phineas gage case study ib psychology

• Submit Content
• Business And Management
• Social Anthropology
• World Religions
• Biology 2016
• Design Technology
• Environmental Systems And Societies
• Sports Exercise And Health Science
• Mathematics Studies
• Mathematics SL
• Mathematics HL
• Computer Science
• Visual Arts
• Theory Of Knowledge
• Extended Essay
• Creativity Activity Service
• Video guides
• External links

The biological level of analysis

• General learning outcomes
• GLO1 : Outline principles that define...
• GLO2 : Explain how principles that de...
• GLO3 : Discuss how and why particular...
• GLO4 : Discuss ethical considerations...
• Physiology and Behaviour
• PB1 : Explain one study related to l...
• PB2 : Using one or more examples, ex...
• PB3 : Using one or more examples, ex...
• PB4 : Discuss two effects of the env...
• PB5 : Examine one interaction betwee...
• PB6 : Discuss the use of brain imagi...
• Genetics and Behaviour
• GB1 : With reference to relevant to ...
• GB2 : Examine one evolutionary expla...
• GB3 : Discuss ethical considerations...

The cognitive level of analysis

• Cognitive Processes
• CP1 : Evaluate schema theory with re...
• CP2 : Evaluate two models or theorie...
• CP3 : Explain how biological factors...
• CP4 : Discuss how social or cultural...
• CP5 : With reference to relevant res...
• CP6 : Discuss the use of technology ...
• Cognition and Emotion
• CE1 : To what extent do cognitive an...
• CE2 : Evaluate one theory of how emo...

The sociocultural level of analysis

• Sociocultural cognition
• SC1 : Describe the role of situation...
• SC2 : Discuss two errors in attribut...
• SC3 : Evaluate social identity theor...
• SC4 : Explain the formation of stere...
• Social Norms
• SN1 : Explain social learning theory...
• SN2 : Discuss the use of compliance ...
• SN3 : Evaluate research on conformit...

Explain one study related to localization of function in the brain.

Introduction.

• State what you are doing in the essay 
• This essay will attempt to give a detailed account including reasons or causes of localisation of the brain 
• Define Localisation of Function (LOF) 
• LOF is the theory that certain areas of the brain correspond to certain functions; in that specific areas of the brain control different functions carried out by the brain.
• It refers to the idea that behaviour, emotions and thoughts originate in the brain in specific locations. 
• Therefore, damage to relevant areas of the brain can cause drastic loss of that function and even more, depending on the individual.
• Therefore it is said that many functions of the brain are strictly “localised.? 
• State/Introduce the parts of the brain The basic set-up of the brain includes: 
• 2 main hemispheres: 
• Left – logic, problem solving, maths, and language, controls RHS of body 
• Right – creativity, emotion, beliefs controls RHS of body
• 4 main lobes:
• Occipital – vision 
• Parietal – higher senses and language functions 
• Frontal – reasoning, problem solving, judgement and creativity 
• Temporal – perception, hearing (sound recognition), memory and meaning. 
• Other important areas of the brain include:
• Broca’s Area – inability to produce language, but could understand/comprehend. 
• Wernicke’s Area – inability to understand language, but could communicate/speak
• Introduce research into LOF
• Research from the 19th and 20th centuries has guided us towards a much better understanding of how we should carry out such research into the brain, but more specially, how functions of the brain are localized.
• Possible studies to use for this essay
• Some studies which appear to support and demonstrate localisation of function are: 
• Broca – Tan (1861)
• Harlow – Phineas Gage (1849)
• Raine et al. (1997)
• *Roger Sperry (1968) – If this study is chosen, make sure you explicitly state how it is localisation of function.
• *Wernicke (1874)
• Milner – HM (1966)

* The studies with the stars are studies you can incorporate into your response, making sure you explicitly state how it relates to LOF as they are not clear or contain different intentions other than LOF. - For example Wernicke – you can't really explain the study as he never really conducted an official study, but if you choose Broca then try and explain Wernicke’s study with it.

• Introduce research into LOF (be more specific)
• Scientific research into brain function was, until the 20th century, largely limited to case studies of individuals who were known to have suffered some kind of brain damage or head injury.
• This type of research, not being of an experimental nature, could never clearly establish a cause and effect relationship between the behaviour of the person before death and location of the brain damage.

Study 1: Phineas Gage (1848)

• To investigate the localisation of function in Phineas Gage’s case of how his brain damage resulted in a change of behaviour.
• Specifically, Harlow wanted to investigate how the particular brain damage altered his behaviour.
• Phineas Gage, a 25-year-old railroad worker in the 19th century who survived the passing of an iron rod through his head/skull.
• It entered below his left cheek and exited through the top of his skull on the frontal lobe. 
• J.M Harlow nursed Gage to recovery observing his behaviour.
• Harlow observed and studied Gage, having undergone dramatic changes in personality after the injury, which he didn?t show beforehand. 
• Harlow described him as having little restraint, using extremely rude language, and making grand plans for the future, which would be instantly replaced with others. 

Conclusion: 

• From Harlow’s study of Phineas Gage, it can be concluded that Gage’s frontal lobes were indeed damaged in the left pre-frontal region, which accounted for his disinhibited behaviour. 
• Harlow’s study exemplifies how different parts of the brain, in this case, the frontal lobe which controls personality, relating back to the theory of localization of function, which is that specific regions of the brain are responsible for different functions. 

Study 2: Broca – “Tan” (1861)

• Introduce study and link to question: 
• Another study from the 19th century which further revealed important and new information about the function of specific areas of the brain was by Paul Broca (1824-80)
• To investigate the localisation of function in a patient called “Tan.”
• Broca wanted to investigate Tan’s unusually language ability/capability by studying his brain.
• Broca studied a patient over a number of years (as it was a longitudinal study), known as “Tan,” because it was one of the few sounds he could make.
• After Tan died, Broca conducted a post-mortem autopsy on this patient (and several others) to figure out what part of the brain caused his or similar conditions.
• After performing the autopsy, he now had evidence that damage to a specific area of the brain was responsible for the loss of ability to produce coherent speech.
• This area became known as Broca’s area.
• The effects of damage to this part of the brain can most easily be observed in the speech of stroke victims, many of whom are temporarily or permanently unable to produce language, a condition known as Broca’s aphasia.

Conclusion:

• Broca concluded that the area named after him (Broca’s area) is responsible for an impairment of language in a person.
• Through this study, new understanding and research had arised of “localised functions? of different parts of the brain, as a result of this finding from early research into the brain by scientists such as Broca.

Study 3: Wernicke (1874)

• Introduce study and link to question:
• A further study from the 19th century, very similar to Broca’s which also revealed important and new information about the function of another specific area of the brain was by Carl Wernicke (1874)
• *May want to link with Broca’s area.
• To investigate the localisation of function in patients with brain damage. 
• Like Broca, Wernicke wanted to investigate another speech/language and comprehension disorder, in which he believed, resulted from a different area than Broca’s area responsible for the comprehension of speech. 

Method: 

• Wernicke worked in a similar fashion to Broca, by noting behaviour and conducting post-mortem autopsies to locate brain damage after patients had died, particularly in stroke victims. 
• After performing the autopsies, Wernicke concluded that there was a section of the brain which was responsible for the comprehension of speech. 
• The area later became known as Wernicke’s area. 
• Individuals with this type of aphasia might have problems understanding the speech of others or might substitute wrong words into planned phrases. 
• He now had evidence that damage to Wernicke’s area was responsible for the loss of ability to comprehend and understand speech, but still being able to speak. 

Conclusion:  

• Through this study, Wernicke concluded that the area named after him (Wernicke’s area) is responsible for an impairment of comprehending/understanding language. 
• Through studies like Wernicke and Broca’s, it became clear that specific parts of the brain were responsible for specific human activities and behaviour. 
• However, it was still very difficult to find ways to investigate this further, as cases like these were usually rare. 
• Furthermore, people could not be operated on as it is deemed to be unethical. 

Study 4: Raine et al. (1997)

Aims: The aim of the experiment was to discover (using PET scans) if murderers who pleaded not guilty by reason of insanity (NGRI) to show evidence of brain abnormalities (by observing the cortical and subcortical parts of the brain)

• Was to compare the functioning of various brain structures between NGRI'S and normal subjects using PET scanning technologies

Variables: The independent variable in this study was whether the participant was a NGRI or not. The dependent variable was the PET scan results between the controls and the NGRIs. 

Controlled: 1 for each subject 

• matched for age / sex  
• schizophrenics with non-murderer schizophrenics  
• all controls screened for mental/physical health) 

Methods: 

• 41 participants (39 male, 2 female) who pleaded not guilty for reasons of insanity (average age of 34.3 
• Matched with 41 participants (controls) was selected based on sex, age and matched to a NGRI participant 
• Each participant was injected with a glucose tracer (bonds to substances like glucose) (for PET scans) 
• As the brain uses substances like glucose (as energy) the areas of the brain that are most active absorb it
• The glucose is broken down but the radioactive materials remain and it emits positively charged particles called positrons, which are picked up by the scan
• This information can be read by the computer, producing coloured images on the level of activity throughout the brains
• They had to perform tasks requiring them to detect target signals for 32 minutes 
• Compared level of activity (glucose metabolism) in the right and left hemispheres of the brains and the control participants 

Results: 

• Less activity in the parietal and pre-frontal cortex of the brain of those participants charged with murder 
• More activity in the occipital areas and no difference in their temporal areas 
• Group 1 (those charged with murder): 
• Inability to grasp long-term implications of a situation
• Inappropriate emotional expression
• Lack of activity in the amygdala - indicating that violence was due to unusual emotional responses (e.g. lack of fear) 

Evaluation: 

Strengths: 

• A large sample was used with many controls to rule out alternative effects on brain activity. 
• Previous findings on brain structures involved in violence are supported and new findings revealed. 
• The PET scan method can lack precision, as the findings apply only to a subgroup of violent offenders (not to other types of violence or crime) and caution in the interpretation of the findings is needed, which need to be replicated. 
• The findings do not mean violence is caused by biology alone (other social, psychological and situational factors are involved). 
• It does not demonstrate that the murderers are not responsible for their actions. 
• It does not mean PET scans can diagnose murderers and do not say whether the brain abnormalities are a cause or effect of behaviour. 
• No control over the level of violence used in the murder. 
• Brain scans can be difficult to interpret. 
• Ethical implications of socially sensitive research. 
• Raine et al's study on NGRI's illustrated localisation of function 
• Differences were found in the amygdala and corpus callosum of the NGRI's, amongst various structures, suggesting differences in their experience of emotion of fear and their inability to contemplate consequences of their actions 
• The use of this new technology enables psychologists to see the functioning structures of the brain whilst performing specific tasks 
• This hence allowed Raine to compare the functions of various brain regions, effectively showing changes in these areas in NGRI subjects and how they subsequently affect subjects' functioning 

Study 5: Sperry (1968)

• An influential study, which helped neuroscientists to understand the way brain functions appear to be not only localized in specific regions, but also lateralized – that is, the left and right hemispheres seem to be more or less responsible for certain activities was from the work of Roger Sperry (1968).
• *Be careful with this study, and be explicit about the localization of function that Sperry demonstrated.
• Note that laterization of function is not the same as localization of function, so answers using Sperry need to focus on the function of the corpus callosum, not on differences between left and right hemispheres of the brain.
• To investigate both the localisation and laterization of brain functions.
• To test the effects of a severed corpus callosum, and therefore prove that the two hemispheres have separate functions.
• He selected 11 patients who had severed corpus callosums, where the corpus callosums were severed in epilepsy sufferers to prevent seizures crossing from one side of the brain to another. 
• The patients were asked to perform hemisphere-related tasks.
• The tasks included being shown an image on the left or right hand side of their body, where they were asked to identify it or asked to drawn pictures with their left or right hands based off an example.
• Sperry found that the patients could redraw pictures with their left hands, but not with their right.
• This could be due to the fact that the left hand side of the body is controlled by the right hemisphere, which is also the creative hemisphere.
• Sperry also found that when a picture was shown on the left they could not identify it, but could recognise it out of a variety of objects (right hemisphere knows object function but not name). 
• Inversely, when the object was shown on the right the patients were able to identify what it was.

Evaluation:

• Although, Sperry only had 11 participants, he found significant information into the insight of localization of brain function as well as laterization, which is the theory that the two hemispheres have separate functions.

Limitations:

• His study was seen to have low ecological validity, as it only had 11 participants/patients. 
• Furthermore, more research needs to be undertaken regarding people who do not have a severed corpus callosum, so that it can be distinguished as to whether Sperry’s results can be applied to the general population.
• Through this study, Sperry found significant information into the insight of localization of brain function as well as laterization, which is the theory that the two hemispheres have separate functions.
• Laterization of function include the assertion that the right half of the brain is dominant for visuo-spatial ability (demonstrated in tasks like reading maps or recognizing faces), as well as musical abilities and understanding intonation in speech.
• The left half of the brain seems to be more positive than the right and is dominant for language and logical or mathematical abilities.
• His research allowed other research to form and take place to gain more insight into how the different parts of the brain functions.
• What has been discovered through this essay? Make a link to the learning outcome 
• The theory of localization of function within the brain is clearly established, and has relevant studies to support it as seen by Harlow’s work on Phineas Gage and other studies. 
• It is generally accepted that there are two hemispheres within the brain which each control separate functions.
• Similarly, the four lobes of the brain and other areas of the brain are understood to have separate functions, primarily to do with the senses. 
• What did Harlow’s study (or other study) signify? 
• Harlow’s study (1848) helped to demonstrate localization of brain function, in how different parts of the brain are responsible for specific human activities and behaviour.
• State explicitly what area of the brain affected what behaviour in Phineas Gage’s condition.  
• In Gage’s case, Harlow discovered that the frontal lobes were responsible a change in personality and emotional vibe, which Gage showed a significant change in behaviour of. 
• However, more research needs to be undertaken in this area to ensure better understanding of the human brain.

Hints & Tips

• Short-answer questions may require you to write an explanation of a study connected with localization of function. 
• In order to write a good response, you need to describe the study and clearly indicate how it shows that brain functions are localized. 
• Specifically: detailing what part of the brain was affected, how the researcher found out, and what the effect on behaviour, cognition or emotion was. 

• school Campus Bookshelves
• menu_book Bookshelves
• perm_media Learning Objects
• login Login
• how_to_reg Request Instructor Account
• hub Instructor Commons
• Download Page (PDF)
• Download Full Book (PDF)
• Periodic Table
• Physics Constants
• Scientific Calculator
• Reference & Cite
• Tools expand_more
• Readability

selected template will load here

This action is not available.

1.3: The Case of Phineas Gage- Connecting Brain to Behavior

• Last updated
• Save as PDF
• Page ID 173107

• Multiple Authors
• ASCCC Open Educational Resources Initiative (OERI)

Learning Objectives

• Discuss the Case of Phineas Gage and its contribution to biological psychology.

While experiments are necessary to establish cause and effect relationships, in-depth studies of unique individuals or groups of people who share an experience can be used to inform our understanding of things that we can not study experimentally. Surgical errors, extreme mistreatment, and tragic accidents are impactful events that can alter individuals significantly, providing unique opportunities to study the effects of experiences which can not be ethically studied experimentally. There have been a number of these case studies which have revealed the role of different parts of the brain on our thinking and behavior. One such case is Phineas Gage. Gage lived 12 years after a rod pierced his skull, damaging his left frontal lobe. Researchers were able to gather information about his functioning before and observe his cognitive ability and personality after the accident. His case enabled the field to understand the role of frontal lobe in personality and mental processes.

The Tale of Phineas Gage

The case of Phineas Gage is worthy of expanded coverage as his tragic accident establishes a clear connection between the brain and who we are. Gage, a 25-year-old man, was employed in railroad construction at the time of the accident. As the company's most capable employee, with a well-balanced mind and a sense of leadership, he was directing a rock-splitting workgroup while preparing the bed of the Rutland and Burlington Railroad south of Cavendish, Vermont, USA. At 4:30 PM on September 13, 1848, he and his group were blasting a rock, and Gage was assigned to put gunpowder in a deep hole inside it.

The moment he pressed the gunpowder into the hole with a bar, the friction caused sparks, and the powder exploded. The resulting blast projected the meter-long bar, which was 1.25 inches in diameter and weighed about 13.2 pounds, through his skull at high speed. The bar entered his left cheek, destroyed his eye, passed through the left front of his brain, and left his head at the top of the skull on the right side. Gage was thrown on his back and had some brief convulsions, but he woke up and spoke in a few minutes, walked with a little help, and sat in an ox cart for the 0.7-mile trip to where he was living.

About 30 minutes after the accident, a doctor arrived to provide medical care. Gage had lost a lot of blood, and the next days that followed were quite difficult. The wound became infected, and Phineas was anemic and remained semi-comatose for more than two weeks. He also developed a fungal infection in the exposed brain that needed to be surgically removed. His condition slowly improved after doses of calomel and beaver oil. By mid-November he was already walking around the city.

The Consequences

For three weeks after the accident, the wound was treated by doctors. During this time, he was assisted by Dr. John Harlow, who covered the head wound and then reported the case in the Boston Medical Surgery Journal. In November 1849, invited by the professor of surgery at Harvard Medical School, Henry Jacob Bigelow, Harlow took Gage to Boston and introduced him to a meeting of the Boston Society for Medical Improvement .

In his reports, Harlow described that the physical injury profoundly altered Gage's personality. Although his memory, cognition, and strength had not been altered, his once gentle personality slowly degraded. He became a man of bad and rude ways, disrespectful to colleagues, and unable to accept advice. His plans for the future were abandoned, and he acted without thinking about the consequences. And here was the main point of this curious story: Gage became irritable, irreverent, rude and profane, aspects that were not part of his way of being. His mind had changed radically. His transformation was so great that everyone said that “Gage is no longer himself.”

As a result of this personality change, he was fired and could no longer hold a steady job. He became a circus attraction and even tried life in Chile, later returning to the United States. However, there is something still little known about Gage: his personality changes lasted for about four years, slowly reverting later. As a proof of this, he worked as a long-haul driver in Chile, a job that required considerable planning and focus skills. He died on May 21, 1861, 12 years after the accident, from an epileptic seizure that was almost certainly related to his brain injury.

After his body was removed from its grave, Gage's mother donated his skull to Dr. Harlow who in turn donated it to Harvard University.

Gage's case is considered to be one of the first examples of scientific evidence indicating that damage to the frontal lobes may alter personality, emotions, and social interaction. Prior to this case, the frontal lobes were considered silent structures, without function and unrelated to human behavior. Scottish neurologist, David Ferrier, was motivated by this fact to investigate the role of frontal lobes in brain function. Ferrier removed the frontal lobes in monkeys and noted that there were no major physiological changes, but the character and behavior of the animals were altered. In other words, he confirmed the role of the frontal lobes that was suggested by Gage's accident in an experiment with a non-human animal.

Knowledge that the frontal lobe was involved with emotions continued to be studied. The surgeon Burkhardt in 1894 performed a series of surgeries in which he selectively destroyed the frontal lobes of several patients in whom he sought to control psychotic symptoms, being the modern prototype of what was later known through Antonio Egas Moniz as psychosurgery. Today, it is well understood that the prefrontal cortex of the brain controls the organization of behavior, including emotions and inhibitions.

Folkloric as it may be, but nonetheless remarkable, the contribution of Phineas Gage's case should not be overlooked, as it provided scientists the baseline for the promotion of studies in neuropsychiatry, and a source of inspiration for world medicine. In 2012, a team of neuroscientists used computer tomography of Gage's skull with typical brain MRI scans to simulate how extensive Gage's brain damage was. They confirmed that most of the damaged area was the left frontal lobe. However, surrounding areas and their neural network were also extensively severed. And it is not just the researchers who keep coming back to Gage. Medical and psychology students still learn about Gage from their history lessons. Neurosurgeons and neurologists still sometimes use Gage as a reference when evaluating certain cases. The final chapter of his life also offers us a thought-provoking discovery about cases of massive brain damage, indicating that rehabilitation may be possible.

Phineas Gage made a huge contribution to our understanding of the frontal lobe damage and its subsequent change in personality. Furthermore, his case expanded knowledge in neurology in several areas, including the study of brain topography in behavioral disorders, the development of psychosurgery, and finally the study of brain rehabilitation. Also, Gage's case had a tremendous influence on early neuropsychiatry. The specific changes observed in his behavior pointed to theories about the localization of brain function and correlated with cognitive and behavioral sequelae, thereby acquainting us with the role of the frontal cortex in higher-order actions such as reasoning, behavior and social cognition. In those years, while neuropsychiatry was in its infancy, Gage's extraordinary story served as one of the first pillars of evidence that the frontal lobe is involved in personality, which helped solidify his remarkable legacy in world medical history.

Attributions

Adapted from Phineas Gage’s Great Legacy by Vieira Teles Filho, Ricardo. Licensed CC BY 4.0 .

HIGH SCHOOL

• ACT Tutoring
• SAT Tutoring
• PSAT Tutoring
• ASPIRE Tutoring
• SHSAT Tutoring
• STAAR Tutoring

GRADUATE SCHOOL

• MCAT Tutoring
• GRE Tutoring
• LSAT Tutoring
• GMAT Tutoring
• AIMS Tutoring
• HSPT Tutoring
• ISAT Tutoring
• SSAT Tutoring

Search 50+ Tests

Loading Page

math tutoring

• Elementary Math
• Pre-Calculus
• Trigonometry

science tutoring

Foreign languages.

• Mandarin Chinese

elementary tutoring

• Computer Science

Search 350+ Subjects

• Video Overview
• Tutor Selection Process
• Online Tutoring
• Mobile Tutoring
• Instant Tutoring
• How We Operate
• Our Guarantee
• Impact of Tutoring
• Reviews & Testimonials
• Media Coverage
• About Varsity Tutors

IB Psychology HL : Qualitative research study

Study concepts, example questions & explanations for ib psychology hl, all ib psychology hl resources, example questions, example question #1 : qualitative research study.

The case of Phineas Gage enabled psychologists to study the effects of personality and behavior in relation to damage associated with his frontal lobe. Gage was injured when a rod pierced his skull and destroyed most of his left frontal lobe. Researchers studied Gage and noted changes in his behavior the occurred directly after and as a result of the incident. As a result, they concluded that the frontal lobe plays a key role in a person's behavior. This case is best categorized by which of the following methods of psychological research? 

None of these

Participant observation

Phineas Gage was a key psychological "case study." A case study is defined as a particular instance of a phenomenon that is observed and analyzed in order to illustrate a thesis or principal. In this particular instance, psychologists were able to better understand the frontal lobe's ability to dictate a person's behavior and personality. 

Example Question #1 : Qualitative Research In Psychology

Example question #3 : qualitative research study.

Which of the following is not a qualitative research method used in psychology?

