research proposal on drug abuse

An official website of the United States government

Here’s how you know

Official websites use .gov A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

NIDA Challenges Program

Current challenges, “barriers and solutions to building community partnerships in deploying remote assessments” challenge.

The National Institute on Drug Abuse (NIDA), one of the components of the National Institutes of Health (NIH), is announcing the “Barriers and Solutions to Building Community Partnership in Deploying Remote Assessments” Challenge. The Challenge goal is to inspire the creation of actionable steps for creating and sustaining bidirectional researcher-community partnerships that will reduce barriers and mistrust between academic, clinical, and research-conducting institutions and communities to increase recruitment and retention of participants in remote, including virtual, clinical research studies. NIDA expects that the contest will allow participants to identify areas of opportunity to build community trust and empower community voices, address systemic and personal factors that discourage adoption of remote research platforms, and develop remote platforms that are ethical, safe, and meaningful to communities. NIDA seeks broad input from individuals and groups both within and outside the addiction science field, with the hope and expectation that successful examples of strong researcher-community partnerships will provide the NIDA research community with insights and tools to strengthen its use of remote assessments and serve its mission to advance science on drug use and addiction and to apply that knowledge to improve individual and public health.

Get more information on the “Barriers and Solutions to Building Community Partnership in Deploying Remote Assessments” Challenge.

“Remote Assessments of Substance Use Disorder (SUD)-Relevant Measurements” Challenge

The National Institute on Drug Abuse (NIDA), one of the components of the National Institutes of Health (NIH), is announcing the “Remote Assessments of Substance Use Disorder (SUD)-Relevant Measurements” Challenge. The goal of the Challenge is to identify and highlight the current best practices and state-of-the-art approaches to collect remotely assessed measurements of SUD-relevant cognitive, behavioral, physiologic, and environmental information, and compare these to measurements collected in controlled experimental settings (e.g., laboratory or clinical settings). Examples of relevant measurements include physiologic and biological measures, cognitive task performance, behavioral and social measures, and environmental characterizations. Further, remote assessment approaches should demonstrate the ability to lower the burdens of participation for research participants, particularly disproportionality affected groups and/or under-resourced communities. NIDA expects that the Challenge will inspire adoption of best practices in remote assessment of SUD-relevant measurements by the wider research community. To accomplish these goals, this Challenge will provide both monetary support and exposure to current best practices and methodologies. NIDA will also convene a meeting to highlight the winning submission(s) to foster a community of current and future remote assessment practitioners.

Get more information on the “Remote Assessments of Substance Use Disorder (SUD)-Relevant Measurements” Challenge.

What is a Challenge/Prize?

Challenges are an appeal to a diverse array of potential ‘solvers’ to provide a solution for a particular goal.
Typically, Challenges are ‘crowdsourced’ to a large group of people, commonly via the internet, to obtain a needed service, idea, concept, product, etc. from sources non-traditional sources.
Prizes – monetary and/or non-monetary – often accompany challenges.
Challenges/prizes are an alternative funding mechanism to contracts or grants.
Challenges are specific, detailed, and actionable. They need to be formulated, posted to a wide-audience, tracked, judged and awarded.

Past Challenges

The National Institute on Drug Abuse (NIDA) announced the 2024 “$100,000 Start an SUD Startup” Challenge in July of 2024, and now that the submissions have gone through the judging process, NIDA is delighted to share the results of the Challenge.

The following teams have been selected by the NIDA judges to receive the Stage 1 prize of personalized entrepreneurial mentoring for each team. Winner notification letters with instructions will be sent to the email addresses of the Team Leader.

Congratulations to all Winners!

