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Here's What You Need to Understand About Research Methodology

Table of Contents

Research methodology involves a systematic and well-structured approach to conducting scholarly or scientific inquiries. Knowing the significance of research methodology and its different components is crucial as it serves as the basis for any study.

Typically, your research topic will start as a broad idea you want to investigate more thoroughly. Once you’ve identified a research problem and created research questions , you must choose the appropriate methodology and frameworks to address those questions effectively.

What is the definition of a research methodology?

Research methodology is the process or the way you intend to execute your study. The methodology section of a research paper outlines how you plan to conduct your study. It covers various steps such as collecting data, statistical analysis, observing participants, and other procedures involved in the research process

The methods section should give a description of the process that will convert your idea into a study. Additionally, the outcomes of your process must provide valid and reliable results resonant with the aims and objectives of your research. This thumb rule holds complete validity, no matter whether your paper has inclinations for qualitative or quantitative usage.

Studying research methods used in related studies can provide helpful insights and direction for your own research. Now easily discover papers related to your topic on SciSpace and utilize our AI research assistant, Copilot , to quickly review the methodologies applied in different papers.

The need for a good research methodology

While deciding on your approach towards your research, the reason or factors you weighed in choosing a particular problem and formulating a research topic need to be validated and explained. A research methodology helps you do exactly that. Moreover, a good research methodology lets you build your argument to validate your research work performed through various data collection methods, analytical methods, and other essential points.

Just imagine it as a strategy documented to provide an overview of what you intend to do.

While undertaking any research writing or performing the research itself, you may get drifted in not something of much importance. In such a case, a research methodology helps you to get back to your outlined work methodology.

A research methodology helps in keeping you accountable for your work. Additionally, it can help you evaluate whether your work is in sync with your original aims and objectives or not. Besides, a good research methodology enables you to navigate your research process smoothly and swiftly while providing effective planning to achieve your desired results.

What is the basic structure of a research methodology?

Usually, you must ensure to include the following stated aspects while deciding over the basic structure of your research methodology:

1. Your research procedure

Explain what research methods you’re going to use. Whether you intend to proceed with quantitative or qualitative, or a composite of both approaches, you need to state that explicitly. The option among the three depends on your research’s aim, objectives, and scope.

2. Provide the rationality behind your chosen approach

Based on logic and reason, let your readers know why you have chosen said research methodologies. Additionally, you have to build strong arguments supporting why your chosen research method is the best way to achieve the desired outcome.

3. Explain your mechanism

The mechanism encompasses the research methods or instruments you will use to develop your research methodology. It usually refers to your data collection methods. You can use interviews, surveys, physical questionnaires, etc., of the many available mechanisms as research methodology instruments. The data collection method is determined by the type of research and whether the data is quantitative data(includes numerical data) or qualitative data (perception, morale, etc.) Moreover, you need to put logical reasoning behind choosing a particular instrument.

4. Significance of outcomes

The results will be available once you have finished experimenting. However, you should also explain how you plan to use the data to interpret the findings. This section also aids in understanding the problem from within, breaking it down into pieces, and viewing the research problem from various perspectives.

5. Reader’s advice

Anything that you feel must be explained to spread more awareness among readers and focus groups must be included and described in detail. You should not just specify your research methodology on the assumption that a reader is aware of the topic.  

All the relevant information that explains and simplifies your research paper must be included in the methodology section. If you are conducting your research in a non-traditional manner, give a logical justification and list its benefits.

6. Explain your sample space

Include information about the sample and sample space in the methodology section. The term "sample" refers to a smaller set of data that a researcher selects or chooses from a larger group of people or focus groups using a predetermined selection method. Let your readers know how you are going to distinguish between relevant and non-relevant samples. How you figured out those exact numbers to back your research methodology, i.e. the sample spacing of instruments, must be discussed thoroughly.

For example, if you are going to conduct a survey or interview, then by what procedure will you select the interviewees (or sample size in case of surveys), and how exactly will the interview or survey be conducted.

7. Challenges and limitations

This part, which is frequently assumed to be unnecessary, is actually very important. The challenges and limitations that your chosen strategy inherently possesses must be specified while you are conducting different types of research.

The importance of a good research methodology

You must have observed that all research papers, dissertations, or theses carry a chapter entirely dedicated to research methodology. This section helps maintain your credibility as a better interpreter of results rather than a manipulator.

A good research methodology always explains the procedure, data collection methods and techniques, aim, and scope of the research. In a research study, it leads to a well-organized, rationality-based approach, while the paper lacking it is often observed as messy or disorganized.

You should pay special attention to validating your chosen way towards the research methodology. This becomes extremely important in case you select an unconventional or a distinct method of execution.

Curating and developing a strong, effective research methodology can assist you in addressing a variety of situations, such as:

• When someone tries to duplicate or expand upon your research after few years.
• If a contradiction or conflict of facts occurs at a later time. This gives you the security you need to deal with these contradictions while still being able to defend your approach.
• Gaining a tactical approach in getting your research completed in time. Just ensure you are using the right approach while drafting your research methodology, and it can help you achieve your desired outcomes. Additionally, it provides a better explanation and understanding of the research question itself.
• Documenting the results so that the final outcome of the research stays as you intended it to be while starting.

Instruments you could use while writing a good research methodology

As a researcher, you must choose which tools or data collection methods that fit best in terms of the relevance of your research. This decision has to be wise.

There exists many research equipments or tools that you can use to carry out your research process. These are classified as:

a. Interviews (One-on-One or a Group)

An interview aimed to get your desired research outcomes can be undertaken in many different ways. For example, you can design your interview as structured, semi-structured, or unstructured. What sets them apart is the degree of formality in the questions. On the other hand, in a group interview, your aim should be to collect more opinions and group perceptions from the focus groups on a certain topic rather than looking out for some formal answers.

In surveys, you are in better control if you specifically draft the questions you seek the response for. For example, you may choose to include free-style questions that can be answered descriptively, or you may provide a multiple-choice type response for questions. Besides, you can also opt to choose both ways, deciding what suits your research process and purpose better.

c. Sample Groups

Similar to the group interviews, here, you can select a group of individuals and assign them a topic to discuss or freely express their opinions over that. You can simultaneously note down the answers and later draft them appropriately, deciding on the relevance of every response.

d. Observations

If your research domain is humanities or sociology, observations are the best-proven method to draw your research methodology. Of course, you can always include studying the spontaneous response of the participants towards a situation or conducting the same but in a more structured manner. A structured observation means putting the participants in a situation at a previously decided time and then studying their responses.

Of all the tools described above, it is you who should wisely choose the instruments and decide what’s the best fit for your research. You must not restrict yourself from multiple methods or a combination of a few instruments if appropriate in drafting a good research methodology.

Types of research methodology

A research methodology exists in various forms. Depending upon their approach, whether centered around words, numbers, or both, methodologies are distinguished as qualitative, quantitative, or an amalgamation of both.

1. Qualitative research methodology

When a research methodology primarily focuses on words and textual data, then it is generally referred to as qualitative research methodology. This type is usually preferred among researchers when the aim and scope of the research are mainly theoretical and explanatory.

The instruments used are observations, interviews, and sample groups. You can use this methodology if you are trying to study human behavior or response in some situations. Generally, qualitative research methodology is widely used in sociology, psychology, and other related domains.

2. Quantitative research methodology

If your research is majorly centered on data, figures, and stats, then analyzing these numerical data is often referred to as quantitative research methodology. You can use quantitative research methodology if your research requires you to validate or justify the obtained results.

In quantitative methods, surveys, tests, experiments, and evaluations of current databases can be advantageously used as instruments If your research involves testing some hypothesis, then use this methodology.

3. Amalgam methodology

As the name suggests, the amalgam methodology uses both quantitative and qualitative approaches. This methodology is used when a part of the research requires you to verify the facts and figures, whereas the other part demands you to discover the theoretical and explanatory nature of the research question.

The instruments for the amalgam methodology require you to conduct interviews and surveys, including tests and experiments. The outcome of this methodology can be insightful and valuable as it provides precise test results in line with theoretical explanations and reasoning.

The amalgam method, makes your work both factual and rational at the same time.

Final words: How to decide which is the best research methodology?

If you have kept your sincerity and awareness intact with the aims and scope of research well enough, you must have got an idea of which research methodology suits your work best.

Before deciding which research methodology answers your research question, you must invest significant time in reading and doing your homework for that. Taking references that yield relevant results should be your first approach to establishing a research methodology.

Moreover, you should never refrain from exploring other options. Before setting your work in stone, you must try all the available options as it explains why the choice of research methodology that you finally make is more appropriate than the other available options.

You should always go for a quantitative research methodology if your research requires gathering large amounts of data, figures, and statistics. This research methodology will provide you with results if your research paper involves the validation of some hypothesis.

Whereas, if  you are looking for more explanations, reasons, opinions, and public perceptions around a theory, you must use qualitative research methodology.The choice of an appropriate research methodology ultimately depends on what you want to achieve through your research.

Frequently Asked Questions (FAQs) about Research Methodology

1. how to write a research methodology.

You can always provide a separate section for research methodology where you should specify details about the methods and instruments used during the research, discussions on result analysis, including insights into the background information, and conveying the research limitations.

2. What are the types of research methodology?

There generally exists four types of research methodology i.e.

• Observation
• Experimental
• Derivational

3. What is the true meaning of research methodology?

The set of techniques or procedures followed to discover and analyze the information gathered to validate or justify a research outcome is generally called Research Methodology.

4. Where lies the importance of research methodology?

Your research methodology directly reflects the validity of your research outcomes and how well-informed your research work is. Moreover, it can help future researchers cite or refer to your research if they plan to use a similar research methodology.

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What Is Research Methodology? A Plain-Language Explanation & Definition (With Examples)

By Derek Jansen (MBA)  and Kerryn Warren (PhD) | June 2020 (Last updated April 2023)

If you’re new to formal academic research, it’s quite likely that you’re feeling a little overwhelmed by all the technical lingo that gets thrown around. And who could blame you – “research methodology”, “research methods”, “sampling strategies”… it all seems never-ending!

In this post, we’ll demystify the landscape with plain-language explanations and loads of examples (including easy-to-follow videos), so that you can approach your dissertation, thesis or research project with confidence. Let’s get started.

Research Methodology 101

• What exactly research methodology means
• What qualitative , quantitative and mixed methods are
• What sampling strategy is
• What data collection methods are
• What data analysis methods are
• How to choose your research methodology
• Example of a research methodology

What is research methodology?

Research methodology simply refers to the practical “how” of a research study. More specifically, it’s about how  a researcher  systematically designs a study  to ensure valid and reliable results that address the research aims, objectives and research questions . Specifically, how the researcher went about deciding:

• What type of data to collect (e.g., qualitative or quantitative data )
• Who  to collect it from (i.e., the sampling strategy )
• How to  collect  it (i.e., the data collection method )
• How to  analyse  it (i.e., the data analysis methods )

Within any formal piece of academic research (be it a dissertation, thesis or journal article), you’ll find a research methodology chapter or section which covers the aspects mentioned above. Importantly, a good methodology chapter explains not just   what methodological choices were made, but also explains  why they were made. In other words, the methodology chapter should justify  the design choices, by showing that the chosen methods and techniques are the best fit for the research aims, objectives and research questions. 

So, it’s the same as research design?

Not quite. As we mentioned, research methodology refers to the collection of practical decisions regarding what data you’ll collect, from who, how you’ll collect it and how you’ll analyse it. Research design, on the other hand, is more about the overall strategy you’ll adopt in your study. For example, whether you’ll use an experimental design in which you manipulate one variable while controlling others. You can learn more about research design and the various design types here .

Need a helping hand?

What are qualitative, quantitative and mixed-methods?

Qualitative, quantitative and mixed-methods are different types of methodological approaches, distinguished by their focus on words , numbers or both . This is a bit of an oversimplification, but its a good starting point for understanding.

Let’s take a closer look.

Qualitative research refers to research which focuses on collecting and analysing words (written or spoken) and textual or visual data, whereas quantitative research focuses on measurement and testing using numerical data . Qualitative analysis can also focus on other “softer” data points, such as body language or visual elements.

It’s quite common for a qualitative methodology to be used when the research aims and research questions are exploratory  in nature. For example, a qualitative methodology might be used to understand peoples’ perceptions about an event that took place, or a political candidate running for president. 

Contrasted to this, a quantitative methodology is typically used when the research aims and research questions are confirmatory  in nature. For example, a quantitative methodology might be used to measure the relationship between two variables (e.g. personality type and likelihood to commit a crime) or to test a set of hypotheses .

As you’ve probably guessed, the mixed-method methodology attempts to combine the best of both qualitative and quantitative methodologies to integrate perspectives and create a rich picture. If you’d like to learn more about these three methodological approaches, be sure to watch our explainer video below.

What is sampling strategy?

Simply put, sampling is about deciding who (or where) you’re going to collect your data from . Why does this matter? Well, generally it’s not possible to collect data from every single person in your group of interest (this is called the “population”), so you’ll need to engage a smaller portion of that group that’s accessible and manageable (this is called the “sample”).

How you go about selecting the sample (i.e., your sampling strategy) will have a major impact on your study.  There are many different sampling methods  you can choose from, but the two overarching categories are probability   sampling and  non-probability   sampling .

Probability sampling  involves using a completely random sample from the group of people you’re interested in. This is comparable to throwing the names all potential participants into a hat, shaking it up, and picking out the “winners”. By using a completely random sample, you’ll minimise the risk of selection bias and the results of your study will be more generalisable  to the entire population. 

Non-probability sampling , on the other hand,  doesn’t use a random sample . For example, it might involve using a convenience sample, which means you’d only interview or survey people that you have access to (perhaps your friends, family or work colleagues), rather than a truly random sample. With non-probability sampling, the results are typically not generalisable .

To learn more about sampling methods, be sure to check out the video below.

What are data collection methods?

As the name suggests, data collection methods simply refers to the way in which you go about collecting the data for your study. Some of the most common data collection methods include:

• Interviews (which can be unstructured, semi-structured or structured)
• Focus groups and group interviews
• Surveys (online or physical surveys)
• Observations (watching and recording activities)
• Biophysical measurements (e.g., blood pressure, heart rate, etc.)
• Documents and records (e.g., financial reports, court records, etc.)

The choice of which data collection method to use depends on your overall research aims and research questions , as well as practicalities and resource constraints. For example, if your research is exploratory in nature, qualitative methods such as interviews and focus groups would likely be a good fit. Conversely, if your research aims to measure specific variables or test hypotheses, large-scale surveys that produce large volumes of numerical data would likely be a better fit.

What are data analysis methods?

Data analysis methods refer to the methods and techniques that you’ll use to make sense of your data. These can be grouped according to whether the research is qualitative  (words-based) or quantitative (numbers-based).

Popular data analysis methods in qualitative research include:

• Qualitative content analysis
• Thematic analysis
• Discourse analysis
• Narrative analysis
• Interpretative phenomenological analysis (IPA)
• Visual analysis (of photographs, videos, art, etc.)

Qualitative data analysis all begins with data coding , after which an analysis method is applied. In some cases, more than one analysis method is used, depending on the research aims and research questions . In the video below, we explore some  common qualitative analysis methods, along with practical examples.  

Moving on to the quantitative side of things, popular data analysis methods in this type of research include:

• Descriptive statistics (e.g. means, medians, modes )
• Inferential statistics (e.g. correlation, regression, structural equation modelling)

Again, the choice of which data collection method to use depends on your overall research aims and objectives , as well as practicalities and resource constraints. In the video below, we explain some core concepts central to quantitative analysis.

