biomedical research institute stellenbosch university

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• 08 May 2023

New biomedical research facility to advance African health science

• Engela Duvenage

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Nico Gey van Pittius, vice-dean of research and internationalisation at SU's Faculty of Medicine and Health Sciences Credit: Engela Duvenage

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A new Biomedical Research Institute (BMRI) at Stellenbosch University (SU) will aim to be an incubator for solutions to prevent and treat health challenges in Africa — from tuberculosis, and HIV, to rare genetic disorders, heart diseases, neurological, and fertility problems.

“The BMRI is dedicated to understanding the genetic and bio-molecular basis of disease, with an African focus,” says Nico Gey van Pittius, vice-dean of research and internationalisation at SU's Faculty of Medicine and Health Sciences (FMHS).

Most of the funding for R1.2 billion (US$66 million) 13,938m2 facility on SU's Tygerberg Medicine and Health Sciences campus in Cape Town came from the university, with support from South Africa's National Department of Higher Education, Science and Innovation.

BMRI provides workspace for more than 500 biomedical researchers and students in the fields such as tuberculosis (both in humans and animals ), neuroscience, epidemic response and innovation , cardio-metabolics , rare disease genomics , clinical mycobacteriology and epidemiology , Parkinson's disease , and r eproductive health research .

“In our planning we asked our top researchers what they thought would be needed in the next 20 years or more. We designed BMRI with the future in mind, and to host the technology of the future," says Gey van Pittius, who since 2012 has steered the project, along with Eben Mouton, FMHS's director for business management.

“Plans around BMRI's building were among the reasons why I decided to establish CERI, the Centre for Epidemic Response and Innovation , at SU,” says Tulio de Oliveira, the scientist who first identified the Omicron variant of the virus that causes COVID-19.

Novel Chegou, the professor who leads research into tuberculosis immunology and TB biomarkers at SU, remembers how space was already a luxury in the old building when he started his honours studies in biomedical sciences some 18 years ago. Fridges storing valuable samples blocked narrow passageways. Later he and three other senior staffers had to share an office.

Chiegou's team now has ample temperature controlled lab space and access to world-class equipment for, among others, DNA sequencing and advanced biomarker detection through the first Curiox system in Africa. The building houses a 600 m 2 biosafety laboratory, the largest in Africa, where TB and HIV samples and airborne infectious agents and toxins can safely be handled.

For Biobanking, specimens can be safely stored and retrieved through a truck-sized Hamilton Bios, while the automated robotic biological storage system can house some 3.5 million samples.

“It was the first automated storage system of this scale to be commissioned in the Southern Hemisphere,” says Rubeshan Nayager, manager of the BMRI Biorepository Unit which also provides sample processing, -190˚C vapour phase storage and the shipping of samples to clients in academia and industry.

BMRI also hosts electron microscopy laboratories, a bioinformatics hub, proteomics and flow cytometry services labs and the SU Department of Psychiatry's Virtual Reality lab.

The design team had a modern rethink of the Medical Morphology learning centre where undergraduate medical students spend much time with dissections, and the Sunskill laboratory where registrars of various surgical disciplines receive hands-on training.

doi: https://doi.org/10.1038/d44148-023-00112-4

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Stellenbosch University unveils new biomedical research complex in Cape Town

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14th April 2023

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Stellenbosch University (SU) formally launched its new Biomedical Research Institute (BMRI), on its Tygerberg campus (next to Tygerberg Hospital) in Cape Town, on Friday. Regarding its facilities and research capabilities the new complex is one of the best in the world, and unequalled in Africa and even, SU believes, in the entire southern hemisphere.

“The realisation of the BMRI resonates with SU’s vision of being Africa’s leading research-intensive university with the objective of being globally recognised for our excellence in innovation to advance knowledge in service of society,” affirmed SU Rector and Vice-Chancellor Professor Wim de Villiers .

The creation of the BMRI required an investment of R1.2-billion. Construction started in 2018 and was completed this year, despite the challenges posed by the Covid-19 pandemic. The complex was designed to be ‘future-proof’, and is able to accommodate future developments by being modular and sustainable.

“Scientists at the BMRI conduct research that translates into discoveries that help improve the diagnosis, prevention and treatment of illnesses affecting the people of South Africa and the rest of Africa,” highlighted SU Medicine and Health Sciences Faculty Vice Dean: Research and Internationalisation Professor Nico Gey van Pittius .