Submission #6030 Team Members: Jim O’Neill, Vannak Chhay, and Alex Paar Proposal Title: Recovery Jobs Platform; addressing social determinants of health (SDOHs) through employment support innovation
Submission #6032 Team Members: Mikael Rubin, Santiago Papini, and Rushi Rawal Proposal Title: ElevateAR: Augmented Reality to Enhance Remote SUD Treatment
Submission #6033 Team Members: Jessica Northcott-Brillatti, Whitney Menarcheck,and Annette Mich, Proposal Title: SUDCx: The Hub for SUD Innovation and Networking
Submission #6039 Team Members: Zach Dyce, Layla Aboukhater, and Neil Ok Proposal Title: Thrive Well: Patient Engagement and Case Management for Community Health Organizations
Submission #6042 Team Members: Pavana Rotti, Zia Barnard, and Stephan Lindenthal Proposal Title: Nervoid: Novel therapies for opioid overdose
Submission #6045 Team Members: Nicholas Kovalsky, Eshan Dosani, Bijan Toulabi, Thomas Blalock, Michaela Kovalsky, and Daedalus Fitzgerald Proposal Title: CareTailor - A Machine Learning Innovation for Substance Use Disorder Treatment
Submission #6046 Team Members: Jae Sevelius, Rachel Lynn Golden, and Brooke Stott Proposal Title: Kindred, an innovative model that integrates ketamine-assisted therapy into group therapy
Submission #6048 Team Members: Henry Brown, Duncan Van Dusen, and Sierra Castedo de Martell Proposal Title: Economic evaluation calculators (CeCalc) and services for recovery community organizations
Submission #6052 Team Members: Evan Crosby, Katia Kutina, and Julia Pottorff Proposal Title: User Friendly: Building a Handheld Raman Spectroscopy "Keychain" to End Fentanyl Overdoses Among Recreational Users
Submission #6054 Team Members: Jose Gutierrez, Liz Nguyen, Erik Quan, Remy Bizimungu, Alex Ruiz, John Marx, and Tyler Steffenson Proposal Title: Project SafeUse: A Mobile Technology Solution for Reducing Overdose Deaths through Community-Based Monitoring and Intervention
Submission #6055 Team Members: Markeita Hope, Maryam Hassani, and Ericka Dupclay Proposal Title: MARY, a wellness wearable and peer led service

NIDA sincerely appreciates all the solvers who entered the Challenge and applauds their efforts to translate their research ideas into products that address substance use disorders.

If you have questions about this challenge, contact the NIDA Challenge team at [email protected] .

Get more information on NIDA’s 2024 “$100,000 Start an SUD Startup” Challenge .

The National Institute on Drug Abuse (NIDA) announced the 2023 “$100,000 Start an SUD Startup” Challenge in August of 2023, and now that the submissions have gone through the judging process, NIDA is delighted to share the results of the Challenge.

Submission #4354 Team Members: Barbara St. Marie, Nate Shaw, Alison Lynch, Laura Markewicz, Doug Nelson, and You Wang Proposal Title: Reducing Opioid Misuse and Opioid Use Disorder Through Early Identification
Submission #4426 Team Members: Clara Guo, Aleksandra Galaszewicz, and Nicolas Kim Proposal Title: Lucid.Care Labs: quantifying behavioral health
Submission #4437 Team Members: Heidi Lynch, Charlotte Blais, and Lydie Blundon Proposal Title: Kadia Health Digital App
Submission #4442 Team Members: Sarah Clingan and Lori Mattingly Proposal Title: XR Remedy: Immersive Telehealth Designed with the Patient's Needs in Mind
Submission #4444 Team Members: Beth Stormshak, Lisa Reiter, and Milagra Tyler Proposal Title: A digital health tool for families to prevent substance use disorders in children
Submission #4446 Team Members: Rosita Wong, Sean Allen, Yogesh Khatri, and Michael Tong Proposal Title: Develop an Office of AI JayBots
Submission #4447 Team Members: Alex Hatoum and Spencer Huggett Proposal Title: Algorithms to Power the Next Wave of Drug Discovery for Substance Use Disorders
Submission #4448 Team Members: Kelly Vinh, Ethan Hernandez, Ben Breen, and Rachel Sloans Proposal Title: Vaping Cessation Device: Reimagining the E-Cigarette
Submission #4453 Team Members: David Lee, Juan Carlos Pacheco, Alan Brookhart, and Kyle Jensen Proposal Title: Combatting the dual chronic pain and opioid epidemic through a machine learning software for improved medicinal cannabis care
Submission #4454 Team Members: Somilez Francis, Shawkut Ali, and Arletha Lizana Proposal Title: EquiCare: Bridging Health Gaps through Substance Use Support
Submission #4460 Team Members: Kaileigh Byrne, Alain Litwin, and Sab Babu Proposal Title: Digital App for Stimulant Use Disorder Recovery Initiation and Maintenance
Submission #4461 Team Members: Asher Varon, Mahima Srivastava, and Srinivasan Raghavan Proposal Title: QuikReversal: Accessible and Disposable Closed-Loop Wearable for Overdose Detection and Antidote Delivery
Submission #4467 Team Members: Lola Akintola, Yang Wang, and Luana Colloca Proposal Title: A Personalized Virtual Reality Environment Tool to Mitigate Opioid Use Disorder
Submission #4470 Team Members: Chandra Fincke, Jeanie Chung, and Andrew Penna Proposal Title: TaeSun: a convenient, portable, and all-inclusive fentanyl testing solution
Submission #4472 Team Members: Samay Shah, Huzefa Johar, Cole Olson, and Amy Pham Proposal Title: Cellulose Nanofiber Hydrogel Bandage to Address the Xylazine Ulcer Epidemic