How do I choose a research methodology?

As you’ve probably picked up by now, your research aims and objectives have a major influence on the research methodology . So, the starting point for developing your research methodology is to take a step back and look at the big picture of your research, before you make methodology decisions. The first question you need to ask yourself is whether your research is exploratory or confirmatory in nature.

If your research aims and objectives are primarily exploratory in nature, your research will likely be qualitative and therefore you might consider qualitative data collection methods (e.g. interviews) and analysis methods (e.g. qualitative content analysis). 

Conversely, if your research aims and objective are looking to measure or test something (i.e. they’re confirmatory), then your research will quite likely be quantitative in nature, and you might consider quantitative data collection methods (e.g. surveys) and analyses (e.g. statistical analysis).

Designing your research and working out your methodology is a large topic, which we cover extensively on the blog . For now, however, the key takeaway is that you should always start with your research aims, objectives and research questions (the golden thread). Every methodological choice you make needs align with those three components. 

Example of a research methodology chapter

In the video below, we provide a detailed walkthrough of a research methodology from an actual dissertation, as well as an overview of our free methodology template .

Psst... there’s more!

This post was based on one of our popular Research Bootcamps . If you're working on a research project, you'll definitely want to check this out ...

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Thanks for your comment.

We can’t write your methodology for you. If you’re looking for samples, you should be able to find some sample methodologies on Google. Alternatively, you can download some previous dissertations from a dissertation directory and have a look at the methodology chapters therein.

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MLA Jansen, Derek, and Kerryn Warren. “What (Exactly) Is Research Methodology?” Grad Coach, June 2021, gradcoach.com/what-is-research-methodology/.

APA Jansen, D., & Warren, K. (2021, June). What (Exactly) Is Research Methodology? Grad Coach. https://gradcoach.com/what-is-research-methodology/

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• How to Write Your Methods

Ensure understanding, reproducibility and replicability

What should you include in your methods section, and how much detail is appropriate?

Why Methods Matter

The methods section was once the most likely part of a paper to be unfairly abbreviated, overly summarized, or even relegated to hard-to-find sections of a publisher’s website. While some journals may responsibly include more detailed elements of methods in supplementary sections, the movement for increased reproducibility and rigor in science has reinstated the importance of the methods section. Methods are now viewed as a key element in establishing the credibility of the research being reported, alongside the open availability of data and results.

A clear methods section impacts editorial evaluation and readers’ understanding, and is also the backbone of transparency and replicability.

For example, the Reproducibility Project: Cancer Biology project set out in 2013 to replicate experiments from 50 high profile cancer papers, but revised their target to 18 papers once they understood how much methodological detail was not contained in the original papers.

What to include in your methods section

What you include in your methods sections depends on what field you are in and what experiments you are performing. However, the general principle in place at the majority of journals is summarized well by the guidelines at PLOS ONE : “The Materials and Methods section should provide enough detail to allow suitably skilled investigators to fully replicate your study. ” The emphases here are deliberate: the methods should enable readers to understand your paper, and replicate your study. However, there is no need to go into the level of detail that a lay-person would require—the focus is on the reader who is also trained in your field, with the suitable skills and knowledge to attempt a replication.

A constant principle of rigorous science

A methods section that enables other researchers to understand and replicate your results is a constant principle of rigorous, transparent, and Open Science. Aim to be thorough, even if a particular journal doesn’t require the same level of detail . Reproducibility is all of our responsibility. You cannot create any problems by exceeding a minimum standard of information. If a journal still has word-limits—either for the overall article or specific sections—and requires some methodological details to be in a supplemental section, that is OK as long as the extra details are searchable and findable .

Imagine replicating your own work, years in the future

As part of PLOS’ presentation on Reproducibility and Open Publishing (part of UCSF’s Reproducibility Series ) we recommend planning the level of detail in your methods section by imagining you are writing for your future self, replicating your own work. When you consider that you might be at a different institution, with different account logins, applications, resources, and access levels—you can help yourself imagine the level of specificity that you yourself would require to redo the exact experiment. Consider:

• Which details would you need to be reminded of? 
• Which cell line, or antibody, or software, or reagent did you use, and does it have a Research Resource ID (RRID) that you can cite?
• Which version of a questionnaire did you use in your survey? 
• Exactly which visual stimulus did you show participants, and is it publicly available? 
• What participants did you decide to exclude? 
• What process did you adjust, during your work? 

Tip: Be sure to capture any changes to your protocols

You yourself would want to know about any adjustments, if you ever replicate the work, so you can surmise that anyone else would want to as well. Even if a necessary adjustment you made was not ideal, transparency is the key to ensuring this is not regarded as an issue in the future. It is far better to transparently convey any non-optimal methods, or methodological constraints, than to conceal them, which could result in reproducibility or ethical issues downstream.

Visual aids for methods help when reading the whole paper

Consider whether a visual representation of your methods could be appropriate or aid understanding your process. A visual reference readers can easily return to, like a flow-diagram, decision-tree, or checklist, can help readers to better understand the complete article, not just the methods section.

Ethical Considerations

In addition to describing what you did, it is just as important to assure readers that you also followed all relevant ethical guidelines when conducting your research. While ethical standards and reporting guidelines are often presented in a separate section of a paper, ensure that your methods and protocols actually follow these guidelines. Read more about ethics .

Existing standards, checklists, guidelines, partners

While the level of detail contained in a methods section should be guided by the universal principles of rigorous science outlined above, various disciplines, fields, and projects have worked hard to design and develop consistent standards, guidelines, and tools to help with reporting all types of experiment. Below, you’ll find some of the key initiatives. Ensure you read the submission guidelines for the specific journal you are submitting to, in order to discover any further journal- or field-specific policies to follow, or initiatives/tools to utilize.

Tip: Keep your paper moving forward by providing the proper paperwork up front

Be sure to check the journal guidelines and provide the necessary documents with your manuscript submission. Collecting the necessary documentation can greatly slow the first round of peer review, or cause delays when you submit your revision.

Randomized Controlled Trials – CONSORT The Consolidated Standards of Reporting Trials (CONSORT) project covers various initiatives intended to prevent the problems of  inadequate reporting of randomized controlled trials. The primary initiative is an evidence-based minimum set of recommendations for reporting randomized trials known as the CONSORT Statement . 

Systematic Reviews and Meta-Analyses – PRISMA The Preferred Reporting Items for Systematic Reviews and Meta-Analyses ( PRISMA ) is an evidence-based minimum set of items focusing  on the reporting of  reviews evaluating randomized trials and other types of research.

Research using Animals – ARRIVE The Animal Research: Reporting of In Vivo Experiments ( ARRIVE ) guidelines encourage maximizing the information reported in research using animals thereby minimizing unnecessary studies. (Original study and proposal , and updated guidelines , in PLOS Biology .) 

Laboratory Protocols Protocols.io has developed a platform specifically for the sharing and updating of laboratory protocols , which are assigned their own DOI and can be linked from methods sections of papers to enhance reproducibility. Contextualize your protocol and improve discovery with an accompanying Lab Protocol article in PLOS ONE .

Consistent reporting of Materials, Design, and Analysis – the MDAR checklist A cross-publisher group of editors and experts have developed, tested, and rolled out a checklist to help establish and harmonize reporting standards in the Life Sciences . The checklist , which is available for use by authors to compile their methods, and editors/reviewers to check methods, establishes a minimum set of requirements in transparent reporting and is adaptable to any discipline within the Life Sciences, by covering a breadth of potentially relevant methodological items and considerations. If you are in the Life Sciences and writing up your methods section, try working through the MDAR checklist and see whether it helps you include all relevant details into your methods, and whether it reminded you of anything you might have missed otherwise.

Summary Writing tips

The main challenge you may find when writing your methods is keeping it readable AND covering all the details needed for reproducibility and replicability. While this is difficult, do not compromise on rigorous standards for credibility!

• Keep in mind future replicability, alongside understanding and readability.
• Follow checklists, and field- and journal-specific guidelines.
• Consider a commitment to rigorous and transparent science a personal responsibility, and not just adhering to journal guidelines.
• Establish whether there are persistent identifiers for any research resources you use that can be specifically cited in your methods section.
• Deposit your laboratory protocols in Protocols.io, establishing a permanent link to them. You can update your protocols later if you improve on them, as can future scientists who follow your protocols.
• Consider visual aids like flow-diagrams, lists, to help with reading other sections of the paper.
• Be specific about all decisions made during the experiments that someone reproducing your work would need to know.

Don’t

• Summarize or abbreviate methods without giving full details in a discoverable supplemental section.
• Presume you will always be able to remember how you performed the experiments, or have access to private or institutional notebooks and resources.
• Attempt to hide constraints or non-optimal decisions you had to make–transparency is the key to ensuring the credibility of your research.
• How to Write a Great Title
• How to Write an Abstract
• How to Report Statistics
• How to Write Discussions and Conclusions
• How to Edit Your Work

The contents of the Peer Review Center are also available as a live, interactive training session, complete with slides, talking points, and activities. …

The contents of the Writing Center are also available as a live, interactive training session, complete with slides, talking points, and activities. …

There’s a lot to consider when deciding where to submit your work. Learn how to choose a journal that will help your study reach its audience, while reflecting your values as a researcher…

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Organizing Your Social Sciences Research Paper

• 6. The Methodology
• Purpose of Guide
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• Common Grammar Mistakes
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The methods section describes actions taken to investigate a research problem and the rationale for the application of specific procedures or techniques used to identify, select, process, and analyze information applied to understanding the problem, thereby, allowing the reader to critically evaluate a study’s overall validity and reliability. The methodology section of a research paper answers two main questions: How was the data collected or generated? And, how was it analyzed? The writing should be direct and precise and always written in the past tense.

Kallet, Richard H. "How to Write the Methods Section of a Research Paper." Respiratory Care 49 (October 2004): 1229-1232.

Importance of a Good Methodology Section

You must explain how you obtained and analyzed your results for the following reasons:

• Readers need to know how the data was obtained because the method you chose affects the results and, by extension, how you interpreted their significance in the discussion section of your paper.
• Methodology is crucial for any branch of scholarship because an unreliable method produces unreliable results and, as a consequence, undermines the value of your analysis of the findings.
• In most cases, there are a variety of different methods you can choose to investigate a research problem. The methodology section of your paper should clearly articulate the reasons why you have chosen a particular procedure or technique.
• The reader wants to know that the data was collected or generated in a way that is consistent with accepted practice in the field of study. For example, if you are using a multiple choice questionnaire, readers need to know that it offered your respondents a reasonable range of answers to choose from.
• The method must be appropriate to fulfilling the overall aims of the study. For example, you need to ensure that you have a large enough sample size to be able to generalize and make recommendations based upon the findings.
• The methodology should discuss the problems that were anticipated and the steps you took to prevent them from occurring. For any problems that do arise, you must describe the ways in which they were minimized or why these problems do not impact in any meaningful way your interpretation of the findings.
• In the social and behavioral sciences, it is important to always provide sufficient information to allow other researchers to adopt or replicate your methodology. This information is particularly important when a new method has been developed or an innovative use of an existing method is utilized.

Bem, Daryl J. Writing the Empirical Journal Article. Psychology Writing Center. University of Washington; Denscombe, Martyn. The Good Research Guide: For Small-Scale Social Research Projects . 5th edition. Buckingham, UK: Open University Press, 2014; Lunenburg, Frederick C. Writing a Successful Thesis or Dissertation: Tips and Strategies for Students in the Social and Behavioral Sciences . Thousand Oaks, CA: Corwin Press, 2008.

Structure and Writing Style

I.  Groups of Research Methods

There are two main groups of research methods in the social sciences:

• The e mpirical-analytical group approaches the study of social sciences in a similar manner that researchers study the natural sciences . This type of research focuses on objective knowledge, research questions that can be answered yes or no, and operational definitions of variables to be measured. The empirical-analytical group employs deductive reasoning that uses existing theory as a foundation for formulating hypotheses that need to be tested. This approach is focused on explanation.
• The i nterpretative group of methods is focused on understanding phenomenon in a comprehensive, holistic way . Interpretive methods focus on analytically disclosing the meaning-making practices of human subjects [the why, how, or by what means people do what they do], while showing how those practices arrange so that it can be used to generate observable outcomes. Interpretive methods allow you to recognize your connection to the phenomena under investigation. However, the interpretative group requires careful examination of variables because it focuses more on subjective knowledge.

II.  Content

The introduction to your methodology section should begin by restating the research problem and underlying assumptions underpinning your study. This is followed by situating the methods you used to gather, analyze, and process information within the overall “tradition” of your field of study and within the particular research design you have chosen to study the problem. If the method you choose lies outside of the tradition of your field [i.e., your review of the literature demonstrates that the method is not commonly used], provide a justification for how your choice of methods specifically addresses the research problem in ways that have not been utilized in prior studies.

The remainder of your methodology section should describe the following:

• Decisions made in selecting the data you have analyzed or, in the case of qualitative research, the subjects and research setting you have examined,
• Tools and methods used to identify and collect information, and how you identified relevant variables,
• The ways in which you processed the data and the procedures you used to analyze that data, and
• The specific research tools or strategies that you utilized to study the underlying hypothesis and research questions.

In addition, an effectively written methodology section should:

• Introduce the overall methodological approach for investigating your research problem . Is your study qualitative or quantitative or a combination of both (mixed method)? Are you going to take a special approach, such as action research, or a more neutral stance?
• Indicate how the approach fits the overall research design . Your methods for gathering data should have a clear connection to your research problem. In other words, make sure that your methods will actually address the problem. One of the most common deficiencies found in research papers is that the proposed methodology is not suitable to achieving the stated objective of your paper.
• Describe the specific methods of data collection you are going to use , such as, surveys, interviews, questionnaires, observation, archival research. If you are analyzing existing data, such as a data set or archival documents, describe how it was originally created or gathered and by whom. Also be sure to explain how older data is still relevant to investigating the current research problem.
• Explain how you intend to analyze your results . Will you use statistical analysis? Will you use specific theoretical perspectives to help you analyze a text or explain observed behaviors? Describe how you plan to obtain an accurate assessment of relationships, patterns, trends, distributions, and possible contradictions found in the data.
• Provide background and a rationale for methodologies that are unfamiliar for your readers . Very often in the social sciences, research problems and the methods for investigating them require more explanation/rationale than widely accepted rules governing the natural and physical sciences. Be clear and concise in your explanation.
• Provide a justification for subject selection and sampling procedure . For instance, if you propose to conduct interviews, how do you intend to select the sample population? If you are analyzing texts, which texts have you chosen, and why? If you are using statistics, why is this set of data being used? If other data sources exist, explain why the data you chose is most appropriate to addressing the research problem.
• Provide a justification for case study selection . A common method of analyzing research problems in the social sciences is to analyze specific cases. These can be a person, place, event, phenomenon, or other type of subject of analysis that are either examined as a singular topic of in-depth investigation or multiple topics of investigation studied for the purpose of comparing or contrasting findings. In either method, you should explain why a case or cases were chosen and how they specifically relate to the research problem.
• Describe potential limitations . Are there any practical limitations that could affect your data collection? How will you attempt to control for potential confounding variables and errors? If your methodology may lead to problems you can anticipate, state this openly and show why pursuing this methodology outweighs the risk of these problems cropping up.

