biomedical research centre nottingham

Inside the lab leading Notts' scientific fight against Covid

It's researched different vaccines and treatments

• 04:13, 27 DEC 2021

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Throughout the pandemic, the Nottingham Biomedical Research Centre (BRC) has been helping the national effort to fight back against Covid and bring back some level of normality.

The centre was first established back in April 2017, at the same time as the Nottingham Clinical Research Facility, and both centres focus on new experimental sciences and are funded by the National Institute for Health Research.

It's all to research brand new healthcare treatments and medicines to help patients, carers and families who need them.

Since the pandemic began, like many others, the centre had to adapt and change the way it worked, and a focus on researching different areas of Covid was taken on.

The centre has worked with the University of Nottingham to trial the Oxford AstraZeneca and Valneva vaccines and deliver findings based on how well they perform on patients who wished to participate.

Oxford AstraZeneca is available in the UK, and while the UK government decided to cancel its order of Valneva vaccines earlier this year, the European Commission has approved it, meaning all European Union member states can access it from the start of next year.

In his own words, Professor Ian Hall, the director of the centre, explains its contribution to crucial Covid research into treatments, vaccines and more.

"It's easy to forget that around 18 months or so ago, there were simply no treatments for Covid.

There was this disease which resulted in lockdowns and there was no clear exit strategy of how we would get out of it.

In the BRC, there was a clear steer to refocus our efforts on Covid right from the very beginning, and the very first thing we did was to contribute to the national effort into clinical studies to find medicines to help patients that were in hospital, and we did that mostly through the recovery trial.

By recruiting large numbers, the trial rapidly led to findings that a drug called dexamethasone, which can be and is usually used to treat things like severe skin conditions, severe allergies and conditions such as lupus, was an effective treatment.

Clinical trials have now resulted in a number of other drugs that are used and are effective.

Locally, we also facilitated the hunt for a vaccine.

We worked with the University of Nottingham to deliver vaccine studies, and we were an early site for the Oxford AstraZeneca vaccine and a site for the Valneva vaccine.

It wasn't all done by ourselves, it was a consequence of contributing, as we helped in discovery work that led to us having our first vaccines for the treatment of Covid.

Vaccines really have been the way to help get out of the worst effects of the pandemic, and nationally, more than 90% of the adult population have antibodies, whether that's because of having a vaccine or having Covid.

We've also contributed through leadership roles to the national effort to try and work out what drugs to use at an earlier stage of infection.

We've been involved with government's joint committee on vaccination and immunisation, I've been on the UK Covid therapeutic advisory panel (UK-CTAP) through which we've made recommendations to the Department for Health and Social Care for drugs to go into clinical trials.

UK-CTAP has also worked with Eddie George, who's the antiviral lead appointed by government to deliver oral antivirals for use in the community.

Antivirals are medications used for treating specific infections, such as Covid in this case.

While the studies primarily took place in the USA, the UK was the first country in the world to have licenced the use of antiviral treatment for early stage Covid disease.

That means now we've got drugs we can use early when someone has the virus, and it's particularly important and helpful for those who are more clinically vulnerable and get infected.

We've also been looking into long Covid and any interventions, as around 1.2million people in the UK suffer from symptoms of it.

There's been a lot of work in Nottingham driven by the BRC through the research clinic to investigate its effects and we're looking at interventions that could help with long Covid.

We're now using samples to identify how severe cases of Covid might be identified at an early stage through blood tests taken when individuals are admitted to hospital.

We've already got samples from around 700 patients.

It's been a pretty rough 20 months or so, and I would like to thank everyone within the NHS delivering care to patients, in hospitals, in the community, and all those who helped to deliver research programmes.

There is still a lot of work to do, but we should all be extremely grateful for the efforts of healthcare professionals and everyone who has helped to deal with the pandemic.

And a massive thank you to everyone who has helped to make studies happen and the participants on the research side of things, as without that, we wouldn't have the treatments we have today."

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BioResource Centre - Nottingham is hosted by the Nottingham BRC and has recently joined our national network of centres to support recruitment of research volunteers from the local area.

The Nottingham BioResource Centre is part of the NIHR Nottingham Biomedical Research Centre (BRC), hosted by the Nottingham University Hospitals NHS Trust and partnered with the University of Nottingham .

The NIHR Nottingham BioResource Centre joined in December 2022 along with 5 additional new BioResource Centres . More details will be published soon.

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NIHR announces nearly £800m to turn research into new treatments

Published: 14 October 2022

The NIHR has awarded nearly £800 million to 20 Biomedical Research Centres across England, to translate scientific discoveries into new treatments, diagnostic tests and medical technologies to improve patients' lives.