NIDA sincerely appreciates all the solvers who entered the Challenge and applauds their efforts to translate their research ideas into products that address substance use disorders. If you have questions about this challenge, contact the NIDA Challenge team at [email protected] .

Get more information on NIDA’s 2023 “$100,000 Start an SUD Startup” Challenge .

The National Institute on Drug Abuse (NIDA), one of the components of the National Institutes of Health (NIH), is launching the “Substance Use Prevention Services in Primary Care” Challenge. The United States is experiencing a significant behavioral health crisis, putting substantial strain on the health care system. Primary care practices are one potential setting in which to address this crisis, but primary care providers (PCPs) face substantial barriers in identifying individuals who may be at risk for substance use and delivering evidence-based prevention interventions to reduce the risk for use. This Challenge seeks creative, visionary, and actionable plans to implement substance use prevention interventions in primary care.

Winners Announced

In February 2023, the National Institute on Drug Abuse (NIDA) announced the “Substance Use Prevention Services in Primary Care” Challenge. The judging of submissions is now complete. NIDA thanks all solvers for their thoughtful primary care-based models and is delighted to share the results of the Challenge.

NIDA is thrilled to announce three winners of $25,000 prizes for their submissions to the “Substance Use Prevention Services in Primary Care” Challenge.

Submission Title: Community Health Worker-led Substance Use Prevention Model for Recently Incarcerated Persons ( Overview, PDF, 54KB )
Submission Title: Making Substance Use Prevention as Easy as Vaccination! Leveraging Machine Learning to Deliver Personalized Substance Use Prevention Interventions in Primary Care& ( Overview, PDF, 30KB )
Submission Title: Clinical Screening and Peer Interventions to Prevent Substance Use in At-Risk Adolescents ( Overview, PDF, 44KB )

NIDA is also excited to announce the following honorable mention winners, which will receive cash prizes of $5,000 each.

University of Arkansas – The Rapid Razorback Screening Campaign (RRSC)
University of North Carolina and University of Wisconsin-Milwaukee, with community experts from WakeMed Children’s Primary Care , RTI International , Arizona State University , Boston University , and Kaiser Permanente – Substance Use Prevention Screening and Intervention in Primary Care: The Prevention 2U Model
Arizona State University , University of Utah , Bayless Integrated Healthcare , and Family Check-Up 4 Health Community Advisory Board – Family Check-Up 4 Health (FCU4Health)
University of Washington and Justice for Girls Coalition of Washington State – Girls advocacy and impact network +: A gender-responsive substance use prevention model for girl-identified youth

NIDA sincerely appreciates all the solvers who entered the Challenge and applauds their efforts in developing innovative models for substance use risk screening and prevention services in primary care.

Get more information on the Substance Use Prevention Services in Primary Care Challenge .

The National Institute on Drug Abuse (NIDA), one of the components of the National Institutes of Health (NIH), announces the annual “$100,000 Start an SUD Startup” Challenge. The Challenge goal is to support research ideas in the area of Substance Use Disorders (SUDs) that are intended to be the foundation for the development of successful new startups. NIDA expects that the Challenge will enable the winning teams to test the premise that their research idea can be fostered into a biotech startup, and that eventually, the newly created startups will contribute to the pool of innovative small business companies that can successfully compete for NIDA’s Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) funding.

