COMMENTS

  1. Schizophrenia Research

    The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.

  2. Schizophrenia outcomes in the 21st century: A systematic review

    1. INTRODUCTION. This paper reports a review of outcomes in schizophrenia in the twenty‐first century and is an extension of the work undertaken by the late Dr Richard Warner in his seminal book, "Recovery from Schizophrenia: Psychiatry and Political Economy" (1985 (Warner, 1985); 2004 (Warner, 2004)).The present work was started with Dr Warner's involvement, and the preliminary results ...

  3. Current Concepts and Treatments of Schizophrenia

    Schizophrenia is a debilitating mental illness which involves three groups of symptoms, i.e., positive, negative and cognitive, and has major public health implications. According to various sources, it affects up to 1% of the population. The pathomechanism of schizophrenia is not fully understood and current antipsychotics are characterized by ...

  4. Systematic literature review of schizophrenia clinical practice

    The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2009. Schizophr. Bull. 36, 94-103 (2010). Article PubMed Google Scholar ...

  5. Neurobiology of Schizophrenia: A Comprehensive Review

    Schizophrenia is a debilitating disease that presents with both positive and negative symptoms affecting cognition and emotions. Extensive studies have analyzed the different factors that contribute to the disorder. There is evidence of significant genetic etiology involving multiple genes such as dystrobrevin binding protein 1 (DTNBP1) and ...

  6. Schizophrenia in 2020: Trends in diagnosis and therapy

    The number of published studies in schizophrenia research has been rapidly increasing over the last 25 years and an analysis of medline, a relevant database of international scientific publications, shows that the increase of schizophrenia-related publications since 1990 is much larger than the increase of the total number of all research ...

  7. Research articles

    Transplantation of gut microbiota derived from patients with schizophrenia induces schizophrenia-like behaviors and dysregulated brain transcript response in mice. Nana Wei. Mingliang Ju. Yi Dong ...

  8. Thirty years of research on negative symptoms of schizophrenia: A

    1. Introduction. Negative symptoms have been considered a core symptom of schizophrenia since the late 19th century (Kraepelin, 1919), with at least two main components: a loss of motivation and a reduction of emotional expression.With the discovery of first-generation antipsychotics, research has mainly focused on treating positive symptoms that are more easily recognizable and treatable ...

  9. Schizophrenia

    Schizophrenia is a severe and debilitating psychiatric disorder that involves psychotic symptoms such as hallucinations and delusions, accompanied with regressive behaviour. Latest Research and ...

  10. (PDF) Schizophrenia: An Overview

    schizophrenia is a mental disorder that is. characterized by delusions, hallucinations, disorganized speech, grossly disorganized or. catatonic behavior, and negative symptoms. including ...

  11. Schizophrenia

    Schizophrenia, characterised by psychotic symptoms and in many cases social and occupational decline, remains an aetiological and therapeutic challenge. Contrary to popular belief, the disorder is modestly more common in men than in women. Nor is the outcome uniformly poor. A division of symptoms into positive, negative, and disorganisation syndromes is supported by factor analysis.

  12. On the Origins of Schizophrenia

    Still only about 10% of schizophrenia patients will find (or hold) gainful employment . Life expectancy in schizophrenia is reduced by almost 15 years, and this has not improved over recent decades . Patients with schizophrenia are rarely able to establish a family, at least when judged by reproductive fitness or fecundity . The reason is not ...

  13. Functioning in schizophrenia from the perspective of ...

    Schizophrenia is a severe mental disorder associated with impairment in functioning. A multidisciplinary approach is essential to help individuals with this health condition, and psychological interventions are considered a priority. The International Classification of Functioning, Disability and Health (ICF) offers a theoretical framework for assessing functioning and disability.

  14. (PDF) Schizophrenia: Epidemiology, Causes, Neurobiology

    Schizophrenia is a severe mental illness that has devastating consequences for those who suffer from the disorder. The epidemiology of schizophrenia indicates that it occurs relatively often, in ...

  15. Schizophrenia: Overview and Treatment Options

    The serotonin hypothesis for the development of schizophrenia emerged as a result of the discovery that lysergic acid diethylamide (LSD) enhanced the effects of serotonin in the brain. 1 Subsequent research led to the development of drug compounds that blocked both dopamine and serotonin receptors, in contrast to older medications, which affected only dopamine receptors.