NOTE :   Once you have written all of the elements of the methods section, subsequent revisions should focus on how to present those elements as clearly and as logically as possibly. The description of how you prepared to study the research problem, how you gathered the data, and the protocol for analyzing the data should be organized chronologically. For clarity, when a large amount of detail must be presented, information should be presented in sub-sections according to topic. If necessary, consider using appendices for raw data.

ANOTHER NOTE : If you are conducting a qualitative analysis of a research problem , the methodology section generally requires a more elaborate description of the methods used as well as an explanation of the processes applied to gathering and analyzing of data than is generally required for studies using quantitative methods. Because you are the primary instrument for generating the data [e.g., through interviews or observations], the process for collecting that data has a significantly greater impact on producing the findings. Therefore, qualitative research requires a more detailed description of the methods used.

YET ANOTHER NOTE :   If your study involves interviews, observations, or other qualitative techniques involving human subjects , you may be required to obtain approval from the university's Office for the Protection of Research Subjects before beginning your research. This is not a common procedure for most undergraduate level student research assignments. However, i f your professor states you need approval, you must include a statement in your methods section that you received official endorsement and adequate informed consent from the office and that there was a clear assessment and minimization of risks to participants and to the university. This statement informs the reader that your study was conducted in an ethical and responsible manner. In some cases, the approval notice is included as an appendix to your paper.

III.  Problems to Avoid

Irrelevant Detail The methodology section of your paper should be thorough but concise. Do not provide any background information that does not directly help the reader understand why a particular method was chosen, how the data was gathered or obtained, and how the data was analyzed in relation to the research problem [note: analyzed, not interpreted! Save how you interpreted the findings for the discussion section]. With this in mind, the page length of your methods section will generally be less than any other section of your paper except the conclusion.

Unnecessary Explanation of Basic Procedures Remember that you are not writing a how-to guide about a particular method. You should make the assumption that readers possess a basic understanding of how to investigate the research problem on their own and, therefore, you do not have to go into great detail about specific methodological procedures. The focus should be on how you applied a method , not on the mechanics of doing a method. An exception to this rule is if you select an unconventional methodological approach; if this is the case, be sure to explain why this approach was chosen and how it enhances the overall process of discovery.

Problem Blindness It is almost a given that you will encounter problems when collecting or generating your data, or, gaps will exist in existing data or archival materials. Do not ignore these problems or pretend they did not occur. Often, documenting how you overcame obstacles can form an interesting part of the methodology. It demonstrates to the reader that you can provide a cogent rationale for the decisions you made to minimize the impact of any problems that arose.

Literature Review Just as the literature review section of your paper provides an overview of sources you have examined while researching a particular topic, the methodology section should cite any sources that informed your choice and application of a particular method [i.e., the choice of a survey should include any citations to the works you used to help construct the survey].

It’s More than Sources of Information! A description of a research study's method should not be confused with a description of the sources of information. Such a list of sources is useful in and of itself, especially if it is accompanied by an explanation about the selection and use of the sources. The description of the project's methodology complements a list of sources in that it sets forth the organization and interpretation of information emanating from those sources.

Azevedo, L.F. et al. "How to Write a Scientific Paper: Writing the Methods Section." Revista Portuguesa de Pneumologia 17 (2011): 232-238; Blair Lorrie. “Choosing a Methodology.” In Writing a Graduate Thesis or Dissertation , Teaching Writing Series. (Rotterdam: Sense Publishers 2016), pp. 49-72; Butin, Dan W. The Education Dissertation A Guide for Practitioner Scholars . Thousand Oaks, CA: Corwin, 2010; Carter, Susan. Structuring Your Research Thesis . New York: Palgrave Macmillan, 2012; Kallet, Richard H. “How to Write the Methods Section of a Research Paper.” Respiratory Care 49 (October 2004):1229-1232; Lunenburg, Frederick C. Writing a Successful Thesis or Dissertation: Tips and Strategies for Students in the Social and Behavioral Sciences . Thousand Oaks, CA: Corwin Press, 2008. Methods Section. The Writer’s Handbook. Writing Center. University of Wisconsin, Madison; Rudestam, Kjell Erik and Rae R. Newton. “The Method Chapter: Describing Your Research Plan.” In Surviving Your Dissertation: A Comprehensive Guide to Content and Process . (Thousand Oaks, Sage Publications, 2015), pp. 87-115; What is Interpretive Research. Institute of Public and International Affairs, University of Utah; Writing the Experimental Report: Methods, Results, and Discussion. The Writing Lab and The OWL. Purdue University; Methods and Materials. The Structure, Format, Content, and Style of a Journal-Style Scientific Paper. Department of Biology. Bates College.

Writing Tip

Statistical Designs and Tests? Do Not Fear Them!

Don't avoid using a quantitative approach to analyzing your research problem just because you fear the idea of applying statistical designs and tests. A qualitative approach, such as conducting interviews or content analysis of archival texts, can yield exciting new insights about a research problem, but it should not be undertaken simply because you have a disdain for running a simple regression. A well designed quantitative research study can often be accomplished in very clear and direct ways, whereas, a similar study of a qualitative nature usually requires considerable time to analyze large volumes of data and a tremendous burden to create new paths for analysis where previously no path associated with your research problem had existed.

To locate data and statistics, GO HERE .

Another Writing Tip

Knowing the Relationship Between Theories and Methods

There can be multiple meaning associated with the term "theories" and the term "methods" in social sciences research. A helpful way to delineate between them is to understand "theories" as representing different ways of characterizing the social world when you research it and "methods" as representing different ways of generating and analyzing data about that social world. Framed in this way, all empirical social sciences research involves theories and methods, whether they are stated explicitly or not. However, while theories and methods are often related, it is important that, as a researcher, you deliberately separate them in order to avoid your theories playing a disproportionate role in shaping what outcomes your chosen methods produce.

Introspectively engage in an ongoing dialectic between the application of theories and methods to help enable you to use the outcomes from your methods to interrogate and develop new theories, or ways of framing conceptually the research problem. This is how scholarship grows and branches out into new intellectual territory.

Reynolds, R. Larry. Ways of Knowing. Alternative Microeconomics . Part 1, Chapter 3. Boise State University; The Theory-Method Relationship. S-Cool Revision. United Kingdom.

Yet Another Writing Tip

Methods and the Methodology

Do not confuse the terms "methods" and "methodology." As Schneider notes, a method refers to the technical steps taken to do research . Descriptions of methods usually include defining and stating why you have chosen specific techniques to investigate a research problem, followed by an outline of the procedures you used to systematically select, gather, and process the data [remember to always save the interpretation of data for the discussion section of your paper].

The methodology refers to a discussion of the underlying reasoning why particular methods were used . This discussion includes describing the theoretical concepts that inform the choice of methods to be applied, placing the choice of methods within the more general nature of academic work, and reviewing its relevance to examining the research problem. The methodology section also includes a thorough review of the methods other scholars have used to study the topic.

Bryman, Alan. "Of Methods and Methodology." Qualitative Research in Organizations and Management: An International Journal 3 (2008): 159-168; Schneider, Florian. “What's in a Methodology: The Difference between Method, Methodology, and Theory…and How to Get the Balance Right?” PoliticsEastAsia.com. Chinese Department, University of Leiden, Netherlands.

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Home » Dissertation Methodology – Structure, Example and Writing Guide

Dissertation Methodology – Structure, Example and Writing Guide

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Dissertation Methodology

In any research, the methodology chapter is one of the key components of your dissertation. It provides a detailed description of the methods you used to conduct your research and helps readers understand how you obtained your data and how you plan to analyze it. This section is crucial for replicating the study and validating its results.

Here are the basic elements that are typically included in a dissertation methodology:

• Introduction : This section should explain the importance and goals of your research .
• Research Design : Outline your research approach and why it’s appropriate for your study. You might be conducting an experimental research, a qualitative research, a quantitative research, or a mixed-methods research.
• Data Collection : This section should detail the methods you used to collect your data. Did you use surveys, interviews, observations, etc.? Why did you choose these methods? You should also include who your participants were, how you recruited them, and any ethical considerations.
• Data Analysis : Explain how you intend to analyze the data you collected. This could include statistical analysis, thematic analysis, content analysis, etc., depending on the nature of your study.
• Reliability and Validity : Discuss how you’ve ensured the reliability and validity of your study. For instance, you could discuss measures taken to reduce bias, how you ensured that your measures accurately capture what they were intended to, or how you will handle any limitations in your study.
• Ethical Considerations : This is where you state how you have considered ethical issues related to your research, how you have protected the participants’ rights, and how you have complied with the relevant ethical guidelines.
• Limitations : Acknowledge any limitations of your methodology, including any biases and constraints that might have affected your study.
• Summary : Recap the key points of your methodology chapter, highlighting the overall approach and rationalization of your research.

Types of Dissertation Methodology

The type of methodology you choose for your dissertation will depend on the nature of your research question and the field you’re working in. Here are some of the most common types of methodologies used in dissertations:

Experimental Research

This involves creating an experiment that will test your hypothesis. You’ll need to design an experiment, manipulate variables, collect data, and analyze that data to draw conclusions. This is commonly used in fields like psychology, biology, and physics.

Survey Research

This type of research involves gathering data from a large number of participants using tools like questionnaires or surveys. It can be used to collect a large amount of data and is often used in fields like sociology, marketing, and public health.

Qualitative Research

This type of research is used to explore complex phenomena that can’t be easily quantified. Methods include interviews, focus groups, and observations. This methodology is common in fields like anthropology, sociology, and education.

Quantitative Research

Quantitative research uses numerical data to answer research questions. This can include statistical, mathematical, or computational techniques. It’s common in fields like economics, psychology, and health sciences.

Case Study Research

This type of research involves in-depth investigation of a particular case, such as an individual, group, or event. This methodology is often used in psychology, social sciences, and business.

Mixed Methods Research

This combines qualitative and quantitative research methods in a single study. It’s used to answer more complex research questions and is becoming more popular in fields like social sciences, health sciences, and education.

Action Research

This type of research involves taking action and then reflecting upon the results. This cycle of action-reflection-action continues throughout the study. It’s often used in fields like education and organizational development.

Longitudinal Research

This type of research involves studying the same group of individuals over an extended period of time. This could involve surveys, observations, or experiments. It’s common in fields like psychology, sociology, and medicine.

Ethnographic Research

This type of research involves the in-depth study of people and cultures. Researchers immerse themselves in the culture they’re studying to collect data. This is often used in fields like anthropology and social sciences.

Structure of Dissertation Methodology

The structure of a dissertation methodology can vary depending on your field of study, the nature of your research, and the guidelines of your institution. However, a standard structure typically includes the following elements:

• Introduction : Briefly introduce your overall approach to the research. Explain what you plan to explore and why it’s important.
• Research Design/Approach : Describe your overall research design. This can be qualitative, quantitative, or mixed methods. Explain the rationale behind your chosen design and why it is suitable for your research questions or hypotheses.
• Data Collection Methods : Detail the methods you used to collect your data. You should include what type of data you collected, how you collected it, and why you chose this method. If relevant, you can also include information about your sample population, such as how many people participated, how they were chosen, and any relevant demographic information.
• Data Analysis Methods : Explain how you plan to analyze your collected data. This will depend on the nature of your data. For example, if you collected quantitative data, you might discuss statistical analysis techniques. If you collected qualitative data, you might discuss coding strategies, thematic analysis, or narrative analysis.
• Reliability and Validity : Discuss how you’ve ensured the reliability and validity of your research. This might include steps you took to reduce bias or increase the accuracy of your measurements.
• Ethical Considerations : If relevant, discuss any ethical issues associated with your research. This might include how you obtained informed consent from participants, how you ensured participants’ privacy and confidentiality, or any potential conflicts of interest.
• Limitations : Acknowledge any limitations in your research methodology. This could include potential sources of bias, difficulties with data collection, or limitations in your analysis methods.
• Summary/Conclusion : Briefly summarize the key points of your methodology, emphasizing how it helps answer your research questions or hypotheses.

How to Write Dissertation Methodology

Writing a dissertation methodology requires you to be clear and precise about the way you’ve carried out your research. It’s an opportunity to convince your readers of the appropriateness and reliability of your approach to your research question. Here is a basic guideline on how to write your methodology section:

1. Introduction

Start your methodology section by restating your research question(s) or objective(s). This ensures your methodology directly ties into the aim of your research.

2. Approach

Identify your overall approach: qualitative, quantitative, or mixed methods. Explain why you have chosen this approach.

• Qualitative methods are typically used for exploratory research and involve collecting non-numerical data. This might involve interviews, observations, or analysis of texts.
• Quantitative methods are used for research that relies on numerical data. This might involve surveys, experiments, or statistical analysis.
• Mixed methods use a combination of both qualitative and quantitative research methods.

3. Research Design

Describe the overall design of your research. This could involve explaining the type of study (e.g., case study, ethnography, experimental research, etc.), how you’ve defined and measured your variables, and any control measures you’ve implemented.

4. Data Collection

Explain in detail how you collected your data.

• If you’ve used qualitative methods, you might detail how you selected participants for interviews or focus groups, how you conducted observations, or how you analyzed existing texts.
• If you’ve used quantitative methods, you might detail how you designed your survey or experiment, how you collected responses, and how you ensured your data is reliable and valid.

5. Data Analysis

Describe how you analyzed your data.

• If you’re doing qualitative research, this might involve thematic analysis, discourse analysis, or grounded theory.
• If you’re doing quantitative research, you might be conducting statistical tests, regression analysis, or factor analysis.

Discuss any ethical issues related to your research. This might involve explaining how you obtained informed consent, how you’re protecting participants’ privacy, or how you’re managing any potential harms to participants.

7. Reliability and Validity

Discuss the steps you’ve taken to ensure the reliability and validity of your data.

• Reliability refers to the consistency of your measurements, and you might discuss how you’ve piloted your instruments or used standardized measures.
• Validity refers to the accuracy of your measurements, and you might discuss how you’ve ensured your measures reflect the concepts they’re supposed to measure.

8. Limitations

Every study has its limitations. Discuss the potential weaknesses of your chosen methods and explain any obstacles you faced in your research.

9. Conclusion

Summarize the key points of your methodology, emphasizing how it helps to address your research question or objective.

Example of Dissertation Methodology

An Example of Dissertation Methodology is as follows:

Chapter 3: Methodology

• Introduction

This chapter details the methodology adopted in this research. The study aimed to explore the relationship between stress and productivity in the workplace. A mixed-methods research design was used to collect and analyze data.

Research Design

This study adopted a mixed-methods approach, combining quantitative surveys with qualitative interviews to provide a comprehensive understanding of the research problem. The rationale for this approach is that while quantitative data can provide a broad overview of the relationships between variables, qualitative data can provide deeper insights into the nuances of these relationships.

Data Collection Methods

Quantitative Data Collection : An online self-report questionnaire was used to collect data from participants. The questionnaire consisted of two standardized scales: the Perceived Stress Scale (PSS) to measure stress levels and the Individual Work Productivity Questionnaire (IWPQ) to measure productivity. The sample consisted of 200 office workers randomly selected from various companies in the city.

Qualitative Data Collection : Semi-structured interviews were conducted with 20 participants chosen from the initial sample. The interview guide included questions about participants’ experiences with stress and how they perceived its impact on their productivity.

Data Analysis Methods

Quantitative Data Analysis : Descriptive and inferential statistics were used to analyze the survey data. Pearson’s correlation was used to examine the relationship between stress and productivity.

Qualitative Data Analysis : Interviews were transcribed and subjected to thematic analysis using NVivo software. This process allowed for identifying and analyzing patterns and themes regarding the impact of stress on productivity.