Get more information on the 2022 Start an SUD Startup Challenge .

UPDATE: NIDA sincerely appreciates all the solvers who entered the Challenge and is excited to announce the winners. See the official announcement .

The National Institute on Drug Abuse (NIDA), one of the components of the National Institutes of Health (NIH), is launching the “Cause of Death Elucidated (CODE) in Drug Overdose” Challenge, which is soliciting ideas for novel postmortem toxicology screening tools that would be used to inform and streamline suspected drug overdose death investigations and to improve drug specification in overdose death counts. It is not expected or required that solvers currently have working prototypes. Solvers with prototypes at any stage of development or with prototypes that may be pivoted to postmortem toxicology screening are encouraged to submit their ideas to the Challenge. Ideas submitted to the Challenge must have a strong and rigorous scientific basis and should demonstrate that the proposed solution will be technically feasible with further support for development. To complement NIDA’s efforts with this Challenge, NIDA also intends to announce separate funding opportunities, available to all interested parties and subject to applicable competitive processes, to support research and development efforts in this area.

Get more information on the CODE in Drug Overdose Challenge .

The National Institute on Drug Abuse (NIDA), one of the components of the National Institutes of Health (NIH), is announcing the “Product Prototypes to Combat Drug Craving” Challenge. The Challenge goal is to solicit working prototypes of multifaceted products that will help with drug craving in people who experience substance use problems or with substance use disorder (SUD). Ideally, these multifaceted product prototypes would combine several different tools or features to address drug craving, providing long-term, on-demand, and personalized comprehensive assistance that can ultimately reduce the likelihood of return to use (also known as recurrence). NIDA expects that the Challenge will inspire many different product prototypes to help people address their drug cravings and prevent recurrence of drug use.

Get more information on the Product Prototypes to Combat Drug Craving Challenge

UPDATE: NIDA sincerely appreciates all the solvers who entered the Challenge and is excited to announce the winners. See the official announcement.

The Challenge goal is to inspire the creation of actionable patient journey maps that might further the understanding of the obstacles that patients face in getting treatment for drug addiction, particularly while our country is in the middle of an ongoing opioid crisis. NIDA invites participants to identify specific points during the patient journey where patients encounter the most difficulty, enabling NIDA to focus new research efforts into alleviating those areas of difficulty in patients’ drug addiction treatment journeys. The Challenge will offer up to three awards for first, second, and third place entries of $50,000, $30,000, and $20,000 each, respectively. The total purse is up to $100,000.

Get more information about the Mapping Patient Journeys in Drug Addiction Treatment Challenge .

The National Institute on Drug Abuse (NIDA) in partnership with the Northwest Portland Area Indian Health Board (NPAIHB), through the We R Native program is hosting two challenge competitions to recognize the inherent strengths and resiliencies of Indigenous people and culture that foster healthy communities and protect against substance use.

Art Challenge : We invite youth to submit any original form of art and describe how it depicts resilience against drug abuse to win $500 (individual submission) or $1000 (group submission). We will award approximately 25 prizes!
Community Project Intervention Challenge : We invite youth to develop plans for a a project that they believe would augment resilience to substance abuse in communities, submitting to us a plan for the project and video description. Prizes for each proposed project will be up to $10,000 (minimum award $2000).

UPDATE: NIDA is excited to announce the Challenge winners. See the official announcement

The National Institute on Drug Abuse (NIDA), one of the components of the National Institutes of Health (NIH), announces the annual “$100,000 for Start a SUD Startup” Challenge. The Challenge goal is to support research ideas in the area of Substance Use Disorders (SUDs) that are intended to be the foundation for the development of successful new startups. NIDA expects that the Challenge will enable the winners to test the premise that their research idea can be fostered into a biotech startup, and that eventually the newly created startups will contribute to the pool of innovative small business companies that can successfully compete for NIDA’s Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) funding.