Focus groups

Participant observations

Case studies

Informal interviews 

Qualitative research methods collects data utilizing naturalistic and verbal reports. Qualitative research methods rely data that is not numerical in nature. Qualitative data are collected in the following methods: case studies, participant observations, focus groups, and informal interviews. Case studies such as the Genie (the feral child) and Phineas Gage incorporate the observation and study of subjects for extended periods of time. Participant observation is a qualitative method of study preferred by those who wish to learn more about a particular group or culture through social immersion where the researcher takes on the dual role of both participant and observer. Focus groups are a common qualitative method that use semistructured interviews with a small group of individuals to gather data on particular phenomena. Likewise, informal interviews use semistructured guides to ask subjects questions in order to gather information regarding particular phenomena. On the other hand, surveys are quantitative by nature. Surveys typically use dichotomous, rating, Likert, and semantic differential scales to analyze and code respondent's answers to perform statistical operations that help to explain a particular phenomenon. 

Example Question #4 : Qualitative Research Study

A group of psychologists decide to study language acquisition and development of children in a particular Amish community. They decide to use ethnographic methods to study this particular phenomenon. Which of the following methods of data collection would these individuals most likely use?

Historical analysis 

Experimentation

Self-reporting surveys

In this situation, the psychologists would most likely use methods of participant observation. Ethnographers imbed themselves in a community and take on the dual role of both participant and observer. In this way, they collect data through direct observations. These observations are then analyzed and coded in order to generate conclusions about the Amish community. The other methods—experimentation, surveys, and historical analysis—utilize methods that are not commonly associated with ethnography. These methods can supplement ethnographic analysis; however, they are not a primary component of ethnography.

Example Question #5 : Qualitative Research Study

Example question #6 : qualitative research study.

Report an issue with this question

If you've found an issue with this question, please let us know. With the help of the community we can continue to improve our educational resources.

DMCA Complaint

If you believe that content available by means of the Website (as defined in our Terms of Service) infringes one or more of your copyrights, please notify us by providing a written notice (“Infringement Notice”) containing the information described below to the designated agent listed below. If Varsity Tutors takes action in response to an Infringement Notice, it will make a good faith attempt to contact the party that made such content available by means of the most recent email address, if any, provided by such party to Varsity Tutors.

Your Infringement Notice may be forwarded to the party that made the content available or to third parties such as ChillingEffects.org.

Please be advised that you will be liable for damages (including costs and attorneys’ fees) if you materially misrepresent that a product or activity is infringing your copyrights. Thus, if you are not sure content located on or linked-to by the Website infringes your copyright, you should consider first contacting an attorney.

Please follow these steps to file a notice:

You must include the following:

A physical or electronic signature of the copyright owner or a person authorized to act on their behalf; An identification of the copyright claimed to have been infringed; A description of the nature and exact location of the content that you claim to infringe your copyright, in \ sufficient detail to permit Varsity Tutors to find and positively identify that content; for example we require a link to the specific question (not just the name of the question) that contains the content and a description of which specific portion of the question – an image, a link, the text, etc – your complaint refers to; Your name, address, telephone number and email address; and A statement by you: (a) that you believe in good faith that the use of the content that you claim to infringe your copyright is not authorized by law, or by the copyright owner or such owner’s agent; (b) that all of the information contained in your Infringement Notice is accurate, and (c) under penalty of perjury, that you are either the copyright owner or a person authorized to act on their behalf.

Send your complaint to our designated agent at:

Charles Cohn Varsity Tutors LLC 101 S. Hanley Rd, Suite 300 St. Louis, MO 63105

Or fill out the form below:

Contact Information

Complaint details.

• Bipolar Disorder
• Therapy Center
• When To See a Therapist
• Types of Therapy
• Best Online Therapy
• Best Couples Therapy
• Best Family Therapy
• Managing Stress
• Sleep and Dreaming
• Understanding Emotions
• Self-Improvement
• Healthy Relationships
• Student Resources
• Personality Types
• Verywell Mind Insights
• 2023 Verywell Mind 25
• Mental Health in the Classroom
• Editorial Process
• Meet Our Review Board
• Crisis Support

Phineas Gage: His Accident and Impact on Psychology

Kendra Cherry, MS, is a psychosocial rehabilitation specialist, psychology educator, and author of the "Everything Psychology Book."

Emily is a board-certified science editor who has worked with top digital publishing brands like Voices for Biodiversity, Study.com, GoodTherapy, Vox, and Verywell.

Author unknown / Wikimedia Commons

• Phineas Gage's Accident
• Change in Personality
• Severity of Brain Damage
• Impact on Psychology

What Happened to Phineas Gage After the Brain Damage?

Phineas Gage is often referred to as the "man who began neuroscience." He experienced a traumatic brain injury when an iron rod was driven through his skull, destroying much of his frontal lobe .

Gage miraculously survived the accident. However, his personality and behavior were so changed as a result of the frontal lobe damage that many of his friends described him as an almost different person entirely. The impact that the accident had has helped us better understand what the frontal lobe does, especially in relation to personality .

At a Glance

In 1948, Phineas Gage had a workplace accident in which an iron tamping rod entered and exited his skull. He survived but it is said that his personality changed as a result, leading to a greater understanding of the brain regions involved in personality, namely the frontal lobe.

Phineas Gage's Accident

On September 13, 1848, 25-year-old Gage was working as the foreman of a crew preparing a railroad bed near Cavendish, Vermont. He was using an iron tamping rod to pack explosive powder into a hole.

Unfortunately, the powder detonated, sending the 43-inch-long, 1.25-inch-diameter rod hurling upward. The rod penetrated Gage's left cheek, tore through his brain , and exited his skull before landing 80 feet away.

Gage not only survived the initial injury but was able to speak and walk to a nearby cart so he could be taken into town to be seen by a doctor. He was still conscious later that evening and able to recount the names of his co-workers. Gage even suggested that he didn't wish to see his friends since he would be back to work in "a day or two" anyway.

The Recovery Process

After developing an infection, Gage spent September 23 to October 3 in a semi-comatose state. On October 7, he took his first steps out of bed, and, by October 11, his intellectual functioning began to improve.

Descriptions of Gage's injury and mental changes were made by Dr. John Martyn Harlow. Much of what researchers know about the case is based on Harlow's observations.

Harlow noted that Gage knew how much time had passed since the accident and remembered clearly how the accident occurred, but had difficulty estimating the size and amounts of money. Within a month, Gage was well enough to leave the house.

In the months that followed, Gage returned to his parent's home in New Hampshire to recuperate. When Harlow saw Gage again the following year, the doctor noted that while Gage had lost vision in his eye and was left with obvious scars from the accident, he was in good physical health and appeared recovered.

Theories About Gage's Survival and Recovery

The type of injury sustained by Phineas Gage could have easily been fatal. While it cannot be said with certainty why Gage was able to survive the accident, let alone recover from the injury and still function, several theories exist. They include:

• The rod's path . Some researchers suggest that the rod's path likely played a role in Gage's survival in that if it had penetrated other areas of the head—such as the pterygoid plexuses or cavernous sinus—Gage may have bled to death.
• The brain's selective recruitment . In a 2022 study of another individual who also had an iron rod go through his skull—whom the researchers referred to as a "modern-day Phineas Gage"—it was found that the brain is able to selectively recruit non-injured areas to help perform functions previously assigned to the injured portion.
• Work structure . Others theorize that Gage's work provided him structure, positively contributing to his recovery and aiding in his rehabilitation.

How Did Phineas Gage's Personality Change?

Popular reports of Gage often depict him as a hardworking, pleasant man before the accident. Post-accident, these reports describe him as a changed man, suggesting that the injury had transformed him into a surly, aggressive heavy drinker who was unable to hold down a job.

Harlow presented the first account of the changes in Gage's behavior following the accident. Where Gage had been described as energetic, motivated, and shrewd prior to the accident, many of his acquaintances explained that after the injury, he was "no longer Gage."

Severity of Gage's Brain Damage

Since there is little direct evidence of the exact extent of Gage's injuries aside from Harlow's report, it is difficult to know exactly how severely his brain was damaged. Harlow's accounts suggest that the injury did lead to a loss of social inhibition, leading Gage to behave in ways that were seen as inappropriate.

In a 1994 study, researchers utilized neuroimaging techniques to reconstruct Phineas Gage's skull and determine the exact placement of the injury. Their findings indicate that he suffered injuries to both the left and right prefrontal cortices, which would result in problems with emotional processing and rational decision-making .

Another study conducted in 2004 used three-dimensional, computer-aided reconstruction to analyze the extent of Gage's injury. It found that the effects were limited to the left frontal lobe.

In 2012, new research estimated that the iron rod destroyed approximately 11% of the white matter in Gage's frontal lobe and 4% of his cerebral cortex.

Some evidence suggests that many of the supposed effects of the accident may have been exaggerated and that Gage was actually far more functional than previously reported.

Why Is Phineas Gage Important to Psychology?

Gage's case had a tremendous influence on early neurology. The specific changes observed in his behavior pointed to emerging theories about the localization of brain function, or the idea that certain functions are associated with specific areas of the brain.

In those years, neurology was in its infancy. Gage's extraordinary story served as one of the first sources of evidence that the frontal lobe was involved in personality.

Today, scientists better understand the role that the frontal cortex has to play in important higher-order functions such as reasoning , language, and social cognition .

After the accident, Gage was unable to continue his previous job. According to Harlow, Gage spent some time traveling through New England and Europe with his tamping iron to earn money, supposedly even appearing in the Barnum American Museum in New York.

He also worked briefly at a livery stable in New Hampshire and then spent seven years as a stagecoach driver in Chile. He eventually moved to San Francisco to live with his mother as his health deteriorated.

After a series of epileptic seizures, Gage died on May 21, 1860, almost 12 years after his accident. Seven years after his death, Gage's body was exhumed. His brother gave his skull and the tamping rod to Dr. Harlow, who subsequently donated them to the Harvard University School of Medicine. They are still exhibited in its museum today.

Bottom Line

Gage's accident and subsequent experiences serve as a historical example of how case studies can be used to look at unique situations that could not be replicated in a lab. What researchers learned from Phineas Gage's skull and brain injury played an important role in the early days of neurology and helped scientists gain a better understanding of the human brain and the impact that damage could have on both functioning and behavior.

Sevmez F, Adanir S, Ince R. Legendary name of neuroscience: Phineas Gage (1823-1860) . Child's Nervous System . 2020. doi:10.1007/s00381-020-04595-6

Twomey S. Phineas Gage: Neuroscience's most famous patient .  Smithsonian Magazine.

Harlow JM. Recovery after severe injury to the head . Bull Massachus Med Soc . 1848. Reprinted in  Hist Psychiat. 1993;4(14):274-281. doi:10.1177/0957154X9300401407

Harlow JM. Passage of an iron rod through the head . 1848. J Neuropsychiatry Clin Neurosci . 1999;11(2):281-3. doi:10.1176/jnp.11.2.281

Itkin A, Sehgal T. Review of Phineas Gage's oral and maxillofacial injuries . J Oral Biol . 2017;4(1):3.

de Freitas P, Monteiro R, Bertani R, et al. E.L., a modern-day Phineas Gage: Revisiting frontal lobe injury . The Lancet Regional Health - Americas . 2022;14:100340. doi:10.1016/j.lana.2022.100340

Macmillan M, Lena ML. Rehabilitating Phineas Gage . Neuropsycholog Rehab . 2010;20(5):641-658. doi:10.1080/09602011003760527

O'Driscoll K, Leach JP. "No longer Gage": An iron bar through the head. Early observations of personality change after injury to the prefrontal cortex . BMJ . 1998;317(7174):1673-4. doi:10.1136/bmj.317.7174.1673a

Damasio H, Grabowski T, Frank R, Galaburda AM, Damasio AR. The return of Phineas Gage: Clues about the brain from the skull of a famous patient . Science . 1994;264(5162):1102-5. doi:10.1126/science.8178168

Ratiu P, Talos IF. Images in clinical medicine. The tale of Phineas Gage, digitally remastered . N Engl J Med . 2004;351(23):e21. doi:10.1056/NEJMicm031024

Van Horn JD, Irimia A, Torgerson CM, Chambers MC, Kikinis R, Toga AW. Mapping connectivity damage in the case of Phineas Gage . PLoS One . 2012;7(5):e37454. doi: 10.1371/journal.pone.0037454

Macmillan M. An Odd Kind of Fame: Stories of Phineas Gage . MIT Press.

Shelley B. Footprints of Phineas Gage: Historical beginnings on the origins of brain and behavior and the birth of cerebral localizationism . Archives Med Health Sci . 2016;4(2):280-6. doi:10.4103/2321-4848.196182

By Kendra Cherry, MSEd Kendra Cherry, MS, is a psychosocial rehabilitation specialist, psychology educator, and author of the "Everything Psychology Book."

An official website of the United States government

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

• Publications
• Account settings

Preview improvements coming to the PMC website in October 2024. Learn More or Try it out now .

• Advanced Search
• Journal List
• Dement Neuropsychol
• v.14(4); 2020 Dec

Language: English | Portuguese

Phineas Gage's great legacy

O grande legado de phineas gage, ricardo vieira teles, filho.

1 Faculty of Medicine, Universidade Federal de Goiás – Goiânia, GO, Brazil.

The case of Phineas Gage is an integral part of medical folklore. His accident still causes astonishment and curiosity and can be considered as the case that most influenced and contributed to the nineteenth century's neuropsychiatric discussion on the mind-brain relationship and brain topography. It was perhaps the first case to suggest the role of brain areas in determining personality and which specific parts of the brain, when affected, can induce specific mental changes. In addition, his case contributed to the emergence of the scientific approaches that would later culminate in psychosurgery. Gage is a fixed element in the studies of neurology, psychology, and neuroscience, having been solidified as one of the greatest medical curiosities of all time, deserving its prominence.

O caso de Phineas Gage é parte integrante do folclore médico. Seu acidente ainda causa espanto e curiosidade, e pode ser considerado como o caso que mais influenciou e contribuiu para a discussão neuropsiquiátrica do século XIX sobre a relação mente-cérebro e topografia cerebral. Foi talvez o primeiro caso a sugerir o papel de áreas cerebrais na determinação da personalidade e que partes específicas do cérebro, quando afetadas, podem induzir mudanças mentais específicas. Além disso, seu caso contribuiu para o surgimento de abordagens cientificas que culminariam posteriormente na psicocirurgia. Gage é um elemento fixo nos estudos de neurologia, psicologia e neurociências, tendo sido solidificado como uma das grandes curiosidades médicas de todos os tempos que merece seu destaque.

THE ACCIDENT

Gage, a 25-year-old male, 1.70 m in height and weighing approximately 70 kg, was employed in railroad construction at the time of the accident. As the company's most capable employee, with a well-balanced mind and a sense of leadership, he was directing a rock-splitting workgroup while preparing the bed of the Rutland & Burlington Railroad south of Cavendish, Vermont, USA. At 4:30 PM on September 13, 1848, he and his group were blasting a rock, and Gage was assigned to put gunpowder in a deep hole inside it. 1

The moment he pressed the gunpowder into the hole with a bar, the friction caused sparks, and the powder exploded. The resulting blast projected the meter-long bar, which was 3.2 cm in diameter and weighed about 6 kg, through his skull at high speed. The bar entered his left cheek, destroyed his eye, passed through the left front of the brain, and finally completely left his head at the top of the skull on the right side. Gage was thrown on his back and had some brief convulsions, but he woke up and spoke in a few minutes, walked with a little help, and sat in an ox cart for the 1.2-km trip to his quarters. 1

In the city about 30 minutes after the accident, Doctor Edward H. Williams arrived to provide medical care. Gage had lost a lot of blood, and his following days were quite difficult. 1 The wound became infected, and Phineas was anemic and remained semicomatose for more than two weeks. He also developed a fungal infection in the exposed brain that needed to be surgically removed. His condition slowly improved after doses of calomel and beaver oil. By mid-November he was already walking around the city. 2

THE CONSEQUENCES

For three weeks after the accident, the wound was treated by doctors. During this time, he was assisted by Dr. John Harlow, who covered the head wound and then reported the case in the Boston Medical Surgery Journal. In November 1849, invited by the professor of surgery at Harvard Medical School, Henry Jacob Bigelow, Harlow took Gage to Boston and introduced him to a meeting of the Boston Society for Medical Improvement ( Figure 1 ). 3

In his reports, Harlow described that the physical injury profoundly altered Gage's personality. Although his memory, cognition and strength had not been altered, his once gentle personality slowly degraded. He became a man of bad and rude ways, disrespectful to colleagues, and unable to accept advice. His plans for the future were abandoned, and he proceeded without thinking about the consequences. 4 And here was the main point of this curious story: Gage became irritable, irreverent, rude and profane, aspects that were not part of his way of being. His mind had changed radically. His transformation was so great that everyone said that “Gage is no longer himself.” 5

As a result of this personality change, he was fired for indiscipline and could no longer hold a steady job. He became a circus attraction and even tried life in Chile, later returning to the United States. However, there is something still little known about Gage: his personality changes lasted for about four years, slowly reverting later. As a proof of this, he worked as a long-haul driver in Chile, a job that required considerable planning and focus skills. He died on May 21, 1861, 12 years after the accident, from an epileptic seizure that was almost certainly related to his brain injury. He was not submitted to an autopsy, but his mother, after exhumation of the body, donated his skull and iron rod at the request of Dr. Harlow, which, in turn, sometime later donated them to Harvard University ( Figure 2 ). 1

Gage's case is considered to be one of the first examples of scientific evidence indicating that damage to the frontal lobes may alter personality, emotions and social interaction. 6 Prior to this case, the frontal lobes were considered silent structures, without function and unrelated to human behavior. Scottish neurologist, David Ferrier, was motivated by this fact to investigate the role of frontal lobes in brain function. Ferrier removed the frontal lobes in monkeys and noted that there were no major physiological changes, but the character and behavior of the animals were altered. 7

Knowledge that the frontal lobe was involved with emotions continued to be studied. The surgeon Burkhardt in 1894 performed a series of surgeries in which he selectively destroyed the frontal lobes of several patients in whom he thought might control psychotic symptoms, being the modern prototype of what was later known through Egas Moniz as psychosurgery. 7 Today, it is well understood that the prefrontal cortex of the brain controls the organization of behavior, including emotions and inhibitions.

Folkloric as it may be, but nonetheless remarkable, the contribution of Phineas Gage's case should not be overlooked, as it provided scientists the baseline for the promotion of studies in neuropsychiatry, and a source of inspiration for world medicine. 8 In 2012, a team of neuroscientists used computed tomography of Gage's skull with typical brain MRI scans to show how the Gage brain connection could have been affected. 9 And it is not just the researchers who keep coming back to Gage. Medical and psychology students still learn about Gage from their history lessons. Neurosurgeons and neurologists still sometimes use Gage as a reference when evaluating certain cases. 10 The final chapter of his life also offers us a thought-provoking learning about cases of massive brain damage, showing us that rehabilitation may be possible. 11

Therefore, Gage — inadvertently — made a huge contribution to neurology in several areas, including the study of brain topography in behavioral disorders, the development of psychosurgery, and finally the study of brain rehabilitation. Also, Gage's case had a tremendous influence on early neuropsychiatry. The specific changes observed in his behavior pointed to theories about the localization of brain function and correlated with cognitive and behavioral sequelae, thereby acquainting us with the role of the frontal cortex in higher-order actions such as reasoning, behavior and social cognition. In those years, while neuropsychiatry was in its infancy, Gage's extraordinary story served as one of the first pillars of evidence that the frontal lobe is involved in personality, which helped solidify his remarkable legacy in world medical history.

This study was conducted at the Universidade Federal de Goiás, Goiânia, GO, Brazil.

Funding: none.

Featured Topics

Featured series.

A series of random questions answered by Harvard experts.

Explore the Gazette

Read the latest.

Lifting a few with my chatbot

Hate mosquitoes? Who doesn’t? But maybe we shouldn’t.

‘Harvard Thinking’: Climate alignment is no easy task

Video: Editor Kai-Jae Wang; videographers Joe Sherman and Kai-Jae Wang; interviews by Ned Brown

Lessons of the brain: The Phineas Gage story

Harvard Correspondent

In 1848, an iron bar pierced his brain, his case providing new insights on both trauma and recovery

Imagine the modern-day reaction to a news story about a man surviving a three-foot, 7-inch, 13½-pound iron bar being blown through his skull — taking a chunk of his brain with it.

Then imagine that this happened in 1848, long before modern medicine and neuroscience. That was the case of Phineas Gage.

Whether the Vermont construction foreman, who was laying railroad track and using explosives at the time of the industrial accident, was lucky or unlucky is a judgment that Warren Anatomical Museum curator Dominic Hall puzzles over to this day.

“It is an impossible question, because he was extraordinarily unlucky to have an iron bar borne through his skull, but equally lucky to have survived, on such a low level of care,” said Hall. “We are lucky, to have him.”

Gage’s skull, along with the tamping iron that bore through it, are two of the approximately 15,000 artifacts and case objects conserved at the Warren, which is a part of the Center for the History of Medicine in Harvard’s Francis A. Countway Library of Medicine .

The resultant change in Gage’s personality — when he went from being well-liked and professionally successful to being “fitful, irreverent, and grossly profane, showing little deference for his fellows” and unable to keep his job — is widely cited in modern psychology as the textbook case for post-traumatic social disinhibition.

But as the years have gone by and we’ve learned more about his life, argued Hall, the teachings have changed.

“In 1848, he was seen as a triumph of human survival. Then, he becomes the textbook case for post-traumatic personality change. Recently, people interpret him as having found a form of independence and social recovery, which he didn’t get credit for 15 years ago.”

When Gage died 12 years after the accident, following epileptic seizures, his body was exhumed, while his skull and tamping iron were sent to the physician who had cared for him since the accident, John Harlow. Harlow later donated the items to the Warren, where they have remained for 160 years.

“In many ways, I see Gage similarly to how you would see a portrait of one of the famous professors hanging on the wall — he’s an important part of Harvard Medical School’s identity,” said Hall. “By continually reflecting on his case, it allows us to change how we reflect on the human brain and how we interact with our historical understanding of neuroscience.”

Share this article

You might like.