Reliability and Validity

To ensure reliability and validity, standardized measures with good psychometric properties were used. In qualitative data analysis, triangulation was employed by having two researchers independently analyze the data and then compare findings.

Ethical Considerations

All participants provided informed consent prior to their involvement in the study. They were informed about the purpose of the study, their rights as participants, and the confidentiality of their responses.

Limitations

The main limitation of this study is its reliance on self-report measures, which can be subject to biases such as social desirability bias. Moreover, the sample was drawn from a single city, which may limit the generalizability of the findings.

Where to Write Dissertation Methodology

In a dissertation or thesis, the Methodology section usually follows the Literature Review. This placement allows the Methodology to build upon the theoretical framework and existing research outlined in the Literature Review, and precedes the Results or Findings section. Here’s a basic outline of how most dissertations are structured:

• Acknowledgements
• Literature Review (or it may be interspersed throughout the dissertation)
• Methodology
• Results/Findings
• References/Bibliography

In the Methodology chapter, you will discuss the research design, data collection methods, data analysis methods, and any ethical considerations pertaining to your study. This allows your readers to understand how your research was conducted and how you arrived at your results.

Advantages of Dissertation Methodology

The dissertation methodology section plays an important role in a dissertation for several reasons. Here are some of the advantages of having a well-crafted methodology section in your dissertation:

• Clarifies Your Research Approach : The methodology section explains how you plan to tackle your research question, providing a clear plan for data collection and analysis.
• Enables Replication : A detailed methodology allows other researchers to replicate your study. Replication is an important aspect of scientific research because it provides validation of the study’s results.
• Demonstrates Rigor : A well-written methodology shows that you’ve thought critically about your research methods and have chosen the most appropriate ones for your research question. This adds credibility to your study.
• Enhances Transparency : Detailing your methods allows readers to understand the steps you took in your research. This increases the transparency of your study and allows readers to evaluate potential biases or limitations.
• Helps in Addressing Research Limitations : In your methodology section, you can acknowledge and explain the limitations of your research. This is important as it shows you understand that no research method is perfect and there are always potential weaknesses.
• Facilitates Peer Review : A detailed methodology helps peer reviewers assess the soundness of your research design. This is an important part of the publication process if you aim to publish your dissertation in a peer-reviewed journal.
• Establishes the Validity and Reliability : Your methodology section should also include a discussion of the steps you took to ensure the validity and reliability of your measurements, which is crucial for establishing the overall quality of your research.

About the author

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What is Research Methodology? Definition, Types, and Examples

Research methodology 1,2 is a structured and scientific approach used to collect, analyze, and interpret quantitative or qualitative data to answer research questions or test hypotheses. A research methodology is like a plan for carrying out research and helps keep researchers on track by limiting the scope of the research. Several aspects must be considered before selecting an appropriate research methodology, such as research limitations and ethical concerns that may affect your research.

The research methodology section in a scientific paper describes the different methodological choices made, such as the data collection and analysis methods, and why these choices were selected. The reasons should explain why the methods chosen are the most appropriate to answer the research question. A good research methodology also helps ensure the reliability and validity of the research findings. There are three types of research methodology—quantitative, qualitative, and mixed-method, which can be chosen based on the research objectives.

What is research methodology ?

A research methodology describes the techniques and procedures used to identify and analyze information regarding a specific research topic. It is a process by which researchers design their study so that they can achieve their objectives using the selected research instruments. It includes all the important aspects of research, including research design, data collection methods, data analysis methods, and the overall framework within which the research is conducted. While these points can help you understand what is research methodology, you also need to know why it is important to pick the right methodology.

Why is research methodology important?

Having a good research methodology in place has the following advantages: 3

• Helps other researchers who may want to replicate your research; the explanations will be of benefit to them.
• You can easily answer any questions about your research if they arise at a later stage.
• A research methodology provides a framework and guidelines for researchers to clearly define research questions, hypotheses, and objectives.
• It helps researchers identify the most appropriate research design, sampling technique, and data collection and analysis methods.
• A sound research methodology helps researchers ensure that their findings are valid and reliable and free from biases and errors.
• It also helps ensure that ethical guidelines are followed while conducting research.
• A good research methodology helps researchers in planning their research efficiently, by ensuring optimum usage of their time and resources.

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Types of research methodology.

There are three types of research methodology based on the type of research and the data required. 1

• Quantitative research methodology focuses on measuring and testing numerical data. This approach is good for reaching a large number of people in a short amount of time. This type of research helps in testing the causal relationships between variables, making predictions, and generalizing results to wider populations.
• Qualitative research methodology examines the opinions, behaviors, and experiences of people. It collects and analyzes words and textual data. This research methodology requires fewer participants but is still more time consuming because the time spent per participant is quite large. This method is used in exploratory research where the research problem being investigated is not clearly defined.
• Mixed-method research methodology uses the characteristics of both quantitative and qualitative research methodologies in the same study. This method allows researchers to validate their findings, verify if the results observed using both methods are complementary, and explain any unexpected results obtained from one method by using the other method.

What are the types of sampling designs in research methodology?

Sampling 4 is an important part of a research methodology and involves selecting a representative sample of the population to conduct the study, making statistical inferences about them, and estimating the characteristics of the whole population based on these inferences. There are two types of sampling designs in research methodology—probability and nonprobability.

• Probability sampling

In this type of sampling design, a sample is chosen from a larger population using some form of random selection, that is, every member of the population has an equal chance of being selected. The different types of probability sampling are:

• Systematic —sample members are chosen at regular intervals. It requires selecting a starting point for the sample and sample size determination that can be repeated at regular intervals. This type of sampling method has a predefined range; hence, it is the least time consuming.
• Stratified —researchers divide the population into smaller groups that don’t overlap but represent the entire population. While sampling, these groups can be organized, and then a sample can be drawn from each group separately.
• Cluster —the population is divided into clusters based on demographic parameters like age, sex, location, etc.
• Convenience —selects participants who are most easily accessible to researchers due to geographical proximity, availability at a particular time, etc.
• Purposive —participants are selected at the researcher’s discretion. Researchers consider the purpose of the study and the understanding of the target audience.
• Snowball —already selected participants use their social networks to refer the researcher to other potential participants.
• Quota —while designing the study, the researchers decide how many people with which characteristics to include as participants. The characteristics help in choosing people most likely to provide insights into the subject.

What are data collection methods?

During research, data are collected using various methods depending on the research methodology being followed and the research methods being undertaken. Both qualitative and quantitative research have different data collection methods, as listed below.

Qualitative research 5

• One-on-one interviews: Helps the interviewers understand a respondent’s subjective opinion and experience pertaining to a specific topic or event
• Document study/literature review/record keeping: Researchers’ review of already existing written materials such as archives, annual reports, research articles, guidelines, policy documents, etc.
• Focus groups: Constructive discussions that usually include a small sample of about 6-10 people and a moderator, to understand the participants’ opinion on a given topic.
• Qualitative observation : Researchers collect data using their five senses (sight, smell, touch, taste, and hearing).

Quantitative research 6

• Sampling: The most common type is probability sampling.
• Interviews: Commonly telephonic or done in-person.
• Observations: Structured observations are most commonly used in quantitative research. In this method, researchers make observations about specific behaviors of individuals in a structured setting.
• Document review: Reviewing existing research or documents to collect evidence for supporting the research.
• Surveys and questionnaires. Surveys can be administered both online and offline depending on the requirement and sample size.

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What are data analysis methods.

The data collected using the various methods for qualitative and quantitative research need to be analyzed to generate meaningful conclusions. These data analysis methods 7 also differ between quantitative and qualitative research.

Quantitative research involves a deductive method for data analysis where hypotheses are developed at the beginning of the research and precise measurement is required. The methods include statistical analysis applications to analyze numerical data and are grouped into two categories—descriptive and inferential.

Descriptive analysis is used to describe the basic features of different types of data to present it in a way that ensures the patterns become meaningful. The different types of descriptive analysis methods are:

• Measures of frequency (count, percent, frequency)
• Measures of central tendency (mean, median, mode)
• Measures of dispersion or variation (range, variance, standard deviation)
• Measure of position (percentile ranks, quartile ranks)

Inferential analysis is used to make predictions about a larger population based on the analysis of the data collected from a smaller population. This analysis is used to study the relationships between different variables. Some commonly used inferential data analysis methods are:

• Correlation: To understand the relationship between two or more variables.
• Cross-tabulation: Analyze the relationship between multiple variables.
• Regression analysis: Study the impact of independent variables on the dependent variable.
• Frequency tables: To understand the frequency of data.
• Analysis of variance: To test the degree to which two or more variables differ in an experiment.

Qualitative research involves an inductive method for data analysis where hypotheses are developed after data collection. The methods include:

• Content analysis: For analyzing documented information from text and images by determining the presence of certain words or concepts in texts.
• Narrative analysis: For analyzing content obtained from sources such as interviews, field observations, and surveys. The stories and opinions shared by people are used to answer research questions.
• Discourse analysis: For analyzing interactions with people considering the social context, that is, the lifestyle and environment, under which the interaction occurs.
• Grounded theory: Involves hypothesis creation by data collection and analysis to explain why a phenomenon occurred.
• Thematic analysis: To identify important themes or patterns in data and use these to address an issue.

How to choose a research methodology?

Here are some important factors to consider when choosing a research methodology: 8

• Research objectives, aims, and questions —these would help structure the research design.
• Review existing literature to identify any gaps in knowledge.
• Check the statistical requirements —if data-driven or statistical results are needed then quantitative research is the best. If the research questions can be answered based on people’s opinions and perceptions, then qualitative research is most suitable.
• Sample size —sample size can often determine the feasibility of a research methodology. For a large sample, less effort- and time-intensive methods are appropriate.
• Constraints —constraints of time, geography, and resources can help define the appropriate methodology.

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How to write a research methodology .

A research methodology should include the following components: 3,9

• Research design —should be selected based on the research question and the data required. Common research designs include experimental, quasi-experimental, correlational, descriptive, and exploratory.
• Research method —this can be quantitative, qualitative, or mixed-method.
• Reason for selecting a specific methodology —explain why this methodology is the most suitable to answer your research problem.
• Research instruments —explain the research instruments you plan to use, mainly referring to the data collection methods such as interviews, surveys, etc. Here as well, a reason should be mentioned for selecting the particular instrument.
• Sampling —this involves selecting a representative subset of the population being studied.
• Data collection —involves gathering data using several data collection methods, such as surveys, interviews, etc.
• Data analysis —describe the data analysis methods you will use once you’ve collected the data.
• Research limitations —mention any limitations you foresee while conducting your research.
• Validity and reliability —validity helps identify the accuracy and truthfulness of the findings; reliability refers to the consistency and stability of the results over time and across different conditions.
• Ethical considerations —research should be conducted ethically. The considerations include obtaining consent from participants, maintaining confidentiality, and addressing conflicts of interest.

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Frequently Asked Questions

Q1. What are the key components of research methodology?

A1. A good research methodology has the following key components:

• Research design
• Data collection procedures
• Data analysis methods
• Ethical considerations

Q2. Why is ethical consideration important in research methodology?

A2. Ethical consideration is important in research methodology to ensure the readers of the reliability and validity of the study. Researchers must clearly mention the ethical norms and standards followed during the conduct of the research and also mention if the research has been cleared by any institutional board. The following 10 points are the important principles related to ethical considerations: 10

• Participants should not be subjected to harm.
• Respect for the dignity of participants should be prioritized.
• Full consent should be obtained from participants before the study.
• Participants’ privacy should be ensured.
• Confidentiality of the research data should be ensured.
• Anonymity of individuals and organizations participating in the research should be maintained.
• The aims and objectives of the research should not be exaggerated.
• Affiliations, sources of funding, and any possible conflicts of interest should be declared.
• Communication in relation to the research should be honest and transparent.
• Misleading information and biased representation of primary data findings should be avoided.

Q3. What is the difference between methodology and method?

A3. Research methodology is different from a research method, although both terms are often confused. Research methods are the tools used to gather data, while the research methodology provides a framework for how research is planned, conducted, and analyzed. The latter guides researchers in making decisions about the most appropriate methods for their research. Research methods refer to the specific techniques, procedures, and tools used by researchers to collect, analyze, and interpret data, for instance surveys, questionnaires, interviews, etc.

Research methodology is, thus, an integral part of a research study. It helps ensure that you stay on track to meet your research objectives and answer your research questions using the most appropriate data collection and analysis tools based on your research design.

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• Research methodologies. Pfeiffer Library website. Accessed August 15, 2023. https://library.tiffin.edu/researchmethodologies/whatareresearchmethodologies
• Types of research methodology. Eduvoice website. Accessed August 16, 2023. https://eduvoice.in/types-research-methodology/
• The basics of research methodology: A key to quality research. Voxco. Accessed August 16, 2023. https://www.voxco.com/blog/what-is-research-methodology/
• Sampling methods: Types with examples. QuestionPro website. Accessed August 16, 2023. https://www.questionpro.com/blog/types-of-sampling-for-social-research/
• What is qualitative research? Methods, types, approaches, examples. Researcher.Life blog. Accessed August 15, 2023. https://researcher.life/blog/article/what-is-qualitative-research-methods-types-examples/
• What is quantitative research? Definition, methods, types, and examples. Researcher.Life blog. Accessed August 15, 2023. https://researcher.life/blog/article/what-is-quantitative-research-types-and-examples/
• Data analysis in research: Types & methods. QuestionPro website. Accessed August 16, 2023. https://www.questionpro.com/blog/data-analysis-in-research/#Data_analysis_in_qualitative_research
• Factors to consider while choosing the right research methodology. PhD Monster website. Accessed August 17, 2023. https://www.phdmonster.com/factors-to-consider-while-choosing-the-right-research-methodology/
• What is research methodology? Research and writing guides. Accessed August 14, 2023. https://paperpile.com/g/what-is-research-methodology/
• Ethical considerations. Business research methodology website. Accessed August 17, 2023. https://research-methodology.net/research-methodology/ethical-considerations/

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How to Write Research Methodology

Last Updated: May 21, 2023 Approved

This article was co-authored by Alexander Ruiz, M.Ed. and by wikiHow staff writer, Jennifer Mueller, JD . Alexander Ruiz is an Educational Consultant and the Educational Director of Link Educational Institute, a tutoring business based in Claremont, California that provides customizable educational plans, subject and test prep tutoring, and college application consulting. With over a decade and a half of experience in the education industry, Alexander coaches students to increase their self-awareness and emotional intelligence while achieving skills and the goal of achieving skills and higher education. He holds a BA in Psychology from Florida International University and an MA in Education from Georgia Southern University. wikiHow marks an article as reader-approved once it receives enough positive feedback. In this case, several readers have written to tell us that this article was helpful to them, earning it our reader-approved status. This article has been viewed 518,840 times.

The research methodology section of any academic research paper gives you the opportunity to convince your readers that your research is useful and will contribute to your field of study. An effective research methodology is grounded in your overall approach – whether qualitative or quantitative – and adequately describes the methods you used. Justify why you chose those methods over others, then explain how those methods will provide answers to your research questions. [1] X Research source

Describing Your Methods

• In your restatement, include any underlying assumptions that you're making or conditions that you're taking for granted. These assumptions will also inform the research methods you've chosen.
• Generally, state the variables you'll test and the other conditions you're controlling or assuming are equal.