The Challenge will offer up to ten awards of $10,000 each and technical expertise and mentoring from NIDA biomedical entrepreneurship experts. The Challenge total purse is up to $100,000.

Get more information about the 2021 $100,000 Start an SUD Startup challenge

Congratulations to all new Winners!

The judging of the NIDA “$100,000 for Start a SUD Startup 2020” Spring Challenge is now completed. The following startup ideas have been selected by the NIDA judges to receive a cash prize award in the amount of $10,000 per proposal plus the access to the personalized entrepreneurial mentoring for each team. Winner notification letters with instructions will be sent to the email addresses of the main applicant/proposal submitter.

Applicant: Team 24: Josh Israel, team leader Proposal: The Hale Device, a digital therapeutic to reduce nicotine withdrawal symptoms
Applicant: Team 35: Diana Martinez, Qi Wang and Howard Levin Proposal: Development of ‘On Demand Electrostimulation’ for addiction
Applicant: Team 9: Marc Kaufman, team leader Proposal: Rapid attenuation of withdrawal symptoms in people with Opioid Use Disorder by on-demand Xe inhalation.
Applicant: Team 43: Phillip Torralva, team leader Proposal: Drug discovery for FIRE (“fentanyl induced respiratory effects”) syndrome
Applicant: Team 23: Timothy Murphy, team leader Proposal: Transcatheter occlusion of gastric arteries to treat Substance Use Disorders
Applicant: Team 32: Beth Lambeth, team leader Proposal: Optimization of a container molecule technology for treating METH overdoses
Applicant: Team 47: Jeff Stuewig and June Tangney Proposal: 13 million Missed Opportunities: Brief Computerized Interventions to Reduce Jail Inmates’ Substance Misuse and Recidivism
Applicant: Team 13: Courtney Miller, Patrick Griffin, Theodore Kamenecka Proposal: Developing a novel medication for Methamphetamine Use Disorders
Applicant: Team 61: James Lott, Vernon Gair, Nadeen Siddiqui Proposal: A SaaS Platform That Enables Initiation of Medication-Assisted Treatment Care at Local Community Pharmacies
Applicant: Team 60: Michael Toledano, Kevin Beier, Milton Greenberg Proposal: Development of a novel prophylactic biopharmaceutical to prevent relapse in SUD patients
Applicant: Team 16: Hugh Lee, Chi Hwan Lee, Jacqueline Linnes, Craig Goergen Proposal: Towards closed-loop automatic antidote delivery system for opioid overdose
Applicant: Team 3: Minhee Sung, Lena Goldstein, Sol Bloomfield, Joshua Ip, Jacob Garetti, Chandra Fincke Proposal: EnlighteN Naloxone Sensory Injector

For Further Information Contact:

Elena Koustova, Ph.D., MBA, Director, Office of Translational Initiatives and Program Innovations (OTIPI), NIDA Challenge Manager, National Institute on Drug Abuse (NIDA), 6001 Executive Blvd Room 4206, MSC 9555 Bethesda, MD 20892-9555. Phone: (301) 496-8768, Email: [email protected]

The judging of the Challenge is now completed. Based upon the Challenge criteria, the judging panel has selected 9 submissions for the Challenge awards:

Applicant: Biomotivate Proposal: Biomotivate: A digital motivation platform for motivation to stay sober from substance use disorders
Applicant: District Connect Proposal: District Connect: A mobile grocery store
Applicant: Kaleidoscopes Proposal: Virtual reality platform for enhancing self-regulation through biofeedback
Applicant: KTO (Knowledge to Own) Proposal: Affordable Housing
Applicant: Neurotype Proposal: Assessing drug cue reactivity (DCR) with Neurotype DCR
Applicant: PillSafe Proposal: PillSafe: Addressing SUD among adolescents
Applicant: PrescribeAI Proposal: A platform that helps insurance companies to identify high-risk opioid prescribers
Applicant: RecoverWe Proposal: RecoverWe Platform for mapping of addition recovery resources and a peer navigation service
Applicant: U-Check-IT Proposal: U-Check-It™ System: A non-invasive health monitoring system to track stress and opioid usage in real-time

Award Winners

The judging of the Challenge is now completed. Based upon the Challenge criteria, the judging panel has selected 10 submissions for the Challenge awards:

Applicant: Premedly Proposal: A learning platform to help rehabilitation staff add key soft skill competencies to improve patient outcomes
Applicant: We are Marcus Proposal: An enterprise mentoring platform for schools directed at improving student outcomes on substance abuse and increase engagement in school and youth programs
Applicant: Scite Proposal: A Citation Analysis Platform (R-factor: the measure of scientific veracity)
Applicant: SYNVENTA Proposal: Removing liabilities with novel FDC
Applicant: GOODLER Proposal: Technology to build resilience in distressed communities
Applicant: Sound Life Sciences Proposal: Second Chance: opioid overdose detection using smartphones
Applicant: Data Quality Label Proposal: Analytics Platform for risk management in drug discovery
Applicant: Henry Heath Proposal: Culturally sensitive teletherapy for SUD
Applicant: FMB Technologies Proposal: A miniaturized telemetry device for data collection and transmission
Applicant: Sure Med Compliance Proposal: Care Continuity Program (CCP)

Award Winners:

Team 1: Prapela (Frank Minella, Leslie Prichep, Alejandro Zamorano, William Koppes) Challenge Submission Title: Prapela – an award-winning solution for Neonatal Abstinence Syndrome
Team 2: Pillsy (Optimize Health) Challenge Submission Title: Connected Pharmacy Platform to Improve Adherence for Opioid Agonists
Team 3: Cornell University Challenge Submission Title: Cornell Engineering World Health – SUD Startup Challenge Proposal
Team 4: Yale University Challenge Submission Title: Test Your Addictions
Team 5: Mindset-SUD Challenge Submission Title: Mindset-SUD: A Mobile Dialectical Behavioral Therapy Tool
Team 6: Hey, Charlie Challenge Submission Title: Hey, Charlie: A Digital Platform for Social Rebuilding During Recovery
Team 7: OPAT (F3 Healthcare) Challenge Submission Title: Opioid Prescribing Awareness Tool
Team 8: Neurocarrus Challenge Submission Title: Non-addictive Pain Therapeutics by Sensory Neuron Targeting
Team 9: S-3 Research Challenge Submission Title: A Solution to Automatically Detect, Classify, and Report Illicit Online Pharmacies Selling Controlled Substances
Team 10: UCLA (BDH Pharma) Challenge Submission Title: Medication Development for Substance Use Disorders
Team 1: PainQx Inc. (Frank Minella, Leslie Prichep, Alejandro Zamorano, William Koppes) Challenge Submission Title: PQX Objective Pain Measurement 1R44 DA045385-01 : Development of a Clinical Tool Utilizing an EEG Based Algorithm for the Objective Quantification of Pain The 1R44 DA045385-01 application was not discussed during the review meeting. The PainQx researchers proposed to develop a quantitative electro-encephalogram (qEEG) measure of pain. Reviewers found that validating the qEEG measure against self-reported pain in a chronic pain cohort is contradictory. It wasn’t clear that this will result in a “better” measure of pain compared to self-report. The proposal was found lacking details on the actual system prototype, pain classification algorithm, a proper control group in Phase I, discussion of factors other than age that might influence pain perception, and clear milestones to show feasibility of pain prediction and to justify progression to Phase II. After discussion of the Summary of Statement with OPIPI the application was submitted in December 2017 to RFA-DA-18-012 as 1R44 DA046964-01 : Development of a Medical Device Utilizing an EEG-Based Algorithm for the Objective Quantification of Pain. The application is currently pending NIDA review.
Team 2: Vlad Verkhusha and Daria Shcherbakova from Albert Einstein College of Medicine Challenge Submission Title: Near-infrared biosensors and optogenetics to advance preclinical studies in neurobiology This team was not incorporated a small business by the end of 2017 and keeps working with OTIPI to develop MVP and SBIR application
Team 3: Florida International University team (Francisco R. Ortega, Armando Barreto, Jules Calella, Alain Galvan, Santiago Bolivar) Challenge Submission Title: Bio-Interactive Device for SUD This team received the OTIPI mentorship and performed significant work to develop MVP. As the result of due diligences, they determine no path of the product to the market due to the product cost and regulatory hurdles. The team was not incorporated a small business.
Team 4: Beacon Health. Co (Shrenik Jain) Challenge Submission Title: Applying Natural Language Processing to Increase Provider Efficiency in SUD group therapy setting Created team for the SBIR application (Jain Shrenik, Ranney Megan, Kristen Morgan, Francesca Beaudoin, Langdon, Kirsten J, Roche Dan) 1R43 DA045402-01 : Applying Natural Language Processing to Increase Provider Efficiency and Patient Engagement in SUD Group Therapy. The 1R43 DA045402-01 application was not discussed during the review meeting. Beacon Tech proposed to use a mobile app with underlying NLP for sentiment analysis to improve management of substance abuse disorders. Reviewers found that application presents underdeveloped scientific model of sentiment analysis influencing app enhancement, patient engagement, and clinical outcomes. Despite of listed extensive expertise, there was little description of project management and investigator coordination. The study design as a controlled trial was lacking a description of measurable results. The study portion of the application could benefit from involvement of a statistician familiar with clinical trials and clarifying the role of the involved personal. Currently, OTIPI is working with the team to address review comments, straight the team and resubmit application.