Sociologist Sherry Turkle warns against growing trend of turning to AI for companionship, counsel

Entomologist says there is much scientists don’t know about habitats, habits, impacts on their environments

Experts at the Salata Institute outline tensions between global and local priorities

College accepts 1,937 to Class of 2028

Students represent 94 countries, all 50 states

Pushing back on DEI ‘orthodoxy’

Panelists support diversity efforts but worry that current model is too narrow, denying institutions the benefit of other voices, ideas

Aspirin cuts liver fat in trial

10 percent reduction seen in small study of disease that affects up to a third of U.S. adults

• Search Menu
• Browse content in Arts and Humanities
• Browse content in Archaeology
• Anglo-Saxon and Medieval Archaeology
• Archaeological Methodology and Techniques
• Archaeology by Region
• Archaeology of Religion
• Archaeology of Trade and Exchange
• Biblical Archaeology
• Contemporary and Public Archaeology
• Environmental Archaeology
• Historical Archaeology
• History and Theory of Archaeology
• Industrial Archaeology
• Landscape Archaeology
• Mortuary Archaeology
• Prehistoric Archaeology
• Underwater Archaeology
• Urban Archaeology
• Zooarchaeology
• Browse content in Architecture
• Architectural Structure and Design
• History of Architecture
• Residential and Domestic Buildings
• Theory of Architecture
• Browse content in Art
• Art Subjects and Themes
• History of Art
• Industrial and Commercial Art
• Theory of Art
• Biographical Studies
• Byzantine Studies
• Browse content in Classical Studies
• Classical Literature
• Classical Reception
• Classical History
• Classical Philosophy
• Classical Mythology
• Classical Art and Architecture
• Classical Oratory and Rhetoric
• Greek and Roman Papyrology
• Greek and Roman Archaeology
• Greek and Roman Epigraphy
• Greek and Roman Law
• Late Antiquity
• Religion in the Ancient World
• Digital Humanities
• Browse content in History
• Colonialism and Imperialism
• Diplomatic History
• Environmental History
• Genealogy, Heraldry, Names, and Honours
• Genocide and Ethnic Cleansing
• Historical Geography
• History by Period
• History of Emotions
• History of Agriculture
• History of Education
• History of Gender and Sexuality
• Industrial History
• Intellectual History
• International History
• Labour History
• Legal and Constitutional History
• Local and Family History
• Maritime History
• Military History
• National Liberation and Post-Colonialism
• Oral History
• Political History
• Public History
• Regional and National History
• Revolutions and Rebellions
• Slavery and Abolition of Slavery
• Social and Cultural History
• Theory, Methods, and Historiography
• Urban History
• World History
• Browse content in Language Teaching and Learning
• Language Learning (Specific Skills)
• Language Teaching Theory and Methods
• Browse content in Linguistics
• Applied Linguistics
• Cognitive Linguistics
• Computational Linguistics
• Forensic Linguistics
• Grammar, Syntax and Morphology
• Historical and Diachronic Linguistics
• History of English
• Language Evolution
• Language Reference
• Language Variation
• Language Families
• Language Acquisition
• Lexicography
• Linguistic Anthropology
• Linguistic Theories
• Linguistic Typology
• Phonetics and Phonology
• Psycholinguistics
• Sociolinguistics
• Translation and Interpretation
• Writing Systems
• Browse content in Literature
• Bibliography
• Children's Literature Studies
• Literary Studies (Romanticism)
• Literary Studies (American)
• Literary Studies (Modernism)
• Literary Studies (Asian)
• Literary Studies (European)
• Literary Studies (Eco-criticism)
• Literary Studies - World
• Literary Studies (1500 to 1800)
• Literary Studies (19th Century)
• Literary Studies (20th Century onwards)
• Literary Studies (African American Literature)
• Literary Studies (British and Irish)
• Literary Studies (Early and Medieval)
• Literary Studies (Fiction, Novelists, and Prose Writers)
• Literary Studies (Gender Studies)
• Literary Studies (Graphic Novels)
• Literary Studies (History of the Book)
• Literary Studies (Plays and Playwrights)
• Literary Studies (Poetry and Poets)
• Literary Studies (Postcolonial Literature)
• Literary Studies (Queer Studies)
• Literary Studies (Science Fiction)
• Literary Studies (Travel Literature)
• Literary Studies (War Literature)
• Literary Studies (Women's Writing)
• Literary Theory and Cultural Studies
• Mythology and Folklore
• Shakespeare Studies and Criticism
• Browse content in Media Studies
• Browse content in Music
• Applied Music
• Dance and Music
• Ethics in Music
• Ethnomusicology
• Gender and Sexuality in Music
• Medicine and Music
• Music Cultures
• Music and Media
• Music and Culture
• Music and Religion
• Music Education and Pedagogy
• Music Theory and Analysis
• Musical Scores, Lyrics, and Libretti
• Musical Structures, Styles, and Techniques
• Musicology and Music History
• Performance Practice and Studies
• Race and Ethnicity in Music
• Sound Studies
• Browse content in Performing Arts
• Browse content in Philosophy
• Aesthetics and Philosophy of Art
• Epistemology
• Feminist Philosophy
• History of Western Philosophy
• Metaphysics
• Moral Philosophy
• Non-Western Philosophy
• Philosophy of Language
• Philosophy of Mind
• Philosophy of Perception
• Philosophy of Action
• Philosophy of Law
• Philosophy of Religion
• Philosophy of Science
• Philosophy of Mathematics and Logic
• Practical Ethics
• Social and Political Philosophy
• Browse content in Religion
• Biblical Studies
• Christianity
• East Asian Religions
• History of Religion
• Judaism and Jewish Studies
• Qumran Studies
• Religion and Education
• Religion and Health
• Religion and Politics
• Religion and Science
• Religion and Law
• Religion and Art, Literature, and Music
• Religious Studies
• Browse content in Society and Culture
• Cookery, Food, and Drink
• Cultural Studies
• Customs and Traditions
• Ethical Issues and Debates
• Hobbies, Games, Arts and Crafts
• Lifestyle, Home, and Garden
• Natural world, Country Life, and Pets
• Popular Beliefs and Controversial Knowledge
• Sports and Outdoor Recreation
• Technology and Society
• Travel and Holiday
• Visual Culture
• Browse content in Law
• Arbitration
• Browse content in Company and Commercial Law
• Commercial Law
• Company Law
• Browse content in Comparative Law
• Systems of Law
• Competition Law
• Browse content in Constitutional and Administrative Law
• Government Powers
• Judicial Review
• Local Government Law
• Military and Defence Law
• Parliamentary and Legislative Practice
• Construction Law
• Contract Law
• Browse content in Criminal Law
• Criminal Procedure
• Criminal Evidence Law
• Sentencing and Punishment
• Employment and Labour Law
• Environment and Energy Law
• Browse content in Financial Law
• Banking Law
• Insolvency Law
• History of Law
• Human Rights and Immigration
• Intellectual Property Law
• Browse content in International Law
• Private International Law and Conflict of Laws
• Public International Law
• IT and Communications Law
• Jurisprudence and Philosophy of Law
• Law and Society
• Law and Politics
• Browse content in Legal System and Practice
• Courts and Procedure
• Legal Skills and Practice
• Primary Sources of Law
• Regulation of Legal Profession
• Medical and Healthcare Law
• Browse content in Policing
• Criminal Investigation and Detection
• Police and Security Services
• Police Procedure and Law
• Police Regional Planning
• Browse content in Property Law
• Personal Property Law
• Study and Revision
• Terrorism and National Security Law
• Browse content in Trusts Law
• Wills and Probate or Succession
• Browse content in Medicine and Health
• Browse content in Allied Health Professions
• Arts Therapies
• Clinical Science
• Dietetics and Nutrition
• Occupational Therapy
• Operating Department Practice
• Physiotherapy
• Radiography
• Speech and Language Therapy
• Browse content in Anaesthetics
• General Anaesthesia
• Neuroanaesthesia
• Clinical Neuroscience
• Browse content in Clinical Medicine
• Acute Medicine
• Cardiovascular Medicine
• Clinical Genetics
• Clinical Pharmacology and Therapeutics
• Dermatology
• Endocrinology and Diabetes
• Gastroenterology
• Genito-urinary Medicine
• Geriatric Medicine
• Infectious Diseases
• Medical Toxicology
• Medical Oncology
• Pain Medicine
• Palliative Medicine
• Rehabilitation Medicine
• Respiratory Medicine and Pulmonology
• Rheumatology
• Sleep Medicine
• Sports and Exercise Medicine
• Community Medical Services
• Critical Care
• Emergency Medicine
• Forensic Medicine
• Haematology
• History of Medicine
• Browse content in Medical Skills
• Clinical Skills
• Communication Skills
• Nursing Skills
• Surgical Skills
• Medical Ethics
• Browse content in Medical Dentistry
• Oral and Maxillofacial Surgery
• Paediatric Dentistry
• Restorative Dentistry and Orthodontics
• Surgical Dentistry
• Medical Statistics and Methodology
• Browse content in Neurology
• Clinical Neurophysiology
• Neuropathology
• Nursing Studies
• Browse content in Obstetrics and Gynaecology
• Gynaecology
• Occupational Medicine
• Ophthalmology
• Otolaryngology (ENT)
• Browse content in Paediatrics
• Neonatology
• Browse content in Pathology
• Chemical Pathology
• Clinical Cytogenetics and Molecular Genetics
• Histopathology
• Medical Microbiology and Virology
• Patient Education and Information
• Browse content in Pharmacology
• Psychopharmacology
• Browse content in Popular Health
• Caring for Others
• Complementary and Alternative Medicine
• Self-help and Personal Development
• Browse content in Preclinical Medicine
• Cell Biology
• Molecular Biology and Genetics
• Reproduction, Growth and Development
• Primary Care
• Professional Development in Medicine
• Browse content in Psychiatry
• Addiction Medicine
• Child and Adolescent Psychiatry
• Forensic Psychiatry
• Learning Disabilities
• Old Age Psychiatry
• Psychotherapy
• Browse content in Public Health and Epidemiology
• Epidemiology
• Public Health
• Browse content in Radiology
• Clinical Radiology
• Interventional Radiology
• Nuclear Medicine
• Radiation Oncology
• Reproductive Medicine
• Browse content in Surgery
• Cardiothoracic Surgery
• Gastro-intestinal and Colorectal Surgery
• General Surgery
• Neurosurgery
• Paediatric Surgery
• Peri-operative Care
• Plastic and Reconstructive Surgery
• Surgical Oncology
• Transplant Surgery
• Trauma and Orthopaedic Surgery
• Vascular Surgery
• Browse content in Science and Mathematics
• Browse content in Biological Sciences
• Aquatic Biology
• Biochemistry
• Bioinformatics and Computational Biology
• Developmental Biology
• Ecology and Conservation
• Evolutionary Biology
• Genetics and Genomics
• Microbiology
• Molecular and Cell Biology
• Natural History
• Plant Sciences and Forestry
• Research Methods in Life Sciences
• Structural Biology
• Systems Biology
• Zoology and Animal Sciences
• Browse content in Chemistry
• Analytical Chemistry
• Computational Chemistry
• Crystallography
• Environmental Chemistry
• Industrial Chemistry
• Inorganic Chemistry
• Materials Chemistry
• Medicinal Chemistry
• Mineralogy and Gems
• Organic Chemistry
• Physical Chemistry
• Polymer Chemistry
• Study and Communication Skills in Chemistry
• Theoretical Chemistry
• Browse content in Computer Science
• Artificial Intelligence
• Computer Architecture and Logic Design
• Game Studies
• Human-Computer Interaction
• Mathematical Theory of Computation
• Programming Languages
• Software Engineering
• Systems Analysis and Design
• Virtual Reality
• Browse content in Computing
• Business Applications
• Computer Games
• Computer Security
• Computer Networking and Communications
• Digital Lifestyle
• Graphical and Digital Media Applications
• Operating Systems
• Browse content in Earth Sciences and Geography
• Atmospheric Sciences
• Environmental Geography
• Geology and the Lithosphere
• Maps and Map-making
• Meteorology and Climatology
• Oceanography and Hydrology
• Palaeontology
• Physical Geography and Topography
• Regional Geography
• Soil Science
• Urban Geography
• Browse content in Engineering and Technology
• Agriculture and Farming
• Biological Engineering
• Civil Engineering, Surveying, and Building
• Electronics and Communications Engineering
• Energy Technology
• Engineering (General)
• Environmental Science, Engineering, and Technology
• History of Engineering and Technology
• Mechanical Engineering and Materials
• Technology of Industrial Chemistry
• Transport Technology and Trades
• Browse content in Environmental Science
• Applied Ecology (Environmental Science)
• Conservation of the Environment (Environmental Science)
• Environmental Sustainability
• Environmentalist Thought and Ideology (Environmental Science)
• Management of Land and Natural Resources (Environmental Science)
• Natural Disasters (Environmental Science)
• Nuclear Issues (Environmental Science)
• Pollution and Threats to the Environment (Environmental Science)
• Social Impact of Environmental Issues (Environmental Science)
• History of Science and Technology
• Browse content in Materials Science
• Ceramics and Glasses
• Composite Materials
• Metals, Alloying, and Corrosion
• Nanotechnology
• Browse content in Mathematics
• Applied Mathematics
• Biomathematics and Statistics
• History of Mathematics
• Mathematical Education
• Mathematical Finance
• Mathematical Analysis
• Numerical and Computational Mathematics
• Probability and Statistics
• Pure Mathematics
• Browse content in Neuroscience
• Cognition and Behavioural Neuroscience
• Development of the Nervous System
• Disorders of the Nervous System
• History of Neuroscience
• Invertebrate Neurobiology
• Molecular and Cellular Systems
• Neuroendocrinology and Autonomic Nervous System
• Neuroscientific Techniques
• Sensory and Motor Systems
• Browse content in Physics
• Astronomy and Astrophysics
• Atomic, Molecular, and Optical Physics
• Biological and Medical Physics
• Classical Mechanics
• Computational Physics
• Condensed Matter Physics
• Electromagnetism, Optics, and Acoustics
• History of Physics
• Mathematical and Statistical Physics
• Measurement Science
• Nuclear Physics
• Particles and Fields
• Plasma Physics
• Quantum Physics
• Relativity and Gravitation
• Semiconductor and Mesoscopic Physics
• Browse content in Psychology
• Affective Sciences
• Clinical Psychology
• Cognitive Psychology
• Cognitive Neuroscience
• Criminal and Forensic Psychology
• Developmental Psychology
• Educational Psychology
• Evolutionary Psychology
• Health Psychology
• History and Systems in Psychology
• Music Psychology
• Neuropsychology
• Organizational Psychology
• Psychological Assessment and Testing
• Psychology of Human-Technology Interaction
• Psychology Professional Development and Training
• Research Methods in Psychology
• Social Psychology
• Browse content in Social Sciences
• Browse content in Anthropology
• Anthropology of Religion
• Human Evolution
• Medical Anthropology
• Physical Anthropology
• Regional Anthropology
• Social and Cultural Anthropology
• Theory and Practice of Anthropology
• Browse content in Business and Management
• Business Ethics
• Business History
• Business Strategy
• Business and Technology
• Business and Government
• Business and the Environment
• Comparative Management
• Corporate Governance
• Corporate Social Responsibility
• Entrepreneurship
• Health Management
• Human Resource Management
• Industrial and Employment Relations
• Industry Studies
• Information and Communication Technologies
• International Business
• Knowledge Management
• Management and Management Techniques
• Operations Management
• Organizational Theory and Behaviour
• Pensions and Pension Management
• Public and Nonprofit Management
• Strategic Management
• Supply Chain Management
• Browse content in Criminology and Criminal Justice
• Criminal Justice
• Criminology
• Forms of Crime
• International and Comparative Criminology
• Youth Violence and Juvenile Justice
• Development Studies
• Browse content in Economics
• Agricultural, Environmental, and Natural Resource Economics
• Asian Economics
• Behavioural Finance
• Behavioural Economics and Neuroeconomics
• Econometrics and Mathematical Economics
• Economic History
• Economic Methodology
• Economic Systems
• Economic Development and Growth
• Financial Markets
• Financial Institutions and Services
• General Economics and Teaching
• Health, Education, and Welfare
• History of Economic Thought
• International Economics
• Labour and Demographic Economics
• Law and Economics
• Macroeconomics and Monetary Economics
• Microeconomics
• Public Economics
• Urban, Rural, and Regional Economics
• Welfare Economics
• Browse content in Education
• Adult Education and Continuous Learning
• Care and Counselling of Students
• Early Childhood and Elementary Education
• Educational Equipment and Technology
• Educational Strategies and Policy
• Higher and Further Education
• Organization and Management of Education
• Philosophy and Theory of Education
• Schools Studies
• Secondary Education
• Teaching of a Specific Subject
• Teaching of Specific Groups and Special Educational Needs
• Teaching Skills and Techniques
• Browse content in Environment
• Applied Ecology (Social Science)
• Climate Change
• Conservation of the Environment (Social Science)
• Environmentalist Thought and Ideology (Social Science)
• Natural Disasters (Environment)
• Social Impact of Environmental Issues (Social Science)
• Browse content in Human Geography
• Cultural Geography
• Economic Geography
• Political Geography
• Browse content in Interdisciplinary Studies
• Communication Studies
• Museums, Libraries, and Information Sciences
• Browse content in Politics
• African Politics
• Asian Politics
• Chinese Politics
• Comparative Politics
• Conflict Politics
• Elections and Electoral Studies
• Environmental Politics
• European Union
• Foreign Policy
• Gender and Politics
• Human Rights and Politics
• Indian Politics
• International Relations
• International Organization (Politics)
• International Political Economy
• Irish Politics
• Latin American Politics
• Middle Eastern Politics
• Political Behaviour
• Political Economy
• Political Institutions
• Political Theory
• Political Methodology
• Political Communication
• Political Philosophy
• Political Sociology
• Politics and Law
• Public Policy
• Public Administration
• Quantitative Political Methodology
• Regional Political Studies
• Russian Politics
• Security Studies
• State and Local Government
• UK Politics
• US Politics
• Browse content in Regional and Area Studies
• African Studies
• Asian Studies
• East Asian Studies
• Japanese Studies
• Latin American Studies
• Middle Eastern Studies
• Native American Studies
• Scottish Studies
• Browse content in Research and Information
• Research Methods
• Browse content in Social Work
• Addictions and Substance Misuse
• Adoption and Fostering
• Care of the Elderly
• Child and Adolescent Social Work
• Couple and Family Social Work
• Developmental and Physical Disabilities Social Work
• Direct Practice and Clinical Social Work
• Emergency Services
• Human Behaviour and the Social Environment
• International and Global Issues in Social Work
• Mental and Behavioural Health
• Social Justice and Human Rights
• Social Policy and Advocacy
• Social Work and Crime and Justice
• Social Work Macro Practice
• Social Work Practice Settings
• Social Work Research and Evidence-based Practice
• Welfare and Benefit Systems
• Browse content in Sociology
• Childhood Studies
• Community Development
• Comparative and Historical Sociology
• Economic Sociology
• Gender and Sexuality
• Gerontology and Ageing
• Health, Illness, and Medicine
• Marriage and the Family
• Migration Studies
• Occupations, Professions, and Work
• Organizations
• Population and Demography
• Race and Ethnicity
• Social Theory
• Social Movements and Social Change
• Social Research and Statistics
• Social Stratification, Inequality, and Mobility
• Sociology of Religion
• Sociology of Education
• Sport and Leisure
• Urban and Rural Studies
• Browse content in Warfare and Defence
• Defence Strategy, Planning, and Research
• Land Forces and Warfare
• Military Administration
• Military Life and Institutions
• Naval Forces and Warfare
• Other Warfare and Defence Issues
• Peace Studies and Conflict Resolution
• Weapons and Equipment

• < Previous chapter
• Next chapter >

41 Phineas Gage: A Neuropsychological Perspective of a Historical Case Study

Alan G. Lewandowski, Clinical Neuropsychologist, Neuropsychology Associates

Joshua D. Weirick, Post-Doctoral Research Fellow, Department of Speech, Language and Hearing Sciences, Purdue University

Caroline A. Lewandowski, Private Practice

Jack Spector, Clinical Neuropsychologist, Independent Practice

• Published: 07 May 2020
• Cite Icon Cite
• Permissions Icon Permissions

The case of Phineas Gage is one of the most frequently cited cases from 19th century medical literature and represents the first of a series of famous cases involving the brain and behavior. While many reiterations of Gage’s case have been published, it remains important to modern neuroscience due to its unique historical significance, ongoing clinical relevance, and the insights it offers neuropsychology into the functional effects of brain injury on thinking, emotions, and behavior. This chapter revisits the critical aspects of this landmark case from a contemporary clinical perspective and discusses the implications of injury to the prefrontal cortex and pathways.

Introduction

On Wednesday, September 13, 1848, a construction crew working for the Rutland and Burlington Railroad near Duttonsville, Vermont, was excavating rock to prepare the ground for track that was soon to be laid. In charge of the crew was a 25-year-old foreman named Phineas Gage, who was using an iron bar to pack black powder into a hole that had been drilled into the rock. For an unknown reason, a spark ignited the black powder and the ensuing explosion propelled the metal rod through the left side of Gage’s face, entering at a slight angle below his zygomatic arch. It passed behind his left eye, through the left frontal lobe, and exited the skull anterior to the juncture of the sagittal and coronal sutures, landing about one hundred feet behind him. Incredibly, Gage endured the injuries and lived another eleven and a half years. Due to his survival of an accident of this magnitude, he entered into the annals of scientific and historical literature as a frequently cited example of a frontal cortical injury.

One week after the accident, on September 21, 1848, the Free Soil Union newspaper in Ludlow, Vermont, published the following account:

Horrible Accident—As Phineas P. Gage, a foreman on the railroad in Cavendish, was yesterday engaged in tamkin [sic] for a blast, the powder exploded, carrying an iron instrument through his head an inch and a fourth in circumference, and three feet and eight inches in length, which he was using at the time. The iron entered on the side of his face, shattering the upper jaw, and passing back of the left eye, and out at the top of his head. The most singular circumstance connected with this melancholy affair is, that he was alive at two o’clock this afternoon, and in full possession of his reason, and free from pain. (Macmillan, 2000a , p. 12)

A review of the medical notes kept by the John Harlow, the physician who treated Gage immediately after his injury are not fully consistent with this newspaper account, especially with regard to the patient having been “free from pain.” Interestingly, 161 years later in July 2009, the Los Angeles Times published an article titled “A piercing image of Phineas Gage” (Maugh, 2009 ), which described the discovery of “the only known image of legendary brain-injury patient Phineas Gage” in a daguerreotype image. The LA Times account claims that “it [the bar] was successfully removed” and “contemporary accounts suggest that Gage’s personality was dramatically altered because he was disfigured in the accident” (Maugh, 2009 ). Unfortunately, but perhaps not surprisingly, more than a century and a half later the complexities of the case continue to pose challenges.

Phineas Gage, his treating physicians, the witnesses to the accident, and Cavendish, Vermont: the characters and setting of this story are, individually, unremarkable. Yet united by the circumstances of a remarkable event, they have contributed uniquely to the development of neuropsychology and continue to be relevant to modern psychological practice. Gage’s case is a story of the right projectile, at the right speed and the right distance, passing through the right area of the brain, of the right patient, who was treated by the right doctor, at the right time in history (Lewandowski, 2003 ). The result is that his injury, treatment, and long-term recovery continue to lend interest and relevance to contemporary neuroscientists across a broad range of medical and psychological disciplines.

Although birth documentation for Gage is lacking, he was probably born on September 9, 1823, in Lebanon, New Hampshire, and was named after his paternal grandfather. Genealogy records confirm that his father was Jesse Gage and his mother was Hannah Swetland, who married on April 27, 1823. He was the oldest of five children: his siblings Laura and Roswell were born in 1826, Dexter was born in 1831, and Phoebe was born in 1832 (Macmillan, 1986 ).

At the time of the injury Gage was 25 years old, and was described as “a perfectly healthy, strong and active young man” prior to the accident, standing “five feet six inches in height” with an “average weight one hundred and fifty pounds.” He possessed “an iron frame” and a “muscular system unusually well developed,” thus indicating that he was in excellent physical health (Harlow, 1868 , p. 330).