• If you want to research and document measurable social trends, or evaluate the impact of a particular policy on various variables, use a quantitative approach focused on data collection and statistical analysis.
• If you want to evaluate people's views or understanding of a particular issue, choose a more qualitative approach.
• You can also combine the two. For example, you might look primarily at a measurable social trend, but also interview people and get their opinions on how that trend is affecting their lives.

• For example, if you conducted a survey, you would describe the questions included in the survey, where and how the survey was conducted (such as in person, online, over the phone), how many surveys were distributed, and how long your respondents had to complete the survey.
• Include enough detail that your study can be replicated by others in your field, even if they may not get the same results you did. [4] X Research source

• Qualitative research methods typically require more detailed explanation than quantitative methods.
• Basic investigative procedures don't need to be explained in detail. Generally, you can assume that your readers have a general understanding of common research methods that social scientists use, such as surveys or focus groups.

• For example, suppose you conducted a survey and used a couple of other research papers to help construct the questions on your survey. You would mention those as contributing sources.

Justifying Your Choice of Methods

• Describe study participants specifically, and list any inclusion or exclusion criteria you used when forming your group of participants.
• Justify the size of your sample, if applicable, and describe how this affects whether your study can be generalized to larger populations. For example, if you conducted a survey of 30 percent of the student population of a university, you could potentially apply those results to the student body as a whole, but maybe not to students at other universities.

• Reading other research papers is a good way to identify potential problems that commonly arise with various methods. State whether you actually encountered any of these common problems during your research.

• If you encountered any problems as you collected data, explain clearly the steps you took to minimize the effect that problem would have on your results.

• In some cases, this may be as simple as stating that while there were numerous studies using one method, there weren't any using your method, which caused a gap in understanding of the issue.
• For example, there may be multiple papers providing quantitative analysis of a particular social trend. However, none of these papers looked closely at how this trend was affecting the lives of people.

Connecting Your Methods to Your Research Goals

• Depending on your research questions, you may be mixing quantitative and qualitative analysis – just as you could potentially use both approaches. For example, you might do a statistical analysis, and then interpret those statistics through a particular theoretical lens.

• For example, suppose you're researching the effect of college education on family farms in rural America. While you could do interviews of college-educated people who grew up on a family farm, that would not give you a picture of the overall effect. A quantitative approach and statistical analysis would give you a bigger picture.

• If in answering your research questions, your findings have raised other questions that may require further research, state these briefly.
• You can also include here any limitations to your methods, or questions that weren't answered through your research.

• Generalization is more typically used in quantitative research. If you have a well-designed sample, you can statistically apply your results to the larger population your sample belongs to.

Template to Write Research Methodology

Community Q&A

• Organize your methodology section chronologically, starting with how you prepared to conduct your research methods, how you gathered data, and how you analyzed that data. [13] X Research source Thanks Helpful 0 Not Helpful 0
• Write your research methodology section in past tense, unless you're submitting the methodology section before the research described has been carried out. [14] X Research source Thanks Helpful 2 Not Helpful 0
• Discuss your plans in detail with your advisor or supervisor before committing to a particular methodology. They can help identify possible flaws in your study. [15] X Research source Thanks Helpful 0 Not Helpful 0

You Might Also Like

• ↑ http://expertjournals.com/how-to-write-a-research-methodology-for-your-academic-article/
• ↑ http://libguides.usc.edu/writingguide/methodology
• ↑ https://www.skillsyouneed.com/learn/dissertation-methodology.html
• ↑ https://uir.unisa.ac.za/bitstream/handle/10500/4245/05Chap%204_Research%20methodology%20and%20design.pdf
• ↑ https://elc.polyu.edu.hk/FYP/html/method.htm

About This Article

To write a research methodology, start with a section that outlines the problems or questions you'll be studying, including your hypotheses or whatever it is you're setting out to prove. Then, briefly explain why you chose to use either a qualitative or quantitative approach for your study. Next, go over when and where you conducted your research and what parameters you used to ensure you were objective. Finally, cite any sources you used to decide on the methodology for your research. To learn how to justify your choice of methods in your research methodology, scroll down! Did this summary help you? Yes No

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15 Research Methodology Examples

Research methodologies can roughly be categorized into three group: quantitative, qualitative, and mixed-methods.

• Qualitative Research : This methodology is based on obtaining deep, contextualized, non-numerical data. It can occur, for example, through open-ended questioning of research particiapnts in order to understand human behavior. It’s all about describing and analyzing subjective phenomena such as emotions or experiences.
• Quantitative Research: This methodology is rationally-based and relies heavily on numerical analysis of empirical data . With quantitative research, you aim for objectivity by creating hypotheses and testing them through experiments or surveys, which allow for statistical analyses.
• Mixed-Methods Research: Mixed-methods research combines both previous types into one project. We have more flexibility when designing our research study with mixed methods since we can use multiple approaches depending on our needs at each time. Using mixed methods can help us validate our results and offer greater predictability than just either type of methodology alone could provide.

Below are research methodologies that fit into each category.

Qualitative Research Methodologies

1. case study.

Conducts an in-depth examination of a specific case, individual, or event to understand a phenomenon.

Instead of examining a whole population for numerical trend data, case study researchers seek in-depth explanations of one event.

The benefit of case study research is its ability to elucidate overlooked details of interesting cases of a phenomenon (Busetto, Wick & Gumbinger, 2020). It offers deep insights for empathetic, reflective, and thoughtful understandings of that phenomenon.

However, case study findings aren’t transferrable to new contexts or for population-wide predictions. Instead, they inform practitioner understandings for nuanced, deep approaches to future instances (Liamputtong, 2020).

2. Grounded Theory

Grounded theory involves generating hypotheses and theories through the collection and interpretation of data (Faggiolani, n.d.). Its distinguishing features is that it doesn’t test a hypothesis generated prior to analysis, but rather generates a hypothesis or ‘theory’ that emerges from the data.

It also involves the application of inductive reasoning and is often contrasted with the hypothetico-deductive model of scientific research. This research methodology was developed by Barney Glaser and Anselm Strauss in the 1960s (Glaser & Strauss, 2009). 

The basic difference between traditional scientific approaches to research and grounded theory is that the latter begins with a question, then collects data, and the theoretical framework is said to emerge later from this data.

By contrast, scientists usually begin with an existing theoretical framework , develop hypotheses, and only then start collecting data to verify or falsify the hypotheses.

3. Ethnography

In ethnographic research , the researcher immerses themselves within the group they are studying, often for long periods of time.

This type of research aims to understand the shared beliefs, practices, and values of a particular community by immersing the researcher within the cultural group.

Although ethnographic research cannot predict or identify trends in an entire population, it can create detailed explanations of cultural practices and comparisons between social and cultural groups.

When a person conducts an ethnographic study of themselves or their own culture, it can be considered autoethnography .

Its strength lies in producing comprehensive accounts of groups of people and their interactions.

Common methods researchers use during an ethnographic study include participant observation , thick description, unstructured interviews, and field notes vignettes. These methods can provide detailed and contextualized descriptions of their subjects.

Example Study

Liquidated: An Ethnography of Wall Street by Karen Ho involves an anthropologist who embeds herself with Wall Street firms to study the culture of Wall Street bankers and how this culture affects the broader economy and world.

4. Phenomenology

Phenomenology to understand and describe individuals’ lived experiences concerning a specific phenomenon.

As a research methodology typically used in the social sciences , phenomenology involves the study of social reality as a product of intersubjectivity (the intersection of people’s cognitive perspectives) (Zahavi & Overgaard, n.d.).

This philosophical approach was first developed by Edmund Husserl.

5. Narrative Research

Narrative research explores personal stories and experiences to understand their meanings and interpretations.

It is also known as narrative inquiry and narrative analysis(Riessman, 1993).

This approach to research uses qualitative material like journals, field notes, letters, interviews, texts, photos, etc., as its data.

It is aimed at understanding the way people create meaning through narratives (Clandinin & Connelly, 2004).

6. Discourse Analysis

A discourse analysis examines the structure, patterns, and functions of language in context to understand how the text produces social constructs.

This methodology is common in critical theory , poststructuralism , and postmodernism. Its aim is to understand how language constructs discourses (roughly interpreted as “ways of thinking and constructing knowledge”).

As a qualitative methodology , its focus is on developing themes through close textual analysis rather than using numerical methods. Common methods for extracting data include semiotics and linguistic analysis.

7. Action Research

Action research involves researchers working collaboratively with stakeholders to address problems, develop interventions, and evaluate effectiveness.

Action research is a methodology and philosophy of research that is common in the social sciences.

The term was first coined in 1944 by Kurt Lewin, a German-American psychologist who also introduced applied research and group communication (Altrichter & Gstettner, 1993).

Lewin originally defined action research as involving two primary processes: taking action and doing research (Lewin, 1946).

Action research involves planning, action, and information-seeking about the result of the action.

Since Lewin’s original formulation, many different theoretical approaches to action research have been developed. These include action science, participatory action research, cooperative inquiry, and living educational theory among others.

Using Digital Sandbox Gaming to Improve Creativity Within Boys’ Writing (Ellison & Drew, 2019) is a study conducted by a school teacher who used video games to help teach his students English. It involved action research, where he interviewed his students to see if the use of games as stimuli for storytelling helped draw them into the learning experience, and iterated on his teaching style based on their feedback (disclaimer: I am the second author of this study).

See More: Examples of Qualitative Research

Quantitative Research Methodologies

8. experimental design.

As the name suggests, this type of research is based on testing hypotheses in experimental settings by manipulating variables and observing their effects on other variables.

The main benefit lies in its ability to manipulate specific variables to determine their effect on outcomes which is a great method for those looking for causational links in their research.

This is common, for example, in high-school science labs, where students are asked to introduce a variable into a setting in order to examine its effect.

9. Non-Experimental Design

Non-experimental design observes and measures associations between variables without manipulating them.

It can take, for example, the form of a ‘fly on the wall’ observation of a phenomenon, allowing researchers to examine authentic settings and changes that occur naturally in the environment.

10. Cross-Sectional Design

Cross-sectional design involves analyzing variables pertaining to a specific time period and at that exact moment.

This approach allows for an extensive examination and comparison of distinct and independent subjects, thereby offering advantages over qualitative methodologies such as case studies or surveys.

While cross-sectional design can be extremely useful in taking a ‘snapshot in time’, as a standalone method, it is not useful for examining changes in subjects after an intervention. The next methodology addresses this issue.

The prime example of this type of study is a census. A population census is mailed out to every house in the country, and each household must complete the census on the same evening. This allows the government to gather a snapshot of the nation’s demographics, beliefs, religion, and so on.

11. Longitudinal Design

Longitudinal research gathers data from the same subjects over an extended period to analyze changes and development.

In contrast to cross-sectional tactics, longitudinal designs examine variables more than once, over a pre-determined time span, allowing for multiple data points to be taken at different times.

A cross-sectional design is also useful for examining cohort effects , by comparing differences or changes in multiple different generations’ beliefs over time.

With multiple data points collected over extended periods ,it’s possible to examine continuous changes within things like population dynamics or consumer behavior. This makes detailed analysis of change possible.

12. Quasi-Experimental Design

Quasi-experimental design involves manipulating variables for analysis, but uses pre-existing groups of subjects rather than random groups.

Because the groups of research participants already exist, they cannot be randomly assigned to a cohort as with a true experimental design study. This makes inferring a causal relationship more difficult, but is nonetheless often more feasible in real-life settings.

Quasi-experimental designs are generally considered inferior to true experimental designs.

13. Correlational Research

Correlational research examines the relationships between two or more variables, determining the strength and direction of their association.

Similar to quasi-experimental methods, this type of research focuses on relationship differences between variables.

This approach provides a fast and easy way to make initial hypotheses based on either positive or negative correlation trends that can be observed within dataset.

Methods used for data analysis may include statistic correlations such as Pearson’s or Spearman’s.

Mixed-Methods Research Methodologies

14. sequential explanatory design (quan→qual).

This methodology involves conducting quantitative analysis first, then supplementing it with a qualitative study.

It begins by collecting quantitative data that is then analyzed to determine any significant patterns or trends.

Secondly, qualitative methods are employed. Their intent is to help interpret and expand the quantitative results.

This offers greater depth into understanding both large and smaller aspects of research questions being addressed.

The rationale behind this approach is to ensure that your data collection generates richer context for gaining insight into the particular issue across different levels, integrating in one study, qualitative exploration as well as statistical procedures.

15. Sequential Exploratory Design (QUAL→QUAN)

This methodology goes in the other direction, starting with qualitative analysis and ending with quantitative analysis.

It starts with qualitative research that delves deeps into complex areas and gathers rich information through interviewing or observing participants.

After this stage of exploration comes to an end, quantitative techniques are used to analyze the collected data through inferential statistics.

The idea is that a qualitative study can arm the researchers with a strong hypothesis testing framework, which they can then apply to a larger sample size using qualitative methods.

When I first took research classes, I had a lot of trouble distinguishing between methodologies and methods.

The key is to remember that the methodology sets the direction, while the methods are the specific tools to be used. A good analogy is transport: first you need to choose a mode (public transport, private transport, motorized transit, non-motorized transit), then you can choose a tool (bus, car, bike, on foot).

While research methodologies can be split into three types, each type has many different nuanced methodologies that can be chosen, before you then choose the methods – or tools – to use in the study. Each has its own strengths and weaknesses, so choose wisely!

Altrichter, H., & Gstettner, P. (1993). Action Research: A closed chapter in the history of German social science? Educational Action Research , 1 (3), 329–360. https://doi.org/10.1080/0965079930010302

Audi, R. (1999). The Cambridge dictionary of philosophy . Cambridge ; New York : Cambridge University Press. http://archive.org/details/cambridgediction00audi

Clandinin, D. J., & Connelly, F. M. (2004). Narrative Inquiry: Experience and Story in Qualitative Research . John Wiley & Sons.

Creswell, J. W. (2008). Educational Research: Planning, Conducting, and Evaluating Quantitative and Qualitative Research . Pearson/Merrill Prentice Hall.

Faggiolani, C. (n.d.). Perceived Identity: Applying Grounded Theory in Libraries . https://doi.org/10.4403/jlis.it-4592

Gauch, H. G. (2002). Scientific Method in Practice . Cambridge University Press.

Glaser, B. G., & Strauss, A. L. (2009). The Discovery of Grounded Theory: Strategies for Qualitative Research . Transaction Publishers.

Kothari, C. R. (2004). Research Methodology: Methods and Techniques . New Age International.

Kuada, J. (2012). Research Methodology: A Project Guide for University Students . Samfundslitteratur.

Lewin, K. (1946). Action research and minority problems. Journal of Social Issues , 2,  4 , 34–46. https://doi.org/10.1111/j.1540-4560.1946.tb02295.x

Mills, J., Bonner, A., & Francis, K. (2006). The Development of Constructivist Grounded Theory. International Journal of Qualitative Methods , 5 (1), 25–35. https://doi.org/10.1177/160940690600500103

Mingers, J., & Willcocks, L. (2017). An integrative semiotic methodology for IS research. Information and Organization , 27 (1), 17–36. https://doi.org/10.1016/j.infoandorg.2016.12.001

OECD. (2015). Frascati Manual 2015: Guidelines for Collecting and Reporting Data on Research and Experimental Development . Organisation for Economic Co-operation and Development. https://www.oecd-ilibrary.org/science-and-technology/frascati-manual-2015_9789264239012-en

Peirce, C. S. (1992). The Essential Peirce, Volume 1: Selected Philosophical Writings (1867–1893) . Indiana University Press.