Team 5: Epidemic Solutions, Inc. (Joseph Insler, Scott Weiner, John Moustoukas, Ajoy Basu, Michael Gilbert) Challenge Submission Title: Opioid Recovery Bracelet 1R43 DA045423-01 : Overdose Recovery Bracelet: A wearable device that detects opioid overdose and automatically injects life-saving naloxone without the help of others. The 1R43 DA045423-01 application was not discussed during the review meeting. Epidemic Solutions Inc. proposed development of a wearable system that can detect episode of opioid overdose and automatically inject antidote. Review found that there are practical and safety issues associated with the proposed system, and the research approach was poorly developed. Although the research team is strong in the clinical side, there is a lack of strong engineering/technical members to ensure the success of this project. Overall, while the medical need is strong, the concerns of practicality and safety and the poorly developed research approach tempered the enthusiasm of the reviewers for this proposal.
Team 6: JADE Biotech (John Lowman, Randall Brenn, Elora Hilmas, Dan Charytonowicz) Challenge Submission Title: Developing a Solution to Prevent the Diversion, Abuse, and Addiction to Hospital Narcotic Waste This team received the OTIPI mentorship and performed significant work to develop MVP. As the result of due diligences, they determine no path of the product to the market due to the product cost and regulatory hurdles. The team was not incorporated a small business.
Team 7: University of Kentucky College of Medicine, Bodhi Inc. (Michael Wesley, Josh Lile, Arit Harvanko, David Hempy) Challenge Submission Title: BiOfeedback and brain stimulation DEvicE The team was incorporated a small business in September 2017 and submitted the proposal as a response to PHS2018-1 NIDA, the topic #164 “Development of Portable Neuromodulatory Devices for the Treatment of Substance Use Disorders”. The proposal is currently pending NIDA review.
Team 8 : Care Analytics, University of Texas Health Science Center (Benson M Irungu, Mon-Ju Wu, Phillip Beckett, Tom Lee) Challenge Submission Title: A software tool to predict relapse related readmissions and provide post-discharge care coordination During MVP development process the team joined Medical Innovators Company LLC 1R43 DA045405-01 : A software solution to provide seamless care coordination and objective risk stratification to reduce relapse in substance use. 1R43 DA045405-01 application was discussed during the review study section and received the Priority Score of 68. The Medical Innovators Company proposed to develop software as a service (SAAS) technology that will be able to facilitate collection, curation and end-user co-creation of community social resource information. The tool is to identify people at risk for substance use disorder (SUD) relapse. Reviewer found that this project was lacking input from experts in SUD and statisticians. The approach discussed interviews but the participant group and the methods are not clear. There are also no specifics about how the data will be obtained from patients, and no clear methods and description of the predictive algorithm were presented. Reviewers founded also weakness in the supportive cited literature. OTIPI discussed the Summary Statement to address comments and propose the way to align budget efforts to actual proposed work. Following the significant revision of the application, the team has submitted it to the NSF SBIR program and was selected for funding in December 2017.
Team 9: Clare Zhu and Anin Sayana Challenge Submission Title : Blockchain-Based Healthcare Data Management The team had only junior scientists with minimal expertise for the product development who could not allocate the efforts and resources to complete MVP development. The team received the OTIPI training but decided do not incorporate a small business and do not submit a SBIR application.
Team 10: Viralchemy Bioscience (Trevor Gale, Tim Horton, Ben Bradley) Challenge Submission Title: Proteomics, Informatics, & Data Mining to Reduce Costs of Drug Development for Substance Use Disorders The team had only junior scientists with minimal expertise for the product development who could not allocate the efforts and resources to complete MVP development. The team received the OTIPI training but decided do not incorporate a small business and do not submit a SBIR application.