Gage’s premorbid psychological and cognitive status is also portrayed in very positive terms. He was reportedly of “well balanced mind,” and “was looked upon by those who knew him as a shrewd, smart businessman, very energetic and persistent in executing all his plans of operation.” In addition, he was of “considerable energy of character” (Harlow, 1868 , p. 340), and was regarded by his employers as “the most efficient and capable in their employ” (Harlow, 1868 , p. 399). Harlow observed that Gage possessed “an iron will” and a “nervo bilious temperament” (Harlow, 1868 , p. 330). His use of the term “nervo bilious” is a subtle indicator of phrenology’s influence on Harlow, as bilious (fibrous) and nervous are two of the four phrenological temperaments (Combe, 1830 , pp. 42–34).

Interestingly, Gage is described as having been “untrained in the schools” (Harlow, 1868 , p. 340); however, considering he could read and write (which may have assisted him in securing employment in a supervisory position as a railroad foreman), Macmillan ( 2000a ) suggests that this description refers to a lack of secondary education.

Cavendish past and present

Gage’s accident occurred outside Duttonsville, Vermont, which was a small village in the township of Cavendish, incorporated in 1761 (at present, however, “Cavendish” is the name of both the township and village). It is located east of the Green Mountains range of the Appalachians in Windsor County, approximately 25 miles southeast of Killington, Vermont (Cavendish Connects, n.d.) . As shown in Figure 41.1 , if one were to compare a historical map of Cavendish to a current topographical map, little change would be noted (Chase, 1856 ). The railroad bed that Gage and his construction crew were preparing is located approximately ¾ of a mile south of Main Street and to the east of Depot Street (Macmillan, 2000c ).

To fully appreciate the circumstances leading to Gage’s accident, it behooves one to have some familiarization with the state of transportation in the United States at that time in history. Prior to the development of railways in the early 1800s, the only available methods of travel or transporting goods in the northeast was limited to walking or using horses or pack animals attached to carriages or wagons when roads were available or the terrain permitted. Whereas transportation by steamer, canal boat, or barge offered an alternative, movement was restricted by the location and direction of the river or waterway and still required some land travel at the point of disembarking. As a result, the movement of people and their possessions across land remained very slow, inefficient, and cumbersome until John Stevens, the father of American railroads, sought to improve the speed and efficiency of transportation by proposing a rail line between New York and Lake Erie in 1815 (Winchester, 2014 ), generally following the Erie Canal. Stevens built a steam locomotive that he demonstrated at his New Jersey estate in an attempt to secure funding from local legislators. While he never lived to see this project completed, his efforts proved the viability of railway transportation such that, by the first half of the 1800’s, railroad construction exploded. The meager 20 miles of railroad track that had existed in 1828, expanded to almost 3000 miles by 1836 (Winchester, 2014 ).

Initially railroads were designed to connect major ports and their surrounding communities, but by 1870 rapid expansion resulted in the railroad industry becoming the nation’s second largest employer of men organized by innumerable work crews responsible for preparing the ground and laying track (Winchester, 2014 ). Over time railways developed to connect cities and therefore the ground required preparation by either excavation or filling in low areas. This drive to expand railway transportation to increase the efficiency of commerce is ultimately why Gage and his crew were engaged in the foothills outside of Duttonsville in 1848.

Gage was employed by the Rutland and Burlington railroad as a foreman of a construction crew. At the time of the accident he and his crew were excavating rock approximately ¾ mile southeast of Duttonsville in order to prepare the ground for track. This task, on its surface, seems relatively simple: Gage and his crew drilled holes in the to-be-excavated rock and filled those holes with gunpowder. The charges were then detonated, and the fragmented rock could be removed or placed in low-lying areas to level the grade. However, with the inherent risks in excavating rock by using explosives and the rudimentary equipment available, the danger and complexity of this type of work should not be underestimated. In order to fully grasp the planning, organization, and complexity required of Gage to execute these tasks, a cursory understanding of drilling and blasting with 19th century technology is necessary.

In the 1800s the method for drilling blasting holes in solid rock involved the use of a team of men working in close proximity and in concert to strike an iron drill bit with sledge hammers. One member of the gang was assigned the position of holding a drill bit, while one or two other members of the crew struck the head of the bit with a hammer. The force of the blow drove the bit into the rock, and the worker holding the bit turned it with each blow. The accrued rock dust was then removed by pouring small amounts of water into the hole to create a mud that stuck to the bit and was periodically removed by tapping the bit against a rock or wiping it clean with the worker’s hand. The bit was then replaced in the hole and the process continued, substituting bits of greater length as the hole deepened.

One can only speculate as to the skill and precision required of Gage and his crew as his men alternated hammer blows in a rhythmic manner, while one turned the bit with one or both hands. Holes approximately 2 yards deep could be bored into granite in about 5 to 6 hours, and several holes would be “drilled” across the area of rock to be excavated. Once the rock was loosened by the blast, a derrick crane and boom were used to load the rock onto animal- drawn carts for removal or placement into low-lying areas to level the ground for the rails (Lynch & Rowland, 2005 ).

After drilling, holes were packed with explosive powder. While some Gage citations have suggested the use of dynamite or blasting powder, the process of removing rock in the early 1800s involved the use of black powder. Dynamite was not yet invented and would not be available until Alfred Nobel introduced it to the United States in 1868 (Schuck & Sohlman, 1929 , p. 101).

Blasting powder uses detonation from the Latin word “de-tonare,” meaning to (expend) thunder, and therefore creates a supersonic combustion through shock compression that splits rock. In contrast, black powder, more commonly known as gunpowder, occurs through deflagration from the Latin word “de-flagrare,” meaning to burn down. The combination of heat and gas result in an effective propellant, as was the case in Gage’s tamping iron. As a result, black powder creates a subsonic combustion that occurs through thermal conductivity that heaves rock (Lynch, 2002 , p. 168).

Black powder is an inherently unstable chemical that combines proportionate measures of sulphur, potassium nitrate (saltpeter) and charcoal. While sulphur and charcoal act as the fuel, saltpeter acts as an oxidizer (Lynch, 2002 ). Its advantage (and danger) lies in the fact that it is relatively easy to ignite. A small spark is sufficient to set it off, as can be seen in the use of muzzle-loading weapons that use either flint or a percussion cap to ignite the powder packed into a breech. The force of the blast depends on a number of variables that include the amount of powder, the size of the grains, and the pressure under which the blast is initiated. Pressure and combustion are obtained by the ratio of fuel to the oxidizing agent and how tightly the powder is packed into a receptacle such as the breech of a gun, or in this case, the hole that Gage was drilling into solid rock (Krehl, 2009 ).

Blasting rock is done by placing black powder into a deep hole of fairly narrow diameter with a fuse positioned to the same depth. The fuse is then trailed onto the ground and of sufficient length to allow the person who ignites the fuse time to move a safe distance away. Layered in the hole on top of the black powder is a collection of aggregate such as sand or soft clay. Sand was commonly used because it is a readily available, easily obtainable, inexpensive, and can be compacted tightly to fill up the small spaces in a hole. As a result, pressure is created by trapping expanding gases, thus leading to combustion sufficient to heave rock (Ihlseng & Wilson, 1907 ). The process of drilling and tamping is demonstrated in Figure 41.2 .

Drilling blasting holes

Another variable that added to the danger of Gage’s work was the fuse. In the early 1800s fuses were known as “coils” or “quills” and were hand made by filling quills or straw with black powder, by covering lengths of hemp of varying thickness with tar and black powder, or by wrapping hemp around a core of powder-filled straw and coating the resulting fuse in tar to protect it from moisture (U.S. Department of the Army, 1984 ). Because of variability in their individual manufacture, fuses lacked uniformity and it was difficult to estimate their burn rate. Safety fuses were not introduced to civil engineering until 1831 when William Bickford introduced a half-inch “coil” to the British mining industry. Safety fused were probably uncommon among railroad workers in America at the time of Gage’s accident (Smith, 1909 , pp. 112–117).

Given the instability of black powder combined with the unreliable fuses, it is easy to see the inherent danger in Gage’s work during a period when explosives technology was in its infancy. At the time of Gage’s accident, railroading in general was a very dangerous profession. Although railroad worker fatalities were not reliably documented until the late 1800s, Aldrich ( 2006 ) found that nearly 4000 workers were killed in 1845 as a result of various railroad construction accidents, although the actual deaths were likely to have been higher than recorded.

The missile that caused the injury was an iron bar measuring 3 feet 7 inches long and weighing 13 ¼ pounds (shown in Figure 41.3 ). It is described as a “tamping iron,” named for its purpose. A tamper is a device used to compact or flatten aggregate to increase compression. Gage’s iron was used to “tamp” or pack down the loose sand that was placed on top of black powder during the process of blasting rock.

The terms “tamper” and “tamping” are derived from the Middle English “tampion,” which is a type of plug placed in a gun or cannon muzzle in order to protect it from dirt or moisture in the environment. “Tampion” itself may be a borrowing from Old French “tapon,” which referred to a piece of cloth used for plugging a hole (Tamp, n.d.) .

Tamping refers to the use of a “tamper” or, as in Gage’s work, a tool designed to compress aggregate. Typically, sand is placed over explosive powder and packed tightly in order to increase compression of gases to render a more powerful blast. In his 1850 publication, Bigelow describes that the iron was “forged by a neighboring blacksmith” and that it was “unlike any other having been made to please the fancy of the owner” (p. 14), indicating that Gage probably had his tamping iron custom made.

Gage’s tamping iron

An inspection of the tamping iron reveals that it is about 1¼ inch in diameter and roughly speaking the width of a common broom or mop handle. The texture is smooth and one end of the bar is gradually shaped to a point (Lewandowski, 2001 ). This is this end that was propelled into Gage’s lower left face and through his head.

It may be questioned as to why the bar was designed to be pointed at one end, when its primary purpose was packing aggregate. Tools, and particularly farm implements, are most often designed to serve multiple purposes. Consider a hammer that is designed to drive as well as remove nails, or a wrench with both open and closed ends). It is not unreasonable to assume that Gage instructed the blacksmith who forged the tamping iron to shape the end to a gradual point, as was common among miners, who often referred to this type of tool as a “needle” (Lewandowski, 2003 ). The tapered shape allowed for the tool to be used for holes of different diameters, for shaping a hole, or as a wedge or lever that could be used for dislodging split rock (Ihlseng & Wilson, 1907 ).

The Accident Site

Navigating to the accident site from the center of modern-day Cavendish would involve traveling down Main Street until Depot Street is reached, and then following Depot Street to the south. A set of railroad tracks will be encountered. The accident occurred east of this area near the first bend of the track heading to the south (Lewandowski, 1998 ; Macmillan, 2000c ; Pate, 1999 ).

More important than the exact site of the accident, which is not precisely known, is the topography of the immediate area (Lewandowski, 2001 ). The railroad bed where Gage was injured is nested in a corridor between two vertical walls of rock of about 30 feet in height and of considerable length (as shown in Figure 41.4 ).

Railroad track and rock near the accident site

The Accident

Gage’s accident occurred on September 13, 1848 at approximately 4:30 in the afternoon. The account is well documented by John Harlow, the local physician who treated Gage, and to whom it can be assumed Gage provided details during his period of recovery. Harlow ( 1868 ) recounts the accident as follows:

He was engaged in charging a hole drilled in the rock, for the purpose of blasting, sitting at the time upon a shelf of rock above the hole. His men were engaged in the pit, a few feet behind him, loading rock upon a platform car, with a derrick. The powder and fuse had been adjusted in the hole, and he was in the act of ‘tamping it in,’ as it was called, previous to pouring the sand. While doing this, his attention was attracted by his men in the pit behind him. Averting his head and looking over his right shoulder, at the same instant dropping the iron upon the charge, it struck fire upon the rock, and the explosion followed, which projected the iron obliquely upwards, in a line of its axis, passing completely through his head, and high into the air, falling to the ground several rods behind him, where it was afterwards picked up by his men, smeared with blood and brain. The missile entered by is pointed end, the left side of the face, immediately anterior to the angle of the lower jaw and passing obliquely upwards, and obliquely backwards, emerged in the median line, at the back part of the frontal bone, near the coronal suture. (Harlow, 1868 , p. 331)

After the accident Gage reportedly suffered “a few convulsive motions of the extremities,” but was soon conscious and able to speak (p. 331). Astonishingly there are no reports of Gage having lost consciousness or experiencing post-traumatic amnesia. His men carried him approximately 10 yards to the road where he was placed in a sitting position in a cart and transported about ¾ of a mile to Adams’s Inn. Gage left the cart with only a little assistance from bystanders and made his way to a chair on the porch where he awaited medical assistance from the local physician. During this time documents support that he remained alert and oriented.

Eyewitness Accounts

One of the first witnesses to Gage’s condition after the accident was Joseph Adams, the proprietor of the local tavern where some of the railway workers boarded. This is the hotel to which witnesses refer and where Gage was taken after the injury. In addition to being the local tavern owner, Adams was also the local Justice of the Peace who provided an affidavit for Harlow at the request of Henry Bigelow who also examined Gage months after the accident (Bigelow, 1850 ).

It is understandable that many did not believe that a person could survive such a devastating injury and therefore his public position and testimony lent credibility in the subsequent documentation. The notification of a local cabinet maker named Winslow who owned a shop about four buildings down from the tavern provides a good example. Winslow was told of the accident and subsequently measured Gage in order to begin work on a coffin for his anticipated death (Macmillan, 2000a ).

In his affidavit Adams testifies as follows:

This is to certify that P.P. Gage had boarded in my house for several weeks previous to his being injured upon the railroad, and that I saw him and conversed with him soon after the accident, and am of opinion that he was perfectly conscious of what was passing around him. He rode to the house, three-quarters of a mile, sitting in a cart, and walked from the cart into the piazza, and thence upstairs, with but little assistance. I noticed the state of the left eye, and know, from experiment, that he could see with it for several days though not distinctly. In regard to the elevated appearance of the wound, and the introduction of the finger into it, I can fully confirm the certificate of my nephew, Washington Adams, and others, and would add that I repeatedly saw him eject matter from the mouth similar in appearance to that discharged from the head. (Bigelow, 1850 , p. 14)

Adams, along with others, presented a compelling picture of Gage’s physical condition immediately after the injury. In addition, he must have recognized the importance of the tool, as he went searching for the bar the following day:

The morning subsequent to the accident I went in quest of the bar, and found it at a smith’s shop, near the pit in which he was engaged. The men in his pit asserted that ‘they found the iron, covered with blood and brains,’ several rods behind where Mr. Gage stood, and that they washed it in the brook, and returned it with the other tools; which representation was fully corroborated by the greasy feel and look of the iron, and the fragments of the brain which I saw upon the rock where it fell (Bigelow, 1850 , pp. 14–15).

A second and equally important witness was a local Protestant minister who observed Gage as he was taken out of the cart and assisted onto a porch chair. Reverend Joseph Freeman spoke with Gage, discussed the incident with some of his crew, and inspected the accident site and the tamping tool that was taken to the blacksmith’s shop. Because of his position in the community, Reverend Freeman also provided an affidavit and further verified the facts of the incident. On December 14, 1849 he testified as follows:

I was home on the day Mr. Gage was hurt; and seeing an Irishman ride rapidly up to your door, I stepped over to ascertain the cause, and then went immediately to meet those who I was informed were bringing him to our village. I found him in a cart, sitting up without aid, with his back against the fore board. When we reached his quarters, he rose to his feet without aid, and walked quick, though with an unsteady step, to the hind end of the cart, when two of his men came forward and aided him out, and walked with him, supporting him to the house. I then asked his men how he came to be hurt? The reply was, ‘The blast went off when he was tamping it, and the tamping-iron passed through his head.’ I said, ‘That is impossible.’ Soon after this, I went to the place where the accident happened. As I came up to them, they pointed me to the iron, which has since attracted so much attention, standing outside the shop-door. They said they found it covered with brains and dirt, and had washed it in the brook. The appearance of the iron corresponded with this story. It had a greasy appearance, and was so to the touch. (Bigelow, 1850 , p. 15)

Dr. Edward Williams, who spoke with Gage and collaborated with Harlow immediately after Gage’s injury, also provided an affidavit. In a letter dated December 4, 1849, from his home in Northfield, Vermont he wrote:

Dr. Bigelow: Dear Sir—Dr. Harlow having requested me to transmit to you a description of the appearance of Mr. Gage at the time I first saw him after the accident, which happened to him in September 1848, I now hasten to do so with pleasure. Dr. Harlow being absent at the time of the accident, I was sent for, and was the first physician who saw Mr. G., some twenty-five or thirty minutes after he received the injury; he at that time was sitting in a chair upon the piazza of Mr. Adams’s hotel, in Cavendish. (Bigelow, 1850 , pp. 14–16)

Williams’s contribution was in detailing Gage’s appearance and his examination findings.

First Responder

Dr. John Harlow, the physician best known for his treatment of Gage, was not immediately available when Gage was brought to Adams’s Inn. As a result, Dr. Edward Higginson Williams, another local physician, was summoned in his stead, and it was Williams who was the first to evaluate Gage’s injury and render immediate assistance. In a sense, he was ex post facto the emergency physician who first attended Gage, and the portico of the Adams’s Inn was his de facto emergency and trauma bay where he began his assessment.

Williams was a twenty-four-year-old graduate of Vermont Medical School when he attended to Gage. His obituary in the New York Times , appearing in December 1899, notes that he practiced as a physician for only a short period of time before he left medicine to work in the railroad industry, eventually securing part ownership of the Baldwin Locomotive Works (New York Times, 1899 ). Although a young physician at the time he treated Gage, he had sufficient medical experience to begin addressing the penetrating head wound, verify the presenting history and mechanism by which the injury occurred, confirm the symptoms, and do what he could to stabilize the patient until Harlow arrived.

Most students of psychology, neuroscience, and medicine are very familiar with the quotation attributed to Gage’s family and friends that, “He was no longer Gage” (Harlow, 1868 ); however, Williams provides a quote from Gage himself that, while lesser-known, is equally compelling. Consider the circumstances under which he and Gage were introduced: the patient had just suffered a horrific injury that should have killed him. He was then transported back to town on an oxcart three quarters of a mile to a local tavern where he sat in a chair on a veranda waiting for half an hour for a physician to arrive. When Dr. Williams arrived in his carriage, Gage addressed him. Williams recalled, “When I drove up he said, ‘ Doctor, here is business enough for you .’ ” This simple statement by Gage confirms his self-reliant character and offers marvelous insight into his personality.

Dr. Williams’ comments about Gage’s injuries suggest that he was in disbelief of the circumstances of the injury. He was decisively convinced following a personal examination in addition to the confirmatory comments of the railroad crew members who were present at the time of the accident (Figure 41.5 ):

I first noticed the wound upon the head before I alighted from my carriage the pulsations of the brain being very distinct; there was also an appearance which before I examined the head, I could not account for: the top of the head appeared somewhat like an inverted funnel; this was owing, I discovered, to the bone being fractured about the opening for a distance of about two inches in every direction. I ought to have mentioned above that the opening through the skull and integuments was not far from one and a half inch in diameter; the edges of this opening were everted and the whole wound appeared as if some wedge-shaped body had passed from below upward. (Bigelow, 1850 , p. 16)

Williams’ initial observations of Gage’s behavior may be of interest to neurological clinicians. Recall that his examination took place within an hour of the traumatic brain injury. Gage was probably in shock, but had not yet succumbed to infection, hence delirium had not yet set in. Retrospectively, Williams’s interactions with Gage provide behavioral observations that could be considered a rudimentary mental status examination. He was able to establish that Gage was oriented to person, place, time, and purpose. In addition, Williams’s observations of visual, verbal, and motor responding, which are supported by affidavits, establish that Gage’s eyes were open, he conversed normally, and he obeyed commands. By today’s emergency and trauma standards for head injury evaluation, one could speculate that Gage demonstrated a normal Glasgow Coma Scale score of 15 (Teasdale & Jennett, 1974 ), which would lend some support to a positive outcome from his traumatic brain injury.

Gage’s skull

Williams continues:

At the time I was examining this wound, he was relating the manner in which he was injured to the bystanders; he talked so rationally and was so willing to answer questions, that I directed my inquiries to him in preference to the men who were with him at the time of the accident and who were standing about at this time. Mr. G. then related to me some of the circumstances as he has since done; and I can safely say that neither at that time nor any subsequent occasion, save once, did I consider him to be other than perfectly rational. The one time to which I allude was about a fortnight after the accident, and then he persisted in calling me John Kirwin; yet he answered all my questions correctly.

Despite being the first physician to directly assess Gage’s injury, Williams nonetheless remained skeptical. In an affidavit to Bigelow he reported:

I did not believe Mr. Gage’s statement at that time, but thought he was deceived; I asked him where the bar entered, and he pointed to the wound on his cheek, which I had not before discovered; this was a slit running from the angle of the jaw forward about one and a half inch; it was very much stretched laterally, and was discolored by powder and iron rust, or at least appeared so. Mr. Gage persisted in saying that the bar went through his head.

The Treating Physician

Dr. John Martyn Harlow arrived at Adams’s Inn at approximately 6 p.m., and was clearly taken by Gage’s presentation: “the picture presented was, to one unaccustomed to military surgery, truly terrific; but the patient bore his sufferings with the most heroic firmness.” At that point both physicians combined their medical skill to stabilize Gage’s condition. He walked up a flight of stairs to an upper bedroom “with a little assistance” (Harlow, 1848 , p. 390) and was placed in a bed so that Harlow could begin a more detailed examination. In this sense, Harlow actions were similar to those of a modern-day trauma surgeon.

Harlow found Gage’s wound so significant and complete that he “passed in the index finger its whole length without the least resistance, in the direction of the wound in the cheek, which received the other finger in like manner” (Harlow, 1848 , p. 390). Although this procedure may seem alarming by modern standards, it should be recalled that at the time, an understanding of pathogens and infectious disease (germ theory) was not yet commonplace in American medicine. In fact, many physicians educated in the 19th century continued to debate the Miasma theory of disease transmission (Halliday, 2001 ; Last, 2007 ). Consider that Lister’s use of phenol in aseptic surgical techniques would not be introduced until 1867 and not widely accepted into clinical practice until the late 1800s (Greenwood, 1998 ; Lister, 1867 , 1868 ).

While Harlow and Williams dressed the wound, Gage’s behavior was compliant and cooperative, and he was “perfectly conscious, answering all questions, and calling his friends by name as they came into the room.” At the same time, however, he was observed to be losing a significant amount of blood “both externally and internally,” vomited several times, and began to fatigue. Gage’s pulse was weak at 60, but Harlow does not report where he palpated his patient. Harlow reports that “he was getting exhausted from the hemorrhage, which was very perfuse both exterally [sic] and internally, the blood finding its way into the stomach, which rejected it as often as every 15 or 20 minutes.” The blood loss was clearly significant, as Harlow reports that, “His person, and the bed on which he was laid, were literally one gore of blood” (p. 390). Given this description, it seems likely that the effects of hypovolemic shock were occurring as Gage’s hemoglobin was decreasing.