Reese, W. L. (1980). Dictionary of Philosophy and Religion: Eastern and Western Thought . Humanities Press.

Riessman, C. K. (1993). Narrative analysis . Sage Publications, Inc.

Saussure, F. de, & Riedlinger, A. (1959). Course in General Linguistics . Philosophical Library.

Thomas, C. G. (2021). Research Methodology and Scientific Writing . Springer Nature.

Zahavi, D., & Overgaard, S. (n.d.). Phenomenological Sociology—The Subjectivity of Everyday Life .

Tio Gabunia (B.Arch, M.Arch)

Tio Gabunia is an academic writer and architect based in Tbilisi. He has studied architecture, design, and urban planning at the Georgian Technical University and the University of Lisbon. He has worked in these fields in Georgia, Portugal, and France. Most of Tio’s writings concern philosophy. Other writings include architecture, sociology, urban planning, and economics.

• Tio Gabunia (B.Arch, M.Arch) #molongui-disabled-link 6 Types of Societies (With 21 Examples)
• Tio Gabunia (B.Arch, M.Arch) #molongui-disabled-link 25 Public Health Policy Examples
• Tio Gabunia (B.Arch, M.Arch) #molongui-disabled-link 15 Cultural Differences Examples
• Tio Gabunia (B.Arch, M.Arch) #molongui-disabled-link Social Interaction Types & Examples (Sociology)

Chris Drew (PhD)

Dr. Chris Drew is the founder of the Helpful Professor. He holds a PhD in education and has published over 20 articles in scholarly journals. He is the former editor of the Journal of Learning Development in Higher Education. [Image Descriptor: Photo of Chris]

• Chris Drew (PhD) https://helpfulprofessor.com/author/chris-drew-phd/ 5 Top Tips for Succeeding at University
• Chris Drew (PhD) https://helpfulprofessor.com/author/chris-drew-phd/ 50 Durable Goods Examples
• Chris Drew (PhD) https://helpfulprofessor.com/author/chris-drew-phd/ 100 Consumer Goods Examples
• Chris Drew (PhD) https://helpfulprofessor.com/author/chris-drew-phd/ 30 Globalization Pros and Cons

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Writing Survey Questions

Perhaps the most important part of the survey process is the creation of questions that accurately measure the opinions, experiences and behaviors of the public. Accurate random sampling will be wasted if the information gathered is built on a shaky foundation of ambiguous or biased questions. Creating good measures involves both writing good questions and organizing them to form the questionnaire.

Questionnaire design is a multistage process that requires attention to many details at once. Designing the questionnaire is complicated because surveys can ask about topics in varying degrees of detail, questions can be asked in different ways, and questions asked earlier in a survey may influence how people respond to later questions. Researchers are also often interested in measuring change over time and therefore must be attentive to how opinions or behaviors have been measured in prior surveys.

Surveyors may conduct pilot tests or focus groups in the early stages of questionnaire development in order to better understand how people think about an issue or comprehend a question. Pretesting a survey is an essential step in the questionnaire design process to evaluate how people respond to the overall questionnaire and specific questions, especially when questions are being introduced for the first time.

For many years, surveyors approached questionnaire design as an art, but substantial research over the past forty years has demonstrated that there is a lot of science involved in crafting a good survey questionnaire. Here, we discuss the pitfalls and best practices of designing questionnaires.

Question development

There are several steps involved in developing a survey questionnaire. The first is identifying what topics will be covered in the survey. For Pew Research Center surveys, this involves thinking about what is happening in our nation and the world and what will be relevant to the public, policymakers and the media. We also track opinion on a variety of issues over time so we often ensure that we update these trends on a regular basis to better understand whether people’s opinions are changing.

At Pew Research Center, questionnaire development is a collaborative and iterative process where staff meet to discuss drafts of the questionnaire several times over the course of its development. We frequently test new survey questions ahead of time through qualitative research methods such as  focus groups , cognitive interviews, pretesting (often using an  online, opt-in sample ), or a combination of these approaches. Researchers use insights from this testing to refine questions before they are asked in a production survey, such as on the ATP.

Measuring change over time

Many surveyors want to track changes over time in people’s attitudes, opinions and behaviors. To measure change, questions are asked at two or more points in time. A cross-sectional design surveys different people in the same population at multiple points in time. A panel, such as the ATP, surveys the same people over time. However, it is common for the set of people in survey panels to change over time as new panelists are added and some prior panelists drop out. Many of the questions in Pew Research Center surveys have been asked in prior polls. Asking the same questions at different points in time allows us to report on changes in the overall views of the general public (or a subset of the public, such as registered voters, men or Black Americans), or what we call “trending the data”.

When measuring change over time, it is important to use the same question wording and to be sensitive to where the question is asked in the questionnaire to maintain a similar context as when the question was asked previously (see  question wording  and  question order  for further information). All of our survey reports include a topline questionnaire that provides the exact question wording and sequencing, along with results from the current survey and previous surveys in which we asked the question.

The Center’s transition from conducting U.S. surveys by live telephone interviewing to an online panel (around 2014 to 2020) complicated some opinion trends, but not others. Opinion trends that ask about sensitive topics (e.g., personal finances or attending religious services ) or that elicited volunteered answers (e.g., “neither” or “don’t know”) over the phone tended to show larger differences than other trends when shifting from phone polls to the online ATP. The Center adopted several strategies for coping with changes to data trends that may be related to this change in methodology. If there is evidence suggesting that a change in a trend stems from switching from phone to online measurement, Center reports flag that possibility for readers to try to head off confusion or erroneous conclusions.

Open- and closed-ended questions

One of the most significant decisions that can affect how people answer questions is whether the question is posed as an open-ended question, where respondents provide a response in their own words, or a closed-ended question, where they are asked to choose from a list of answer choices.

For example, in a poll conducted after the 2008 presidential election, people responded very differently to two versions of the question: “What one issue mattered most to you in deciding how you voted for president?” One was closed-ended and the other open-ended. In the closed-ended version, respondents were provided five options and could volunteer an option not on the list.

When explicitly offered the economy as a response, more than half of respondents (58%) chose this answer; only 35% of those who responded to the open-ended version volunteered the economy. Moreover, among those asked the closed-ended version, fewer than one-in-ten (8%) provided a response other than the five they were read. By contrast, fully 43% of those asked the open-ended version provided a response not listed in the closed-ended version of the question. All of the other issues were chosen at least slightly more often when explicitly offered in the closed-ended version than in the open-ended version. (Also see  “High Marks for the Campaign, a High Bar for Obama”  for more information.)

Researchers will sometimes conduct a pilot study using open-ended questions to discover which answers are most common. They will then develop closed-ended questions based off that pilot study that include the most common responses as answer choices. In this way, the questions may better reflect what the public is thinking, how they view a particular issue, or bring certain issues to light that the researchers may not have been aware of.

When asking closed-ended questions, the choice of options provided, how each option is described, the number of response options offered, and the order in which options are read can all influence how people respond. One example of the impact of how categories are defined can be found in a Pew Research Center poll conducted in January 2002. When half of the sample was asked whether it was “more important for President Bush to focus on domestic policy or foreign policy,” 52% chose domestic policy while only 34% said foreign policy. When the category “foreign policy” was narrowed to a specific aspect – “the war on terrorism” – far more people chose it; only 33% chose domestic policy while 52% chose the war on terrorism.

In most circumstances, the number of answer choices should be kept to a relatively small number – just four or perhaps five at most – especially in telephone surveys. Psychological research indicates that people have a hard time keeping more than this number of choices in mind at one time. When the question is asking about an objective fact and/or demographics, such as the religious affiliation of the respondent, more categories can be used. In fact, they are encouraged to ensure inclusivity. For example, Pew Research Center’s standard religion questions include more than 12 different categories, beginning with the most common affiliations (Protestant and Catholic). Most respondents have no trouble with this question because they can expect to see their religious group within that list in a self-administered survey.

In addition to the number and choice of response options offered, the order of answer categories can influence how people respond to closed-ended questions. Research suggests that in telephone surveys respondents more frequently choose items heard later in a list (a “recency effect”), and in self-administered surveys, they tend to choose items at the top of the list (a “primacy” effect).

Because of concerns about the effects of category order on responses to closed-ended questions, many sets of response options in Pew Research Center’s surveys are programmed to be randomized to ensure that the options are not asked in the same order for each respondent. Rotating or randomizing means that questions or items in a list are not asked in the same order to each respondent. Answers to questions are sometimes affected by questions that precede them. By presenting questions in a different order to each respondent, we ensure that each question gets asked in the same context as every other question the same number of times (e.g., first, last or any position in between). This does not eliminate the potential impact of previous questions on the current question, but it does ensure that this bias is spread randomly across all of the questions or items in the list. For instance, in the example discussed above about what issue mattered most in people’s vote, the order of the five issues in the closed-ended version of the question was randomized so that no one issue appeared early or late in the list for all respondents. Randomization of response items does not eliminate order effects, but it does ensure that this type of bias is spread randomly.

Questions with ordinal response categories – those with an underlying order (e.g., excellent, good, only fair, poor OR very favorable, mostly favorable, mostly unfavorable, very unfavorable) – are generally not randomized because the order of the categories conveys important information to help respondents answer the question. Generally, these types of scales should be presented in order so respondents can easily place their responses along the continuum, but the order can be reversed for some respondents. For example, in one of Pew Research Center’s questions about abortion, half of the sample is asked whether abortion should be “legal in all cases, legal in most cases, illegal in most cases, illegal in all cases,” while the other half of the sample is asked the same question with the response categories read in reverse order, starting with “illegal in all cases.” Again, reversing the order does not eliminate the recency effect but distributes it randomly across the population.

Question wording

The choice of words and phrases in a question is critical in expressing the meaning and intent of the question to the respondent and ensuring that all respondents interpret the question the same way. Even small wording differences can substantially affect the answers people provide.

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An example of a wording difference that had a significant impact on responses comes from a January 2003 Pew Research Center survey. When people were asked whether they would “favor or oppose taking military action in Iraq to end Saddam Hussein’s rule,” 68% said they favored military action while 25% said they opposed military action. However, when asked whether they would “favor or oppose taking military action in Iraq to end Saddam Hussein’s rule  even if it meant that U.S. forces might suffer thousands of casualties, ” responses were dramatically different; only 43% said they favored military action, while 48% said they opposed it. The introduction of U.S. casualties altered the context of the question and influenced whether people favored or opposed military action in Iraq.

There has been a substantial amount of research to gauge the impact of different ways of asking questions and how to minimize differences in the way respondents interpret what is being asked. The issues related to question wording are more numerous than can be treated adequately in this short space, but below are a few of the important things to consider:

First, it is important to ask questions that are clear and specific and that each respondent will be able to answer. If a question is open-ended, it should be evident to respondents that they can answer in their own words and what type of response they should provide (an issue or problem, a month, number of days, etc.). Closed-ended questions should include all reasonable responses (i.e., the list of options is exhaustive) and the response categories should not overlap (i.e., response options should be mutually exclusive). Further, it is important to discern when it is best to use forced-choice close-ended questions (often denoted with a radio button in online surveys) versus “select-all-that-apply” lists (or check-all boxes). A 2019 Center study found that forced-choice questions tend to yield more accurate responses, especially for sensitive questions.  Based on that research, the Center generally avoids using select-all-that-apply questions.

It is also important to ask only one question at a time. Questions that ask respondents to evaluate more than one concept (known as double-barreled questions) – such as “How much confidence do you have in President Obama to handle domestic and foreign policy?” – are difficult for respondents to answer and often lead to responses that are difficult to interpret. In this example, it would be more effective to ask two separate questions, one about domestic policy and another about foreign policy.

In general, questions that use simple and concrete language are more easily understood by respondents. It is especially important to consider the education level of the survey population when thinking about how easy it will be for respondents to interpret and answer a question. Double negatives (e.g., do you favor or oppose  not  allowing gays and lesbians to legally marry) or unfamiliar abbreviations or jargon (e.g., ANWR instead of Arctic National Wildlife Refuge) can result in respondent confusion and should be avoided.

Similarly, it is important to consider whether certain words may be viewed as biased or potentially offensive to some respondents, as well as the emotional reaction that some words may provoke. For example, in a 2005 Pew Research Center survey, 51% of respondents said they favored “making it legal for doctors to give terminally ill patients the means to end their lives,” but only 44% said they favored “making it legal for doctors to assist terminally ill patients in committing suicide.” Although both versions of the question are asking about the same thing, the reaction of respondents was different. In another example, respondents have reacted differently to questions using the word “welfare” as opposed to the more generic “assistance to the poor.” Several experiments have shown that there is much greater public support for expanding “assistance to the poor” than for expanding “welfare.”

We often write two versions of a question and ask half of the survey sample one version of the question and the other half the second version. Thus, we say we have two  forms  of the questionnaire. Respondents are assigned randomly to receive either form, so we can assume that the two groups of respondents are essentially identical. On questions where two versions are used, significant differences in the answers between the two forms tell us that the difference is a result of the way we worded the two versions.

One of the most common formats used in survey questions is the “agree-disagree” format. In this type of question, respondents are asked whether they agree or disagree with a particular statement. Research has shown that, compared with the better educated and better informed, less educated and less informed respondents have a greater tendency to agree with such statements. This is sometimes called an “acquiescence bias” (since some kinds of respondents are more likely to acquiesce to the assertion than are others). This behavior is even more pronounced when there’s an interviewer present, rather than when the survey is self-administered. A better practice is to offer respondents a choice between alternative statements. A Pew Research Center experiment with one of its routinely asked values questions illustrates the difference that question format can make. Not only does the forced choice format yield a very different result overall from the agree-disagree format, but the pattern of answers between respondents with more or less formal education also tends to be very different.

One other challenge in developing questionnaires is what is called “social desirability bias.” People have a natural tendency to want to be accepted and liked, and this may lead people to provide inaccurate answers to questions that deal with sensitive subjects. Research has shown that respondents understate alcohol and drug use, tax evasion and racial bias. They also may overstate church attendance, charitable contributions and the likelihood that they will vote in an election. Researchers attempt to account for this potential bias in crafting questions about these topics. For instance, when Pew Research Center surveys ask about past voting behavior, it is important to note that circumstances may have prevented the respondent from voting: “In the 2012 presidential election between Barack Obama and Mitt Romney, did things come up that kept you from voting, or did you happen to vote?” The choice of response options can also make it easier for people to be honest. For example, a question about church attendance might include three of six response options that indicate infrequent attendance. Research has also shown that social desirability bias can be greater when an interviewer is present (e.g., telephone and face-to-face surveys) than when respondents complete the survey themselves (e.g., paper and web surveys).

Lastly, because slight modifications in question wording can affect responses, identical question wording should be used when the intention is to compare results to those from earlier surveys. Similarly, because question wording and responses can vary based on the mode used to survey respondents, researchers should carefully evaluate the likely effects on trend measurements if a different survey mode will be used to assess change in opinion over time.

Question order

Once the survey questions are developed, particular attention should be paid to how they are ordered in the questionnaire. Surveyors must be attentive to how questions early in a questionnaire may have unintended effects on how respondents answer subsequent questions. Researchers have demonstrated that the order in which questions are asked can influence how people respond; earlier questions can unintentionally provide context for the questions that follow (these effects are called “order effects”).

One kind of order effect can be seen in responses to open-ended questions. Pew Research Center surveys generally ask open-ended questions about national problems, opinions about leaders and similar topics near the beginning of the questionnaire. If closed-ended questions that relate to the topic are placed before the open-ended question, respondents are much more likely to mention concepts or considerations raised in those earlier questions when responding to the open-ended question.