  16. PDF Treatment outcomes in schizophrenia: qualitative study of the views of

    A qualitative study using in-depth semi-structured inter-views was conducted with self-identified'carersof a family ' member with a diagnosis of schizophrenia made at least 2 years previously. Ethical approval was obtained from NHS East of Scotland Research Ethics Service (EoSRES) REC 1 by proportionate review (Application Number 13/ ES/0143).

  17. Schizophrenia: A review of current research and thinking

    Introduction. Schizophrenia is the major mental illness of our time. It was first described by. Kraepelin (1896) as "dementia praecox" and later given the name "schizophrenia" by. Bleuler ...

  18. Model-Based Approaches to Investigating Mismatch Responses in Schizophrenia

    Here, we adopt a typology of model-based approaches from computational cognitive neuroscience, providing an overview of the study of mismatch responses and their alterations in schizophrenia from four complementary perspectives: (a) connectivity models, (b) decoding models, (c) neural network models, and (d) cognitive models.

  19. Schizophrenia

    Schizophrenia ( ) (online) npj Schizophrenia publishes high-quality research relevant to all aspects of schizophrenia and psychosis. The journal is fully open access and published in partnership ...

  20. SARS-CoV-2 infection is associated with an increase in new diagnoses of

    Amid the ongoing global repercussions of SARS-CoV-2, it is crucial to comprehend its potential long-term psychiatric effects. Several recent studies have suggested a link between COVID-19 and subsequent mental health disorders. Our investigation joins this exploration, concentrating on Schizophrenia Spectrum and Psychotic Disorders (SSPD). Different from other studies, we took acute ...

  21. PDF Schizophrenia: A Systematic Review

    Abstract. Schizophrenia is a mental disorder characterized by disruptions in thought processes, perceptions, emotional responsiveness, and social interactions. Schizophrenia affects approx. 24 million people or 1 in 300 people (0.32%) worldwide. This rate is 1 in 222 people (0.45%) among adults.

  22. Depression, Schizophrenia and Bipolar Disorder Are Linked with Ancient

    The following essay is reprinted with permission from The Conversation, an online publication covering the latest research. Around 8% of human DNA is made up of genetic sequences acquired from ...

  23. Recent advances in understanding schizophrenia

    Abstract. Schizophrenia is a highly disabling disorder whose causes remain to be better understood, and treatments have to be improved. However, several recent advances have been made in diagnosis, etiopathology, and treatment. Whereas reliability of diagnosis has improved with operational criteria, including Diagnostic and Statistical Manual ...

  24. Schizophrenia Research Paper -Research Paper Examples- iResearchNet

    Schizophrenia Research Paper. This sample schizophrenia research paper features: 6600 words (approx. 22 pages), an outline, and a bibliography with 6 sources. Browse other research paper examples for more inspiration. If you need a thorough research paper written according to all the academic standards, you can always turn to our experienced ...

  25. Did the human genome project affect research on Schizophrenia?

    Schizophrenia, thought by many to be a genetic disorder, was specifically targeted for study by the Human Genome Project.. Extensive genetic studies have identified almost 300 risk genes but no causal gene. • NIMH invested extensive resources in this research with little to show for it and at the expense of alternative research projects.. Since schizophrenia does not appear to be a genetic ...

  26. Brain cell-type shifts in Alzheimer's disease, autism, and ...

    The first consideration is the deconvolution algorithm method, which can be reference-based (supervised) or reference-free (unsupervised). The success of reference-free methods [which typically implement variations of sparse principal components analysis (PCA) or surrogate variable analysis (SVA) (10, 13)] reflects the fact that subtle differences in cell-type composition across samples drive ...

  27. Hope for People With Schizophrenia

    Recovery from psychotic disorders is possible. Public perceptions of schizophrenia lead to false conclusions about recovery outcomes. There are many factors associated with recovery in different ...

  28. Study connects genetic risk for autism to changes observed in the brain

    The research is part of a larger National Institutes of Health initiative that seeks to uncover the mechanisms behind neurodevelopmental conditions like autism and mental illnesses like schizophrenia and bipolar disorder. ... The PsychENCODE papers are presented as a collection on the Science website.

  29. Researchers identify a genetic cause of intellectual disability

    It underscores the need to look beyond coding regions, which could reveal many other genetic causes, opening new diagnostic possibilities and research opportunities." The paper is titled ...