Williams and Harlow then shaved Gage’s head, removed the dried blood and a very small sharp piece of bone, and resected “a portion of the brain which hung by a pedicle” (p. 390). Larger pieces of the frontal bone were replaced as close to their original position as possible, the scalp was closed with “adhesive straps,” and a compression dressing was applied, over which they placed a night cap. This concluded the initial resuscitation and stabilization of the patient, and, in a cursory sense, it was not too dissimilar to that of contemporary protocols exercised by emergency room physicians and trauma surgeons.

Historically, injuries to the brain were more often than not fatal due to the trauma itself, intracerebral infection, and herniation from increased intracranial pressure, blood loss, etc. (Bollet, 2002 ; Cronyn, 1871 ; Karger, Sudhues, & Brinkmann, 2001 ). It was not until Percivall Pott’s publication of Observations on the nature and consequences of those injuries to which the head is liable from external violence in 1768 that physicians would be offered clear guidance on the medical management of acceleration and deceleration head injuries, not just injury to the skull, but to the treatment of the brain (Pott, 1768 ). Pott addressed cerebral contusions, skull fractures, concussions, and the management of pus (McCrory, 2001 ), and his writings were recognized in the 19th century as revolutionary in the treatment of head wounds (Butler, 1851 , p. 99). Thus, his medical treatises would have been well known to Harlow’s professors at Jefferson Medical College.

Interestingly, in his report, Harlow is somewhat defensive when he addresses the issue of “probing” the brain, noting that he had later been questioned as to why he did not do so. He presents his rationale as follows: “I think no surgeon of discretion would have upheld me in the trial of such a foolhardy experiment, in the risk of disturbing lacerated vessels from which the hemorrhage was near being staunched [sic], and thereby rupturing the attenuated thread, by which the sufferer still held life” (Bigelow, 1850 , p. 17; Harlow, 1848 , p. 390).

Probes in the 19th century were essentially long stiff metal wires with porcelain tips used to extract skull and bone fragments from the brain after penetrating head injuries. Such an instrument was used by US Surgeon General Dr. Joseph Barnes, who attended to President Lincoln after his assassination. Accompanying Barnes were Lincoln’s personal civilian physician, Dr. Robert Stone, and other US Army physicians who included Dr. Anderson Abbott, the first African-Canadian doctor, and Dr. Charles Crane, Assistant Surgeon General. As the ranking officer, Barnes directed the trauma treatment and, with the assistance of U.S. Army surgeon Dr. Charles Leale, probed Lincoln’s brain first with his (nonsterile) fingers and then with a Nelaton probe. Given the absence of modern neuroimaging, the use of a probe was judged necessary to discern the location and trajectory of the bullet (Trunkey & Farjah, 2005 , pp. 977–978). This porcelain tipped medical instrument was used to explore the wound and break blood clots, which likely increased the loss of blood and in doing so may have expedited Lincoln’s death (Bollet, 2002 ; Trunkey and Farjah, 2005 ). (An excellent example of this type of probe can be found on display at the Armed Forces Institute of Pathology museum in Washington, D.C., which displays the actual probe Barnes and Leale used, alongside fragments of the President’s skull and the 41 caliber lead ball fired from Booth’s derringer.)

Harlow’s treatment of Gage was guided by having been taught to avoid probing a brain (Harlow, 1848 , p. 390). In his medical education at Jefferson Medical College in Philadelphia (now Thomas Jefferson University) he had the benefit of being trained by several famous faculty members who historically have been referred to as the “faculty of ‘41” (Aptowicz, 2014 , p. 83; Elliot, 1911 ; Macmillan, 2001 ).

One of Harlow’s professors was Thomas Dent Mutter, a pioneer of reconstructive surgery, who was known for advocating for antiseptic techniques, replacing bone fragments, allowing for wound drainage, treating with purgatives and cathartics, and never probing. His influence is clearly seen in Harlow’s detailed description of his treatment of Gage (Harris, 1994 ). Further medical insight pertinent to this particular type of injury came from Professor Joseph Pancoast. Pancoast is still well known to surgeons today, and, like Mutter, he pioneered a number of procedures particularly with early reconstructive techniques. He authored A Treatise on Operative Surgery (Pancoast, 1844 ) in which he addresses the treatment of intracerebral pus, and chaired both the Departments of Surgery and Anatomy (Radbill, 1986 ). Lastly, Professor Robley Dunglison was Thomas Jefferson’s private physician who immigrated from England to establish the medical school at the University of Virginia (Gemmill, 1972 ). He published books on health, hygiene, morals, and intellect (Dunglison, 1835 ); human physiology and the history of medicine; and the medicinal use of marijuana (Dunglison, 1846 , p. 153). Known as the father of American Physiology (The National Cyclopaedia of American Biography, 1909, p. 270) Dunglison chaired Jefferson Medical College’s Department of Medicine and was best known for his publication Human Physiology , in which he addressed human temperament and idiosyncrasies, individual and cultural differences, and phrenology (Dunglison, 1832 , pp. 445–479). In addition to these accomplishments, perhaps equally important to Gage’s survival were his extensive prescriptions for multiple medical conditions (Dunglison, 1846 , 1833 ).

Harlow’s Physical Medicine and Rehabilitation

From the time of his arrival at bedside about 6 p.m. on Wednesday, September 13 until Saturday, November 18, 1848, Harlow made detailed observations of his treatment (Bigelow, 1850 , 1900 ; Harlow, 1848 , 1868 ). A review of his medical record indicates that he managed Gage’s medical trauma in a manner commensurate with prevailing medical practice and is rightfully credited with Gage’s stabilization and ultimate recovery. In addition, however, the circumstances of Gage’s wound and his preinjury status may have contributed to his survival. As the noted neurologist Charles Symonds declared, “It is not only the kind of injury that matters, but the kind of head” (Richardson, 2013 , p. 168).

Both Bigelow and Harlow report in some detail about Gage’s pre-injury status (Bigelow, 1850 , 1900 ; Harlow, 1848 , 1868 ), as this was pertinent in their discussion of his subsequent survival and later changes in demeanor. Recall that Gage was described by those who knew him as healthy, strong, active, muscular, physically well developed, shrewd, and intelligent. One can assume, then, that Gage’s premorbid physical and mental condition was not complicated by any significant known or documented premorbid disease, insults, or injuries. This is entirely consistent with Harlow’s ( 1868 ) report that Gage “had scarcely a day’s illness from his childhood to the date of this injury (p. 330). As a result, Gage’s state of health at the time the accident likely contributed positively to his chances of recovery.

A second variable that has not been previously discussed is the effects of the skull fracture that occurred as the tamping iron exited Gage’s cranium. It is very likely that Harlow’s efforts to stabilize his patient were inadvertently aided by the shattering of his skull resulting in a de facto decompressive craniectomy.

A decompressive craniectomy is a neurosurgical procedure sometimes employed in cases of severe brain trauma to allow for brain expansion where swelling occurs as the result of increased intracranial pressure within the skull vault. If left untreated, the interruption of the autoregulation of normal cerebral blood flow can result in increased cerebral perfusion pressure causing marked intracranial edema and ultimately leading to herniation and death (Aarabi et al., 2006 ; Reitan & Wolfson, 1986 ). The energy expended from the acceleration force drove the iron under Gage’s zygomatic arch, through the brain and dura, and exited the calvarium, resulting in bone loss that in turn, allowed for a natural expansion of the brain. Although Harlow and Williams replaced the pieces of bone available, all of the fragments were not recovered and part of the exit wound remained uncovered. This is apparent when examining any photograph or drawing of the skull or when viewing Gage’s life mask. Harlow ( 1868 ) observed that, “The fragments of bone being lifted up, the brain protruding from the opening and hanging in shreds upon the hair, it was evident that the opening in the skull was occasioned by some force acting from below.” He specifically describes how the frontal bone “was extensively fractured, leaving an irregular oblong opening in the skull of two by three and one-half inches” and goes on to report that “the pulsations of the brain were distinctly seen and felt” (p. 332).

After dressing the wound with Williams, Harlow stayed with Gage until 10 p.m., noting that “sensorial powers remain as yet unimpaired” (p. 391). Gage remained fully oriented as evidenced by his ability to name his friends and their residences. His unfaltering and committed character is reflected in his statement to Harlow that he expected to return to work in one or two days, even though he continued to hemorrhage for the next 48 hours.

The next morning Gage’s face became quite swollen and, although in pain, he was able to speak and was noted to be rational. Day two post injury (the 15th) his hemorrhaging stopped, but he began to show signs of delirium and was observed to be “disconnected and incoherent.” At this point Harlow recorded a prescription of “vin. Colchicum ℥ 3 ss every six hours until it purges him” (p. 391). Following the Apothecaries’ system of pharmacy common to 19th century United States at that time (Hasegawa, 2006 ), Harlow administered one half dram, or about 2 ml of colchicine, which in high doses is a toxic alkaloid derived from the corms of the autumn crocus (Colchicum autumnale). This flower extract was frequently used by physicians at that time for its pain-relieving, sedative, and anti-inflammatory properties. In small to moderate doses it produces gastrointestinal side effects that can be used as a sedative, cathartic, diuretic, and emetic (Kyle, et al., 1997 ; Rodnan & Benedek, 1970 ). Because its side effects include gastrointestinal movement, Harlow used it to induce bowel evacuation.

Day three post injury Harlow ( 1848 ) reported a discharge of foul smelling and thin watery pus intermixed with brain material and a fungus at the outside corner where the upper and lower eyelids of the left (injured) eye meet. Gage described the feeling of the left side of his head as “banked up” (p. 391) and had not yet had a bowel movement. Harlow applied ice water to Gage’s eye and head to address the inflammation and prescribed “sulph. magnesia ℥, repeated every four hours until it operates” (p. 391), hence an ounce of magnesium sulfate that was used as a laxative to initiate bowel motility.

Day four post injury, Harlow ( 1848 ) recorded the success of the laxative, noting that Gage “purged freely,” experienced some remission from his delirium, and that he was “rational and knows his friends.” While his facial wounds were healing, Gage’s abscess increased in volume, became foul smelling, and was described by Harlow as “very foetid and sanous” (p. 391).

Day five post injury Harlow ( 1848 ) observed that Gage slept throughout the night and showed preference for lying on his right side, probably because of pain and discomfort. His tongue was described as “red and dry” and his breath as “foetid,” suggesting probable dehydration. Harlow’s interventions that day included probing the skull at its base “without giving pain,” prescribing a cathartic “which operated freely,” and applying cold to the wound. While Gage remained psychologically optimistic and reported to Harlow that “he shall recover,” he continued to experience delirium marked by periods of coherence (p. 391).

Day six through day eight post injury, Gage’s mental and physical condition remained compromised but stable. Harlow ( 1848 ) recorded symptoms of restlessness, dry hot skin, red tongue, and excessive thirst over these three days, as well as impaired mental status marked by “talking incoherently with himself, and directing his men” (p. 391). By this description, Gage clearly continued to suffer from acute confusion, ongoing infection, and dehydration.

Gage’s impaired mental status continued through the morning of the 9th day post injury when he reported “he shall not live long.” His physical agitation and behavioral noncompliance now complicated the clinical picture as evidenced by Harlow’s ( 1848 ) description that his patient “Throws his hands and feet about, and tries to get out of bed.” Harlow described fever (“head hot”) and prescribed “a cathartic of calomel and rhubarb, to be followed by castor oil, if it does not operate in six hours” (p. 391).

Harlow’s use of medications to regularly purge Gage was consistent with 19th century “heroic medicine.” This philosophy advocated alleviating nerve and blood overstimulation that were assumed to cause all disease. Common treatments to restore health included blistering, bloodletting, vomiting, and purging (Duffy, 1990 ; Stavrakis, 1997 ). Harlow’s choice of Calomel is understandable as it was a commonly prescribed therapeutic in the 1800s. In its pharmaceutical form, it is an odorless powder that was commonly prescribed for internal use to treat multiple medical conditions such as constipation, infectious disease, fever, cholera, pleurisy, dropsy, gout, worms, and eclampsia (Weatherall, 2006 ). Externally its use was intended as a disinfectant to treat smallpox sores, syphilitic ulcers, and warts (Risse, 1973 ). Calomel is mercury chloride and therefore is no longer used as a therapeutic agent. Consistent with standards of practice at that time, Harlow used it with Gage in small does as a stool softener and laxative, and in larger does as a purgative.

For the next 11 days (Saturday September 23 through Tuesday October 3) Harlow’s records indicate that Gage remained semi-comatose, “seldom speaking unless spoken to, and then answering only in monosyllables” and that he lost vision in his injured eye (p. 392). Harlow treated the fungal brain and orbit abscess with cold compresses to the head and silver nitrate. Prior to the advent of modern antibiotics, silver nitrate was used medicinally as an antimicrobial. It can be assumed that Harlow applied the antiseptic to Gage’s wounds to treat the infection and prevent sepsis and further tissue decomposition. Gage’s dressings were changed every 8 hours and laxatives were administered regularly. Nevertheless, during this time an infection occurred in the occipitofrontalis muscle that Harlow punctured to drain about 8 ounces of pus.

Twenty-two through 24 days post injury Harlow observed wound discharge, which he referred to as “laudable pus” (p. 392), which, at the time, was thought to be associated with healing (Alexander, 1985 ). Gage’s improvement was also evidence by his ability to raise his head. During this time Harlow also prescribed that Gage sit up at bedside for five minutes at a time before returning to bed, a practice not dissimilar from modern rehabilitation methods used on intensive care units.

Twenty-eight days post injury Harlow recorded Gage’s responses to that which constituted brief mental status questions. While he had already documented that Gage was oriented to person, he was now able to establish orientation to place, time, and purpose. That is, when asked about the date of injury, Gage confirmed accurately that the accident occurred “four weeks this afternoon at 4 ½ o’clock” (p. 392). Given the severity of the brain trauma, the contemporary neuropsychologist or physician might assume significant anterograde and retrograde amnesia. Surprisingly, this was not the case, as Gage was able to recall how the accident took place and his transport to Adam’s Inn. In addition, he kept an accurate account of the day and recognized most of his visitors. In fact, Harlow described Gage’s memory as being “perfect as ever.” However, Gage is also described as being unable to perform some simple activities of daily living, which included estimating “size or money” or “exchanging $1000 for a few pebbles” (p. 392), suggesting limitations to executive reasoning. In contrast, his physical condition showed progressive improvement as the abscess in the posterior part of his mouth continued to diminish with the topical use of silver nitrate.

At thirty-seven days post injury Gage was able to get out of bed independently and sit up at bedside for 30 minutes at a time; however, he was noted to be “very childish” and asked Harlow to allow him to return to his home in New Hampshire. Considering his physical condition, his request probably reflected an early indication of his lack of insight. Two months after the injury on November 8, Gage was no longer confined to his bed. Harlow kept him on a “low diet” and noted normal appetite, sleep, digestive, and bowel patterns. Gage’s increased physical activity included sitting up “most of the time during the day,” ambulating about the stairs and porch of Adams’s Inn, and walking in the street. Given his apparent stable mental and physical status, Harlow left for a week and instructed his patient “to avoid excitement and exposure” (p. 392).

In spite of his directives, when Harlow returned a week later he was told that Gage was reportedly “in the street every day except Sunday” and that “his desire to be out and to go home to Lebanon has been uncontrollable by his friends, and he has been making arrangements to that effect” (p. 392). At one point, Gage walked half a mile to a store in the cold wet weather without benefit of a coat or proper footwear. When Harlow checked on him, Gage was in bed and described as “depressed and very irritable” with “hot and dry skin,” thirsty, constipated, and complained of stabbing pain on the left side of his face. Harlow’s use of the term “rigors” suggests that Gage’s symptoms included high fever, cold, sweating, and shivering. His treatment included a cold compress to treat the fever and prescribing a “black dose” every six hours. This historical pharmaceutical was compounded by combining elixir of senna (black figs), currants, coriander, and cream of tartar every six hours as a remedy for constipation (Beringer & Griffith, 1921 ). Of equal interest to Harlow was a needle-like piece of bone in the back of Gage’s mouth that he ejected “within a few days” (Harlow, 1848 , p. 393).

The following day, Gage’s physical condition had not improved much. As a result, Harlow appears to have become more aggressive in his treatment, bleeding him about 16 ounces and prescribing 650 mg of calomel, 130 mg of ipecac, and a dose of castor oil. He notes that Gage responded to this intervention and in the evening added 195 mg of “r. Antim. Et potassa tart” (tartar emetic) and 180 ml of simple syrup administered every four hours, likely to address the fever.

Over the next two days, between November 17 and 18, Gage reported “feeling better in every respect.” He was now nine weeks and two days’ post injury, without head pain, and able to ambulate. As a result, Harlow perceived him medically stable, although he clearly had reservations regarding Gage’s psychological condition, as evidenced by his final entry into the medical record that Gage “appears to be in a way of recovering if he can be controlled ” (emphasis added; Harlow, 1848 , p. 393). Harlow provided additional behavioral observations on Gage’s change in mental status in his republication of the case in 1868. However, of particular interest to neuropsychologists is that he signed off in the medical record by noting, “I think the case presents one fact of great interest to the practical surgeon, and, taken as a whole, is exceedingly interesting to the enlightened physiologist and intellectual philosopher ” (emphasis added; Harlow, 1848 , p. 393).

Status Post Discharge

Harlow ( 1868 ) ended his acute care on November 18, which was two months and ten days’ post injury. His last entry into the medical record suggests that his patient was sufficiently physically recovered. Having been released from Harlow’s care, Gage returned to his home in Lebanon, New Hampshire on November 25.

The following week, Harlow traveled the 30 miles for a home visit to Gage and “found him going on well” (p. 338). He also notes a recheck on January 1, now almost 16 weeks after the injury from which Harlow concluded further healing, noting “the opening in the top of his head was entirely closed, and the brain shut out from view, though every pulsation could be distinctly seen and felt” (Harlow, 1868 , p. 338).

Gage remained at home in New Hampshire over the next 12 weeks and continued to recover throughout the winter months. Harlow ( 1868 ) documents that in the spring, he returned to Cavendish and applied for his previous position as a foreman but was not afforded reemployment due to the significant change in his behavior and comportment. Given the convenience of his return, Harlow took the opportunity to reexamine his patient.

Harlow’s Reexamination

Upon his return to Cavendish, Gage was about seven months into his recovery. Harlow’s assessment included observations of Gage’s appearance, physical findings, and behavior, with inferences about his psychological functioning that retrospectively constitute a fairly thorough examination of his physical, behavioral, and psychological status.

Harlow described Gage’s physical status as generally normal, noting the following:

General appearance good; stands quite erect, with his head inclined slightly towards the right side; his gait in walking is steady; his movements rapid, and easily executed. The left side of the face is wider than the right side, the left malar bone being more prominent than its fellow. There is a linear cicatrix near the angle of the lower jaw, an inch in length. Ptosis of the left eyelid; the globe considerably more prominent than its fellow, but not as large as when I last saw him. Can adduct and depress the globe, but cannot move it in other directions; vision lost. A linear cicatrix, length two and one-half inches, from the nasal protuberance to the anterior considerably more prominent than its fellow, but not as large as when I last saw him. Can adduct and depress the globe, but cannot move it in other directions; vision lost. A linear cicatrix, lengths two and one-half inches, from the nasal protuberance to the anterior edge of the raised fragment of the frontal bone, is quite unsightly. Upon the top of the head, and covered with hair, is a large unequal depression and elevation-a quadrangular fragment of bone, which was entirely detached from the frontal and extending low down upon the forehead, being still raised and quite prominent. Behind this is a deep depression, two inches by one and one-half inches wide, beneath which the pulsations of the brain can be perceived. Partial paralysis of the left side of face. His physical health is good, and I am inclined to say that he has recovered.

Harlow’s remarks suggest that Gage’s overall appearance was generally unremarkable, the exception being the ptosis of his left eyelid which can clearly be seen in the daguerreotype discovered in 2009. Harlow also documented apparent changes in Gage’s personality:

Has no pain in the head, but says it has a queer feeling which he is not able to describe. Applied for his situation as foreman, but is undecided whether to work or travel. His contractors, who regarded him as the most efficient and capable foreman in their employ previous to his injury, considered the change in his mind so marked that they could not give him place again. The equilibrium or balance, so to speak, between his intellectual faculties and animal propensities seems to have been destroyed. He is fitful, irreverent, indulging at times in the grossest profanity (which was not previously his custom), manifesting but little deference for his fellows, impatient of restraint or advice when it conflicts with his desires, at times pertinaciously obstinate, yet capricious and vacillating, devising many plans of future operation, which are no sooner arranged than they are abandoned in turn for others appearing more feasible. A child in his intellectual passions of a strong man. Previous to his injury, though untrained in the schools, he possessed a well-balanced mind, and was looked upon by those who knew him as a shrewd, smart business man, very energetic and persistent in executing all his plans of operation. In this regard his mind was radically changed, so decidedly that his friends and acquaintances said he was ‘no longer Gage.’ (Harlow, 1868 , pp. 338–340)

After Harlow published his initial report in December 1848, he was contacted by Dr. Henry Bigelow, a prominent Boston surgeon and Harvard professor. Bigelow ( 1850 ) acknowledged having been verbally informed of the accident but was highly skeptical as to the facts of the case. Using Harlow as an intermediary, he provided funds for Gage to travel to Boston for an examination. Given Harlow’s determination that his patient was now “quite well” (p. 330), Gage accepted Bigelow’s offer.

Dr. Henry Bigelow: A Second Opinion

Henry Bigelow, M.D. is perhaps one of the most interesting individuals with whom Gage interacted. Bigelow was a prominent surgeon at Massachusetts General Hospital and a professor of surgery at Harvard University who was instrumental in bringing Gage’s accident to medical prominence. To fully appreciate how his involvement was necessary in validating Gage’s injuries and treatment to the skeptical medical community at that time, one must understand Bigelow’s social background and medical training that allowed him to lend gravitas to Harlow’s report (Schatzki, 1994 ).

Bigelow was the eldest son of an affluent Massachusetts family whose father was a renowned surgeon and Harvard Medical School professor who was socially well connected in Boston society. He entered Harvard at age 15 intent on following his father’s medical career. His memoirs suggest an egotistical individual, self-described as having “personal magnetism,” being a “brilliant operator,” and to those who observed his surgical technique “was to recognize a master” (Bigelow, 1894 , pp. 37–38).

In spite of these self-described laudable attributes, Bigelow’s actual behavior was in many circumstances otherwise. While at Harvard, he was reprimanded for noise violations after disturbing the college with a trumpet he made from a tin coffee pot. He also made nitrous oxide for the Rumford student chemistry club and compromised his health from multiple binges. Perhaps as an early indication of his fascination with anesthesia, he rationalized his abuse of the inhalant as being one of his “most important investigations.” While these pranks were tolerated by Harvard’s administration, he was eventually expelled in 1834 along with five freshmen and the entire sophomore class for taking part in a three-month student rebellion. Although he dismissed damages from the uprising by describing it as a “stirring incident,” the revolt included burning a classroom, exploding a device in Holden Chapel, assaulting two watchmen, and using gunpowder to burn the Harvard’s president, Quincy, in effigy (McCaughey, 1970 ). Compounding the group’s vandalism, Bigelow was personally sanctioned for having three muskets in his dorm room at Hollis Hall that he discharged multiple times into a wooden post (pp. 10–12) and for nearly wounding a fellow student named James Elliot Cabot “by the accidental discharge of a gun” (Bigelow, 1894 , pp. 9–13).