For closed-ended opinion questions, there are two main types of order effects: contrast effects ( where the order results in greater differences in responses), and assimilation effects (where responses are more similar as a result of their order).

An example of a contrast effect can be seen in a Pew Research Center poll conducted in October 2003, a dozen years before same-sex marriage was legalized in the U.S. That poll found that people were more likely to favor allowing gays and lesbians to enter into legal agreements that give them the same rights as married couples when this question was asked after one about whether they favored or opposed allowing gays and lesbians to marry (45% favored legal agreements when asked after the marriage question, but 37% favored legal agreements without the immediate preceding context of a question about same-sex marriage). Responses to the question about same-sex marriage, meanwhile, were not significantly affected by its placement before or after the legal agreements question.

Another experiment embedded in a December 2008 Pew Research Center poll also resulted in a contrast effect. When people were asked “All in all, are you satisfied or dissatisfied with the way things are going in this country today?” immediately after having been asked “Do you approve or disapprove of the way George W. Bush is handling his job as president?”; 88% said they were dissatisfied, compared with only 78% without the context of the prior question.

Responses to presidential approval remained relatively unchanged whether national satisfaction was asked before or after it. A similar finding occurred in December 2004 when both satisfaction and presidential approval were much higher (57% were dissatisfied when Bush approval was asked first vs. 51% when general satisfaction was asked first).

Several studies also have shown that asking a more specific question before a more general question (e.g., asking about happiness with one’s marriage before asking about one’s overall happiness) can result in a contrast effect. Although some exceptions have been found, people tend to avoid redundancy by excluding the more specific question from the general rating.

Assimilation effects occur when responses to two questions are more consistent or closer together because of their placement in the questionnaire. We found an example of an assimilation effect in a Pew Research Center poll conducted in November 2008 when we asked whether Republican leaders should work with Obama or stand up to him on important issues and whether Democratic leaders should work with Republican leaders or stand up to them on important issues. People were more likely to say that Republican leaders should work with Obama when the question was preceded by the one asking what Democratic leaders should do in working with Republican leaders (81% vs. 66%). However, when people were first asked about Republican leaders working with Obama, fewer said that Democratic leaders should work with Republican leaders (71% vs. 82%).

The order questions are asked is of particular importance when tracking trends over time. As a result, care should be taken to ensure that the context is similar each time a question is asked. Modifying the context of the question could call into question any observed changes over time (see  measuring change over time  for more information).

A questionnaire, like a conversation, should be grouped by topic and unfold in a logical order. It is often helpful to begin the survey with simple questions that respondents will find interesting and engaging. Throughout the survey, an effort should be made to keep the survey interesting and not overburden respondents with several difficult questions right after one another. Demographic questions such as income, education or age should not be asked near the beginning of a survey unless they are needed to determine eligibility for the survey or for routing respondents through particular sections of the questionnaire. Even then, it is best to precede such items with more interesting and engaging questions. One virtue of survey panels like the ATP is that demographic questions usually only need to be asked once a year, not in each survey.

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• Open access
• Published: 19 April 2024

Asparagine reduces the risk of schizophrenia: a bidirectional two-sample mendelian randomization study of aspartate, asparagine and schizophrenia

• Huang-Hui Liu 1 , 2   na1 ,
• Yao Gao 1 , 2   na1 ,
• Dan Xu 1 , 2 ,
• Xin-Zhe Du 1 , 2 ,
• Si-Meng Wei 1 , 2 ,
• Jian-Zhen Hu 1 , 2 ,
• Yong Xu 1 , 2 &
• Liu Sha 1 , 2  

BMC Psychiatry volume  24 , Article number:  299 ( 2024 ) Cite this article

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Despite ongoing research, the underlying causes of schizophrenia remain unclear. Aspartate and asparagine, essential amino acids, have been linked to schizophrenia in recent studies, but their causal relationship is still unclear. This study used a bidirectional two-sample Mendelian randomization (MR) method to explore the causal relationship between aspartate and asparagine with schizophrenia.

This study employed summary data from genome-wide association studies (GWAS) conducted on European populations to examine the correlation between aspartate and asparagine with schizophrenia. In order to investigate the causal effects of aspartate and asparagine on schizophrenia, this study conducted a two-sample bidirectional MR analysis using genetic factors as instrumental variables.

No causal relationship was found between aspartate and schizophrenia, with an odds ratio (OR) of 1.221 (95%CI: 0.483–3.088, P -value = 0.674). Reverse MR analysis also indicated that no causal effects were found between schizophrenia and aspartate, with an OR of 0.999 (95%CI: 0.987–1.010, P -value = 0.841). There is a negative causal relationship between asparagine and schizophrenia, with an OR of 0.485 (95%CI: 0.262-0.900, P -value = 0.020). Reverse MR analysis indicates that there is no causal effect between schizophrenia and asparagine, with an OR of 1.005(95%CI: 0.999–1.011, P -value = 0.132).

This study suggests that there may be a potential risk reduction for schizophrenia with increased levels of asparagine, while also indicating the absence of a causal link between elevated or diminished levels of asparagine in individuals diagnosed with schizophrenia. There is no potential causal relationship between aspartate and schizophrenia, whether prospective or reverse MR. However, it is important to note that these associations necessitate additional research for further validation.

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Introduction

Schizophrenia is a serious psychiatric illness that affects 0.5 -1% of the global population [ 1 ]. The burden of mental illness was estimated to account for 7% of all diseases worldwide in 2016, and nearly 20% of all years lived with disability [ 2 ]. The characteristics of schizophrenia are positive symptoms, negative symptoms, and cognitive symptoms, which are often severe functional impairments and significant social maladaptations for patients suffering from schizophrenia [ 3 ]. It is still unclear what causes schizophrenia and what the pathogenesis is. There are a number of hypotheses based on neurochemical mechanisms, including dopaminergic and glutamatergic systems [ 4 ]. Although schizophrenia research has made significant advances in the past, further insight into its mechanisms and causes is still needed.

Association genetics research and genome-wide association studies have successfully identified more than 24 candidate genes that serve as molecular biomarkers for the susceptibility to treatment- refractory schizophrenia (TRS). It is worth noting that some proteins in these genes are related to glutamate transfer, especially the N-methyl-D-aspartate receptor (NMDAR) [ 5 ]. It is thought that NMDARs are important for neural plasticity, which is the ability of the brain itself to adapt to new environments. With age, NMDAR function usually declines, which may lead to decreased plasticity, leading to learning and memory problems. Consequently, the manifestation of cognitive deficits observed in diverse pathologies, including Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease, schizophrenia, and major depression, can be attributed to the dysfunction of NMDAR [ 4 ]. There are two enantiomers of aspartate (Asp): L and D [ 6 ]. In the brain, D-aspartate (D-Asp) stimulates glutamate receptors and dopaminergic neurons through its direct NMDAR agonist action [ 7 ]. According to the glutamate theory of Sch, glutamate NMDAR dysfunction is a primary contributor to the development of this psychiatric disorder and TRS [ 8 ]. It has been shown in two autopsy studies that D-Asp of prefrontal cortex neurons in patients with schizophrenia are significantly reduced, which is related to an increased expression of D-Asp oxidase [ 9 ] or an increased activity of D-Asp oxidase [ 10 ]. Several studies in animal models and humans have shown that D-amino acids, particularly D-Ser and D-Asp [ 11 ], are able to modulate several NMDAR-dependent processes, including synaptic plasticity, brain development, cognition and brain ageing [ 12 ]. In addition, D-Asp is synthesized in hippocampal and prefrontal cortex neurons, which play an important role in the development of schizophrenia [ 13 ]. It has been reported that the precursor substance of asparagine (Asn), aspartate, activates the N-methyl-D-aspartate receptor [ 14 ]. Asparagine is essential for the survival of all cells [ 15 ], and it was decreased in schizophrenia patients [ 16 ]. Asparagine can cause metabolic disorders of alanine, aspartate, and glutamic acid, leading to dysfunction of the glutamine-glutamate cycle and further affecting it Gamma-Aminobutyric Acid(GABA) level [ 17 ].It is widely understood that the imbalance of GABA levels and NMDAR plays a crucial role in the pathogenesis of schizophrenia, causing neurotoxic effects, synaptic dysfunction, and cognitive impairments [ 18 ].Schizophrenic patients exhibited significantly higher levels of serum aspartate, glutamate, isoleucine, histidine and tyrosine and significantly lower concentrations of serum asparagine, tryptophan and serine [ 19 ]. Other studies have also shown that schizophrenics have higher levels of asparagine, phenylalanine, and cystine, and lower ratios of tyrosine, tryptophan, and tryptophan to competing amino acids, compared to healthy individuals [ 20 ]. Aspartate and asparagine’s association with schizophrenia is not fully understood, and their causal relationship remains unclear.

The MR method is a method that uses Mendelian independence principle to infer causality, which uses genetic variation to study the impact of exposure on outcomes. By using this approach, confounding factors in general research are overcome, and causal reasoning is provided on a reasonable temporal basis [ 21 ]. The instrumental variables for genetic variation that are chosen must adhere to three primary hypotheses: the correlation hypothesis, which posits a robust correlation between single nucleotide polymorphisms (SNPs) and exposure factors; the independence hypothesis, which asserts that SNPs are not affected by various confounding factors; the exclusivity hypothesis, which maintains that SNPs solely influence outcomes through on exposure factors. In a recent study, Mendelian randomization was used to reveal a causal connection between thyroid function and schizophrenia [ 22 ]. According to another Mendelian randomization study, physical activity is causally related to schizophrenia [ 23 ]. Therefore, this study used Mendelian randomization method to explore the causal effects of aspartate on schizophrenia and asparagine on schizophrenia.

To elucidate the causal effects of aspartate and asparagine on schizophrenia. This study used bidirectional MR analysis. In the prospective analysis of MR, the exposure factors under consideration were aspartate and asparagine, while the outcome of interest was the risk of schizophrenia. On the contrary, in the reverse MR analysis, schizophrenia was utilized as the exposure factor, with aspartate and asparagine being chosen as the outcomes.

Materials and methods

Obtaining data sources, select genetic tools closely related to aspartate or asparagine.

In this research, publicly accessible GWAS summary statistical datasets from the MR basic platform were utilized. These datasets consisted of 7721 individuals of European ancestry [ 24 ] for the exposure phenotype instrumental variable of aspartate, and 7761 individuals of European ancestry [ 24 ] for the exposure phenotype instrumental variable of asparagine.

Select genetic tools closely related to schizophrenia

Data from the MR basic platform was used in this study for GWAS summary statistics, which included 77,096 individuals of European ancestry [ 5 ], as instrumental variables related to schizophrenia exposure phenotype.

Obtaining result data

The publicly accessible GWAS summary statistical dataset for schizophrenia was utilized on the MR basic platform, with a sample size of 77096. Additionally, the summary level data for aspartate and asparagine were obtained from the publicly available GWAS summary dataset on the MR basic platform, with sample sizes of 7721 and 7761, respectively, serving as outcome variables.

Instrumental variable filtering

Eliminating linkage disequilibrium.

The selection criteria for identifying exposure related SNPs from the aggregated data of GWAS include: (1) Reaching a significance level that meets the threshold for whole genome research, expressed as P -value < 5 * 10 − 6 [ 25 ]; (2) Ensure the independence of the selected SNPs and eliminate linkage disequilibrium SNPs ( r 2  < 0.001, window size of 10000KB) [ 26 ]; (3) There are corresponding data related to the research results in the GWAS summary data.

Eliminating weak instruments

To evaluate whether the instrumental variables selected for this MR study have weak values, we calculated the F-statistic. If the F-value is greater than 10, it indicates that there are no weak instruments in this study, indicating the reliability of the study. Using the formula F =[(N-K-1)/K] × [R 2 /(1-R 2 )], where N denotes the sample size pertaining to the exposure factor, K signifies the count of instrumental variables, and R 2 denotes the proportion of variations in the exposure factor that can be elucidated by the instrumental variables.

The final instrumental variable obtained

As a result of removing linkage disequilibrium and weak instrumental variables, finally, 3 SNPs related to aspartate and 24 SNPs related to asparagine were selected for MR analysis.

Bidirectional MR analysis

Research design.

Figure  1 presents a comprehensive depiction of the overarching design employed in the MR analysis undertaken in this study. We ascertained SNPs exhibiting robust correlation with the target exposure through analysis of publicly available published data, subsequently investigating the existence of a causal association between these SNPs and the corresponding outcomes. This study conducted two bidirectional MR analyses, one prospective and reverse MR on the causal relationship between aspartate and schizophrenia, and the other prospective and reverse MR on the causal relationship between asparagine and schizophrenia.

A MR analysis of aspartate and schizophrenia (located in the upper left corner). B  MR analysis of schizophrenia and aspartate (located in the upper right corner). C  MR analysis of asparagine and schizophrenia (located in the lower left corner). D  MR analysis of schizophrenia and asparagine (located in the lower right corner)

Statistical analysis

Weighted median, weighted mode, MR Egger, and inverse variance weighting (IVW) were used to conduct a MR study. The primary research findings were derived from the results obtained through IVW, the results of sensitivity analysis using other methods to estimate causal effects are considered. Statistical significance was determined if the P -value was less than 0.05. To enhance the interpretation of the findings, this study converted the beta values obtained in to OR, accompanied by the calculation of a 95% confidence interval (CI).

Test for directional horizontal pleiotropy

This study used MR Egger intercept to test horizontal pleiotropy. If the P -value is greater than 0.05, it indicates that there is no horizontal pleiotropy in this study, meaning that instrumental variables can only regulate outcome variables through exposure factors.

Results of bidirectional MR analysis of aspartate and schizophrenia

Analysis results of aspartate and schizophrenia.

In prospective MR analysis, this study set aspartate as the exposure factor and schizophrenia as the outcome. We used 3 SNPs significantly associated with aspartate screened across the entire genome. The instrumental variables exhibited F-values exceeding 10, signifying the absence of weak instruments and thereby affirming the robustness of our findings. Through MR analysis (Fig.  2 A), we assessed the individual influence of each SNP locus on schizophrenia. The results of the IVW method indicate that no causal effect was found between aspartate and schizophrenia, with an OR of 1.221 (95%CI: 0.483–3.088, P -value = 0.674).

In addition, the analyses conducted using the weighted mode and weighted median methods yielded similar results, indicating the absence of a causal association between aspartate and schizophrenia. Furthermore, the MR Egger analysis demonstrated no statistically significant disparity in effectiveness between aspartate and schizophrenia, as evidenced by a P -value greater than 0.05 (Table  1 ; Fig.  2 B).

In order to test the reliability of the research results, this study used MR Egger intercept analysis to examine horizontal pleiotropy, and the result was P -value = 0.579 > 0.05, indicating the absence of level pleiotropy. Furthermore, a leave-one-out test was conducted to demonstrate that no single SNP had a substantial impact on the stability of the results, indicating that this study has considerable stability (Fig.  2 C). Accordingly, the MR analysis results demonstrate the conclusion that aspartate and schizophrenia do not exhibit a causal relationship.