The goal of this challenge was to create an app to be used by addiction researchers in future studies which will help to improve the scientific understanding of drug use and addiction. The app will: allow researchers to engage “citizen scientists” and to recruit a large and varied number of willing study participants; present informed-consent materials; collect data frequently on a broad range of variables. NIDA encourages addiction researchers to use the newly available technical capabilities of ResearchKit ™ and seek collaboration(s) with app developers and engineers to create the winning research app. (Submission Period: November 3, 2015 - April 29, 2016.) For more information go to nida.ideascale.com (site discontinued)

Based upon the Challenge criteria, the judging panel selected:

First place - Greg Gruse, ICF International Inc., Rockville, MD for the submission entitled “Track the Crave” Track the Crave is an app developed to target smokers who are trying to quit and willing to provide detailed information about the circumstances surrounding their cravings. This app has the potential to help users in their quit attempt as well as provide a wealth of data that can inform future efforts to provide tailored and adaptive cessation interventions to smokers. The study aims to determine predictors of smoking relapse following a quit attempt, and identify if there are different patterns of quit trajectories. Researchers will be able to use this information to better understand the nuances of the quitting process and better assist smokers in permanently quitting.
Second place - Joshua Song, University of Michigan, Ann Arbor, MI for the submission entitled “Substance Abuse Research Assistant (SARA)” SARA is a flexible app platform that is customizable by researchers to integrate multiple data collection tools including wearable sensors, cognitive tasks, and self-report relevant for substance use research. The SARA study will focus on adolescents and emerging adults to understand initiation and escalation of drug use among youth. The app has an innovative engagement strategy providing data visualization and dynamic feedback to users.
Third place - Nancy Saccone, Washington University School of Medicine, St. Louis, MO for the submission entitled “Genomics of Addiction (GENA) App”. GENA app is a platform for adults who are participating in research programs conducted by genomic company 23andMe. The GENA study aims to integrate the existing 23andMe genetic data with substance use information to identify genetic and biological contributors to addiction. Researchers will drive large-scale human genomic studies of substance use disorders, with the goal of discovering important biological mechanisms and ultimately aiding the development of improved treatment and prevention strategies.

We appreciate all of the time and effort that went into each application, and encourage applicants to consider additional NIDA Challenges.

After completing a thorough review of the applications received, the judging panel found that none was sufficiently meritorious and responsive to the concept of the challenge. NIDA has therefore decided not to award any prizes. We appreciate all of the time and effort that went into each application. (Submission Period: May 26, 2015 - June 30, 2015)

After completing a thorough review of the applications received, the judging panel found that none was sufficiently responsive to the concept of the challenge to meet the standard for a First Prize Award. NIDA is awarding a meritorious/ honorable award of $10,000 to Jeremy Martinez, MD, Matrix Institute on Addictions, Los Angeles, CA for the submission title: “The Patient-Oriented Treatment Information Framework (POTIF)”. We appreciate all of the time and effort that went into each application, and encourage applicants to consider additional NIDA Challenges. (Submission Period: Jan. 14, 2015 - June 1, 2015)

Challenge Program Staff

Elena Koustova, Ph.D., MBA Director, Office of Translational Initiatives and Program Innovations (OTIPI) NIDA Challenge Manager National Institute on Drug Abuse (NIDA) 6001 Executive Blvd Room 4286, MSC 9555 Bethesda, MD 20892-9555 Phone: (301) 496-8768