After his expulsion he studied anatomy and physiology at Dartmouth College with Oliver Wendell Holmes, visited Cuba for a period of months to remedy his respiratory difficulties (allegedly from his nitrous abuse), spent time in Italy, Egypt, Paris, and London, where he studied with Longet and reportedly “mastered” auscultation with the stethoscope under Sir James Paget. He finally returned to the Boston, where he eventually he received his medical degree from Harvard in 1841 (Bigelow, 1894 pp. 24–25).

Historically Bigelow is best known for being the first physician to publish on the surgical application of ether, having first watched Morton and Warren demonstrate its use with two cases. in October 1846 (Morton & Woodbury, 1895 ). He used the inhalant on one of his own cases a month later and published his account, thereby circumventing publication by the actual pioneers of the discovery. In doing so was given credit for establishing its medical importance, which contributed to his surgical appointment that same year at Massachusetts General Hospital. Interestingly, he also addressed the anesthetic properties of kerosene after experimenting with self-inhalation of its vapor (Bigelow, 1846 , 1894 ).

Having established his medical credentials, it is not surprising that Bigelow was highly skeptical of the occurrence of Gage’s accident and his survival. The injury as described with the limited loss of function was so inconceivable that many in the medical community were highly doubtful and thought that the facts were misunderstood. In Bigelow’s published remarks, he noted that “A physician who holds in his hand a crowbar, three feet and a half long, and more than thirteen pounds in weight, will not readily believe that it has been driven with a crash through the brain of a man who is still able to walk off, talking with composure and equanimity of the hole in his head” (Bigelow, 1850 , p. 19).

In January 1850, Bigelow secured Gage’s presence and exhibited him to Boston’s medical community for a number of weeks during which Gage was subject to multiple examinations that confirmed the case facts as described by Harlow. Having presented him as a case study in medical rounds, Bigelow reported, “I have been able to satisfy myself as well of the occurrence and extent of the injury as of the manner of its infliction” (Bigelow, 1850 , p. 13). Bigelow demonstrated the injury to colleagues by recreating the path of the tamping iron through an anatomical (cadaver) skull and in doing so verified how the bar could enter, pass through, and exit the cranium without inflicting a fatal lesion. As a result, he wrote, “This is the sort of accident which happens in the pantomime at the theatre, but not elsewhere. Yet there is every reason for supposing it in this case literally true. Being at first wholly skeptical, I have been personally convinced; and this has been the experience of many medical gentlemen who, having first heard of the circumstances, have had a subsequent opportunity to examine the evidence” (Bigelow, 1850 , p. 13).

Bigelow’s importance in Gage’s case lies in his establishing a second opinion and, given his position of prominence in Boston medical society and his reputation, to corroborate Harlow’s findings. In addition, his recapitulation of Harlow’s treatment provided an additional source of documentation in a highly-respected medical publication, The American Journal of the Medical Sciences . In doing so, he afforded the case broader public exposure to the medical community of the northeast United States, which other physicians then began to cite (Butler, 1851 ). Of equal importance to Bigelow’s gravitas was his successful obtainment of a collection of affidavits by those who either witnessed the accident or saw Gage afterwards. Through letters to Harlow, he collected critical documents that formally affirmed the facts of the case, and included these accounts in his 1850 publication. By doing so, he resolved the doubts or reservations held by his medical colleagues who subsequently supported his opinion. “This is no fancy picture drawn to task credulity, but a well authenticated fact” (Butler, 1851 , p. 99).

Gage’s Change in Mental Status: Frontal Cortical Injury

Gage is often cited as an example of a frontal cortical injury with subsequent changes in personality or comportment (Mesulam, 1985 ; Prigatano, 1992 ; Suchy, 2016 ). It has been suggested that there are three principal frontal-subcortical circuits involved in cognitive, emotional, and behavioral processes: dorsolateral, ventromedial, and orbitofrontal, each corresponding to areas of the prefrontal cerebral cortex.

The dorsolateral frontal cortex mainly projects to the dorsolateral head of the caudate nucleus and has been linked to executive functions, such as those measured on tests of mental flexibility, planning, abstraction, and deductive reasoning. It was this link between dorsolateral structures and executive reasoning that led to early conclusions that the frontal lobes were the seat of executive reasoning, so much so that such tasks were described as tests of “frontal lobe functioning.”

The ventromedial circuit projects from the anterior cingulate gyrus to the nucleus accumbens in the basal forebrain. Ventromedial lesions are associated with apathy, amotivational states, social withdrawal, reduced initiation, and motor slowing (Herman, et al., 1992 ; Herman & Cullinan, 1997 ).

It has been proposed that the anterior cingulate cortex (ACC) can be further sectioned into anatomically and functionally distinct subdivisions, based upon its connections to other frontal lobe regions, notably a supracallosal region of the ACC. This area projects to dorsolateral frontal areas and subcallosal portions of the ACC, which then connect to the posterior orbitofrontal regions. While supracallosal ACC lesions are associated with executive impairment and related cognitive inefficiencies, subcallosal ACC lesions are associated with control of respiration, blood pressure, and other autonomic functions (Herman & Cullinan, 1997 ).

The orbitofrontal cortex projects to the ventromedial caudate nucleus and is linked to socially inappropriate behaviors, such as disinhibition, impulsivity, and anti-social behaviors, behavioral inconsistency, and unreliability (Cullinan, et al., 1995 ). These are the behaviors described by Harlow ( 1868 ) in the aftermath of Gage’s injury.

Advances in neuroimaging and modeling technology have led to refined hypotheses as to the likely path of the tamping iron that produced Gage’s brain injury. Based upon magnetic resonance imaging (MRI) data and three dimensional modeling, Damasio and associates (1994) concluded that Gage’s brain lesion involved the anterior half of the left orbital-frontal context, the polar and anterior mesial frontal cortices, and the anterior-most portions of the anterior cingulate gyrus. That is, his lesion affected the ventromedial region of both frontal lobes while sparing the dorsolateral regions. They further concluded that “Gage … fits a neuroanatomical pattern we have identified within a group of individuals with frontal damage. Their ability to make rational decisions in personal and social matters is invariably compromised and so is their processing of emotion.”

More recently, Van Horn and associates (2012) employed diffusion weighted imagery (DWI) and MRI modeling and determined that considerable cortical and subcortical damage to white matter tracts was localized to the left frontal lobe. In their modeling, it was estimated that the tamping iron damaged approximately 11% of the white matter in the frontal lobe and approximately 4% of the cerebral cortex. They hypothesized that damage occurred to the superior longitudinal fasciculus, which connects all lobes in both hemispheres, and the uncinated fasciculus, which links the limbic system to parts of the frontal lobe. As such, some brain structures affected were quite remote from the site of impact, but nonetheless contributed to Gage’s changes in behavior and comportment in the aftermath of his brain injury.

According to Bigelow ( 1850 ), these mental status changes were fairly marked. He described Gage as “fitful” and “irreverent”; he demonstrates “but little deference for his fellows” (a far cry from the Gage who was a “great favorite” of his men) and is “at times pertinaciously obstinate, yet capricious and vacillating”; he employs “the grossest profanity,” which was not typical pre-injury. Harlow also seems to imply that Gage had an unwillingness to carry out his plans, writing that they were “no sooner arranged than they are abandoned in turn for others appearing more feasible” (p. 340). This characterization seems to contrast sharply with Harlow’s descriptions of Gage’s pre-injury mental status, when he was “persistent in executing all his plans of operation” (p. 340) and possessed “an iron will” (p. 330). The Rutland and Burlington railroad company, who previously employed Gage and regarded him as highly capable and dependable, now “considered the change in his mind so marked that they could not give him his place again” (p. 339).

Long-Term Recovery

Harlow ( 1868 ) provided an account of Gage’s long-term recovery, as relayed by Gage’s mother. According to Harlow, sometime after his examination in 1850, Gage traveled throughout New England, including to Boston and New York. While in New York, that Gage spent some time “at Barnum’s,” apparently in reference to P. T. Barnum’s famous New York museum (Bigelow, 1894 , pp. 119–123).

Barnum’s autobiography (Barnum, 1855 ) contains no mention of Gage (an observation also noted by Macmillan, 2000a ), and a review of the Barnum’s Museum Illustrated Guide from 1850 similarly does not mention him (The Lost Museum Archive, n.d.) ; however, there is also some evidence to support Harlow’s assertion that Gage participated in public exhibition. Macmillan and Lena ( 2010 ) describe first a letter by Henry Bigelow which also states that Gage appeared at Barnum’s museum. Second, they describe two advertisements for appearances by Gage, one for an appearance in Concord, New Hampshire, and another for Montpelier, Vermont. While it is unclear if Gage’s stay at Barnum’s was extended or quite brief, he clearly seems to have appeared at the museum for a time and also participated in other public appearances, possibly independent of the museum and possibly under his own management (Macmillan & Lena, 2010 ).

Harlow reports that Gage took a job in the livery stable of Jonathan Currier in 1851, apparently abandoning exhibition due to lack of public interest (Macmillan & Lena, 2010 ). After working in Currier’s stable for “nearly a year and a half” (Harlow, 1868 , p. 340), Gage travelled to Valparaiso, Chile, with an acquaintance who planned to establish a horse drawn coach business to transport passengers from the coastal region to Santiago.

At this point there is evidence that the dates in Harlow’s report become somewhat less accurate; for example, while he ends by stating that Gage died in 1861, records list his burial date as May 23, 1860, making Harlow’s history inaccurate by a year in this regard. Gage likely remained in Chili until 1859, at which time he travelled to San Francisco, home to his mother and sister, reportedly due to failing health. Gage briefly worked on a farm in Santa Clara although “did not remain there long,” and approximately three months before his death suffered seizures, described as “a fit,” followed by “two or three fits in succession” (p. 341). He then suffered a “severe convulsion” the day before his death, followed by repeated convulsions until his time of death at approximately 10 p.m. the following day.

Gage’s Final Resting Place

Gage was first interred at Lone Mountain Cemetery (renamed Laurel Hill in 1864) on May 23, 1860; however, he would not finally lie undisturbed until nearly eight decades later. Gage’s body was exhumed in 1867 at the request of John Harlow. Because no autopsy of Gage was performed upon his death, Harlow requested that Gage’s mother give him possession of the skull and tamping iron for the benefit of the historical record (Harlow, 1868 ). The skull and tamping iron were retrieved and sent to Harlow, who subsequently donated them to the Museum of the Medical Department of Harvard University (now the Warren Anatomical Museum), where they are still on display in the Countway Library of Medicine. The remainder of Gage’s body was reinterred and would remain at Laurel Hill. But unstoppable urban progress prompted San Francisco supervisors to prohibit new burials in the city and eventually declare the city’s old cemeteries a public nuisance. Heated debate over what do with the cemeteries’ tens of thousands of occupants, as well as the many ornate and expensive monuments, prevented any action from being taken for a number of years. By the early 1900s Laurel Hill was in a lamentable state of disrepair:

At Laurel Hill Cemetery high weeds obstructed the once stylish paths and avenues. Statues were overturned and carried off. Scavengers methodically pillaged vaults. Coffins were hacked open and bones strewn about. Entire skeletons were stolen (Svanevik & Burgett, 1992 , p. 28).

Fortunately, Gage was not among the many dead who had their final resting place desecrated by vandals. In 1937 the city of San Francisco ordered the transfer of remains from Laurel Hill to Cypress Lawn in Colma, California (Svanevik & Burgett, 1992 ). Gage’s transfer slip (Figure 41.6 ) indicates his remains were transferred from Laurel Hill on May 17, 1940, and interned in vault 962 of the Pioneer Monument, located in Cypress Lawn Memorial Park (H. Lopez, personal communication, May 21, 1996).

Why Study Gage?

What contemporary significance does the case study of Gage’s injury hold for neuropsychology? The detailed descriptions of his injury and meticulous notes recording his changes in physical and cognitive status during and after recovery lend the case a uniqueness that is unparalleled by most medical case studies of the period. In this sense, Gage’s case provides at least four compelling reasons for ongoing study by clinicians interested in brain-behavior relationships. First, it is of historical importance to neuropsychology. Second, it remains clinically relevant to students, psychologists, physicians, and scientists in the fields of neuroscience, physical medicine, and rehabilitation, particularly for those interested in brain injuries, localization, and the frontal lobes (Macmillan, 1994 ). In addition, most reiterations in texts and scholarly articles contain errors, and lastly, the mechanism of injury and accompanying historical facts continue to maintain a high level of interest that is referenced by multiple medical and scientific disciplines.

Gage’s transfer slip

Historical Importance

The historical importance of Gage’s case can be found in the influence it had on 19th century thinking about the brain and behavior. It was one of the first in a series of single-case medical studies published in the 1800s and early 1900s that provided a foundation for understanding the brain’s function and mental status changes following disease, insult, or injury to the central nervous system.

Following publication of Gage’s injury, Paul Broca ( 1861 ) published his famous case of the patient Leborgne, known as “Tan,” who experienced language deficits associated with a left frontal lesion as the result of syphilis (Lazar & Mohr, 2011 ). In 1880 Josef Breuer presented Bertha Pappenheim, “Anna O.,” to the medical community as an example of psychogenic paralysis of vision and speech, hence an early example of conversion disorder (Breuer & Freud, 2000 ). Sigmund Freud ( 1909 ) published his famous case of severe anxiety of horses of Herbert Graf or “Little Hans,” titled “Analysis of a Phobia in a Five-year-old Boy.” Lastly, in the 1920s Alexander Luria presented his synesthesia case of the journalist Solomon Shereshevsky to describe how stimulation of one sensory pathway leads to automatic, involuntary experiences in a second sensory or cognitive pathway (Luria, 1966 ).

Clinical Relevance

Gage’s injury is significant to neuroscience and neuropsychology, in particular, because his attending doctor, John Harlow, conducted the first detailed documentation of frontal cortical damage altering emotional regulation and behavior. Not surprisingly, many who learned of the accident doubted the mechanism of injury, assuming that survival from a traumatic impalement of the brain of this magnitude was inconceivable. Even the Reverend Joseph Freeman, who saw Gage immediately after the accident, responded with disbelief upon being told that the tamping iron passed through his head, simply stating “That is impossible” (Bigelow, 1850 , p. 15).

Though many are commonly met with skepticism or disbelief, there are a number of historical references to the treatment of traumatic brain injuries (Chaucer, 2005 , p. 770; Cronyn, 1871 ; Karger, 2001 ; Leny, 1793 ). Most describe military surgical interventions following impalement by projectiles such as spears, javelins, lances, and arrows (Bollet, 2002 ). One of the oldest examples is the ancient Egyptian medical text known as the Edwin Smith Papyrus (1600 bce ), which categorized trauma by organ, including brain injuries classified by scalp lacerations, penetration of the skull, and injury to the brain (Nunn, 1996 ; Reitan & Wolfson, 2000 ; Wilkins, 1992 ).

It is understandable that a lack of knowledge about brain functioning led to a simplistic approach to the treatment of brain trauma. For example, in his medical writings Hippocrates addressed head injuries by focusing on consequences of insults to the skull (Wilkins, 1972 ), whereas Galen concentrated on the ventricles and their association with psychic pneuma and the rational soul to explain changes in consciousness (Finger, 1994 ). Ganz ( 2013 ) writes that this approach continued until the 1700s, when French, English, Irish, and Scottish surgeons began to more accurately identify alterations in mental status subsequent to traumatic brain injury to the cerebral cortex. Specifically, he identifies Henri-Francois Le Dran, Percival Pott, James Hill, Sylvester O’Halloran, William Dease, and John Abernethy as being seminal figures in the development of surgical interventions of the brain.

One of the most famous historical examples similar to Gage’s injury is that of Henry V who, as a prince, was wounded in 1403 on the battlefield in Cheshire, England. After a massive barrage of arrows was launched, the future king was struck in the face by an arrow that entered below his eye and to the left side of his nose, penetrating six inches into his skull (Strickland & Hardy, 2011 ). He survived the injury and was treated at Kenilworth castle by John Bradmore, who described in detail his removal of the arrowhead with a mechanical extraction device and the use of resin, wax, herbs, and honey, which served as crude antiseptics, noted to be “good for chilled nerves and sinews” (Cole & Lang, 2003 , p. 97).

Even in the 1800s Gage’s case was not the first to document personality change as a result of frontal lobe injury. Benson and Blumer ( 1975 ) report on a 16-year-old male who suffered a self-inflicted gunshot wound with a black powder pistol which extensively damaged the medial-orbital frontal lobe (de Nobele, 1835 ). Prior to the injury, the adolescent was said to exhibit withdrawn, depressed behavior. Post-injury, his personality seemed markedly changed; he was described as being “happy, vivacious, and jocular” (Stuss & Benson, 1984 , p. 19), despite suffering blindness as a result of the injury. As exemplified here, while Gage’s injury may be the most widely known, frontal lobe injuries due to war, riding or draft animals, hunting, farming, and work accidents were documented long before Gage (Harris, 1847 ; Heustis, 1829 ; Leny, 1793 ) and after his injury (Bird, 1865 ; Cronyn, 1871 ; Fitch, 1852 ; Folsom, 1868 ; Noyes, 1882 ).

Gage’s case however, is unique from other historical examples of traumatic brain injury because of its contribution to our understanding of the role of the frontal lobes. Previously, it had been thought that the frontal lobes had little influence on behavior and cognition, until the absence of executive functioning became apparent following their impairment (Suchy, 2016 ). David Ferrier cited Gage as a primary example of how a frontal lobe injury can alter personality without sensory or motor findings (Neylan, 1999 ) and used Gage’s injury to explain inhibitory and attentional changes in primates and humans. He associated attention with higher cortical functioning and described “its relation to the anatomical substrata of the prefrontal lobes” (Ferrier, 1878 , p. 447). Although he later changed his position, in his first edition of The Functions of the Brain , Ferrier ( 1876 ) proposed a frontal-inhibitory-motor function of the brain and also advocated for cerebral localization using Harlow’s clinical observations to support focal mapping of cerebral functions (Ferrier, 1878 ). Damasio, Grabowski, Frank, Galaburda, and Damasio ( 1994 ) stated that Gage’s case perhaps should have signaled the beginning of the study of the biological basis of behavior, placing Harlow’s observations on par with those of Broca and Wernicke. It is no wonder that most students of neuroscience, medicine, and psychology have been taught about Gage’s change in behavior following cortical damage and the subsequent implication for personality change.

Most Reiterations Contain Errors

It is difficult to find a reiteration of Gage’s case in scholarly articles or texts without finding errors. This is particularly evident in introductory psychology textbooks that discuss Gage’s post-accident recovery and mental status changes (Macmillan, 2000b ); Griggs, 2015 ). Was the instrument of destruction a crowbar or tamping iron (Barker, 1995 )? Did the bar pass through his head or did his physician remove it (Maugh, 2009 )? Did he recover his “faculties of body and mind” (Bigelow, 1850 , p. 14) and retain “in a perfect degree his mental powers” such that “at no time during his recovery was his mind seriously affected” (Butler, 1851 , p. 99) or did he in fact not fully recover his mental faculties, as the American Phrenological Journal claimed after the injury (“Remarkable case of injury,” 1851)? Could he only “briefly sustain work as a stable hand” (Lyketsos, Rosenblatt, & Rabins, 2004 , p. 250) or did he maintain consistent employment after his recovery? After the injury was he rational? Did he demonstrate a lack of foresight (Harlow, 1868 ) or was his disfigurement so traumatic that it altered his personality (Kotowicz, 2007 )? Did Gage’s injury inspire the development of 19th century neurosurgical interventions for brain lesions or the frontal lobotomy procedure (Macmillan, 2000a; Starr, 1848)? The point to be made is that even though the original documents are now easily accessible to researchers and a comprehensive analysis of the case exists (Macmillan, 2000a ), even academic researchers continue to perpetuate errors and get the facts of this case wrong.

In his work, An Odd Kind of Fame: Stories of Phineas Gage , Malcolm Macmillan ( 2000a ) presents what is likely to be the most extensive research of Gage’s injury ever written. Macmillan hypothesized that errors or misrepresentations present in summaries of Gage’s injury, recovery, and subsequent behavioral changes could be the result of later authors’ ignoring some or all of Harlow’s description of Gage’s recovery and life post-injury. This is likely to lead to largely accurate descriptions of the basic facts of the case (date, time, and nature of the accident; the physical properties of the tamping iron; etc.) but vague, incomplete, inaccurate, or exaggerated descriptions of Gage’s behavioral changes and employment—the story becoming less clear as it moves away from its climax. Macmillan suggests that further exaggerations of Gage’s altered behavior may be the result of generalizations or the over-simplification of damage to the frontal lobe from other, similar case studies that may have been projected onto Gage’s history after the fact.

Numerous examples can be found in the literature that inaccurately cite the Gage case to illustrate a particular character trait such as wantonness, virulence, and immorality following damage to this area of the cortex. Inconsistent with Harlow’s behavioral observations, which were also supported by Bigelow’s affidavits collected from eyewitnesses, Biever and Karinch ( 2012 ) describe Gage as having become “sexually promiscuous and hostile” and “totally disinhibited,” and therefore conclude that “Phineas Gage’s limbic brain was apparently destroyed, but his cognitive brain survived intact” (p. 42). To paraphrase what Macmillan has said on a number of occasions (e.g., Kean, 2014 ; Lewandowski, 1998 ; Macmillan, 2000a , p. 333), the initial reports by Harlow and Bigelow come closest to accurately capturing the facts surrounding Gage’s accident, treatment, and recovery, and they should be treated as the primary sources for facts.

Uniqueness and Interest

Lastly, Gage’s injury and his recovery are very interesting. The patient and his attending doctor were very unremarkable people who were brought into the annals of science and history by this one remarkable event (Lewandowski, 2018 ). The mechanism of injury is a source of fascination that has somewhat of a carnival side-show quality. Gage is one of the most frequently cited cases from 19th century medical literature. Harlow himself said in his 1868 publication that Gage was “the man for the case,” that the iron’s smoothness reduced damage to concussion/compression, and that the area of the brain compromised “was the best fitted of any part of the cerebral substance to sustain the injury” (p. 344). As a result, the case of Phineas Gage continues to lend great interest and contemporary relevance to neuroscientists across a broad range of psychological and medical specialties.

Phineas Gage’s improbable survival from the blast that caused a tamping iron to pass through his head occurred during a time when survival from catastrophic brain injury was quite rare. The unique circumstances of the case—including the advantageous size, shape, and texture of Gage’s tamping iron, the limited concussive/compressive damage secondary to the force of impact, and the sequence of techniques employed by Harlow during Gage’s acute treatment—contributed to his survival and the implications of the case for the medical science of the time. Moreover, it occurred at a time when the particular functions associated with the cerebral cortex were for the most part unknown and thought to be unknowable. Because those very few individuals who suffered penetrating brain injuries and sustained pre-frontal trauma survived, it was assumed that these portions of the brain were behaviorally silent.