Analysis results of schizophrenia and aspartate

Different from prospective MR studies, in reverse MR studies, schizophrenia was set as an exposure factor and aspartate was set as the outcome. Through MR analysis (Fig.  2 D), we assessed the individual influence of each SNP locus on aspartate .The results of the IVW method indicate that there is no causal effect between schizophrenia and aspartate, with an OR of 0.999(95%CI: 0.987–1.010, P -value = 0.841). Similarly, the weighted mode, weighted median methods also failed to demonstrate a causal link between schizophrenia and aspartate. Additionally, the MR Egger analysis did not reveal any statistically significant difference in effectiveness between schizophrenia and aspartate ( P -value > 0.05) (Table  1 and Fig . 2 E).

The MR Egger intercept was used to test horizontal pleiotropy, and the result was P -value = 0.226 > 0.05, proving that this study is not affected by horizontal pleiotropy. Furthermore, a leave-one-out test revealed that no individual SNP significantly influenced the robustness of the findings (Fig.  2 F).

Depicts the causal association between aspartate and schizophrenia through diverse statistical analyses, as well as the causal association between schizophrenia and aspartate through diverse statistical analyses. A The forest plot of aspartate related SNPs and schizophrenia analysis results, with the red line showing the MR Egger test and IVW method. B  Scatter plot of the analysis results of aspartate and schizophrenia, with the slope indicating the strength of the causal relationship. C  Leave-one-out test of research results on aspartate and schizophrenia. D The forest plot of schizophrenia related SNPs and aspartate analysis results, with the red line showing the MR Egger test and IVW method. E  Scatter plot of the analysis results of schizophrenia and aspartate, with the slope indicating the strength of the causal relationship. F  Leave-one-out test of research results on schizophrenia and aspartate

Results of bidirectional MR analysis of asparagine and schizophrenia

Analysis results of asparagine and schizophrenia.

In prospective MR studies, we used asparagine as an exposure factor and schizophrenia as a result to investigate the potential causal relationship between them. Through a rigorous screening process, we identified 24 genome-wide significant SNPs associated with asparagine. In addition, the instrumental variable F values all exceeded 10, indicating that this study was not affected by weak instruments, thus proving the stability of the results. This study conducted MR analysis to evaluate the impact of all SNP loci on schizophrenia. (Fig.  3 A). According to the results of IVW, a causal relationship was found between asparagine and schizophrenia, and the relationship is negatively correlated, with an OR of 0.485 (95%CI: 0.262-0.900, P -value = 0.020).

The weighted median results also showed a causal relationship between asparagine and schizophrenia, and it was negatively correlated. In the weighted mode method, asparagine and schizophrenia did not have a causal relationship, while in the MR Egger method, there was no statistically significant difference in efficacy between them ( P -value > 0.05) (Table  1 ; Fig.  3 B).

In order to examine the horizontal pleiotropy, the MR Egger intercept was applied, and P -value = 0.768 > 0.05 result proves that this study is not affected by horizontal pleiotropy Furthermore, a leave-one-out test was conducted to demonstrate that no individual SNP had a substantial impact on the stability of the results, indicating that this study has good stability. (Fig.  3 C). Therefore, MR analysis shows that asparagine is inversely proportional to schizophrenia.

Analysis results of schizophrenia and asparagine

In reverse MR analysis, schizophrenia is considered an exposure factor, and asparagine is considered the result, studying the causal effects of schizophrenia and asparagine. Through MR analysis (Fig.  3 D), we assessed the individual influence of each SNP locus on s asparagine. The IVW method results indicated no potential causal relationship between schizophrenia and asparagine, with an OR of 1.005(95%CI: 0.999–1.011, P -value = 0.132). The research results of weighted mode method and weighted median method did not find a causal effects of schizophrenia and asparagine. Additionally, the MR Egger analysis did not reveal any statistically significant difference in effectiveness between schizophrenia and asparagine ( P -value > 0.05) (Table  1 ; Fig.  3 E).

In order to examine the horizontal pleiotropy, the MR Egger intercept was applied, and the result was P -value = 0.474 > 0.05, proving that this study is not affected by horizontal pleiotropy. Furthermore, a leave-one-out test was conducted to demonstrate that no individual SNP had a substantial impact on the stability of the results, indicating that this study has good stability (Fig.  3 F).

Depicts the causal association between asparagine and schizophrenia through diverse statistical analyses, as well as the causal association between schizophrenia and asparagine through diverse statistical analyses. A  The forest plot of asparagine related SNPs and schizophrenia analysis results, with the red line showing the MR Egger test and IVW method. B  Scatter plot of the analysis results of asparagine and schizophrenia, with the slope indicating the strength of the causal relationship. C Leave-one-out test of research results on asparagine and schizophrenia. D  The forest plot of schizophrenia related SNPs and asparagine analysis results, with the red line showing the MR Egger test and IVW method. E  Scatter plot of the analysis results of schizophrenia and asparagine, with the slope indicating the strength of the causal relationship. F  Leave-one-out test of research results on schizophrenia and asparagine

In this study, the MR analysis results after sensitivity analysis suggested a causal relationship between asparagine and schizophrenia, which was negatively correlated. However, the reverse MR analysis did not reveal any potential relationship between schizophrenia and asparagine, no potential causal relationship between aspartate and schizophrenia was found in both prospective and reverse MR analyses (Fig.  4 ).

Summary of results from bidirectional two-sample MR study

The levels of asparagine in schizophrenia patients decrease, according to studies [ 16 ]. Based on the findings of the Madis Parksepp research team, a continuous five-year administration of antipsychotic drugs (AP) has been observed to induce significant metabolic changes in individuals diagnosed with schizophrenia. Significantly, the concentrations of asparagine, glutamine (Gln), methionine, ornithine, and taurine have experienced a substantial rise, whereas aspartate, glutamate (Glu), and alpha-aminoadipic acid(α-AAA) levels have demonstrated a notable decline. Olanzapine (OLZ) treatment resulted in significantly lower levels of Asn compared to control mice [ 27 ]. Asn and Asp play significant roles in various biological processes within the human body, such as participating in glycoprotein synthesis and contributing to brain functionality. It is worth noting that the ammonia produced in brain tissue needs to have a rapid excretion pathway in the brain. Asn plays a crucial role in regulating cellular function within neural tissues through metabolic control. This amino acid is synthesized by the combination of Asp and ammonia, facilitated by the enzyme asparagine synthase. Additionally, the brain effectively manages ammonia elimination by producing glutamine Gln and Asn. This may be an explanation for the significant increase in Asn and Gln levels (as well as a decrease in Asp and Glu levels) during 5 years of illness and after receiving AP treatment [ 28 ]. The study by Marie Luise Rao’s team compared unmedicated schizophrenic patients, healthy individuals and patients receiving antipsychotic treatment. Unmedicated schizophrenics had higher levels of asparagine, citrulline, phenylalanine, and cysteine, while the ratios of tyrosine, tryptophan, and tryptophan to competing amino acids were significantly lower than in healthy individuals [ 29 ].

The findings of our study demonstrate an inverse association between asparagine levels and the susceptibility to schizophrenia, suggesting that asparagine may serve as a protective factor against the development of this psychiatric disorder. However, we did not find a causal relationship between schizophrenia and asparagine. Consequently, additional investigation and scholarly discourse are warranted to gain a comprehensive understanding of this complex association.

Two different autopsy studies measured D-ASP levels in two different brain samples from patients with schizophrenia and a control group [ 14 ]. The first study, which utilized a limited sample size (7–10 subjects per diagnosis), demonstrated a reduction in D-ASP levels within the prefrontal cortex (PFC) postmortem among individuals diagnosed with schizophrenia, amounting to approximately 101%. This decrease was found to be correlated with a notable elevation in D-aspartate oxidase (DDO) mRNA levels within the same cerebral region [ 30 ]. In addition, the second study was conducted on a large sample size (20 subjects/diagnosis/brain regions). The findings of this study indicated a noteworthy decrease of approximately 30% in D-ASP selectivity within the dorsal lateral PFC (DLPFC) of individuals diagnosed with schizophrenia, when compared to corresponding brain regions of individuals without schizophrenia. However, no significant reduction in D-ASP was observed in the hippocampus of patients with schizophrenia. The decrease in D-Asp content was associated with a significant increase (about 25%) in DDO enzyme activity in the DLPFC of schizophrenia patients. This observation highlights the existence of a dysfunctional metabolic process in DDO activity levels in the brains of schizophrenia patients [ 31 ].

Numerous preclinical investigations have demonstrated the influence of D-Asp on various phenotypes reliant on NMDAR, which are linked to schizophrenia. After administering D-Asp to D-Asp oxidase gene knockout mice, the abnormal neuronal pre-pulse inhibition induced by psychoactive drugs such as MK-801 and amphetamine was significantly reduced by the sustained increase in D-Asp [ 32 ]. According to a review, free amino acids, specifically D-Asp and D-Ser (D-serine), have been identified as highly effective and safe nutrients for promoting mental well-being. These amino acids not only serve as integral components of the central nervous system’s structural proteins, but also play a vital role in maintaining optimal functioning of the central nervous system. This is due to their essential role in regulating neurotransmitter levels, including dopamine, norepinephrine, serotonin, and others. For many patients with schizophrenia, a most persistent and effective improvement therapy may be supplementing amino acids, which can improve the expected therapeutic effect of AP and alleviate positive and negative symptoms of schizophrenia [ 33 ].

Numerous studies have demonstrated a plausible correlation between aspartate and schizophrenia; however, our prospective and reverse MR investigations have failed to establish a causal link between aspartate and schizophrenia. This discrepancy may be attributed to the indirect influence of aspartate on the central nervous system through the stimulation of NMDAR, necessitating further investigation to elucidate the direct relationship between aspartate and schizophrenia.

This study used a bidirectional two-sample MR analysis method to explore the causal relationship between aspartate and asparagine with schizophrenia, as well as its inverse relationship [ 34 ]. The utilization of MR analysis presents numerous benefits in the determination of causality [ 35 ]. Notably, the random allocation of alleles to gametes within this method permits the assumption of no correlation between instrumental variables and confounding factors. Consequently, this approach effectively alleviates bias stemming from confounding factors during the inference of causality. Furthermore, the study’s utilization of a substantial sample size in the GWAS summary data engenders a heightened level of confidence in the obtained results [ 36 ]. Consequently, this investigation not only advances the existing body of research on the relationship between aspartate and asparagine with schizophrenia, but also contributed to clinical treatment decisions for patients with schizophrenia.

Nevertheless, this study possesses certain limitations, as it solely relies on populations of European ancestry for both exposure and results. Consequently, it remains uncertain whether these findings can be replicated among non-European races, necessitating further investigation. In addition, in this study, whether the effects of aspartate and asparagine on schizophrenia vary by gender or age cannot be evaluated, and stratified MR analysis should be performed. Additional experimental research is imperative for a comprehensive understanding of the underlying biological mechanisms connecting aspartate and asparagine with schizophrenia.

In summary, our MR analysis found a negative correlation between asparagine and schizophrenia, indicating that asparagine reduces the risk of schizophrenia. However, there is no potential causal relationship between schizophrenia and asparagine. This study provides new ideas for the early detection of schizophrenia in the clinical setting and offers new insights into the etiology and pathogenesis of schizophrenia. Nonetheless, additional research is required to elucidate the potential mechanisms that underlie the association between aspartate and asparagine with schizophrenia.

Availability of data and materials

The datasets generated and analysed during the current study are available in the GWAS repository. https://gwas.mrcieu.ac.uk/datasets/met-a-388/ , https://gwas.mrcieu.ac.uk/datasets/met-a-638/ , https://gwas.mrcieu.ac.uk/datasets/ieu-b-42/ .

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This work was supported by the National Natural Science Foundation of China (82271546, 82301725, 81971601); National Key Research and Development Program of China (2023YFC2506201); Key Project of Science and Technology Innovation 2030 of China (2021ZD0201800, 2021ZD0201805); China Postdoctoral Science Foundation (2023M732155); Fundamental Research Program of Shanxi Province (202203021211018, 202203021212028, 202203021212038). Research Project Supported by Shanxi Scholarship Council of China (2022 − 190); Scientific Research Plan of Shanxi Health Commission (2020081, 2020SYS03,2021RC24); Shanxi Provincial Administration of Traditional Chinese Medicine (2023ZYYC2034), Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (2022L132); Shanxi Medical University School-level Doctoral Initiation Fund Project (XD2102); Youth Project of First Hospital of Shanxi Medical University (YQ2203); Doctor Fund Project of Shanxi Medical University in Shanxi Province (SD2216); Shanxi Science and Technology Innovation Talent Team (202304051001049); 136 Medical Rejuvenation Project of Shanxi Province, China; STI2030-Major Projects-2021ZD0200700. Key laboratory of Health Commission of Shanxi Province (2020SYS03);

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Huang-Hui Liu and Yao Gao contributed equally to this work.

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Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, NO.85 Jiefang Nan Road, Taiyuan, China

Huang-Hui Liu, Yao Gao, Dan Xu, Xin-Zhe Du, Si-Meng Wei, Jian-Zhen Hu, Yong Xu & Liu Sha

Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China

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Huang-Hui Liu and Yao Gao provided the concept and designed the study. Huang-Hui Liu and Yao Gao conducted the analyses and wrote the manuscript. Dan Xu, Huang-Hui Liu and Yao Gao participated in data collection. Xin-Zhe Du, Si-Meng Wei and Jian-Zhen Hu participated in the analysis of the data. Liu Sha, Yong Xu and Yao Gao revised and proof-read the manuscript. All authors contributed to the article and approved the submitted version.

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Liu, HH., Gao, Y., Xu, D. et al. Asparagine reduces the risk of schizophrenia: a bidirectional two-sample mendelian randomization study of aspartate, asparagine and schizophrenia. BMC Psychiatry 24 , 299 (2024). https://doi.org/10.1186/s12888-024-05765-5

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DOI : https://doi.org/10.1186/s12888-024-05765-5

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Astrophysics > Astrophysics of Galaxies

Title: the lockman--spreso project. main properties of infrared selected star-forming galaxies.

Abstract: Methods.We applied distinct selection criteria to attain an SFG sample with minimal AGN contamination. Multiple approaches were used to estimate the intrinsic extinction, SFR and gas-phase metallicity for the SFGs. In conjunction with findings in the literature, we examined the correlation between SFRs and stellar masses ($M_*$), as well as the metallicity evolution depending on $M_*$. Finally, the 3D relationship between $M_*$, SFR and metallicity, is also studied.} Results. From the initial spectroscopic sample of 409 FIR-selected objects from the Lockman--SpReSO catalogue, 69 (17\%) AGNs have been identified and excluded, which is nearly double the percentage found in local studies, leaving a sample of 340 SFGs. The analysis of the $M_*$--SFR relationship revealed that Lockman--SpReSO IR-selected SFGs show signs of evolution at redshifts $z>0.4$, shifting above the main sequence, with a mean value of $\sim0.4$ dex. They are located within the starburst galaxy region since 78\% of the galaxies fall into this category. In addition, no evident flattening was found in the relation to specific SFR with redshift for $\log M_* (M_\odot) \gtrsim 10.5$. In line with the $M_*$--metallicity relation (MZR) outcomes published in previous studies for optically selected SFGs, however, during the analysis of the MZR, it was found that IR-selected SFGs exhibit lower metallicities than those anticipated on the basis of their $M_*$ and redshift. During the investigation of the 3D $M_*$--SFR--metallicity relation (FP), it was established that the research sample is consistent with relations in the existing literature, with an average scatter of $\sim0.2$ dex. However, a re-calibration of the FP when using the SFR obtained from the IR luminosity is required and, in this case, no attenuation in the correlation for $\log M_* (M_\odot) \gtrsim 10.5$ is observed.

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