Biomedical research in the North and Midlands gets a significant funding boost, with nearly £250 million of the funding invested outside of London, Oxford and Cambridge. A new Biomedical Research Centre has been funded in the South West, increasing the coverage of early stage research across the nation and ensuring everyone has access to cutting edge clinical trials. 

NIHR Biomedical Research Centres are partnerships between healthcare professionals and academics in the country’s leading NHS trusts and universities. The centres, part of NIHR’s research infrastructure, receive substantial levels of sustained funding to attract the best scientists and create an environment where experimental medicine can thrive. 

This fourth round of NIHR Biomedical Research Centre funding, awarded following an open and competitive process judged by international experts and members of the public, will support research over the next five years in areas such as cancer, mental health, dementia and infectious diseases. The new funding will also provide opportunities for a diverse range of professionals to undertake research, expanding research expertise in allied health professionals - such as physiotherapists, radiologists and dietitians - as well as in doctors and nurses.   

The NIHR currently funds 20 BRCs , 12 of which have received additional investment in this new funding round. Over the past nine years, the BRCs have supported almost 60,000 studies and published 55,000 research papers, as well as supported the career development of more than 14,000 junior doctors and research scientists. 

Health and Social Care Secretary and Deputy Prime Minister Thérèse Coffey said:

“The pandemic has highlighted the importance of our booming research sector and the potential it has to not only strengthen health and care services, but lead to lifesaving developments.

“This additional funding will harness the UK's world leading innovation and allow research centres up and down the country to attract experts in their field and conduct research that saves lives.

“From helping develop the Covid vaccine to discovering world-first treatments, these centres have already delivered ground-breaking research and will continue to help us tackle some of the biggest health challenges we face, including cancer, to ensure the NHS continues to deliver world-class care.”

Professor Lucy Chappell, Chief Executive of the NIHR, said: 

“Research by NIHR Biomedical Research Centres has led to a number of ground-breaking new treatments, such as new gene therapies for haemophilia and motor neurone disease, the world-first treatment for Creutzfeldt–Jakob disease, a nose-drop vaccine for whooping cough, and the first UK-wide study into the long-term impact of COVID-19.

“This latest round of funding recognises the strength of expertise underpinning health and care research across the country and gives our nation’s best researchers more opportunities to develop innovative new treatments for patients.”

A major component of the nation’s knowledge economy

The NIHR invests significantly in people, centres of excellence, collaborations, services and facilities to support health and care research in England. Collectively these form the NIHR infrastructure.

NIHR infrastructure funding supports the country’s leading experts to develop and deliver research funded by the NIHR, other public funders, charities and the life sciences industry. In doing so, its investment plays a crucial role in underpinning research in England and supporting economic growth.  

Over the past 9 years, the BRCs have leveraged nearly £9 billion of funding from external organisations to undertake experimental medicine and early translational research. The centres have collaborated with almost 3,000 small and medium-sized companies, as well as 2,000 other partners in the life sciences industry. More than 11,800 patents have been generated by BRCs and 85 spin out companies, with intellectual property from the centres generating more than £800m in revenue.

Supporting innovative research for COVID-19 and beyond 

The 20 existing BRCs have had a key role in responding to the COVID-19 pandemic. The sustained, long term funding they have received meant that resources could be mobilised quickly to help diagnose and treat COVID-19 and support vaccine research.

For example, BRC researchers have helped to understand immune responses to COVID-19 and vaccines , developed a new bedside molecular test for COVID-19 , investigated how the virus affects ethnic minority healthcare workers, and worked with Formula 1 engineers to create and roll out life-saving breathing machine to prevent patients from needing intensive care .

The impressive BRC track record of research runs over more than 15 years, with study findings improving care for patients. Researchers at the NIHR The Royal Marsden BRC showed that a one-week course of radiotherapy administered through fewer but larger daily doses was as safe and effective as standard care in women with early stage breast cancer . International guidelines subsequently recommended immediate adoption of this new approach, with the proportion of women with breast cancer receiving this new radiotherapy regimen increasing from less than 1% to 60% in a year.

Ultrasound was shown to improve detection of muscle wasting in diseases such as rheumatoid arthritis and inflammatory bowel disease , in research by the NIHR Birmingham Biomedical Research Centre. This method is now being used to assess muscle loss in a national long COVID study funded by NIHR .

Over in Newcastle, BRC researchers have launched the UK arm of a global gene therapy study in Duchenne muscular dystrophy. The study is the first time gene therapy has been given in the UK to a patient with Duchenne muscular dystrophy, a disease for which there are currently no approved treatments that target the disease itself rather than ease symptoms.

