.

Benedetti was a blood and marrow transplant nurse who recalls bonding with Brown over their mutual commitment to work and family. She remembers her as a selfless nurturer who always made time to listen, never looking for the spotlight herself. That was saved for those closest to her. “Family was everything to her,” she said. “Wes was a brilliant, humble, loving, family-oriented person.”

Brown’s biggest disappointment was that she was too ill to return to work after the cancer diagnosis. But she wasn’t about to miss out on the landmark family moments that remained.

She was there for Samantha’s wedding in Los Gatos, California, in the spring and then at her PhD defense at Harvard University. Recently, the whole family spent a weekend at Sierra Family Camp at Fallen Leaf Lake in the Lake Tahoe basin — a Stanford tradition they had enjoyed for years when the kids were growing up.

“That was so important to her — and she hung in there,” Shizuru said. “She was a unique person, and her loss is so tough to grieve. It leaves a big hole. It’s painful.”

Hoffman knows. He said he has a hard time accepting the death of his wife so early. “She was only 63 — she had so much more life to live,” he said. But he draws comfort in the immense legacy she leaves behind. It’s everywhere he looks.

“She was known and loved by so many people,” he said. “I never realized how many people she touched.”

Brown is survived by her husband, Andy Hoffman, and their children — Samantha, Jacob and Zachary Hoffman.

Gifts in memory of Brown can be made at memorial.stanford.edu or by sending a check payable to Stanford University and mailed to Medical Center Development, 485 Broadway, University Hall, 4th Floor, Redwood City, CA 94063. Please indicate on the online form or check that the gift is in memory of Dr. Wes Brown.

About Stanford Medicine

Stanford Medicine is an integrated academic health system comprising the Stanford School of Medicine and adult and pediatric health care delivery systems. Together, they harness the full potential of biomedicine through collaborative research, education and clinical care for patients. For more information, please visit med.stanford.edu .

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PhD. position in the field of Clinical Biochemistry

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Are you curious and finding answers is fun and the meaning of life for you? Then the III. degree of university study (doctoral study) at our institute in the study program clinical biochemistry just for you. You may plan the study according to your expectations. You can participate in research projects by working in a research team or work independently in a laboratory, or within the cooperation use any scientific-research facility of UPJŠ LF according to your interests. In any case, under the auspices of your supervisor, you will solve topics of your choice and seek answers to questions, especially in the study of biomarkers useful in clinical-biochemical diagnostics.

The study program Clinical Biochemistry has been accredited at the institute since 2005. The study is completed by defending a dissertation and awarding a PhD. This fact significantly contributed to the improvement of the scientific work carried out at the institute, as the staff was expanded and rejuvenated by young graduates. Scientific education is carried out under the guidance of experienced staff of the institute in cooperation with other departments of the Faculty of Medicine (e.g. departments of Louis Pasteur University Hospital in Košice, Department of Medical and Clinical Biophysics, Department of Experimental Medicine, Associated Tissue Bank) within projects solved at relevant workplaces (VEGA and APVV). Our students regularly complete internships abroad, participate in domestic and foreign conferences where they can present their scientific research results. More than 40 graduates under the guidance of supervisors and consultants successfully completed their studies.

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