The institute has more than 500 researchers and students, working in numerous laboratories, fitted with the latest equipment and systems. Facilities in the complex include a fully-automated biorepository (where medical samples are preserved, in very low temperature storage) and the largest biosafety level three (BSL-3) laboratory in Africa. (The highest biosafety level is BSL-4.)

“The research conducted in the BMRI builds on SU’s commitment to impactful research which takes into account the natural environment, health, human security as well as systems and technologies for the future,” pointed out SU Deputy Vice-Chancellor: Research, Innovation and Postgraduate Studies Professor Sibusiso Moyo . “At the heart of our scientific endeavours, is the challenge to be locally relevant and globally competitive.”

Edited by Chanel de Bruyn Creamer Media Senior Deputy Editor Online

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Stellenbosch University launches new Biomedical Research Institute

• Stellenbosch University launches new Biomedical Research Institute (BMRI).
• Image Credits :
• Celestine Hendricks
• 15 April 2023, 13:46 [SAST]

Stellenbosch University says its newly opened Biomedical Research Institute at the Tygerberg Campus in Bellville will be used to study infectious agents or toxins that may be transmitted through the air and cause potentially lethal infections.

Construction of the R1.2 billion facility commenced in 2018 and was completed this year despite major challenges posed by the COVID-19 pandemic.

The complex is a high-performance research hub, where experts from various medical fields come together and share knowledge in order to treat many illnesses in Africa.

Stellenbosch University’s Director for the Centre for Epidemic Response and Innovation, Professor Tulio de Oliveira says, “In our lab, we have people that came from 25 African countries, close to 50 fellows that are here for a few weeks to learn how to use genomics to detect and characterize new pathogens..”

He adds: “So a facility like this doesn’t only have an effect on South Africa, but also for Africa and the world, because one thing that we learned from the previous pandemic, the COVID pandemic, is that diseases do not respect borders.”

SU is excited to launch its world-class Biomedical Research Institute situated at its Tygerberg Campus. This R1.2 billion research complex is unparalleled in Africa and the southern hemisphere. Watch this video for more: https://t.co/Clkvl5w0jo . — Stellenbosch University (@StellenboschUni) April 13, 2023

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Cutting-edge Biomedical Research Institute achieves 'Green Building' status  

Stellenbosch University's (SU) brand new, state-of-the-art Biomedical Research Institute (BMRI) not only sets the gold standard for research and education in Africa, but the building itself also leads the way in terms of environmental sustainability. 

This was confirmed when this R1,2 billion, multifaceted research complex was awarded a 4-star (By Design) Green Star rating by the Green Building Council of South Africa (GBCSA).

GBCSA is an independent authority that operates across the commercial, residential and public sectors to ensure that buildings are designed, built and operated in an environmentally sustainable way. The Green Star certification process is governed by the GBCSA and involves certification of buildings using standardised rating tools to evaluate certain types of buildings, or sustainability aspects.

The BMRI was rated according to the Public and Education Building (PEB) Tool where it scored 52 points affording it a 4-star rating, which is considered “Best Practice" in terms of environmentally friendly design and functionality. See below for detailed information on the BMRI's Green Star scoring.

Environmentally sustainable features

The following are some of the environmentally sustainable features of the BMRI that contributed to its 4-star Green Star rating by the GBCSA.

Smart Lighting – The facility is equipped with a Digital Addressable Lighting Interface (DALI) system that allows the user to control and adjust the lighting according to individual requirements. Sensors detect when rooms are empty and lights are dimmed and switched off automatically, resulting in an energy saving.

Building Management System – The BMRI has a state-of-the-art Building Management System (BMS) located in a dedicated control room. All services running in the building, such as air-conditioning, power supply, pressure control in laboratories, access control, and more, consolidate onto the BMS platform, from where it is proactively monitored and managed in order to optimise the use of energy and safety.

Atrium Entry Heating/Cooling System – The atrium entrances are provided with underfloor heating and cooling systems to regulate the temperature of air flowing into the building. This feature helps to moderate the building temperature, which saves energy by taking pressure off the heating, ventilation and air conditioning (HVAC) system. The system uses the remaining energy in returned chilled and hot water from the building, further reducing the energy footprint of the building.

High-performance Glass – A combination of triple and double-glazed glass was used on all façades of the building to help with temperature control. This takes pressure off the HVAC system, resulting in energy saving.

Smart Design – The building orientation is north-facing, which minimizes sun exposure in summer, and increases it in winter, and naturally assists with temperature control. The building was designed with buffer areas, such as office space, in between the sun-facing side of the building and laboratories – where temperature is strictly regulated – to better regulate temperature and save on energy for air conditioning.