The Gage case was the first to extensively document that changes in such complex and seemingly inherent qualities such as judgment, impulse control, demeanor, and temperament were not only associated with the brain, but with particular regions within it. It challenged the medical community to begin to question if temperament could be subject to external influences and therefore amenable to scientific principles such as modification, prediction, and clinical treatment.

Gage’s injury occurred at a time when surgical advances and the treatment of infection had progressed to the point where at least some severely traumatically injured patients could survive long enough to be clinically observed and where individuals so injured would be triaged in a manner that would permit them access to heroic care. This would not have occurred if mediums for the exchange of medical information had not reached a tipping point, such that case reports, procedures, and findings previously occurring in isolation could be posted, compared, and aggregated in recently established medical journals. Consider also that while Harlow did not have the resources of hospitals, medical schools, medical meetings, and apothecaries that his physician colleagues had in urban areas, he was prepared through clinical training by a group of renowned medical professors for this very complex traumatic brain injury that even he equated with a military injury.

Gage is among the first well-documented cases of brain-injury where the roles of the patient and the treating physician evolved into intertwined and extended friendships or stewardships, such that long-term follow-up was possible and the changing nature of brain injuries over time could be detailed and explicated. There are echoes of the relationship between Gage and Harlow in the cases of “S.” (Luria), “Tan” (Broca), and Lelong (Wernicke), through to that between Corkin and the amnest, “H.M.” Gage was the first case of which we are aware that offered rich and compelling descriptions of the effects of brain injury over time. In fact, the copious notes taken by Harlow immediately after the accident and throughout Gage’s treatment and recovery have largely (but not completely) precluded the case from accusations of exaggeration and frank invention that haunt mid-19th century medical scholarship.

This, then, may be the reason that the case of Phineas Gage continues to have an enduring influence on contemporary neuropsychology. Many of us were first drawn to neuropsychology because of our interest in the human consequences of brain injuries, in the ways in which the complex activities of normal people could be dramatically damaged by injuries to their brains, and the ways in which that knowledge could be used to help them adapt or recover. This may be the lasting legacy of the case of Phineas Gage: the degree to which the facts and mythology of this case have captured the imagination of generations of future neuropsychologists.

Aldrich, M. ( 2006 ). Death rode the rails: American railroad accidents and safety, 1828 – 1965 . Baltimore, MD: John Hopkins University Press.

Alexander, J. ( 1985 ). The contributions of infection control to a century of surgical progress.   Annals of Surgery, 201, 423–428.

Google Scholar

Aptowicz, C. ( 2014 ). Dr Mutter’s Marvels: A true tale of intrigue and innovation at the dawn of modern medicine . New York, NY: Avery Books.

Google Preview

Aarabi, B. , Hesdorffer, D. , Ahn, E. , Aresco, C. , Scalea, T. , & Eisenberg, H. ( 2006 ). Outcome following decompressive craniectomy for malignant swelling due to severe head injury.   Journal of Neurosurgery, 104(4), 469–479.

Barker, F. ( 1995 ). Phineas among the Phrenologists: The American crowbar case and nineteenth-century theories of cerebral localization.   Journal of Neurosurgery, 82(4), 672–682.

Barnum, P. ( 1855 ). Autobiography of P. T. Barnum, clerk, merchant, editor, and showman; with his rules for business and making a fortune . London, England: Ward and Lock.

Benson, D. F. , & Blumer, D. ( 1975 ). Psychiatric aspects of neurological disease . New York, NY: Grune & Stratton.

Beringer, A. , & Griffith, I. (Eds.). ( 1921 ). Medical and pharmaceutical notes.   American Journal of Pharmacy: A Record of the Progress of Pharmacy and the Allied Sciences, 93, 569.

Biever, J. , & Karinch, M. ( 2012 ). The wandering mind: Understanding dissociation from daydreams to disorders . New York, NY: Rowman and Littlefield, pp. 41–47.

Bigelow, H. ( 1846 ). Insensibility during surgical operations produced by inhalation.   Boston Medical and Surgical Journal , 35(16), 309–316.

Bigelow, H. ( 1850 ). Dr. Harlow’s case of recovery from the passage of an iron bar through the head.   American Journal of the Medical Sciences, 19(39), 13–22.

Bigelow, H. ( 1894 ). A memoir of Henry Jacob Bigelow, A.M., M.D., LL.D. Boston, MA: Little, Brown, and Co.

Bigelow, H. ( 1900 ). Orthopedic surgery and other medical papers . Boston, MA: Little, Brown, and Co.

Bird, B. ( 1865 ). Compound comminuted fracture of the left temporal region of the skull, with loss of bone, and about six drachms of brain, resulting from the kick of a horse, followed by complete recovery.   American Journal of the Medical Sciences, 49, 552–553.

Bollet, A. ( 2002 ). Civil War medicine: Challenges and triumphs . Tucson, AZ: Galen Press.

Breuer, J. , & Freud, S. ( 2000 ). Studies on hysteria (J. Strachey, trans.). London, England: Hogarth Press. (Original work published 1893.)

Broca, P. ( 1861 ). Remarques sur le siége de la faculté du langage articulé, suivies d’une observation d’aphémie (perte de la parole).   Bulletin Society Anatomique ,., 6 , 330–357.

Butler, S. ( 1851 ). Remarks on Dr. Fitch’s case. Cited in Fitch, J. (1852). Case of fracture of the skull, with loss of a portion of the substance of the brain; recovery.   Canada Medical Journal and Monthly Record of Medical and Surgical Supplies , 1, 96–101.

Cavendish Connects (n.d.). http://www.cavendishconnects.com/history/

Chase, J. (1856). Cavendish, Windsor County, Vermont . Library of Congress Geography and Map Division Washington, DC 20540. http://hdl.loc.gov/loc.gmd/g3753w.la001195

Chaucer, G. ( 2005 ). The Canterbury tales . J. Mann (Ed.). New York, NY: Penguin Books.

Cole, H. , & Lang, T. ( 2003 ). The treating of Prince Henry’s arrow wound, 1403.   Journal of the Society of Archer Antiquaries , 46 , 95–101.

Combe, G. ( 1830 ). A system of phrenology (3rd Ed.). London, England: Longman and Company

Cronyn, D. ( 1871 ). Case of a gunshot wound to the head.   Buffalo Medical and Surgical Journal , 11 , 94–95.

Cullinan, W. E. , Herman, J. P. , Helmreich, D. L. , & Watson, S. J., Jr. ( 1995 ). A neuroanatomy of stress. In M. J. Friedman , D. S. Charney , & A. Y. Deutch (Eds.), Neurobiological and clinical consequences of stress: From normal adaptation to post-traumatic stress disorder (pp. 3–26). Philadelphia, PA, US: Lippincott Williams & Wilkins Publishers.

Damasio, H. , Grabowski, T. , Frank, R. , Galaburda, A. , & Damasio, A. ( 1994 ). The return of Phineas Gage: Clues about the brain from the skull of a famous patient.   Science , 264 (5162), 1102–1105.

De Nobele, E. ( 1835 ). Annales de medecine Belge . Fevr.

Duffy, J. ( 1990 ). French influence on the development of medicine in Louisiana.   Biomedicine and Pharmacotherapy , 44 (3), 147–152.

Dunglison, R. ( 1832 ). Human Physiology . Philadelphia, PA: Carey and Lea.

Dunglison, R. ( 1833 ). A new dictionary of medical science and literature containing a concise account of the various subjects and terms; with the synonymes in different languages; and formule for various officinal and empirical preparation . Boston, MA: Charles Bowen.

Dunglison, R. ( 1835 ). On the influence of atmosphere and locality; change of air and climate; seasons; food; clothing; bathing; exercise; sleep; corporeal and intellectual pursuits, on human health; constituting elements of hygiene . Philadelphia, PA: Carey, Lea and Blanchard.

Dunglison, R. ( 1846 ). New remedies: With formulae for their preparation and administration (5th ed.). Philadelphia, PA: Blanchard and Lea.

Elliot, S. ( 1911 ). Biographical history of Massachusetts: Biographies and autobiographies of the leading men in the state . Boston, MA: Boston Biographical Society.

Ferrier, D. ( 1876 ). Functions of the brain . London, UK: Smith, Elder.

Ferrier, D. ( 1878 ). The Goulstonian lectures on the localisation of cerebral disease.   The British Medical Journal, 1, 397–402, 443–447.

Finger, S. ( 1994 ). The era of cortical localization. Origins of Neuroscience . London, England: Oxford University Press, pp. 32–51.

Fitch, J. ( 1852 ). Case of fracture of the skull, with loss of a portion of the substance of the brain; recovery.   Canada Medical Journal and Monthly Record of Medical and Surgical Science, 1, 96–101.

Folsom, A. ( 1868 ). Extraordinary recover from extensive saw-wound of the skull.   Pacific Medical and Surgical Journal, 2, 550–555.

Fowler, G. S. , & Fowler, L. N. ( 1851 ). Remarkable case of injury.   The American Phrenology Journal and Repository of Science, 13, 89.

Freud, S. ( 1909 ). Analysis of a phobia in a five-year-old boy.   Standard Edition, 14.

Ganz, C. ( 2013 ). Head injuries in the 18th century: The management of the damaged brain.   Neurosurgery, 73(1), 167–176.

Gemmill, C. ( 1972 ). Robley Dunglison’s dictionary of medical science.   Bulletin of the New York Academy of Medicine, 48(5), 791–798.

Greenwood, A. ( 1998 ). Lawson Tait and opposition to germ theory: Defining science in surgical practice.   Journal of the History of Medicine and Allied Sciences, 53(2), 99–131.

Griggs, R. ( 2015 ). Coverage of the Phineas Gage story in introductory psychology textbooks: Was Gage no longer Gage?   Teaching of Psychology, 42(3), 195–202.

Halliday, S. ( 2001 ). Death and Miasma in Victorian London: An obstinate belief.   British Medical Journal, 323(7327), 1469–1471.

Harlow, J. M. ( 1848 ). Passage of an iron rod through the head.   Boston Medical and Surgical Journal , 39 (20), 389–393.

Harlow, J. M. ( 1868 ). Recovery from the passage of an iron bar through the head.   Publications of the Massachusetts Medical Society, 2, 327–347.

Harris, E. , & Morgan, R. ( 1994 ). Thomas Dent Mutter, MD: Early reparative surgeon.   Annals of Plastic Surgery, 33(3), 333–338.

Harris, R. ( 1847 ). Case of compound fracture of the skull, with escape of cerebral substance, ending in recovery.   American Journal of the Medical Sciences, 13, 67–70.

Hasegawa, G. ( 2006 ). Preparing and dispensing prescriptions during the Civil War.   Apothecary’s Cabinet , 10 , 1–10.

Heustis, J. ( 1829 ). Inquiry into the causes, nature, and treatment of eria cerebri.   American Journal of the Medical Sciences, 4, 315–330.

Herman, J. , Cullinan, W. , Young, E. , Akil, H. , & Watson, S. ( 1992 ). Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus cortricotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression.   Brain Research, 592, 228–238.

Herman, J. , & Cullinan, W. ( 1997 ). Neurocircuitry of stress: Central control of the hypothalamo–pituitary–adrenocortical axis.   Trends in Neuroscience, 20, 78–84

Ihlseng, M. C. , & Wilson, E. B. ( 1907 ). A manual of mining: Based on the course of lectures on mining delivered at the school of mines of the state of Colorado (4th ed.). New York, NY: John Wiley & Sons.

Karger, B. , Sudhues, H. , & Brinkmann, B. ( 2001 ). Arrow wounds: Major stimulus in the history of surgery.   Journal of Surgery , 25 , 1550–1555, p. 1553

Kean, S. (2014). Phineas Gage, neuroscience’s most famous patient. Slate. Retrieved from: http://www.slate.com/articles/health_and_science/science/2014/05/phineas_gage_neuroscience_case_true_story_of_famous_frontal_lobe_patient.html

Kotowicz, Z. ( 2007 ). The strange case of Phineas Gage.   History of the Human Sciences, 20(1), 115–131.

Krehl, P. ( 2009 ). History of shockwaves, explosions, and impact: A chronological and bibliographical reference . Leipzig, Germany: Springer-Verlag Berlin Heidelberg, pp. 105–115.

Kyle, R. , Gertz, M. , Greipp, P. , Witzig, T. , Lust, J ., Lacy, M. , & Therneau, T. ( 1997 ). A trial of three regimens for primary amyloidosis: Colchicine alone, melphalan and prednisone, and melphalan, prednisone, and colchicine.   New England Journal of Medicine , 336 , 1202–1207.

Last, J. (Ed.). ( 2007 ). Miasma theory. A Dictionary of Public Health . Westminster College, PA: Oxford University Press.

Lazar, R. M. , & Mohr, J. P. ( 2011 ). Revisiting the contributions of Paul Broca to the study of aphasia.   Neuropsychology Review, 21, 236–239.

Leny, R. ( 1793 ). Remarkable case of a boy who lost a considerable portion of brain, and who recovered, without detriment to any faculty, mental, or corporeal.   Medical Commentaries , 8 , 301–316.

Lewandowski, A. ( 1998 ). Personal interview with M. Macmillan at 1848-1849 Historic Festival: Phineas Gage 150th Anniversary Commemoration, Cavendish, VT.

Lewandowski, A. (2001). Phineas Gage: A historical case of pre cortical frontal injury . Annual presentation as part of the Neuroanatomical Dissection Course: Human Brain and Spinal Cord at Marquette University, Milwaukee, WI.

Lewandowski, A. (2003). Pre cortical frontal injuries and 19th century heroic medicine: The case of Phineas Gage . Annual presentation as part of the Neuroanatomical Dissection Course: Human Brain and Spinal Cord at Marquette University, Milwaukee, WI

Lewandowski, A. (2018). A historical case study of fronto-temporal TBI: Mental status, medications, and gage . Annual presentation as part of the Neuroanatomical Dissection Course: Human Brain and Spinal Cord at Marquette University, Milwaukee, WI.

Lister, J. ( 1867 ). On the antiseptic principle in the practice of surgery.   The Lancet , 90 (2299), 353–356.

Lister, J. ( 1868 ). An address on the antiseptic system of treatment in surgery.   British Medical Journal, 2(394), 53–56.

The Lost Museum Archive (n.d.). American Museum Illustrated Guide Book, 1850 . Retrieved from: http://lostmuseum.cuny.edu/archive/assets/images/archive/barnum_american_museum_illustrated.pdf .

Luria, A. R. ( 1966 ). The mind of a mnemonist: A little book about a vast memory . Cambridge: Harvard University Press, p. 82.

Lyketsos, C. G. , Rosenblatt, A. , & Rabins, P. ( 2004 ). Forgotten frontal lobe syndrome or “executive dysfunction syndrome. ” Psychosomatics, 45(3), 247–255.

Lynch, A. J. , & Rowland, C. A. ( 2005 ). The history of grinding . Littleton, CO: Society for Mining, Metallurgy, and Exploration, pp. 173–174.

Lynch, M. ( 2002 ). Mining in world history . London, England: Reaktion, pp. 64–67.

Macmillan, M. ( 1986 ). A wonderful journey through skull and brains: The travels of Mr. Gage’s tamping iron.   Brain and Cognition, 5(1), 67–107.

Macmillan, M. ( 1992 ). Inhibition and the control of behavior: From Gall to Freud via Phineas Gage and the frontal lobes.   Brain and Cognition, 19, 72–104.

Macmillan, M. (1994). A Gage for interpretation . Paper presented at Cheiron: The International society for the history of behavioral and social sciences annual meeting, Université du Québec à Montréal, Montreal, QC.

Macmillan, M. ( 1996 ). Phineas Gage: A case for all reasons . In C. Code , Y. Wallesch , Y. Joanette , & A. Lecours (Eds.), Classic cases in neuropsychology (pp. 243–262). East Sussex, England: Erlbaum.

Macmillan, M. ( 2000 a). An odd kind of fame: Stories of Phineas Gage . Cambridge, MA: The MIT Press.

Macmillan, M. ( 2000 b). Restoring Phineas Gage: A 150th retrospective.   Journal of the history of the neurosciences, 9(1), 44–46.

Macmillan, M. ( 2000 c). Journal of the history of the neurosciences, 9(1), 90–93.

Macmillan, M. ( 2001 ). John Martyn Harlow: Obscure country physician?   Journal of the History of the Neurosciences , 10 (2), 149–162.

Macmillan, M. , & Lena, M. ( 2010 ). Rehabilitating Phineas Gage.   Neuropsychological Rehabilitation, 20(5), 641–658.

Maugh, T. (2009). A piercing image of Phineas Gage. Los Angeles Times . Retrieved from http://articles.latimes.com/2009/jul/16/science/sci-gage16

McCaughey, R. ( 1970 ). The usable past: A study of the Harvard College rebellion of 1834.   William and Mary Law Review, 11(3), 1–25.

McCrory, P. ( 2001 ). Sir Percivall Pott-the first sports neurologist.   British Journal of Sports Medicine, 35, 278–280.

Mesulam, M. ( 1985 ). Patterns in behavioral neuroanatomy: Association areas, limbic system, and hemispheric specialization. In M. Mesulam (Ed.), Principles of behavioral neurology (pp. 1–70). Philadelphia, PA: F. A. Davis.

Morton, T. , & Woodbury, F. ( 1895 ). The history of the Pennsylvania Hospital, 1751 – 1895 . Philadelphia, PA: Times Printing House.

The National Cyclopaedia of American Biography , Vol. 10. ( 1909 ). New York, NY: James T. White and Co. pp. 269–271.

New York Times . ( 1899 ). Dr. Edward H. Williams dead. Part owner of Baldwin Locomotive Works succumbs to heart trouble.   New York Times , December 22, 1899.

Neylan, T. C. ( 1999 ). Frontal lobe function: Mr. Phineas Gage’s famous injury.   Journal of Neuropsychiatry & Clinical Neurosciences , 11 (2), 280–283.

Noyes, H. ( 1882 ). A case of lodgment of a foreign body in the cavities of the nose, orbit, and cranium, where it remained five months; removal by operation; subsequent trephaning for pus in the brain; death; autopsy.   American Journal of the Medical Sciences, 84, 45–59.

Nunn, J. ( 1996 ). Ancient Egyptian medicine . Norman, OK: University of Oklahoma Press.

Pancoast, J. ( 1844 ). A treatise on operative surgery: Comprising a description of the various processes of the art, including all the new operations; exhibiting the state of surgical science in its present advanced condition; with eighty plates, containing four hundred and eighty-six separate illustrations . Philadelphia: Carey and Hart.

Pate, J. L. ( 1999 ). A note on the commemoration of the 150th anniversary of Phineas Gage’s accident.   History of Psychology, 2(3), 243–247.

Pott, P. ( 1768 ). Observations on the nature and consequences of those injuries to which the head is liable from external violence . London, England: Hawes, Clarke, and Collins.

Prigatano, G. ( 1992 ). Personality disturbances associated with traumatic brain injury.   Journal of Consulting and Clinical Psychology, 60(3), 360–368.

Radbill, S. ( 1986 ). Joseph Pancoast (1805–1882): Jefferson anatomist and surgeon, and his world.   Transactions and Studies of the College of Physicians of Philadelphia, 8(4), 233–245.

Reitan, R. , & Wolfson, D. ( 1986 ). Traumatic Brain Injury, Volume I . Tucson, AZ: Neuropsychology Press.

Reitan, R. , & Wolfson, D. ( 2000 ). Mild head injury: Intellectual, cognitive, and emotional consequences . Tucson, AZ: Neuropsychology Press.

Richardson, J. ( 2013 ). Clinical and neuropsychological aspects of closed head injury . London, England: Psychology Press.

Risse, G. ( 1973 ). Historical vignette. Calomel and the American medical sects during the nineteenth century.   Mayo Clinical Proceedings , 48(1), 57–64.

Rodnan G. , & Benedek T. ( 1970 ). The early history of antirheumatic drugs.   Arthritis and Rheumatism, 13, 145–165.

Schatzki, S. ( 1994 ). Dr. Henry Jacob Bigelow.   American Journal of Radiology , 163 , 574.

Schuck, H. , & Sohlman, R. ( 1929 ). The life of Alfred Nobel . London, England: William Heinemann.

Smith, G. J. ( 1909 ). Bickford’s safety fuse. In E. A. B. Hodgetts & T. G. Tullock (Eds.), The rise and progress of the British explosives industry (112–117). London, England: 7th International Congress of Applied Chemistry.

Starr, M. ( 1848 ). Cortical lesions of the brain: A collection and analysis of the American cases of localized cerebral disease.   American Journal of the Medical Sciences , 87 , 366–391.

Stavrakis, P. ( 1997 ). Heroic medicine, bloodletting, and the sad fate of George Washington.   Maryland Medicine Journal, 46(10), 539–540.

Strickland, S. , & Hardy R. ( 2011 ). The great warbow: From Hastings to the Mary Rose . London, England: Haynes Publishing, pp. 284–285.

Stuss, D. T. , & Benson, D. F. ( 1984 ). Neuropsychological studies of the frontal lobes.   Psychological Bulletin, 95(1), 3–28.

Suchy, Y. ( 2016 ). Executive functioning: A comprehensive guide for clinical practice . New York, NY: Oxford University Press.

Svanevik, M. , & Burgett, S. ( 1992 ). Pillars of the past: A guide to Cypress Lawn Memorial Park . San Francisco, CA: Custom and Limited Editions.

Tamp . (n.d.). Retrieved June 30, 2016, from http://www.merriam-webster.com/dictionary/tamp

Teasdale, G. , & Jennett, B. ( 1974 ). Assessment of coma and impaired consciousness: A practical scale.   The Lancet, 2(7872), 81–84.

Trunkey, D. , & Farjah, F. ( 2005 ). Medical and surgical care of our four assassinated presidents.   Journal of the American College of Surgeons, 201(6), 976–989.

U.S. Department of the Army. ( 1984 ). Department of the Army technical manual: Military explosives . Washington, DC: Author.

Van Horn, J. , Irimia, A. , Torgerson, C. M. , Chambers, M. C. , Kikinis, R. , & Toga, A. ( 2012 ). Mapping connectivity damage in the case of Phineas Gage.   PLoS One , ,   7 (5):e37454. doi:10.1371/journal.pone.0037454. Epub May 16, 2012. 10.1371/journal.pone.0037454

Weatherall, M. ( 2006 ). Drug treatment and the rise of pharmacology. In R. Porter R. (Ed.). The Cambridge history of medicine (pp. 211–237). New York, NY: Cambridge University Press.

Wilkins, R. ( 1972 ). Hippocrates: On injuries to the head. Neurosurgical classics . Rowling Meadows, IL: American Association of Neurological Surgeons, pp. 8–14.

Wilkins, R. ( 1992 ). Neurosurgical classics (2nd ed.). Park Ridge, IL: American Association of Neurological Surgeons.

Winchester, S. ( 2014 ). The men who united the States: America’s Explorers, Inventors, Eccentrics, ad Mavericks, and the Creation of One Nation, Indivisible . Harper Collins, NY.