• Read more about NIHR Biomedical Research Centres

NIHR BRCs 2022-2027 

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Nottingham Biomedical Research Centre (BRC)

Improving the health of millions of people with common diseases like asthma, depression and arthritis

Imaging is at the heart of the Nottingham Biomedical Research Centre (BRC). Nottingham BRC are driving that legacy forward, bringing together the skills, expertise, facilities and data to transform research capabilities.

Nottingham BRC translate research into breakthrough treatments, new technologies and advanced medicines to meet the needs of patients, carers and families locally, nationally and internationally.

Nottingham BRC are a member of the Hearing Medicines Discovery Syndicate . You can find out more about them on  their website .

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Why Nottingham?

• Located in Nottingham University Hospitals NHS Trust, serving a catchment area of more than 4 million people
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We have more than 3000m 2 of purpose- built adult and paediatric inpatient research space, co-located with clinical specialties in one of the biggest hospitals in the UK. Our new mobile Research Unit takes research to local communities with clinic space and a fully equipped lab, adaptable for specific studies.

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Partner Institutions

Nottingham Biomedical Research Centre (BRC) is a research collaboration whose article contributions are accrued to its participating partner institutions below.

• Nottingham University Hospitals NHS Trust (NUH)
• The University of Nottingham (UoN)

Nottingham BioResource

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About the BioResource

Our aim is to improve the health of local people and to contribute to the advancement of clinical practice nationally and internationally by supporting research. Through our established and expanding collection of samples and associated health data, we support world-leading research into health and diseases.

A Human Tissue Authority Licensed Facility

The Nottingham BioResource is a Human Tissue Authority (HTA) licensed facility, which provides tissue and body fluid samples, and increasingly corresponding clinical data, for use in clinical research.

Our samples cover both rare and common diseases in children and adults treated at Nottingham University Hospitals NHS Trust, one the largest and busies teaching hospitals in the UK. This includes a population of over 2.5million local people and through our specialist services, a further 4.5million people from across the East Midlands and nationally.

We work in close collaboration with the NIHR Nottingham Biomedical Research Centre which is leading world-class research into diseases such as asthma, arthritis and liver and gastro-intestinal disease.

Our laboratories are based at Nottingham City Hospital with satellite laboratories and sample storage co-located with the NIHR Nottingham Clinical Research Facility .

The service is managed by the Research & Innovation department at Nottingham University Hospitals NHS Trust. As a department we offer a range of expertise to develop, deliver and manage every aspect of the clinical research lifecycle for NHS, academic and industry partners .

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We can provide cohorts specifically matched to research study criteria.

The Nottingham BioResource has a wide range of samples, covering diseases ranging from COVID-19 to cancers including breast, lung and liver donated thanks to the many thousands of volunteers who have agreed to provide samples for use in clinical research.

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Balancing the value and risk of exercise-based therapy post-COVID-19: a narrative review

Affiliations.

• 1 NIHR Leicester Biomedical Research Centre - Respiratory, Leicester, UK [email protected].
• 2 Department of Respiratory Sciences, University of Leicester, Leicester, UK.
• 3 Centre for Exercise and Rehabilitation Science, University Hospitals of Leicester NHS Trust, Leicester, UK.
• 4 NIHR Leicester Biomedical Research Centre - Respiratory, Leicester, UK.
• 5 Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford UK.
• 6 Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
• 7 Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
• 8 NIHR Nottingham Biomedical Research Centre, Nottingham, UK.
• 9 Respiratory Medicine, Nottingham University Hospitals, Nottingham, UK.
• PMID: 38123233
• PMCID: PMC10731468
• DOI: 10.1183/16000617.0110-2023

Coronavirus disease 2019 (COVID-19) can lead to ongoing symptoms such as breathlessness, fatigue and muscle pain, which can have a substantial impact on an individual. Exercise-based rehabilitation programmes have proven beneficial in many long-term conditions that share similar symptoms. These programmes have favourably influenced breathlessness, fatigue and pain, while also increasing functional capacity. Exercise-based rehabilitation may benefit those with ongoing symptoms following COVID-19. However, some precautions may be necessary prior to embarking on an exercise programme. Areas of concern include ongoing complex lung pathologies, such as fibrosis, cardiovascular abnormalities and fatigue, and concerns regarding post-exertional symptom exacerbation. This article addresses these concerns and proposes that an individually prescribed, symptom-titrated exercise-based intervention may be of value to individuals following infection with severe acute respiratory syndrome coronavirus 2.

Copyright ©The authors 2023.

Publication types

• Exercise Therapy / adverse effects

Grants and funding

• WT_/Wellcome Trust/United Kingdom

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