Building tuning – A green building consultant was brought in to fine tune all building systems to ensure maximum energy efficiency, while maintaining optimum functionality.

Water harvesting – The building ties into the campus's greywater masterplan, which allows for rainwater harvesting and the use of borehole water. All toilets are flushed with non-potable water.

Bicycle storage - A secure bicycle storage area with adjacent shower facilities is located in the basement to encourage staff and students to cycle to work.

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The BMRI scored positively on the following  environmental impact categories on the PEB assessment tool:

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All rights reserved © 2024 Stellenbosch University Private Bag X1, Matieland, 7602, Stellenbosch, South Africa Tel.: +27 21 808 9111

Stellenbosch University Opens Biomedical Research Institute

Stellenbosch University opened the $66 million Biomedical Research Institute (BMRI) in Cape Town in April of 2023. Located on the Tygerburg Campus, the 354,000–sf complex leverages an open design to foster active collaboration between researchers, staff, and students as they investigate the diseases that have the greatest impact on South Africa. Housing the Centre for Epidemic Response and Innovation, this high-performance research hub features a BSL-3 laboratory spanning 6,500 sf, the largest on the continent. A fully automated biorepository with redundant power and active monitoring systems can store 3.5 million clinical samples at a temperature of -80 degrees Celsius. The Sunskill Laboratory provides sophisticated instrumentation for specialist surgical training. The highly flexible and modular structure also includes a bioinformatics core, state-of-the-art dissection halls, a morphology museum, a clinical research unit, conference venues, and labs for proteomics, electron microscopy, and flow cytometry.

Achieving a 4-Star rating from the Green Building Council of South Africa, the BMRI employs an array of sustainable strategies such as energy recovery technologies, an insulated glass façade, and a next-generation Building Management System (BMS). Smart lighting that adjusts to complement natural illumination includes a Digital Addressable Lighting Interface (DALI) that allows users to customize their environments. The project team included Roelof Rabe Architects , Ludwig Design Consulting , JG Afrika , WBHO Construction , Glad Africa , Triocon Consulting Engineers , EKCON Engineers , and lab planner LTS Health . Construction began on the world-class facility in January of 2019.

Victor Mukhin

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Title : Active carbons as nanoporous materials for solving of environmental problems

However, up to now, the main carriers of catalytic additives have been mineral sorbents: silica gels, alumogels. This is obviously due to the fact that they consist of pure homogeneous components SiO2 and Al2O3, respectively. It is generally known that impurities, especially the ash elements, are catalytic poisons that reduce the effectiveness of the catalyst. Therefore, carbon sorbents with 5-15% by weight of ash elements in their composition are not used in the above mentioned technologies. However, in such an important field as a gas-mask technique, carbon sorbents (active carbons) are carriers of catalytic additives, providing effective protection of a person against any types of potent poisonous substances (PPS). In ESPE “JSC "Neorganika" there has been developed the technology of unique ashless spherical carbon carrier-catalysts by the method of liquid forming of furfural copolymers with subsequent gas-vapor activation, brand PAC. Active carbons PAC have 100% qualitative characteristics of the three main properties of carbon sorbents: strength - 100%, the proportion of sorbing pores in the pore space – 100%, purity - 100% (ash content is close to zero). A particularly outstanding feature of active PAC carbons is their uniquely high mechanical compressive strength of 740 ± 40 MPa, which is 3-7 times larger than that of  such materials as granite, quartzite, electric coal, and is comparable to the value for cast iron - 400-1000 MPa. This allows the PAC to operate under severe conditions in moving and fluidized beds.  Obviously, it is time to actively develop catalysts based on PAC sorbents for oil refining, petrochemicals, gas processing and various technologies of organic synthesis.

Victor M. Mukhin was born in 1946 in the town of Orsk, Russia. In 1970 he graduated the Technological Institute in Leningrad. Victor M. Mukhin was directed to work to the scientific-industrial organization "Neorganika" (Elektrostal, Moscow region) where he is working during 47 years, at present as the head of the laboratory of carbon sorbents.     Victor M. Mukhin defended a Ph. D. thesis and a doctoral thesis at the Mendeleev University of Chemical Technology of Russia (in 1979 and 1997 accordingly). Professor of Mendeleev University of Chemical Technology of Russia. Scientific interests: production, investigation and application of active carbons, technological and ecological carbon-adsorptive processes, environmental protection, production of ecologically clean food.   

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