• About Oxford Academic
• Publish journals with us
• University press partners
• What we publish
• New features  
• Open access
• Institutional account management
• Rights and permissions
• Get help with access
• Accessibility
• Advertising
• Media enquiries
• Oxford University Press
• Oxford Languages
• University of Oxford

Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide

• Copyright © 2024 Oxford University Press
• Cookie settings
• Cookie policy
• Privacy policy
• Legal notice

This Feature Is Available To Subscribers Only

Sign In or Create an Account

This PDF is available to Subscribers Only

For full access to this pdf, sign in to an existing account, or purchase an annual subscription.

Phineas Gage

In this post

You may have already heard of Phineas Gage, such is his infamous history with psychology. He was working on a railway line in the USA when there was an explosion, which resulted in an iron rod being fired through his head. He survived the accident even though there were serious injuries to his face and brain but it was soon discovered that in terms of his personality, he was completely different after the accident than he was before it.

Before the accident he was described as a very calm man who was very popular, but afterwards he was considered to be rude and irresponsible.

Gage died 12 years after the accident and after hearing of his death, his doctor, John Harlow, who had worked with him at the time of his accident, asked for his body to be exhumed so that he could look at his skull and try to identify how this caused the change in his personality.

Many years later, Damasio and her colleagues were able to make use of much better technology to further investigate the damage that had been caused to Phineas Gage’s brain and the effects that this had on his personality.

Damasio et al. aimed to build a replica model of Gage’s skull (using the actual skull as a guide) so that they could show exactly where the iron rod entered and exited Gage’s head.

A 3D representation of the skull and the injuries it received meant that it was much clearer which parts of his brain would have been affected by the accident and Damasio et al. wanted to see if any other areas of the brain had also been damaged.

• Pictures and measurements of Gage’s skull were taken
• A 3D replica model was built based on the information from the skull
• Information was also taken from the iron rod (which had been buried with Gage!)
• Information from the rod and the skull together meant that the trajectory of the iron rod could be accurately mapped
• Altogether 20 different points of entry and 16 points of exit were identified and the five most likely paths were chosen
• Each of these five paths were explored to map out which areas of Gage’s brain would have been damaged by each path.

It was thought that damage to both the left and right hemispheres of the brain were likely and that no other area than the frontal lobe would have been affected.

The iron rod would have gone through Gage’s left eye socket and then upwards in its trajectory. This means that rather than affecting the right frontal lobe, only the white matter (tissue containing nerve fibres) in the brain’s left hemisphere would have been affected. However, this meant that neural messages in this area of the brain would not have been transmitted because white matter is where neurons pass messages along axon fibres.

The findings from the 3D model and its implications for the parts of the brain that were thought to be damaged were compared to reports of the changes in Gage’s personality. It was concluded that a specific area of the frontal lobe (the ventromedial area) is responsible for making controlled decisions, regulating impulses and urges and dealing with emotions in a proper way.

These findings were compared to 12 other individuals who had experienced similar brain injuries and the same problems with control and impulse were found, showing that it is likely possible to predict the behaviour of people who have sustained this kind of brain injury.

Strengths of the study

• Modern-day technology is very reliable and therefore the 3D model that was created would have been very accurate and information could be ‘seen’ rather than just guessed at from written reports
• Predictions can now be made about people’s behaviour when they have experienced injuries in specific areas of the brain; this can help people to adjust to new lifestyles and may help in treating them as well.

Weaknesses of the study

• Information about the change in Gage’s personality were gleaned from details written more than a century ago, meaning its accuracy is questionable
• As this was a case study, it is difficult to generalise the findings to a wider population so predictions about possible changes in behaviour may not be applicable to everyone.

Interested in a Psychology GCSE?

We offer the Edexcel GCSE in Psychology through our online campus.

Learn more about our Psychology GCSE courses

Read another one of our posts

A guide to allergens in healthcare.

Understanding Child Development: Key Milestones in Early Years

Building Strong Relationships with Parents

Child Development Theories: An Overview for Caregivers

What is a Playworker?

Transitioning from GCSEs to A-Levels

Exploring Our Planet: Key Concepts from IGCSE Geography

How To Communicate Effectively With Clients in Care

Save your cart?

• Skip to main content
• Keyboard shortcuts for audio player

Your Health

• Treatments & Tests
• Health Inc.
• Public Health

Why Brain Scientists Are Still Obsessed With The Curious Case Of Phineas Gage

Jon Hamilton

Cabinet-card portrait of brain-injury survivor Phineas Gage (1823–1860), shown holding the tamping iron that injured him. Wikimedia hide caption

Cabinet-card portrait of brain-injury survivor Phineas Gage (1823–1860), shown holding the tamping iron that injured him.

It took an explosion and 13 pounds of iron to usher in the modern era of neuroscience.

In 1848, a 25-year-old railroad worker named Phineas Gage was blowing up rocks to clear the way for a new rail line in Cavendish, Vt. He would drill a hole, place an explosive charge, then pack in sand using a 13-pound metal bar known as a tamping iron.

But in this instance, the metal bar created a spark that touched off the charge. That, in turn, "drove this tamping iron up and out of the hole, through his left cheek, behind his eye socket, and out of the top of his head," says Jack Van Horn , an associate professor of neurology at the Keck School of Medicine at the University of Southern California.

Gage didn't die. But the tamping iron destroyed much of his brain's left frontal lobe, and Gage's once even-tempered personality changed dramatically.

"He is fitful, irreverent, indulging at times in the grossest profanity, which was not previously his custom," wrote John Martyn Harlow, the physician who treated Gage after the accident.

This sudden personality transformation is why Gage shows up in so many medical textbooks, says Malcolm Macmillan, an honorary professor at the Melbourne School of Psychological Sciences and the author of An Odd Kind of Fame: Stories of Phineas Gage.

"He was the first case where you could say fairly definitely that injury to the brain produced some kind of change in personality," Macmillan says.

And that was a big deal in the mid-1800s, when the brain's purpose and inner workings were largely a mystery. At the time, phrenologists were still assessing people's personalities by measuring bumps on their skull.

Gage's famous case would help establish brain science as a field, says Allan Ropper , a neurologist at Harvard Medical School and Brigham and Women's Hospital.

One Account Of Gage's Personality Shift

Dr. John Harlow, who treated Gage following the accident, noted his personality change in an 1851 edition of the American Phrenological Journal and Repository of Science.

"If you talk about hard core neurology and the relationship between structural damage to the brain and particular changes in behavior, this is ground zero," Ropper says. It was an ideal case because "it's one region [of the brain], it's really obvious, and the changes in personality were stunning."

So, perhaps it's not surprising that every generation of brain scientists seems compelled to revisit Gage's case.

For example:

• In the 1940s, a famous neurologist named Stanley Cobb diagrammed the skull in an effort to determine the exact path of the tamping iron.
• In the 1980s, scientists repeated the exercise using CT scans.
• In the 1990s, researchers applied 3-D computer modeling to the problem.

And, in 2012, Van Horn led a team that combined CT scans of Gage's skull with MRI scans of typical brains to show how the wiring of Gage's brain could have been affected .

"Neuroscientists like to always go back and say, 'we're relating our work in the present day to these older famous cases which really defined the field,' " Van Horn says.

And it's not just researchers who keep coming back to Gage. Medical and psychology students still learn his story. And neurosurgeons and neurologists still sometimes reference Gage when assessing certain patients, Van Horn says.

"Every six months or so you'll see something like that, where somebody has been shot in the head with an arrow, or falls off a ladder and lands on a piece of rebar," Van Horn says. "So you do have these modern kind of Phineas Gage-like cases."

Two renderings of Gage's skull show the likely path of the iron rod and the nerve fibers that were probably damaged as it passed through. Van Horn JD, Irimia A, Torgerson CM, Chambers MC, Kikinis R, et al./Wikimedia hide caption

Two renderings of Gage's skull show the likely path of the iron rod and the nerve fibers that were probably damaged as it passed through.

There is something about Gage that most people don't know, Macmillan says. "That personality change, which undoubtedly occurred, did not last much longer than about two to three years."

Gage went on to work as a long-distance stagecoach driver in Chile, a job that required considerable planning skills and focus, Macmillan says.

This chapter of Gage's life offers a powerful message for present day patients, he says. "Even in cases of massive brain damage and massive incapacity, rehabilitation is always possible."

Gage lived for a dozen years after his accident. But ultimately, the brain damage he'd sustained probably led to his death.

He died on May 21, 1860, of an epileptic seizure that was almost certainly related to his brain injury.

Gage's skull, and the tamping iron that passed through it, are on display at the Warren Anatomical Museum in Boston, Mass.

• Brain research
• neuroscience
• Brain injuries

• Neuroscience

The Neuroscience of Behavior: Five Famous Cases

Five patients who shaped our understanding of behavior and the brain..

Posted January 16, 2020 | Reviewed by Lybi Ma

“Considering everything, it seems we are dealing here with a special illness… There are certainly more psychiatric illnesses than are listed in our textbooks.” —Alois Alzheimer (In: Benjamin, 2018)

Once thought to be the product of demonic possession, immorality, or imbalanced humors, we now know that psychiatric symptoms are often caused by changes in the brain. Read on to learn about the people who helped us understand the brain as the driving force behind our behaviors.

Phineas Gage

In 1848, John Harlow first described the case of a 25-year-old railroad foreman named Phineas Gage. Gage was a "temperate" man: hardworking, polite, and well-liked by all those around him. One day, Gage was struck through the skull by an iron rod launched in an accidental explosion. The rod traveled through the prefrontal cortex of his brain. Remarkably, he survived with no deficits in his motor function or memory . However, his family and friends noticed major changes in his personality . He became impatient, unreliable, vulgar, and was even described as developing the "animal passions of a strong man." This was the first glimpse into the important role of the prefrontal cortex in personality and social behavior (David, 2009; Thiebaut de Schotten, 2015; Benjamin, 2018).

Louis Victor Leborgne

Pierre Broca first published the case of 50-year-old Louis Victor Leborgne in 1861. Despite normal intelligence , Leborgne inexplicably lost the ability to speak. His nickname was Tan, after this became the only word he ever uttered. He was otherwise unaffected and seemed to follow directions and understand others without difficulty. After he died, Broca examined his brain, finding an abnormal area of brain tissue only in the left anterior frontal lobe. This suggested that the left and right sides of the brain were not always symmetric in their functions, as previously thought. Broca later went on to describe several other similar cases, cementing the role of the left anterior frontal lobe (now called Broca’s area) as a crucial region for producing (but not understanding) language (Dronkers, 2007; David, 2009; Thiebaut de Schotten, 2015).

Auguste Deter

Psychiatrist and neuropathologist Aloysius Alzheimer described the case of Auguste Deter, a 56-year-old woman who passed away in 1906 after she developed strange behaviors, hallucinations, and memory loss. When Alzheimer looked at her brain under the microscope, he described amyloid plaques and neurofibrillary tangles that we now know are a hallmark of the disease that bears his name. This significant discovery was the first time that a biological molecule such as a protein was linked to a psychiatric illness (Shorter, 1997; David, 2009; Kalia & Costa e Silva, 2015).

In 1933, Spafford Ackerly described the case of "JP” who, beginning at a very young age, would do crude things like defecate on others' belongings, expose himself, and masturbate in front of other children at school. These behaviors worsened as he aged, leading to his arrest as a teenager . He was examined by Ackerly who found that the boy had a large cyst, likely present from birth, that caused severe damage to his prefrontal cortices. Like the case of Phineas Gage, JP helped us understand the crucial role that the prefrontal cortex plays in judgment, decision-making , social behaviors, and personality (Benjamin, 2018).

HM (Henry Gustav Molaison)

William Scoville first described the case of HM, a 29-year-old man whom he had treated two years earlier with an experimental surgery to remove his medial temporal lobes (including the hippocampus and amygdala on both sides). The hope was that the surgery would control his severe epilepsy, and it did seem to help. But with that improvement came a very unexpected side effect: HM completely lost the ability to form certain kinds of new memories. While he was still able to form new implicit or procedural memories (like tying shoes or playing the piano), he was no longer able to form new semantic or declarative memories (like someone’s name or major life events). This taught us that memories were localized to a specific brain region, not distributed throughout the whole brain as previously thought (David, 2009; Thiebaut de Schotten, 2015; Benjamin, 2018).

Facebook /LinkedIn image: Gorodenkoff/Shutterstock

Benjamin, S., MacGillivray, L., Schildkrout, B., Cohen-Oram, A., Lauterbach, M.D., & Levin, L.L. (2018). Six landmark case reports essential for neuropsychiatric literacy. J Neuropsychiatry Clin Neurosci, 30 , 279-290.

Shorter, E., (1997). A history of psychiatry: From the era of the asylum to the age of Prozac. New York: John Wiley & Sons, Inc.

Thiebaut de Schotten, M., Dell'Acqua, F., Ratiu, P. Leslie, A., Howells, H., Cabanis, E., Iba-Zizen, M.T., Plaisant, O., Simmons, A, Dronkers, N.F., Corkin, S., & Catani, M. (2015). From Phineas Gage and Monsieur Leborgne to H.M.: Revisiting disconnection syndromes. Cerebral Cortex, 25 , 4812-4827.

David, A.S., Fleminger, S., Kopelman, M.D., Lovestone, S., & Mellers, J. (2009). Lishman's organic psychiatry: A textbook of neuropsychiatry. Hoboken, NJ: Wiley-Blackwell.

Kalia, M., & Costa e Silva, J. (2015). Biomarkers of psychiatric diseases: Current status and future prospects. Metabolism, 64, S11-S15.

Dronkers, N.F., Plaisant, O., Iba-Zizen, M.T., & Cabanis, E.A. (2007). Paul Broca's historic cases: High resolution MR Imaging of the brains of Leborgne and Lelong. Brain , 130, 1432–1441.

Scoville, W.B., & Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions. J. Neurol. Neurosurg. Psychiat., 20, 11-21.

Melissa Shepard, MD , is an assistant professor of psychiatry at the Johns Hopkins School of Medicine.

• Find a Therapist
• Find a Treatment Center
• Find a Psychiatrist
• Find a Support Group
• Find Teletherapy
• United States
• Brooklyn, NY
• Chicago, IL
• Houston, TX
• Los Angeles, CA
• New York, NY
• Portland, OR
• San Diego, CA
• San Francisco, CA
• Seattle, WA
• Washington, DC
• Asperger's
• Bipolar Disorder
• Chronic Pain
• Eating Disorders
• Passive Aggression
• Personality
• Goal Setting
• Positive Psychology
• Stopping Smoking
• Low Sexual Desire
• Relationships
• Child Development
• Therapy Center NEW
• Diagnosis Dictionary
• Types of Therapy

Understanding what emotional intelligence looks like and the steps needed to improve it could light a path to a more emotionally adept world.

• Coronavirus Disease 2019
• Affective Forecasting

Encyclopedia of Personality and Individual Differences pp 1718–1725 Cite as

Gage, Phineas

• Malcolm Macmillan 3 &
• John F. Kihlstrom 4  
• Reference work entry
• First Online: 01 January 2020

27 Accesses

Phineas P. Gage is one of the most famous named cases in the history of psychology and neurology, owing to brain damage suffered in a construction accident which reportedly resulted in a marked alteration in his personality. Gage was the foreman of a gang of workers excavating rock while preparing the bed of a railroad in 1848 near what became Cavendish, Vermont. His survival of a massive injury to the left side of his brain immediately turned him into a medical curiosity. Later reports of changes in his behavior contributed to physiological, psychological, and philosophical debates that continue today over the localization of functions in the brain.

Phineas Gage was born on approximately July 9, 1823, in or around Lebanon, New Hampshire, and died on May 21, 1860 in San Francisco (both the date and place of his birth are uncertain; for an authoritative account of Gage’s life and medical history, see Macmillan 2000a , 2012 ). What detailed knowledge we have of Phineas Gage is limited,...

This is a preview of subscription content, log in via an institution .

Buying options

• Available as PDF
• Read on any device
• Instant download
• Own it forever
• Available as EPUB and PDF
• Durable hardcover edition
• Dispatched in 3 to 5 business days
• Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Barker, F. G. (1993). Treatment of open brain wounds in America, 1810–1880: A survey. Journal of Neurosurgery, 78 , 364A.

Google Scholar  

Barker, F. G. (1995). Phineas among the phrenologists: The American Crowbar Case and nineteenth century theories of cerebral localization. Journal of Neurosurgery, 82 , 672–682. https://doi.org/10.3171/jns.1995.82.4.0672 .

Article   PubMed   Google Scholar  

Damasio, A. R. (1994). Descartes’ error: Emotion, reason, and the human brain . New York: Putnam Publishing.

Damasio, H., Grabowski, T., Frank, R., Galaburda, A. M., & Damasio, A. R. (1994). The return of Phineas Gage: Clues about the brain from the skull of a famous patient. Science, 264 , 1102–1105. https://doi.org/10.1126/science.8178168 .

de Schotten, M. T., Dell’Acqua, F., Ratiu, P., Leslie, A., Howells, H., Cabanis, E., Ib-Zizen, M. T., Plaisant, O., Simmons, A., Dronkers, N. F., Corkin, S., & Catani, M. (2015). From Phineas Gage and Monsieur Leborgne to H.M.: Revisiting disconnection syndromes. Cerebral Cortex, 25 (12), 4812–4827. https://doi.org/10.1093/cercor/bhv173 .

Article   Google Scholar  

Della Sala, S. (2011). A daguerreotype of phineas gage? Cortex, 47 (4), 415. https://doi.org/10.1016/j.cortex.2010.07.013 .

Ferrier, D. (1886). The functions of the brain (2nd ed.). London: Smith, Elder & Co.

Fodor, J. A. (1983). The modularity of mind . Cambridge, MA: MIT Press.

Book   Google Scholar  

Gall, F. J. (1822–1825/1835). On the functions of the brain and each of its parts: With observations on the possibility of determining the instincts, propensities, and talents, or the moral and intellectual dispositions of men and animals, by the configuration of the brain and head . Boston: Marsh, Capen, & Lyon.

Gardner, H. (1983). Frames of mind: The theory of multiple intelligences . New York: Basic Books.

Griggs, R. A. (2015). Coverage of the Phineas Gage story in introductory psychology textbooks: Was Gage no longer Gage? Teaching of Psychology, 42 (3), 195–202. https://doi.org/10.1177/0098628315587614 .

Harlow, J. M. (1868). Recovery from the passage of an iron bar through the head. Publications of the Massachusetts Medical Society, 2 , 327–347.

Kihlstrom, J. F. (2010). Social neuroscience: The footprints of Phineas Gage. Social Cognition, 28 (6), 757–783. https://doi.org/10.1521/soco.2010.28.6.757 .

Luria, A. R. (1962/1966). Higher cortical functions in man . London: Tavistock.

Macmillan, M. (1992). Inhibition and the control of behavior: From Gall to Freud via Phineas Gage and the frontal lobes. Brain and Cognition, 19 (1), 72–104. https://doi.org/10.1016/0278-2626(92)90038-N .

Macmillan, M. (1996). Phineas Gage: A case for all reasons. In C. Code, C. Wallesch, Y. Joanette, & A. R. Lecours (Eds.), Classic cases in neuropsychology . Oxford: Taylor & Francis.

Macmillan, M. (2000a). An odd kind of fame: Stories of Phineas Gage . Cambridge, MA: MIT Press.

Macmillan, M. (2000b). Nineteenth-century inhibitory theories of thinking: Bain, Ferrier, Freud (and Phineas Gage). History of Psychology, 3 (3), 187–217. https://doi.org/10.1037/1093-4510.3.3.187 .

Macmillan, M. (2000c). Restoring Phineas Gage: A 150th retrospective. Journal of the History of the Neurosciences, 9 , 42–62. https://doi.org/10.1076/0964-704X(200004)9:1;1-2;FT046 .

Macmillan, M. (2001). John Martyn Harlow: “Obscure country physician”? Journal of the History of the Neurosciences, 10 (2), 149–162. https://doi.org/10.1076/jhin.10.2.149.7254 .

Macmillan, M. (2004). Inhibition and Phineas Gage: Repression and Sigmund Freud. Neuro-psychoanalysis, 6 (2), 181–192. https://doi.org/10.1080/15294145.2004.10773459 .

Macmillan, M. B. (2012). The Phineas Gage information page. Retrieved 11 August 2018, from https://www.uakron.edu/gage/

Macmillan, M., & Lena, M. L. (2010). Rehabilitating Phineas Gage. Neuropsychological Rehabilitation Psychology, 20 (5), 641–658. https://doi.org/10.1080/09602011003760527 .

Ratiu, P., Talos, I. F., Haker, S., Lieberman, D., & Everett, P. (2004). The tale of Phineas Gage, digitally remastered. Journal of Neurotrauma, 21 , 637–643. https://doi.org/10.1089/089771504774129964 .

Thomsen, I. V., Waldemar, G., & Thomsen, A. M. (1990). Late psychosocial improvement in a case of severe head injury with bilateral fronto-orbital lesions. Neuropsychology, 4 , 1–11. https://doi.org/10.1037/0894-4105.4.1.1 .

Tyler, K. L., & Tyler, H. R. (1982). A “Yankee Invention”: The celebrated American crowbar case. Neurology, 32 (4(Part 2)), A191.

Van Horn, J. D., Irimia, A., Torgerson, C. M., Chambers, M. C., Kikinis, R., & Toga, A. W. (2012). Mapping connectivity damage in the case of Phineas Gage. PLoS One, 7 (5), e37454. https://doi.org/10.1371/journal.pone.0037454 .

Article   PubMed   PubMed Central   Google Scholar  

Wilgus, J., & Wilgus, B. (2009). Face to face with Phineas Gage. Journal of the History of the Neurosciences, 18 , 340–345. https://doi.org/10.1080/09647040903018402 .

Download references

Author information

Authors and affiliations.

University of Melbourne, Melbourne, VIC, Australia

Malcolm Macmillan

University of California, Berkeley, Berkeley, CA, USA

John F. Kihlstrom

You can also search for this author in PubMed   Google Scholar

Corresponding authors

Correspondence to Malcolm Macmillan or John F. Kihlstrom .

Editor information

Editors and affiliations.

Oakland University, Rochester, MI, USA

Virgil Zeigler-Hill

Todd K. Shackelford

Section Editor information

Department of Psychology and Counseling, Northeastern State University, Broken Arrow, OK, USA

April Phillips

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this entry

Cite this entry.

Macmillan, M., Kihlstrom, J.F. (2020). Gage, Phineas. In: Zeigler-Hill, V., Shackelford, T.K. (eds) Encyclopedia of Personality and Individual Differences. Springer, Cham. https://doi.org/10.1007/978-3-319-24612-3_1716

Download citation

DOI : https://doi.org/10.1007/978-3-319-24612-3_1716

Published : 22 April 2020

Publisher Name : Springer, Cham

Print ISBN : 978-3-319-24610-9

Online ISBN : 978-3-319-24612-3

eBook Packages : Behavioral Science and Psychology Reference Module Humanities and Social Sciences Reference Module Business, Economics and Social Sciences

Share this entry

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

• Publish with us

Policies and ethics

• Find a journal
• Track your research